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Cancer Treatment Information > Clinical Trials > News
November 2009
Erythropoiesis-stimulating agents: concern over patterns of use and risks
Tumor pattern after treatment failure predicts glioblastoma prognosis
October 2009
NSAIDs linked to lower mortality after colorectal cancer diagnosis
September 2009
Erbitux extends life in one study, fails in second
New gene-targeted drug offers hope for melanoma patients
Arthralgia more common with aromatase inhibitors
High-dose imatinib appears to speed tumor reduction
August 2009
Key role for bisphosphonates in reducing myeloma bone damage
Peritoneal metastasis in breast cancer signals poor prognosis
Common mutations linked to adverse colorectal cancer outcomes
PET testing reduces futile resections for colorectal liver metastases
Chemotherapy for lung cancer enhances quality-adjusted survival
Bendamustine more effective than chlorambucil for advanced CLL
Cetuximab more cost effective for wild-type KRAS colorectal cancers
Erlotinib improves survival in stage III non-small cell lung cancer
July 2009
Interferon plus sunitinib or bevacizumab improves metastatic renal cell cancer response
Statement indicates need for more research on partial breast irradiation
Temsirolimus effective in some cases of heavily treated mantle cell lymphoma
Motesanib can stabilize some advanced thyroid cancers
CORRECTION Sanofi's Lantus linked to cancer: what is known?
Biomarker HMGB1 could help track brain cancer therapy
June 2009
Blood test may determine short-term risk of death in idiopathic pulmonary fibrosis
Epstein-Barr virus tied to poor prognosis of Hodgkin's lymphoma
Cancer trials with lengthy development time linked with failure to reach accrual goals
May 2009
US FDA advisers back Glaxo, Genmab cancer drug
ASCO issues updated guidance on breast cancer risk reduction
Caveolin-1 is the strongest prognostic marker for breast cancer to date
Stereotactic body radiation slows lung cancer
Stem cells destroy lung metastases in mice
Inactivated virus induces apoptosis in androgen-resistant prostate cancer cells
Gene test predicts survival with mesothelioma
April 2009
No rise in mastectomy rates with greater use of breast MRI
Adding bevacizumab improves chemotherapy for recurrent glioma
Novel therapeutic approach to pancreatic cancer shows promise
Biomarkers may predict rectal cancer response to cetuximab
Spending more to treat early bladder cancer does not alter outcome
March 2009
Roche says Avastin restriction removed
Nitrosylcobalamin acts as "Trojan horse" to target cancer cells
Hollow gold nanospheres promising for photoablation cancer therapy
Chemotherapy may benefit metastatic colon cancer patients
Reviewers oppose testosterone patch for female sexual dysfunction
February 2009
Surrogate endpoints may predict long-term survival in prostate cancer
Tumor cell count useful for monitoring advanced prostate cancer
Carboplatin, paclitaxel, bevacizumab combination promising for stage IV melanoma
Engineered measles virus a novel oncolytic prostate cancer therapy
January 2009
Gene therapy effective for immunodeficiency due to ADA deficiency
Over-the-counter painkillers do not reduce risk of breast cancer
Radiosensitizers generally do not make whole brain radiotherapy more effective
Postsurgical radiotherapy delay not harmful in glioblastoma
Interleukin-4-conjugated exotoxin active against biliary tract carcinoma
Raloxifene associated with thrombosis, fatal stroke in postmenopausal women
Nearly half of grade 2 cervical intraepithelial neoplasias will regress
December 2008
HER-2 status correlates with lapatinib responsiveness
Vaccine curbs anaplastic thyroid cancer in mice
November 2008
VDR polymorphisms linked with survival in advanced NSCLC
Erlotinib does not improve survival in glioblastoma multiforme
October 2008
Tamoxifen may lower osteoporotic fracture risk
Panitumumab works only in wild-type KRAS colorectal tumors
Tocilizumab reduces disease activity in rheumatoid arthritis
U.S. panel urges more cancer research funding
Benefits of sorafenib for renal cancer not age dependent
Low plasma cholesterol linked to less risk of high-grade prostate cancer
Third-generation chemotherapy for advanced NSCLC linked to better survival
Body weight, not diabetes, linked with prostate cancer death
Melanogenesis inhibition sensitizes melanoma cells to radiotherapy
Racial disparities seen in endometrial cancer recurrence
September 2008
Anakinra plus a DMARD improves function in rheumatoid arthritis
Raloxifene reduces risk of endometrial cancer
Accelerated radiation schedule effective, convenient for early breast cancer
Trifunctional bispecific antibody kills B-cell lymphoma cells
Botulinum toxin A effective for persistent cystitis following cancer treatment
Novel photodynamic therapy promising for recurrent prostate cancer
Novartis cancer drug wins U.S. priority review
Change in HER2 status may explain waning response to trastuzumab
Ezetimibe/simvastatin: no effect on aortic-valve stenosis; cancer risk unresolved
Gene panel model predicts progression with high-risk prostate cancer
August 2008
UK's NICE recommends Novartis eye drug Lucentis
July 2008
Erlotinib continues to show promise in lung cancer
Rosiglitazone use does not increase cancer risk
Sorafenib slows progression of advanced liver cancer
Gene expression profiles with clinical data prognostic for early stage lung cancer
Immunotherapy may boost prostate cancer response to hormone therapy
Breast self-examination does not cut breast cancer mortality
No cognitive benefit seen with simvastatin for neurofibromatosis
Vitamin D levels tied to colorectal cancer survival
Preop biomarkers predict prostate cancer relapse
Lenalidomide active in heavily pretreated leukemia
Reducing iron stores by phlebotomy lowers cancer risk in older men
Investigational drug combination plus chemotherapy promising in breast cancer cell lines
Radioimmunotherapy targets metastatic melanoma lesions in phase I trial
June 2008
Abnormal p53 boosts prostate cancer recurrence
Atorvastatin and celecoxib synergistic against colon cancer cells
African American women face higher death risk from metastatic breast cancer
KINK-1 increases melanoma sensitivity to chemotherapy
HER-2 has less prognostic value in inflammatory breast cancer
Rapamycin stops development of epilepsy in mice
Standard chemo better than capecitabine in older women with early breast cancer
May 2008
Early H. pylori treatment reduces risk of gastric cancer
Regenerated bladder appears feasible
Vitamin D deficiency tied to poor breast cancer outcome
Lenalidomide raises clot risk in multiple myeloma patients
April 2008
Estrogen more suppressed with letrozole than anastrozole
Cisplatin-based therapy for anal carcinoma linked to higher colostomy rate
Bias threatens validity of observational studies of cancer treatment
Topical imiquimod an option for Kaposi's skin lesions in HIV-negative adults
CORRECTION: Alternating electric fields shrink breast cancer tumors
REFILE: Stop-and-go oxaliplatin effective in elderly colon cancer patients
Statin/NSAID combo inhibits androgen-independent prostate cancer growth
Stop-and-go oxaliplatin effective in elderly colon cancer patients
Increased lung cancer risk seen with inhaled insulin
New cancer treatment success rates approach 50 percent
March 2008
First-line EGFR inhibition may benefit selected lung cancer patients
Cardiac risk low with dose-dense chemo plus trastuzumab for breast cancer
Anastrozole adherence by breast cancer patients often suboptimal
Gemcitabine plus chemoradiation of small benefit for resected pancreatic cancer
Intensity-modulated radiation therapy is inconsistently delivered
February 2008
Arsenic trioxide aids youngsters with acute promyelocytic leukemia
Recentin fails lung cancer trial
Peptide ligands noninvasively assess cancer response to therapy
Tumor HPV status impacts survival in head/neck cancer patients
Comorbidities affect benefit of conditioning intensity for stem cell transplants
Chemotherapy plus muramyl tripeptide improves osteosarcoma survival
