Posted Date: Mar 14, 2006
Kaposi's sarcoma (KS) is a disease in which cancer (malignant) cells are found in the tissues under the skin or mucous membranes that line the mouth, nose, and anus. KS causes red or purple patches (lesions) on the skin and/or mucous membranes and spreads to other organs in the body, such as the lungs, liver, or intestinal tract.
Until the early 1980's, Kaposi's sarcoma was a very rare disease that was found mainly in older men, patients who had organ transplants, or African men. With the Acquired Immunodeficiency Syndrome (AIDS) epidemic in the early 1980's, doctors began to notice more cases of Kaposi's sarcoma in Africa and in gay men with AIDS. Kaposi's sarcoma usually spreads more quickly in these patients.
If there are signs of KS, a doctor will examine the skin and lymph nodes carefully (lymph nodes are small bean-shaped structures that are found throughout the body; they produce and store infection-fighting cells). The doctor also may order other tests to see if the patient has other diseases.
The chance of recovery (prognosis) depends on what type of Kaposi's sarcoma the patient has, the patient's age and general health, and whether or not the patient has AIDS.
Classic Kaposi's sarcoma usually occurs in older men of Jewish, Italian, or Mediterranean heritage. This type of Kaposi's sarcoma progresses slowly, sometimes over 10 to 15 years. As the disease gets worse, the lower legs may swell and the blood may not be able to flow properly. After some time, the disease may spread to other organs. Many patients with classic Kaposi's sarcoma may develop another type of cancer later on in their lives.
Kaposi's sarcoma may occur in people who are taking drugs to make their immune systems weaker (immunosuppressants). The immune system helps the body fight off infection. People who have had an organ transplant (such as a liver or kidney transplant) have to take drugs to prevent their immune system from attacking the new organ.
Kaposi's sarcoma in patients who have Acquired Immunodeficiency Syndrome (AIDS) is called epidemic Kaposi's sarcoma. AIDS is caused by a virus called the Human Immunodeficiency Virus (HIV), which attacks and weakens the immune system. Infections and other diseases can then invade the body, and the immune system cannot fight against them. Kaposi's sarcoma in people with AIDS usually spreads more quickly than other kinds of Kaposi's sarcoma and often is found in many parts of the body.
There are treatments for all patients with Kaposi's sarcoma. Four kinds of treatment are used:
Radiation therapy is a common treatment of Kaposi's sarcoma. Radiation therapy uses high-dose x-rays or other high-energy rays to kill cancer cells and shrink tumors. Radiation for Kaposi's sarcoma comes from a machine outside the body (external-beam radiation therapy).
Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in a vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells outside the original site. Chemotherapy for Kaposi's sarcoma also may be injected into the lesion (intralesional chemotherapy).
Biological therapy tries to get the body to fight the cancer. It uses materials made by the body or made in a laboratory to boost, direct, or restore the body's natural defenses against disease. Biological therapy is sometimes called biological response modifier (BRM) therapy or immunotherapy.
For the treatment of epidemic Kaposi's sarcoma, a type of biological therapy called highly active antiretroviral therapy (HAART) is used alone, or with other therapies. HAART combines several antiretroviral drugs that target HIV (which is a retrovirus). These drugs help block the virus from multiplying in the body and lower the risk of epidemic Kaposi's sarcoma.
Treatment of Kaposi's sarcoma depends on the type of Kaposi's sarcoma the patient has, and the patient's age and general health.
Standard treatment may be considered because of its effectiveness in patients in past studies, or participation in a clinical trial may be considered. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials are ongoing in most parts of the country for most stages of Kaposi's sarcoma. To learn more about clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
Depending on the patient's condition, the cancer may be controlled if immunosuppressive drugs are stopped. If the patient cannot stop taking these drugs or if this does not work, treatment may be one of the following:
Treatment of recurrent Kaposi's sarcoma depends on the type of Kaposi's sarcoma, and the patient's general health and response to earlier treatments. The patient may want to take part in a clinical trial.
Changes were made to this summary to match those made to the health professional version.
For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 9:00 a.m. to 4:30 p.m. Deaf and hard-of-hearing callers with TTY equipment may call 1-800-332-8615. The call is free and a trained Cancer Information Specialist is available to answer your questions.
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PDQ® is the National Cancer Institute's (NCI's) comprehensive cancer information database. Most of the information contained in PDQ® is available online at NCI's Web site. PDQ® is provided as a service of the NCI. The NCI is part of the National Institutes of Health, the federal government's focal point for biomedical research.
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PDQ® also contains information on clinical trials.
Before starting treatment, patients may want to think about taking part in a clinical trial. A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about new treatments, the risks involved, and how well they do or do not work. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard."
Listings of clinical trials are included in PDQ® and are available online at NCI's Web site. Descriptions of the trials are available in health professional and patient versions. Many cancer doctors who take part in clinical trials are also listed in PDQ®. For more information, call the Cancer Information Service 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
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