Christopher Dolinsky, MD and Christine Hill-Kayser, MD
The University of Pennsylvania Medical School
Last Modified: December 10, 2013
Lung cancer happens when cells in the lung begin to grow out of control. Large collections of cancer cells are called tumors. Lung cancer is not a single disease, but rather a collection of several diseases that are characterized by the affected cell type. Lung cancer is divided into two main categories:
The lungs can also be affected by cancer that has spread from another part of the body, called metastatic cancer. Two other types of cancer that can affect the lungs are mesothelioma, which affects the lining of the lung or abdomen, and carcinoid tumors, which can occur in the lung. These cancers will not be discussed in this article.
Smoking tobacco (currently or in the past), is the leading cause of lung cancer. However, the number of cases in non-smokers has been increasing in recent years. Other risk factors for lung cancer include exposure to radon, radiation, asbestos, and environmental pollution.
Research has found that people who are current or former heavy smokers who have a special type of CT scan done to screen for lung cancer have lung cancer detected in earlier stages and have improved survival. Speak to your healthcare provider to determine if this screening test is right for you.
Unfortunately, the early stages of lung cancer may not have any symptoms. As the tumor grows in size, it can produce a variety of symptoms including:
Many of these symptoms could be caused by a variety of problems; however, your healthcare provider needs to see you if you have any of these problems. A cough is the most common presenting symptom of lung cancer; however, many long-term smokers have a chronic cough, so it is especially important for someone with a chronic cough to see their doctor if their cough changes in character or severity.
When your healthcare provider is suspicious of a lung tumor, they may order tests to further investigate, including:
While all of these tests are important pieces of the puzzle, a biopsy is the only way to know for sure if you have cancer. A biopsy takes a sample of the suspicious area, which is examined under a microscope for the presence of cancer cells. The biopsy also determines the type of lung cancer and if there are cancer cells present in the lymph nodes. The biopsy may be done using a brochoscopy (small camera passed down your throat into the lungs) or by a surgical procedure.
A pathology report is sent to your healthcare provider, detailing if the specimen is cancer or not; and if it is cancerous, what type of tissue it arose from, what subtype of lung cancer it is, how abnormal it looks (known as the grade), and whether or not it is invading surrounding tissues. This is an important piece in planning your treatment. You can request a copy of your report for your records.
In order to guide treatment and offer some insight into prognosis, lung cancer is "staged." This stage is based on the size and location of the tumor, if there are cancer cells in the lymph nodes and if there are cancer cells found in other areas of the body.
Stages range from stage I (smallest, most confined tumors) to stage IV (tumors that have spread to other areas of the body). The stage and type of lung cancer will guide your treatment recommendations.
In general, the following treatments are used:
This article is a basic introduction to lung cancer. You can learn more about your specific type of lung cancer and it’s treatment by using the links below.
Lung Cancer Web-U-Cation Program: This video will help you learn about lung cancer, its diagnosis, staging, potential treatments and side effects. In addition, it will address coping with cancer (practical, emotional & family issues), coping with the stigma of lung cancer, and concerns surrounding work, insurance and disability.
Sep 12, 2012 - Molecular differences have been identified in small cell lung cancer and non-small cell lung cancer cell lines, which may represent potential therapeutic targets, according to a study published online Sept. 6 in Cancer Discovery.
Jul 23, 2010