Combination of implants benefits patients with recurrent glioblastoma
January 2008
Stop-and-go oxaliplatin effective in elderly colon cancer patients
Clinical trial access more limited for teen cancer patients
Comorbidity reduces benefits of androgen suppression in prostate cancer
High-dose chemo doesn't improve survival in metastatic breast cancer
Near infrared imaging device helps classify breast lesions
Statins may reduce cancer incidence in older patients
Capecitabine and oxaliplatin effective for advanced esophageal cancer
Second-cancer risk from Hodgkin therapy seen reduced substantially
Aggressive treatment favored for advanced laryngeal cancer
Benefit of anthracyclines in early breast cancer limited to HER-positive tumors
December 2007
Anticlusterin increases chemotherapy sensitivity in breast cancer cells
Biochemotherapy boosts response but not survival in metastatic melanoma
Celecoxib blocks morphine-induced tumor growth in mice
Transvaginal ultrasound screening fails to detect early-stage ovarian cancer
TP53 mutations linked to reduced survival for head and neck cancer
High-dose chemo with HSCT outdated for breast cancer
Investigational agent eliminates resistance in CML
Extended adjuvant aromatase inhibitor therapy beneficial in breast cancer
Genotype tied to success of breast cancer therapy with tamoxifen
November 2007
Breast cancer pain not controlled as well in non-whites
Treatment with lenalidomide enhances survival of relapsed multiple myeloma
Obesity may be protective in progressive prostate cancer
October 2007
Cardiac disease incidence rises early after starting androgen deprivation therapy
Sunitinib shows promise against advanced hepatocellular carcinoma
Gefitinib inhibits drug resistance in thyroid cancer cell lines
Beta-adrenergic receptor agents may protect against venous leg ulcers
T cells targeted to CD19 eradicate ALL in mice
Broader US label for colorectal cancer drug Erbitux
Low-dose tamoxifen attenuates risk biomarkers in HRT users
September 2007
Capecitabine improves colon cancer survival
REFILE: Anastrozole effective treatment for fibroids in premenopausal women
FDA approves Evista for prevention of breast cancer
Lung cancer guidelines advise against general CT screening
August 2007
Presurgical hypnosis reduces patient's pain perception, lowers hospital costs
Low-dose alosetron controls IBS symptoms with minimal increases in constipation
Avastin improves survival in metastatic cancer, but ups risk of arterial embolism
MRI-guided focused ultrasound surgery a durable treatment for fibroids
CORRECTION: Troxacitabine, gemcitabine may be synergistic in treating pancreatic cancer
UK treatment of childhood cancer ailing
July 2007
Skin rash means erlotinib is working against pancreatic and lung cancer
Troxacitabine, gemcitabine may be synergistic in treating pancreatic cancer
Ovarian cancer vaccine reinforces patient's immune response to tumor
Stage 1 non-small cell lung cancer benefits from early aggressive treatment
FDA approves J&J test for breast cancer metastasis
Tumor "paint" promises better intraoperative visualization of cancer foci
Low-dose ketamine helpful for intractable cancer pain in children
Narrow-band imaging identifies airway lesions not seen with regular bronchoscopy
Lomeguatrib does not improve temozolomide treatment of metastatic melanoma
Nelarabine effective for some leukemia and lymphoma patients
June 2007
Adjuvant therapy for aggressive squamous cell carcinoma found ineffective
Cisplatin superior to carboplatin for treating curable lung cancer
Daily folic acid supplement does not reduce colorectal adenoma risk
External beam radiotherapy no benefit in early endometrial cancer
May 2007
Hormone response can guide prostate cancer therapy
Elderly kidney cancer patients often die from other causes
Radiolabeled monoclonal antibody to CD20 curbs refractory lymphoma
Enzastaurin delays progression in diffuse large B-cell lymphoma
Prior tumors worsen outlook in lung cancer
Study contradicts belief that psychotherapy extends cancer patients' lives
Herceptin gets Europe approval for combination breast cancer treatment
Dasatinib effective against imatinib-resistant leukemia
April 2007
Cervical abnormalities prevalent among HIV-infected adolescent girls
Initial benefit of intracoronary radiation with stenting not sustained
Water diffusion tracks metastatic prostate cancer therapy response
Nanovectors transfer genes without toxicity of viral vectors
Amgen details higher death risk in Aranesp trial
Pentoxifylline not a first-line agent for recurrent mouth ulcers
Radiation therapy provides modest benefit to elderly patients with glioblastoma
Investigational drug for opioid-related constipation linked to heart risk
Celecoxib no help against Barrett's esophagus progression
Zoledronic acid for prostate cancer bone metastasis carries risk of renal toxicity
March 2007
Xeloda approved in Europe for stomach cancer
Ketogenic diet effective against experimental brain cancer
Fractalkine curbs metastatic colon cancer in mice
CD40 agonist active against solid tumors
Misconceptions prevent patient participation in cancer trials
Colorectal cancer salvage therapy better in younger patients
Hypoxia-inducible factor transgene therapy well tolerated in critical limb ischemia
Bisphosphonates inhibit cancer in animal model
February 2007
Pertuzumab extends survival for some prostate cancer patients
Merck's HPV vaccine in demand among UK gay men
Roche suspends enrollment in anemia drug trial
Combination therapy promising against Krabbe's disease
High vitamin D levels linked to improved lung cancer survival
Biogen leukemia drug to get speedy FDA review
COX inhibitors seen of potential value in head/neck cancer
January 2007
Dual tumor suppressors act against lung cancer in mice
G-CSF induces bone loss, promotes bone tumor growth in mice
Octreotide of no benefit in advanced HCC
Survival rate highest with prostatectomy for localized prostate cancer
Breast cancer patients often fail to complete tamoxifen regimen
Intensified chemotherapy does not improve osteosarcoma survival
Gemcitabine prolongs disease-free survival after resection of pancreatic cancer
Genentech cancer drug shows no significant benefit
Imatinib prevents dermal fibrosis in vitro and in mice
Hypothyroidism common with renal cancer drug
December 2006
Long-term low-molecular-weight heparin prevents recurrent venous thromboembolism
NSAIDs inhibit cancer cells via interleukin-24 pathway
Agalsidase-beta therapy may slow Fabry disease progression
CXCR4 antagonist helps mobilize angiogenic cells
Concurrent adjuvant therapy improves local control of breast cancer
New guidelines improve HER2 testing accuracy for breast cancer
Erythrocyte levels maintained with aerobic exercise during radiation therapy
Residue-free NaP tablets effective, well-tolerated for bowel prep
Low serum EGFR levels linked to poor prognosis in breast cancer
November 2006
Intraperitoneal platinum/taxane chemo seen best for ovarian cancer
Protein triggers new prostate cancer treatment
Women with disabilities less likely to get standard breast cancer care
Engineered vesicular stomatitis virus kills malignant glioma in mice
3-D radiation can reduce feeding tube need in head and neck cancers
Gene therapy eradicates ventricular tachycardia after MI in animal study
October 2006
Improved CT colonography an accurate screening tool for colorectal cancer
Aldose reductase blockade curbs colon cancer in mice
Taxotere approved for head, neck cancer
Candidate tumor suppressor could be gene therapy target in lung cancer
September 2006
Low levels of tumor suppressor p66 Shc predict breast cancer response to chemo
Gene "profiling" may improve accuracy of breast cancer prognosis
PSA after treatment predicts survival in metastatic prostate cancer
Race predicts survival in patients with renal cell carcinoma
August 2006
Chemo, radiation and stem cell transplantation effective for brain lymphoma
Celecoxib prevents colorectal adenoma, but raises CVD risk
Bortezomib effective against neuroblastoma in animal studies
Chemo completion vital for patients with small-cell lung cancer
