Last Modified: May 6, 2007
This medication is given through an IV (intravenously, i.e. into a vein) by a trained professional. Vinorelbine is a vesicant, which means that if the medication leaks out of the vein, it can cause serious damage to the tissue. If you notice any swelling, redness or burning during the infusion, notify your nurse or doctor immediately. The actual dose is based on your body size.
You can receive vinorelbine for as long as the cancer cells continue to respond to this therapy and you are able to tolerate any side effects.
Some of the possible side effects and suggestions for dealing with them include:
White blood cells are important for fighting infection. While receiving treatment you are at a higher risk of getting infections. You should wash your hands frequently and avoid large crowds or people who are sick (i.e.: those who have a cold, fever or cough) or large crowds. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4 °), sore throat or cold, shortness of breath, cough, or a sore that doesn't heal. Washing hands, both yours and your visitors, is the best way to prevent the spread of infection.
Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. You should avoid using a razor (you can use an electric razor with caution), playing contact sports, or taking aspirin or ibuprofen products (these can also increase the risk of bleeding). Let your doctor or nurse know if you have any bleeding, including nose bleeds or bleeding gums. If the count becomes too low, you may receive a transfusion of platelets.
Your red blood cells are responsible for carrying oxygen to the tissues in your body. When the red cell count is low, you may feel tired or weak. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing or pain in your chest. If the count gets too low you may receive a blood transfusion.
Your hair may become thin, brittle, or may fall out. This side effect is cumulative, meaning it increases with each dose. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs. The use of scarves, wigs, hats and hairpieces may help. Hair generally starts to regrow soon after treatment is completed. Remember your hair helps keep you warm in cold weather, so a hat is particularly important in cold weather or to protect you from the sun.
Notify your doctor or nurse if your mouth, tongue, or inside of your cheek becomes white, ulcerated or painful. Brush with a soft-bristle toothbrush or cotton swab twice a day. Avoid mouthwashes that contain alcohol. A baking soda and/or salt warm water mouth rinse (2 level teaspoons of baking soda or 1 level teaspoon salt in an eight ounce glass of warm water) is recommended 4 times daily. If your mouth becomes dry, eat moist foods, drink plenty of fluids (at least 6-8 glasses), and suck on sugarless hard candy. Avoid drinking alcoholic beverages and citrus juices, smoking, and chewing tobacco. If mouth sores become painful, your doctor or nurse can recommend a pain reliever.
There are many effective drugs that will prevent, eliminate, or lessen the severity of nausea and vomiting if you need them, so just ask your doctor which is best for you. In addition, dietary adjustments may help. Avoid things that worsen the symptoms, such as heavy or greasy foods. Try antacids, like milk of magnesia and calcium tablets (like Tums), saltines, or ginger ale to lessen symptoms.
See OncoLink's section on fatigue for helpful tips on dealing with this side effect.
Vinorelbine can cause serious constipation, abdominal pain and can even lead to a blockage or stoppage of the bowel (called paralytic ileus) if not treated promptly. There are several things you can do to prevent or relieve constipation. Include fiber in your diet (fruits and vegetables), drink 8-10 glasses of non-alcoholic fluids a day, and keep active. A stool softener once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, you should contact your healthcare team for suggestions to relieve the constipation.
Vinorelbine may affect your appetite. See OncoLink's section on Nutritionfor tips on dealing with this side effect.
This is a toxicity that affects the nerves. The most common affect is called peripheral neuropathy, which causes a numbness or tingling of the hands and feet, which can get progressively worse with subsequent doses. You should let your healthcare provider know if you experience numbness or tingling in the hands and feet, as they may need to change the doses of your medication. See OncoLink's section on peripheral neuropathy for tips on dealing with this side effect.
Patients can develop pain in the tumor site soon after the first treatment with vinorelbine. This pain can last anywhere from 1 hour to 2 days. Your healthcare team can recommend a pain reliever for this problem. In rare cases, patients can have an allergic reaction to the medication. Let your doctor or nurse know right away if you develop any rash, swelling or difficulty breathing.