Last Modified: August 21, 2011
Cladribine is a type of chemotherapy that belongs to a class of drugs called antimetabolites. These medications are taken up by cells and are able to prevent the cells from reproducing by inhibiting DNA synthesis.
Cladribine is given by intravenous (into a vein) infusion. The infusion can be given either over 1-2 hours on several consecutive days, or as a continuous infusion over 5-7 days, depending on the protocol used by the doctor. The actual dose is dependent upon your body size.
There are a number of things you can do to manage the side effects of Cladribine. Talk to your doctor or nurse about these recommendations. They can help you decide what will work best for you. These are some of the most common side effects:
White blood cells (WBC) are important for fighting infection. While receiving treatment, your WBC count can drop, putting you at a higher risk of getting an infection. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4 F), sore throat or cold, shortness of breath, cough, burning with urination, or a sore that doesn't heal.
Tips to preventing infection:
For more suggestions, read the Neutropenia Tip Sheet.
Your red blood cells are responsible for carrying oxygen to the tissues in your body. When the red cell count is low, you may feel tired or weak. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing or pain in your chest. If the count gets too low, you may receive a blood transfusion. Read the anemia tip sheet for more information.
Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. Let your doctor or nurse know if you have any excess bruising or bleeding, including nosebleeds, bleeding gums or blood in your urine or stool. If your platelet count becomes too low, you may receive a transfusion of platelets.
Read the thrombocytopenia tip sheet for more information.
Take anti-nausea medications as prescribed. If you continue to have nausea or vomiting, notify your doctor or nurse so they can help you manage this side effect. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try antacids, (e.g. milk of magnesia, calcium tablets such as Tums), saltines, or ginger ale to lessen symptoms. Read the Nausea & Vomiting Tip Sheet for more suggestions.
Call your doctor or nurse if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time.
There are several things you can do to prevent or relieve constipation. Include fiber in your diet (fruits and vegetables), drink 8-10 glasses of non-alcoholic fluids a day and keep active. Your doctor or nurse can also recommend medications to relieve constipation. A stool softener once or twice a day may prevent constipation.
While on cancer treatment you may need to adjust your schedule to manage fatigue. Plan times to rest during the day and conserve energy for more important activities. Exercise can help combat fatigue; a simple daily walk with a friend can help. Talk to your healthcare team and see OncoLink's section on fatigue for helpful tips on dealing with this side effect.
Your doctor or nurse can recommend medication and other strategies to relive pain. Also view OncoLink's page on pain management.
Fever can occur after the dose of cladribine is given. Fever is most commonly seen when treating hairy cell leukemia. You should always contact your doctor if you develop a fever, as it could be related to an infection.
Jun 14, 2011 - The BRAF V600E mutation is associated with hairy-cell leukemia, according to a study published online June 11 in the New England Journal of Medicine to coincide with its presentation at the 16th Congress of the European Hematology Association, held from June 9 to 12 in London.
Jun 14, 2011
Mar 25, 2013