HIV drug also inhibits HPV in vitro, points to cervical cancer prevention
Trastuzumab cardiotoxicity may be reversible
UK's NICE rejects two new bowel cancer drugs
Circulating tumor cells predict survival in metastatic breast cancer
Psychotropic drugs often prescribed for children with cancer
UK agency nearer backing new breast cancer drugs
Genomic strategy helps predict relapse risk in early lung cancer
EGFR mutations linked to gastrointestinal cancers
Intramyocardial bone marrow cell injections safe in long-term study
July 2006
UK's NICE decides Velcade drug not cost-effective
US OKs Lilly drug for ovarian cancer, spurns panel
Radical prostatectomy for locally advanced prostate cancer feasible, effective
June 2006
Immunization advisory panel recommends HPV vaccine for all girls
Occult prostate cancer lymph node metastases tied to recurrence, mortality risk
Milk thistle compound inhibits experimental lung cancer growth
Methotrexate enhances phototherapy clearance of psoriasis
Imatinib has antiangiogenic effects in prostate cancer metastasis
US FDA approves Hycamtin for cervical cancer
UK's NICE and SMC give green light to Herceptin in early breast cancer
Lapatinib effective in kidney tumors with high EGFR expression
Multiple myeloma responds to lower thalidomide dose
Sunitinib prolongs survival in metastatic clear-cell RCC
May 2006
Guidelines urge doctors to discuss fertility preservation with cancer patients early
April 2006
CHMP recommends Herceptin for early stage-breast cancer
Surgery plus immunotherapy for metastatic melanoma prolongs survival
Raloxifene acts against prostate cancer
CORRECTION: Sunitinib malate shows anti-tumour activity in metastatic renal cell carcinoma
Prolonged survival linked to intravenous vitamin C seen in three cancer patients
Rituximab effective against chronic graft-versus-host disease
Sunitinib malate shows anti-tumour activity in metastatic renal cell carcinoma
Src inhibition a promising therapeutic approach to ovarian cancer
March 2006
Laser treatment promotes choroidal neovascularization
Six patients in phase I monoclonal antibody trial seriously ill
Trovax improves survival in metastatic colorectal cancer in phase II study
US advisers against new indication for Gemzar
Prolonged lymphopenia common with long-term temozolomide for glioma
Saliva-based tests detect oral cancer, Sjogren's syndrome
Adding thalidomide to myeloma therapy of little benefit
Amifostine reduces radiotherapy side effects
Schering: Five patients in HIV drug trial got cancer
Etoposide-based therapy may reduce mortality from bird flu
Family physicians offer safe follow-up for breast cancer patients
February 2006
Neoadjuvant sarcoma chemotherapy results in high toxicity levels
Subcutaneous amifostine feasible during radiotherapy for head and neck cancer
Depot delivery system maintains steady drug level in prostate cancer patients
Roche suspends recruitment in Avastin trial
Intraductal therapy effective in breast cancer model
High magnesium intake lowers colon cancer risk in women
Histone deacetylase blocker active in hematologic malignancies
CDK4 activity tied to breast cancer progression
Stem cell transplant produces complete remission in scleromyxedema
January 2006
Early intervention for chemotherapy-induced anemia beneficial
Xaliproden curbs oxaliplatin-related neuropathy
Cardiac stem cell "patch" bridges myocardial infarct with live tissue
Fetal exposure to noninherited maternal antigens enhances immune tolerance
Immunotherapy may prevent neuroblastoma relapse
Analgesic drug use may cut risk of ovarian cancer
Myeloid markers found on hematopoietic stem cells
Palladium brachytherapy feasible as adjuvant treatment of early breast cancer
Breast cancer chemotherapy increases cardiomyopathy risk
GW Pharma gets U.S. go-ahead for phase III trials of Sativex in cancer pain
Oncolytic virus works with alkylating agent to destroy glioma cells
December 2005
Palliative photodynamic therapy improves survival in bile duct cancer
US approves new drug for advanced kidney cancer
Radiofrequency ablation promising against lung cancer
Meta-analysis contradicts benefits of dietary fiber in protecting against colorectal cancer
No apparent benefit for dose-dense chemotherapy in early breast cancer
UK okays early use of Novartis breast cancer drug
November 2005
T cell depletion boosts vaccine-mediated antitumor immunity
Herbal COX inhibitor acts against prostate cancer cells
HER2/neu vaccine may curb breast cancer recurrence
Gamma-linolenic acid suppresses breast cancer gene expression in vitro
Taxol reduces fibrosis in scleroderma animal model
Tositumomab effective for relapsed or refractory follicular NHL
NSAIDs may protect against esophageal adenocarcinoma
Survival rates in lung cancer higher in women than men
October 2005
EGFR blocker and photodynamics combat ovarian cancer
High-dose strontium-90 brachytherapy effective for posterior uveal melanoma
FDA rejects Abbott prostate cancer drug Xinlay
Treatment with nucleotides and radiation effective in glioma model
ZymoGenetics melanoma drug wins orphan drug status
Concurrent/consolidation regimen provides best survival for stage III lung cancer
September 2005
Flaxseed inhibits breast cancer in animal model
Celgene cancer drug clinical trial suspended -- WSJ
Lactobacillus may prevent atypia of colorectal tumors
Increased monitoring urged after Erbitux infusion
Diet and exercise changes may slow prostate cancer
Telomerase inhibitor prevents lung cancer metastases in mice
Levofloxacin prevents infection in neutropenic cancer patients
MDM2 oncoprotein may predict prostate cancer metastasis
Cannabinoid analog, stem cells show promise in treatment of bladder disorders
August 2005
High-intensity focused ultrasound shows promise in pancreatic cancer
High bone turnover with bisphosphonates tied to worse bone metastasis outcome
Combined gene therapy effective against glioma in rats
Revised staging system predicts survival after breast cancer therapy
Vitamin E supplements do not influence androgen or PSA levels
Methylated vimentin in fecal DNA: a potential colon cancer biomarker
Abgenix, Amgen say cancer drug gets fast-tracked
July 2005
Specific regimen influences risk of myelodysplasia after lymphoma treatment
Conventional prognostic factors for ALL may not hold in developing countries
Biased reporting seen in cancer prognostic studies
Biased reporting skews value of cancer prognostic studies
CORRECTION: Study shows no mortality benefit in breast cancer screening
Study shows no mortality benefit in breast cancer screening
Etanercept RA therapy does not boost skin cancer risk
Age no bar to benefits of lung cancer chemotherapy
High-dose epirubicin, cyclophosphamide for breast cancer tied to secondary AML
June 2005
Europe okays wider use anastrozole for breast cancer
Expanded access to Xinlay for prostate cancer approved
AstraZeneca limits access to cancer drug Iressa
Exercise improves sexual function after prostate cancer radiotherapy
Hormone receptor status independently predicts breast cancer survival
Regulatory T cell blocker curbs breast cancer growth in mice
Progesterone receptor may have a protective role in breast cancer
Immunotherapy promising for malignant mesothelioma
Docetaxel better than fluorouracil in combo breast cancer therapy
May 2005
Drug duo acts synergistically to kill multiple myeloma cells in vitro
Study published showing statins reduce risk of colorectal cancer
Pomegranate juice shows promise as treatment for recurrent prostate cancer
Sorafenib slows disease progression in kidney cancer
Chemohormonal therapy reduces long-term breast cancer mortality
Insulin-like growth factor I receptor promotes gastric cancer
Natural killer cells persist and expand after allogeneic transfer
Trastuzumab induces apoptosis in primary breast cancers
Imatinib provides high efficacy in all phases of chronic myeloid leukemia
Lorus' investigational cancer drug wins FDA orphan status for AML
Stable course of localized prostate cancer supports conservative management
Protozoan protein shows antitumor properties
April 2005
Three genes activated in concert to defend cells against radiation toxicity
