Classification: tyrosine kinase inhibitor
Bosutinib is a tyrosine kinase inhibitor. It works by blocking proteins that cause the rapid growth of certain types of leukemia cells. This helps the bone marrow to start making normal blood cells again.
Bosutinib comes as a tablet to take by mouth. It should be taken once a day with food. Take bosutinib at around the same times every day. If you miss a dose and it is more than 12 hours until the next scheduled dose, you should skip the missed dose and resume the medication with the next scheduled dose. Do not crush, break or chew bosutinib tablets.
Bosutinib is broken down in the body by an enzyme called CYP3A4, which is affected by certain foods and medications. These foods and medications should be avoided while taking bosutinib and include: grapefruit, grapefruit juice, dexamethasone, ketoconazole, rifampin, phenytoin, St. John’s wort, and modafanil. Be sure to tell your healthcare provider about all medications and supplements you take.
Over the counter heartburn medications called proton pump inhibitors (Prilosec, Prevacid, Nexium) can also interfere with bosutinib and should not be taken.
There are a number of things you can do to manage the side effects of Bosutinib. Talk to your doctor or nurse about these recommendations. They can help you decide what will work best for you. These are some of the most common side effects:
White blood cells (WBC) are important for fighting infection. While receiving treatment, your WBC count can drop, putting you at a higher risk of getting an infection. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4° F), sore throat or cold, shortness of breath, cough, burning with urination, or a sore that doesn't heal.
Tips to preventing infection:
For more suggestions, read the Neutropenia Tip Sheet.
Your red blood cells are responsible for carrying oxygen to the tissues in your body. When the red cell count is low, you may feel tired or weak. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing or pain in your chest. If the count gets too low, you may receive a blood transfusion. Read the anemia tip sheet for more information.
Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. Let your doctor or nurse know if you have any excess bruising or bleeding, including nosebleeds, bleeding gums or blood in your urine or stool. If your platelet count becomes too low, you may receive a transfusion of platelets.
Read the thrombocytopenia tip sheet for more information.
Take anti-nausea medications as prescribed. If you continue to have nausea or vomiting, notify your doctor or nurse so they can help you manage this side effect. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try antacids, (e.g. milk of magnesia, calcium tablets such as Tums), saltines, or ginger ale to lessen symptoms. Read the Nausea & Vomiting Tip Sheet for more suggestions.
Call your doctor or nurse if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time.
This medication may cause serious diarrhea and dehydration. If you develop diarrhea, notify your oncology team so they can help you manage it before dehydration develops. Your oncology team can recommend medications to relieve diarrhea.
Try eating low-fiber, bland foods, such as white rice and boiled or baked chicken. Avoid raw fruits, vegetables, whole grain breads, cereals and seeds. Soluble fiber is found in some foods that absorbs fluid and can help relieve diarrhea. Foods high in soluble fiber include: applesauce, bananas (ripe), canned fruit, orange sections, boiled potatoes, white rice and products made with white flour, oatmeal, cream of rice, cream of wheat, and farina. Drink 8-10 glasses on non-alcoholic, un-caffeinated fluid a day to prevent dehydration. Read Low Fiber Diet for Diarrhea for more tips.
Some patients may develop a rash, scaly skin, or red itchy bumps. Use an alcohol free moisturizer on your skin and lips; avoid moisturizers with perfumes or scents. Your doctor or nurse can recommend a topical medication if itching is bothersome. If your skin does crack or bleed, be sure to keep the area clean to avoid infection. For more suggestions, read the Nail and Skin Care Tip Sheet.
While on cancer treatment you may need to adjust your schedule to manage fatigue. Plan times to rest during the day and conserve energy for more important activities. Exercise can help combat fatigue; a simple daily walk with a friend can help. Talk to your healthcare team and see OncoLink's section on fatigue for helpful tips on dealing with this side effect.
Bosutinib has been reported to cause fluid retention. This may result in swelling of the arms or legs, fluid in the lungs (pleural effusion) or heart (pericardial effusion). Notify your healthcare team if you develop swelling in your arms, legs, feet or abdomen, unexpected weight gain, racing heartbeat, shortness of breath or difficulty breathing, or if you develop a dry cough.
Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Effective birth control is necessary during treatment, even if your menstrual cycle stops or you believe your sperm is affected.
Bosutinib can cause liver toxicity. Your oncology team will monitor your liver function with blood tests. Report any yellowing of the skin or whites of the eyes (jaundice), as this can be a sign of liver damage.
Feb 28, 2012 - For patients with chronic myeloid leukemia that fails to respond to interferon alpha therapy, treatment with imatinib is associated with long-term survival of 68 percent, according to a study published online Feb. 27 in Cancer.
May 9, 2013