Posted Date: Aug 31, 2005
Cancer of the salivary gland is a disease in which cancer (malignant) cells are found in the tissues of the salivary glands. The salivary glands make saliva, the fluid that is released into the mouth to keep it moist and to help dissolve food.
Major clusters of salivary glands are found below the tongue, on the sides of the face just in front of the ears, and under the jawbone. Smaller clusters of salivary glands are found in other parts of the upper digestive tract. The smaller glands are called the minor salivary glands.
A doctor should be seen if there is a swelling under the chin or around the jawbone, the face becomes numb, muscles in the face cannot move, or there is pain that does not go away in the face, chin, or neck.
If there are symptoms, a doctor will examine the throat and neck using a mirror and lights. The doctor may order a special x-ray called a computed tomographic or CT scan, which uses a computer to make a picture of the inside of parts of the body. Another type of scan, called a magnetic resonance imaging or MRI scan, uses magnetic waves to make a picture of the head may also be ordered. If tissue that is not normal is found, the doctor will need to cut out a small piece and look at it under the microscope to see if there are any cancer cells. This is called a biopsy.
The chance of recovery (prognosis) depends on where the cancer is in the salivary glands, whether the cancer is just in the area where it started or has spread to other tissues (the stage), how the cancer cells look under a microscope (the grade), and the patient's general state of health.
Once cancer of the salivary gland is found, more tests will be done to find out if cancer cells have spread to other parts of the body. This is called staging. A doctor needs to know the stage of the disease to plan treatment. Salivary gland cancers are also classified by grade, which tells how fast the cancer cells grow, based on how the cells look under a microscope. Low-grade cancers grow more slowly than high-grade cancers.
The following stages are used for cancer of the salivary gland:
Surgery is often used to remove cancers of the salivary gland. Depending on where the cancer is and how far it has spread, a doctor may need to cut out tissue around the cancer. If cancer has spread to lymph nodes in the neck, the lymph nodes may be removed (lymph node dissection).
Radiation therapy is also a common treatment of cancer of the salivary gland. Radiation therapy uses high-energy x-rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external radiation therapy) or from putting materials that produce radiation (radioisotopes) through thin plastic tubes in the area where the cancer cells are found (internal radiation therapy).
Specialized types of radiation have been shown to be effective in treating some salivary gland tumors. Fast-neutron beam radiation is a type of radiation therapy that uses tiny particles called neutrons. Photon-beam radiation therapy reaches deep tumors with high-energy light. Along with radiation therapy, the use of drugs to make cancer cells more sensitive to radiation (radiosensitization) is being tested in clinical trials.
Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in a vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells throughout the body. Chemotherapy for cancer of the salivary gland is still being tested in clinical trials.
Because the salivary glands help digest food and are close to the jaw, a patient may need special help adjusting to the side effects of the cancer and its treatment. A doctor will consult with several kinds of doctors who can help determine the best treatment. Trained medical staff can also help in recovery from treatment. Plastic surgery may be needed if a large amount of tissue or bone around the salivary glands is taken out.
Treatment of cancer of the salivary gland depends on where the cancer is, the stage of the disease, and the patient's age and overall health.
Standard treatment may be considered because of its effectiveness in patients in past studies, or participation in a clinical trial may be considered. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials are ongoing in some parts of the country for patients with cancer of the salivary gland. To learn more about clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
Treatment depends on the type of salivary gland cancer the patient has, where the cancer came back, the treatment the patient had before, and the patient's general health. Specialized radiation therapy may be given, or a patient may choose to take part in a clinical trial of new treatments.
Editorial changes were made to this summary.
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Before starting treatment, patients may want to think about taking part in a clinical trial. A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about new treatments, the risks involved, and how well they do or do not work. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard."
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