Green tea may prevent prostate cancer in men at risk
Onyvax reports early success with osteosarcoma cancer vaccine
TNF blockers may raise lymphoma risk in rheumatoid arthritis patients
Trial of Iressa for advanced NSLCC halted for lack of efficacy
Avastin effective against breast cancer
Rituximab added to standard therapy effective for HIV-related NHL
Evidence for improved cancer survival with erythropoietin inconclusive
Sildenafil may prevent doxorubicin-induced cardiomyopathy
Weight gain after breast cancer diagnosis worsens survival
March 2005
Ligand says lung cancer drug fails in studies
Androgen deprivation for prostate cancer leads to metabolic disturbances
Capecitabine plus irinotecan-radiation seen safe, effective for rectal cancer
Routine CT screening may not reduce mortality from lung cancer
Endometrial cancer more aggressive in African-American women
Triennial Pap testing may be safe for some women with HIV
Isotretinoin of no benefit in head and neck cancer
MIF knockout mice protected from type 1 diabetes
NF-kappa-B inhibitor acts against multiple myeloma
Genta leukemia drug gets 'orphan drug' status
RNA interference protects against neurodegeneration in animal model of ALS
U.S. group asks FDA to ban Iressa
Age alone not a contraindication for adjuvant chemotherapy in breast cancer
February 2005
Rapamycin analog effective in tuberous sclerosis complex model
Drug resistance gene therapy prevents myelosuppression in animal model
Effects of leukemia-related Shp2 mutations elucidated
New drug may treat imatinib-resistant chronic myeloid leukemia
No excess mortality seen for most US prostate cancer patients
Specific tyrosine kinase inhibitor selectively kills ALL cells
Herstatin blocks experimental glioblastoma growth
Radioimmunotherapy effective first-line treatment for follicular lymphoma
Chemotherapy often avoided in treatment of malignant glioma
January 2005
Thalidomide of little value for advanced hepatocellular carcinoma
Preferential K-RAS activation at work in neurofibromatosis 1
Progesterone receptor gene mutants associated with ovarian cancer
December 2004
"Biomarker roadmap" may help guide experimental prostate cancer therapy
Histone deacetylase anti-cancer effect tied to TRAIL
Pregnancy possible after uterine artery embolization for leiomyomata
Diabetes drugs active against myeloma cells
Gene expression profile accurately predicts ovarian cancer outcome
EBV load reflects nasopharyngeal tumor burden after therapy
Timing is everything in combined antiangiogenic/radiation therapy
Cervical cancer an "epidemic" in poor countries
Faslodex effective after aromatase inhibitor therapy in phase ll trials
Ferromagnetic thermal ablation effective in locally recurrent prostate cancer
Multigene assay predicts recurrence of tamoxifen-treated breast cancer
Herpes virus mutant shows potential for neuroblastoma
Genta drug promising in late-stage cancer study
Immune-mediated gene therapy ups survival glioblastoma model
Immune-mediated gene therapy ups survival in glioblastoma model
New bone marrow transplant strategy curbs GVHD but not anti-tumor activity
TNF linked to lung tumor metastasis in mice
November 2004
Genentech colon cancer drug effective in combination regimen
Scale helpful in evaluating prostate cancer MRIs
Intensified chemotherapy reduces need for cranial irradiation in ALL
Stem cell transplant outcomes worse in pediatric leukemia patients
Elderly patients underrepresented in trials of new cancer drugs
High selenium linked to lower colorectal adenoma risk
Mesenchymal stem cells help target tumors
Antisoma's telomere-targeting agent blocks experimental prostate cancer
New CD guides management of liver metastases from colorectal cancer
October 2004
EU funds lung cancer vaccine research
COX-2 inhibitors may help fight cancer
Revised colon cancer staging provides better survival estimates
Cisplatin v. carboplatin for lung cancer?
Tamoxifen may raise stroke risk
Lung cancer deaths soar in France, fall in UK
Lymphocyte transplant can induce regression of metastatic breast cancer
Radiation safely omitted after cure of Hodgkin's disease with chemotherapy
Ovarian radioablation aids breast cancer therapy
September 2004
British, French drug firms lead on marijuana tests
Lycopene plus vitamin E slows human prostate tumor growth in mice
Oregovomab trial doesn't meet endpoint but yields data for further study
ERBB2 kinase mutation offers target in some lung cancers
Retinoic acid may prevent colon adenoma formation
Submandibular gland transfer prevents radiation-induced xerostomia
Testosterone added to HRT may protect against breast cancer
MRI successfully guides RF kidney tumor ablation
August 2004
Cannabinoids block brain tumor angiogenesis via VEGF pathway
Anti-EGF receptor antibody has low antitumor action in renal cancer
Suppressor gene linked with breast cancer treatment response
Lung cancer in nonsmokers seen as distinct disease entity
Modified bone marrow cells engraft more efficiently
Combined EGFR inhibitors amplify control of cancer cells
UK scientists report promising new oesophageal cancer test
July 2004
Gene expression profile of biopsy tissue can predict lung cancer outcome
Immunotherapy strategy shows promise as treatment for glioma
FDA sets up cancer office to speed up new drugs
Aldara approved for superficial basal cell carcinoma
New agent active against imatinib-resistant tumor cells
Long-term soy supplements tied to endometrial hyperplasia
Lymphoma risk in RA not directly tied to therapy
Tumor-specific activated memory T cells have antitumor effects
Higher intake of milk and calcium tied to lower risk of colorectal cancer
June 2004
Hypoxia-inducible factor inhibition curbs gastric cancer
Small interfering RNA can enhance Th1 immune response
Mechanism of tamoxifen resistance and its possible reversal is revealed
Disparities in age, race and sex seen in cancer trials
NSAIDs reduce lung cancer growth, cachexia in mice
U.S. agencies to coordinate on cancer treatment
More evidence shows raloxifene prevents breast cancer
Statins tied to reduced colorectal cancer risk
Taxotere can increase survival in prostate cancer patients
Temozolomide plus radiotherapy ups survival in glioblastoma multiforme
Preventive Services Task Force recommends against routine ovarian cancer screening
RNAi delivery system crosses the blood-brain barrier to thwart cancer
New cancer strides to be unveiled at big meeting
Cathepsin cysteine proteases promote tumor growth
May 2004
Novartis says many UK patients could be denied Glivec
Blood test shows promise in ovarian cancer
Physician apathy, patient fear slowing cancer discoveries
Maxim Pharma stock soars on leukemia drug results
Mouse model supports feasibility of radioimmunotherapy for pneumococcal infection
Vascular disrupting agents promise improved survival for cancer patients
High testosterone levels linked to prostate risk
Celecoxib shows antitumor properties in malignant mesothelioma model
US FDA panel rejects Allos cancer drug
April 2004
FDA staffers say Allos drug benefit unconvincing
Tarceva drug extends life in lung cancer patients
Antibody that activates tumor-killing T cells produced from transgenic animals
Cancer trial participants rarely told of results
CD4 T cell response to cancer antigen may improve cancer vaccine monitoring
Host Langerhans cell depletion can prevent skin graft-versus-host disease
FDA expands access to experimental melanoma drug
Estrogen alone provides no overall benefit in chronic disease prevention
Extended lymph node dissection does not improve gastric cancer survival
Roche cancer drug trial succeeds two years early
Laparoscopic resection of rectosigmoid cancer does not impair survival
Onyx, Bayer cancer drug gets FDA fast track tag
Spain's Zeltia says drugs working well in trials
March 2004
Novel c-Myc oncogene inhibitor to advance to clinical trials
Modified vitamin B12 shuttles lethal cargo to tumors
Praecis says FDA halts trial of cancer drug
Multiple factors contribute to renal cancer survival
Immunotherapy with MALP-2 suppresses pancreatic cancer in mice
Nerve block technique provides sustained relief of pancreatic cancer pain
Peptide activator of p53 may treat peritoneal carcinomatosis
Adolescent cancer rising, and survival lagging
February 2004
Low-fat diet boosts efficacy of androgen deprivation for prostate cancer in mice
Therapeutic vaccine beneficial in clinical stage III melanoma
Polymer binding tempers toxic antitumor agent
New guidelines stress uniformity of clinical trials for relapsed prostate cancer
ImClone wins U.S. approval for cancer drug
Radiolabeled tumor necrosis therapy shows strong binding in liver procedures
Cancer web sites no aid to trial enrollment
FDA OK's Lilly drug for asbestos-related cancer
January 2004
Bevacizumab has direct antivascular effects on human tumors
Trial participation may not improve outcomes for cancer patients
Polymorphism modulates cancer sensitivity to chemotherapy drugs
Erlotinib promising for advanced head and neck cancer
Breast cancer drug Herceptin fails in lung cancer trial
Millennium stops trial of combo cancer drug
December 2003
Older patients with lung cancer benefit from comprehensive anticancer treatments
Recurrent osteosarcoma carries poor prognosis
Adjuvant chemo plus goserelin may be effective for some early breast cancers
Neoadjuvant chemotherapy timing crucial in cervical cancer
EGRF inhibitor delays tumor onset in murine model of breast cancer
Focused ultrasound shows promise as treatment for advanced renal cancer
Millennium ends Velcade cancer drug trial early
Low-dose interferon does not improve survival of high-risk melanoma
MabThera study halted early because of good results
Roche's CERA drug shows promise in cancer
November 2003
US approves new prostate cancer drug
PABA sensitizes tumor cells to chemotherapy and radiation
October 2003
CXCR4 receptor supplants Id1 gene as major player in tumor angiogenesis
Breast cancer vaccine generates immune response in cancer patients
Lycopene helpful after orchidectomy for prostate cancer
Oncogene activation to blame for leukemia with SCID-X1 gene therapy
Sentinel node biopsy already standard of care in breast cancer, despite lack of evidence
Sphingosine kinase inhibition: a potential new anticancer strategy
When angiogenesis is impaired, tumors are more sensitive to Hsp90 inhibition
September 2003
Genentech completes cancer drug filing to FDA
Testing breast cancer tumors for BRCA1 may guide therapy
Aeterna kidney cancer drug trial did not meet goals
Differential binding affinity explains Hsp90 inhibitor's antitumor specificity
European cancer patient coalition formed
Heat shock protein vaccine promising in small pancreatic cancer trial
FDA approves drug for cancer-related hypercalcemia
Short post-treatment PSA doubling time a marker of mortality
New AJCC staging criteria for breast cancer could affect outcome reporting
Scientists say EU laws hamper cancer research
"Murky" data leave doubts over Genta, Aventis antisense cancer drug
Ilex gets fast track for pediatric leukemia drug
Antisense oligonucleotides show activity against Ras-mediated cancers
FDA suspends Antigenics' cancer vaccine trials
August 2003
Age no bar to carboplatin and paclitaxel lung cancer therapy
Bisphosphonates reduce skeletal morbidity of metastatic cancer
Radioactive glucose kills breast cancer cells
Lung cancer trials deemed cost effective
Aromatase inhibitors should not always replace tamoxifen
Radioimmunotherapy kills fungus in mice
Limited-field radiotherapy provides adequate local control for early breast cancer
Vaccine may extend colon cancer survival
Mucosal adhesive film effectively delivers tretinoin in animals
Acute lymphoblastic leukemia curable, normal survival achievable
Genentech, OSI's brain cancer drug gets orphan status
New anti-cancer monoclonal antibody drug effective in preclinical trials
July 2003
Lovastatin induces apoptosis in thyroid cancer cells, but clinical value uncertain
Hyperthermia improves survival with locally advanced cervical carcinoma
Telomerase inhibitor effective in prostate cancer cell lines
FDA head says U.S. plans to speed cancer drug evaluations
Androgen deprivation therapy may be overused for localized prostate cancer
Participation in cancer clinical trials higher than ever in UK
Thapsigargin coupled to PSA substrate curbs experimental prostate cancer
CEOs agree to pay for cancer screening, clinical trials
June 2003
Glaxo, Corixa get U.S. approval for lymphoma drug
Rapamycin induces apoptosis in cancer cells lacking functional p53
IL-2 gene therapy plus radiation generates potent antitumor response
Vitamin D2 analog active against leukemia, myeloma, and colon cancer
Zeltia's Yondelis shows promise in ovarian cancer
Genta begins phase I/II trial of Genasense in breast cancer
Vitamin D analog enhances radiation's effects on breast tumors in mice
Vitamin D analog enhances radiation's effects on experimental breast tumors
U.S. government got poor return on Taxol investment -- GAO report
Platinum-based chemotherapy improves survival of invasive bladder cancer
US court lifts ban on pesticide testing in humans
Millennium says anti-cancer proteasome inhibitor safe over longer term
May 2003
CXCR3 variant helps explain activities of angiostatic chemokines
Sexual taboos may prevent use of HPV vaccine
FDA approves new class of chemotherapy drug
Xenova halts phase III trial of cancer drug tariquidar
PPAR-gamma ligands inhibit pituitary adenoma growth
Colonoscopy more cost-effective than colorectal cancer chemoprophylaxis
PET can assess efficacy of cancer treatment
Laser technique for cancer screening investigated
Metalloproteinase promotes cancer cell migration by modifying surface receptors
Advocacy group argues against approval of Iressa
Latest dietary fiber data support protective effect against colon cancer
April 2003
ASCO set to revamp oversight of cancer clinical trials, conflict of interest policy
FDA approves Genzyme's drug for Fabry disease
Restrictive policies keeping older patients out of cancer clinical trials
YC-1 blocks angiogenesis and inhibits tumor growth
Phase II trial of personalized CML vaccine plus Gleevec under way
Phenoxodiol induces apoptosis in chemoresistant ovarian cancer cells
Demethylation of ovarian cancer gene leads to cisplatin resistance
Estrogen patches helpful in advanced prostate cancer
Strong inverse link between breast cancer and NSAID use
Weight-based dosing of drugs not necessarily ideal approach
March 2003
Intrapleural steroids not effective for malignant effusions
Brain tumour incidence on the rise in U.S. and Europe
Pros and cons of widespread CT lung cancer screening still debated
Deguelin inhibits colon carcinogenesis in mice
Aspirin prevents colorectal adenomas in patients with previous neoplasia
February 2003
Racial gap in rectal cancer outcomes smaller in randomized trials
QLT halts phase III cancer trial for 3 months
Irradiated, GM-CSF-secreting tumor cells can engender lung cancer immunity
Early blast clearance predicts better outcome in acute myeloid leukemia
Endothelin-a receptor antagonist, atrasentan, fails in prostate cancer trial
French researchers developing prosthetic larynx
Access to ImClone drug to be expanded to sickest cancer patients
Synthesized erythropoiesis protein biologically active in vivo
Oligonucleotide IGF2 inhibitor enhances survival in hepatocellular carcinoma
Retinoid therapy may help prevent lung cancer in ex-smokers
Thalidomide analogue shows direct anti-tumour activity in vitro
January 2003
"Chemotherapy sensitivity testing" of biopsy predicts tumor response
Predictors of disease recurrence for high-risk prostate cancer identified
Impotence drugs show activity against leukemia cells
Thalidomide effective for previously untreated multiple myeloma
Tamoxifen lowers risk of estrogen receptor-positive breast cancer
Post-op chemotherapy improves outcomes of early ovarian cancer
Engineered anthrax toxin kills diverse range of malignant cells
Epimmune gets FDA okay to start studies of cancer vaccines
Water-filtered infrared irradiation hasten wart clearance
Salvage radiotherapy shows promise for PSA recurrence after prostatectomy
December 2002
Liposomal tretinoin shows some activity against AIDS-related Kaposi's sarcoma
Dietary carbohydrates slow tumor growth in mice
FDA panel declines backing for Casodex to treat early prostate cancer
FDA advisors back approval of Corixa's NHL drug
Hormone therapy before prostatectomy appropriate for stage T3 prostate cancer
Experimental compounds inhibit tumor production of PTH-like peptide
Inherent racial differences seen in AML outcomes
Phase II study supports Trisenox in multiple myeloma
November 2002
Cancer researchers warn EU red tape could hamper studies
Glivec boosts effects of chemotherapy
Study raises hope of "self-vaccine" against cancer
Diet rich in flaxseed protects mice from prostate cancer
Fiber intake does not protect against adenoma recurrence
October 2002
Shark cartilage extract to treat kidney cancer given US orphan drug status
AstraZeneca backs Iressa after more deaths in Japan
Socioeconomic status, not race, key in predicting outcome in breast cancer
Caution recommended in epoetin use for anemia in hematologic malignancy
Marine organism-derived aplidine advances against rare thyroid cancer
Undertreatment of older cancer patients not justified
Epidermal growth factor receptor inhibitors need more clinical trials
Unique nuclear matrix proteins associated with colon cancer metastases to liver
Japan cites 13 deaths related to cancer drug Iressa
FeRx gets orphan-drug grant for development of liver-cancer drug
MacroChem trials halted by FDA on carcinogenicity fears
Site of bone metastasis useful for prognosis of prostate cancer
Radiation reduces risk of recurrence in node-positive mastectomy patients
"Resistance" to antiangiogenic agents may reflect variance in tumor biology
HER2 expression has prognostic importance in advanced bladder cancer
September 2002
Macrophages implicated in pathogenesis of immunodeficiency-related lymphoma
Endostatin well tolerated in cancer patients
Findings shed light on how selenium prevents cancer
Vaccine strain of measles virus causes regression of experimental glioblastoma
Capsaicin induces apoptosis by inhibiting mitochondrial respiration
Contamination of herbal remedy PC-SPES with several synthetic drugs confirmed
New radiotherapy regimen improves lung cancer survival
Rb2 gene therapy enhances gamma radiation induced tumor apoptosis
August 2002
Fusion protein shows promise in destroying liver tumors
Gleevec and other c-Kit inhibitors might treat Kaposi's sarcoma
Therapeutic potential of caffeine and theophylline explored
Darbepoetin safe and effective for chemotherapy-related anemia
British experts urge study of exotic mushrooms for cancer treatment
Decoy receptor causes vessel regression in neuroblastoma model
Chemotherapy combination promising for mesothelioma
New drug shows promise against hard-to-treat breast and prostate cancers
UK's NICE backs Glivec for chronic myeloid leukaemia
High complication rate and cost seen with negative appendectomy
July 2002
Receptor induction and targeting offers new antileukemia strategy
US grants orphan drug status to melanoma vaccine
Expanded-access program for Lilly's Alimta set for mesothelioma patients
NHLBI halts HRT trial due to increased cancer, cardiovascular disease risks
Early results promising for radium-223 against bone metastases
June 2002
Early results with polymer-bound paclitaxel promising in refractory cancer
Researchers use stem cells to repair vocal cords
Examination of 10 nodes required for accurate gastric carcinoma staging
AML cells with FLT3 mutations killed by FTL3 inhibitor in preclinical tests
Ultra-low-dose naltrexone can prevent opioid tolerance and dependence
Top cancer centers seek to win drug company trials with new network
Vaccination prolongs relapse-free period in patients with advanced melanoma
'Real-world' testing for HER2-positive breast cancer found inaccurate
May 2002
New gene therapy for ovarian cancer permits tumor destruction with ganciclovir
"Pacemaker" could improve tongue reconstruction
Nicotine suppresses antigrowth effects of retinoids in lung cancer cells
UK says evidence lacking for widespread use of imatinib mesylate
Organizational change best way to ensure delivery of preventive services
AML chemotherapy may be appropriate for some HIV-infected patients
Raltitrexed more toxic than other regimens for colorectal cancer
Biochemotherapy extends survival in metastatic melanoma
Web-based service offers one-stop access to cancer clinical trials
April 2002
Menstrual cycle phase seen to affect outcome of mastectomy plus oophorectomy
Serious drug toxicities recognized during postmarketing surveillance
Revised guidelines on cervical cytology issued
Human macrophage metalloelastase expression worsens pancreatic cancer prognosis
Vaccine elicits response in patients with advanced prostate cancer
Retroviral gene marker leads to murine leukemia in gene therapy experiment
Anti-tumor activity of celecoxib is independent of COX-2 inhibition
Soy drink does not relieve hot flashes in breast cancer survivors
New technologies may facilitate patient-tailored approach to cancer therapy
British Biotech gets EU orphan status for leukaemia drug
March 2002
Idiotype-pulsed dendritic cell vaccination can induce regression of B-cell NHL
Serotonin system a possible therapeutic target for Burkitt lymphoma
Hopes high for novel drug class in the treatment of advanced breast cancer
Chemotherapy modestly improves survival in glioma patients
Herceptin treatment every three weeks as safe, effective as weekly dosing
Antiestrogen for tamoxifen-resistant breast tumors has good preclinical results
Initial androgen deprivation therapy for prostate cancer affects sexual function
New rules threaten breast cancer research, expert says
Pemetrexed performs well in metastatic breast cancer trials
p53 appears to inhibit angiogenesis in non-small-cell lung cancer
Modified T cells target tumors, then produce viral vectors locally
Incremental improvements seen in medical content on Web sites
Saliva test to detect breast cancer under development
UK's NICE rejects routine use of three bowel cancer drugs
Elevated Cox-2 expression linked to poor breast cancer prognosis
February 2002
All colorectal cancer screening methods effective; best still uncertain
High response rates to imatinib seen in CML patients
FDA clears Novartis' Zometa for bone metastases
US officials recommend earlier breast cancer screening
IDEC's radioimmunotherapeutic cancer drug approved by FDA
Britain could approve prescription cannabis drugs
Adenosine triphosphate improves nutritional status in lung cancer patients
New definitions of opportunistic invasive fungal infections
Prolonging antigen presentation on dendritic cells enhances antitumor immunity
FDA approves pegylated filgrastim
January 2002
Artificial antigen-presenting cell promotes ex vivo expansion of CD8+ T cells
Specificity of cancer gene therapy vectors increased by more than 1000-fold
Mixed results for phase II study of ovarian cancer drug
FDA approves one-month formulation of leuprolide for prostate cancer
GW Pharmaceuticals to test cannabis spray for cancer pain
Laparoscopic-assisted colectomy offers little quality-of-life benefit
Epidermal nerve fiber density reduced in HIV-associated sensory neuropathy
Enzyme prompts bone loss in prostate cancer
December 2001
Xenogeneic antigen vaccine promotes vigorous response to prostate cancer
Alpha-v integrins not essential for angiogenesis in mice
Celgene's Thalomid wins EU orphan status
Her-2/neu blood test aids breast cancer prognosis
Epratuzumab may enhance rituximab therapy for non-Hodgkin's lymphoma
Anastrozole seen as more effective than tamoxifen for breast cancer
Paclitaxel use by breast cancer patients tied to pneumonitis after radiotherapy
November 2001
Radiofrequency ablation may offer "painless" alternative in treating kidney tumors
Addition of anaerobic bacteria to chemotherapy destroys large tumors in mice
Participants, investigators often have misconceptions about cancer trials
Telomerase-specific suicide gene therapy approach yields promising results
Rise in UK ovarian cancer cases prompts call for action
Novartis cancer drug Glivec gets EU approval
CA-125 doubling predicts ovarian cancer progression when levels remain high
Millennium myeloma drug shows promise in phase I trial
NeoPharm identifies new cancer target
New class of anticancer agents show promise
Chemotherapy drug PG-TXL shows promise in early clinical trials
OxiGene to move anti-angiogenesis drug into phase II trials
October 2001
Novuspharma cancer drug disappoints in trials
Second Zeltia drug shows cancer promise
Screening mammography has no survival benefit
Oxford BioMedica claims early success with cancer vaccine
Preliminary phase I results of cancer vaccine are promising
Recently approved colorectal cancer regimen increases risk of early death
Physicians urged to address sexual problems of ovarian cancer patients
Novel molecule destroys tumor blood vessels in mice
Schering's Campath successful in trial for rare leukaemia
September 2001
Presence of bcr-abl in CML patients increases relapse risk long after BMT
Duo of monoclonal antibodies fights murine colon cancer better than one alone
Computer system helpful in interpreting mammograms
Indian government cracks down on drug trials
Women reluctant to participate in UK trials of breast cancer chemoprevention
FDA panel backs approval of Idec's Zevalin
Indian government cracks down on drug trials
Matrix's localized chemotherapy fails to earn FDA advisors' endorsement
Nicotine addition vaccine ready for phase I trial
Combined chemoradiation therapy improves outcomes in cervical cancer
Targeted injectable retroviral vectors developed for cancer gene therapy
Genetics of medulloblastoma metastasis may provide therapeutic target
August 2001
Michigan surgeon suspended from performing research
Dietary restrictions prior to colon cancer screening may be unnecessary
HER2-transduced dendritic cells generate T killer and Th cell clones
Strict California law requires complete insurance coverage for cancer study subjects
Cryotherapy might be first-line treatment for early lung cancer
Cytyc gets FDA okay to add promising data on ThinPrep's label
European Breast Cancer coalition enumerates breast cancer priorities
Celecoxib studied as lung cancer preventative
Letrozole effective in advanced breast cancer
Tyrosine kinase inhibitor kills acute myeloid leukemia cells with receptor mutation
July 2001
FDA may disqualify Tulsa researcher
Indian physician criticizes drug trial co-led by a Johns Hopkins researcher
Philippines approves SciClone Pharmaceuticals' immune drug Zadaxin for cancer
Paclitaxel and carboplatin offer less toxic treatment option for lung cancer
New drug may help with resistant cancers
Canadian groups release guideline on breast cancer chemoprevention
Response of refractory multiple myeloma to thalidomide spans 2 years
Treatment outcome of AMKL is often poor in absence of Down syndrome
Cannabinoids are effective as antiemetics but not as analgesics
Retroviral endostatin gene transfer inhibits angiogenesis in mice
Purified T-cell transplant treats leukemia, prevents toxicity in mice
June 2001
Breakthrough leukemia drug appears safe in early trials
Cancer research group to be established in Ireland
Gene therapy may greatly improve quality of life in cancer patients
Guidant's Galileo cleared in EU for blockages in long coronary arteries
Soy extract slows prostate cancer growth in mice
Glucocorticoid use increases fungal infection risk after bone marrow transplant
May 2001
Engineered polio virus destroys malignant glioma cells in animal model
Unexpectedly high mortality rate associated with chemotherapy regimen
Chemotherapy before surgery improves survival in esophageal cancer patients
Megestrol appears superior to dronabinol for cancer-related anorexia
Leukemia drug wins US approval after less than 3-month review
Millennium leukemia drug wins FDA approval despite safety concerns
FDA approves Roche's Xeloda for metastatic colorectal cancer
New device collects cervical cells in a single step
Immune response acts as tumour-suppressor system
April 2001
Drug rationing seen as harming bowel cancer treatment in UK
Drug to block tumor metastasis ready to enter human trials
FDA advisors say many adult leukemia trials can apply to children
Molecular markers predict survival after chemotherapy for colon cancer
Bicalutamide reduces risk of prostate cancer progression by 43%
Adenoviral oncogenesis does not require persistence of viral genes
Glivec appears promising for CML, but caution advised
March 2001
New platinum-based cancer drug bests cisplatin in preclinical trial
Company streamlines second opinions for cancer treatment, prognosis
Millennium begins phase II trial of multiple myeloma drug
February 2001
Gene therapy for GVHD supported in preclinical research
Hereditary and sporadic breast cancers show different gene-expression profiles
Brachytherapy for prostate cancer improved by computer model
Pelvic perfusion method safe and effective palliation for recurrent rectal cancer
New colorectal cancer screen wins FDA premarket clearance
ImClone colorectal cancer drug put on fast track by FDA
Patients in cancer trial sue Tulsa researcher, IRB
January 2001
New speculum preferred by patients over bivalves
Many cancer patients unaware of clinical trials
November 2000
Endoscopic cryotherapy has advantages over thermal ablation in some settings
Tumor cell apoptosis induced after treatment with adenovirally expressed TRAIL
Avax's melanoma vaccine M-Vax appears promising for stage IV disease
Serum telomerase levels may be useful in lung cancer screening
Multimodal therapy including hyperthermia useful for unresectable pancreatic cancer
Ribozyme's Angiozyme shows safety, tolerability in phase I/II trial
October 2000
Survival unaffected by chemotherapy after non-small-cell lung cancer resection
Dexamethasone protects against acute, delayed chemotherapy-induced emesis
Genentech's Herceptin receives boxed warning about hypersensitivity reactions
Oxford BioMedica's colorectal cancer vaccine trial receives ethical approval
Imiquimod beneficial for patients with basal cell carcinoma, actinic keratoses
Schering's Intron A may be better than Progenics' GMK vaccine for melanoma
September 2000
PHS extends coverage of clinical trials for cancer patients
Cdc25A phosphatase associated with poor breast cancer survival
BRCA mutation carriers with breast cancer often opt for prophylactic oophorectomies
Selective inhibition of superoxide dismutase may be cancer treatment option
P53 gene therapy shows promise in ovarian cancer
Folate enhances delivery of chemotherapeutic agents
FDA approves Applied Imaging's device for detecting cancer cells
The Lancet launches The Lancet Oncology
August 2000
Cyclopamine blocks Sonic hedgehog signaling; may treat skin cancer
Experimental prostate cancer growth slowed by pHyde gene therapy
Renal cell carcinoma patients derive little benefit from adjuvant 13-cis-retinoic acid
VEGF may be a survival factor for tumor endothelial cells
HIV-1 highly sensitive to flavopiridol, with development of resistance unlikely
Marker of breast cancer, prostate cancer found in tears
Clinical trials no longer cost more than standard care for cancer patients
July 2000
Laser treatment allows killing of breast cancers in situ
Genta's gene drug enhances chemotherapy for breast cancer
AVAX launches new skin cancer vaccine in Australia
Stem cell transplant may be best choice for selected metastatic breast cancers
Heparin's anti-tumor potential said to warrant clinical trials
Paclitaxel blocks invasion of Kaposi's sarcoma cells and interferes with apoptosis
p53-expressing adenovirus gene therapy causes lymphoma regression in mice
Chiron's Proleukin label updated to reflect new durable response data
Compound targeting alpha-tubulin is active against breast and brain tumor cells
Abbott licenses potential cancer therapy from Eisai
Helix begins cervical cancer research with Althea Foundation
CeNeS gets UK approval for cancer pain drug
June 2000
Ampersand licenses Invirion's HPV detection platform
Consumption of nonfiber carbohydrate increases risk of colorectal cancer
Angiogenesis inhibitor found effective in treating hemangiomas
Coley pairs with Germany's Ludwig Institute in cancer therapeutics alliance
Vion shares fall on news of halted cancer study
Breast examinations as effective in community settings as in clinical trials
Acyclovir may protect against AIDS-related lymphoma
FDA issues draft guidance on clinical trials of PTH in treating osteoporosis
Director of NIH's alternative medicine center lays out ambitious agenda
Early detection of non-small-cell lung cancer tumors does not improve survival
HER-2/neu cancer vaccine promising in early trial
Bioniche LifeSciences identifies anticancer agents
NIH funds trial of alternative pancreatic cancer therapy
Fatty acids do not increase cancer risk and may be cardioprotective
Tobacco may be a key to therapeutic vaccine for cervical cancer
Matritech reports successful proof of clinical concept for cancer test
Xenova stock falls as company halts colorectal cancer study
Abbott sues hospital, cancer researcher
Lung cancer responds to experimental drug
May 2000
Unconventional therapies common in children with cancer
Aphton wins patent for cancer-related immunogens
Celsion licenses gene therapy technology from Memorial Sloan-Kettering
Age alone should not rule out chemotherapy after colon cancer surgery
Cancer patients are unaware of trial options
Cost of care for patients in cancer trials equivalent to cost of standard care
Abnormal glucose metabolism associated pancreatic cancer mortality
Techniclone, Oxigene form joint venture for cancer therapeutics development
Avax begins clinical trials of leukemia vaccine
EntreMed stock tumbles after Boston Globe report
Orphan drug designation for Cell Therapeutics' Arsenic TriOxide
British Biotech, ImmunoGen to collaborate on cancer treatment
new gold standard for advanced ovarian cancer
Maxim's Maxamine improves survival in patients with advanced skin cancer
Zarix anticancer drug receives FDA fast track designation
Human studies of TRAIL may need to be delayed
Neose, Bristol-Myers Squibb to expand oncology partnership
Potent activity against colorectal tumors achieved with cytokine gene therapy
April 2000
GenStar Therapeutics receives tumor sensitization patent
Novelos Therapeutics begins enrollment for phase I/II lung cancer trial
IDEC licenses investigational oncology therapies from NCI, UIRF
Copolymer-bound doxorubicin shows potent activity in ovarian cancer model
Copolymer-bound doxorubicin shows potent activity in ovarian cancer model
GW Pharmaceuticals to begin clinical tests of cannabis-based drugs
GW Pharmaceuticals to begin clinical tests of cannabis-based drugs
Acetaminophen may protect against colon carcinogens
March 2000
Neural progenitor cells used to deliver interleukin-4 to glioblastomas
Carbohydrate-based vaccine benefits prostate cancer patients
Prolonged combined androgen blockade may increase survival of prostate cancer patients
Good prognosis for microinvasive breast carcinoma
ASCO releases guidelines on use of bisphosphonates in breast cancer patients
Risk of oropharyngeal cancer rises with amount of alcohol intake but not duration
February 2000
Aetna unit to drop bone marrow transplant coverage for breast cancer patients
Researcher admits misrepresenting results of breast cancer trial
Adjunctive high-dose chemotherapy ineffective for certain breast cancer patients
January 2000
Colitis associated with use of docetaxel for metastatic breast cancer
Genetic testing for breast cancer remains controversial
Interferon gene therapy has anti-angiogenic effect on brain tumors in mice
December 1999
IL-12-expressing acute myeloid leukemia cells might eliminate residual disease
Cryosurgery and video MRI eradicates renal cancer
New Jersey insurers to cover cancer patients' "routine" clinical trial costs
November 1999
increased and intensified total dose of cyclophosphamide not warranted
Racial colon-cancer survival gap is smaller in clinical trials
Long-term survival not improved by Di Bella alternative multitherapy for cancer
Glioblastoma "suicide-gene therapy" more effective than expected but less safe
October 1999
Lower survival rate in blacks with lung cancer compared with whites linked to lower surgery rates
Autotransplantation not effective in subsets of women with advanced breast cancer
Obesity and prior estrogen replacement augment risk of endometrial cancer in tamoxifen users
OXiGENE announces favorable phase I results of angiogenesis inhibitor
September 1999
Survival in early-stage breast cancer cases reduced if axillary node dissection not performed
Histologic exams of axillary lymph nodes in breast cancer cases underestimates node metastases
Patient "navigators" effective coordinators of cancer care in poor women
Photoimmunotherapy enhances cytotoxicity of cisplatin in human ovarian cancer cells ex vivo
Insights from interviews with 24,000+ cancer survivors
August 1999
Depsipeptide shows promise as treatment for chronic lymphocytic leukemia
Mutated HPV DNA vaccine protects mice against cervical cancer
High serum ALT linked to liver cancer in patients with HCV-associated cirrhosis
Value of neoadjuvant chemotherapy for muscle-invasive bladder cancer questionable
Bipartisan "patients' rights" bill to be introduced
Controversy surrounds use of sentinel lymph node biopsy in melanoma patients
Medicare coverage of trial costs for cancer patients proposed
July 1999
Panel issues medical records privacy guidelines
June 1999
Gore calls for boost in cancer research spending
Kinase-targeted compound inhibits colonic tumor growth in murine study
Addition of low-dose chemo to tamoxifen not beneficial in receptor-positive breast cancer
Apoptosis markers help predict response to radiotherapy in patients with localized prostate cancer
Tamoxifen does not improve treatment of advanced malignant melanoma
Tamoxifen useful for breast cancer risk reduction; jury still out on raloxifene
Intraoperative sentinel node exam predicts axillary node status in breast cancer patients
Feasibility of transplanting anergic histoincompatible bone marrow allografts under study
May 1999
Minntech to acquire rights to cancer therapy
Adjuvant chemotherapy recommended for all Dukes' B colon cancer patients
No recommendation yet to use raloxifene to reduce breast cancer risk
Patient costs in cancer clinical trials little more than with standard care
Introgen, RPR Gencell to collaborate with NCI on adenoviral-p53 gene therapy
Arsenic trioxide efficacious in treatment of lymphomas
FDA asked to issue stronger warnings on tamoxifen
April 1999
Soy components reduce growth, metastasis of human prostate cancer cells in murine studies
E-cadherin expression appears to indicate progression of prostate cancer
EntreMed has enough endostatin to begin clinical studies
Medicare cancer clinical trials bill introduced
Role of high-dose chemo plus BMT in breast cancer treatment still inconclusive
Breast implant plaintiffs call for dissolution of scientific panel
Adverse event profile for raloxifene described
Trega reports positive preliminary data on melanocortin blocker for postop pain
March 1999
Estrogen replacement therapy associated with reduced risk of Alzheimer's disease
Topical 5-FU reduces CIN recurrence in HIV-positive women
WHO cancer chief says Britain needs national cancer centre
"Blind insistence" on informed consent in clinical trials called unnecessary
Amgen licenses rights to phase III prostate cancer drug
Transgene begins new phase ii gene therapy trial in mesothelioma
Combination therapy revisited for advanced ovarian cancer
Hepatocellular carcinoma increasingly common in US
Schering to market Techniclone's Oncolym
UK colorectal cancer and chlamydia pilot screening projects launched
Sharp rise in non-Hodgkin's lymphoma spurs request for doubling of NIH funds
February 1999
Illegal dietary supplements linked to serious toxicity
NovaMed to begin human studies of breast implants soon
Triangle and Catalytica will collaborate on investigational HIV drug
First US cases of vancomycin-resistant Staphylococcus aureus reported
AAHP, NIH form collaboration to increase HMO coverage of clinical trials costs
January 1999
Neoadjuvant chemo eliminates all evidence of primary breast tumors in some patients