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Types of Cancer > OncoLink Vet > Veterinary Oncology > Tumors
Papilloma (Papillomatosis)
Supported by the Savannah and Barry French Poodle Memorial Fund
Affiliation:
University of Pennsylvania School of Veterinary Medicine
Last Modified: August 21, 2005
Michael H. Goldschmidt, MSc, BVMS, MRCVS, Diplomate ACVP Professor and Head, Laboratory of Pathology and Toxicology Chief, Surgical Pathology Department of Pathobiology
Frances S. Shofer, PhD, Adjunct Associate Professor of Epidemiology and Biostatistics
Introduction
Definition: A benign exophytic neoplastic proliferation of the squamous epithelium caused by infection with papillomavirus
Synonyms: Warts or verruca vulgaris
Epidemiology and Etiology
- caused by a papovavirus, which is a double stranded DNA virus. Two different papovaviruses are thought to be present in the dog:
- Canine Oral Papilloma Virus (COPV)- responsible for the oral papilloma
- Canine Papilloma Virus (CPV)- responsible for the cutaneous and inverted papilloma
- occur most commonly in dogs less than 3 years of age
- does not show any sex predilection
| Sex | N | Percent |
| Female | 101 | 21% (21%) |
| Female Spayed | 150 | 32% (33%) |
| Male | 108 | 23% (25%) |
| Male Castrated | 111 | 24% (21%) |
| (Normal Population %) |
| Breeds at Increased Risk |
N | Probability | OR | 95% Confidence Interval |
|
|
Whippet
|
5 | <0.0001 | 12.1 | 5.0 | 29.4 |
|
Rhodesian Ridgeback
|
8 | <0.0001 | 6.7 | 3.3 | 13.6 |
|
Weimeraner
|
10 | 0.0001 | 4.5 | 2.40 | 8.4 5 |
|
Mastiff
|
5 | 0.0062 | 4.4 | 1.83 | 10.76 |
|
Greyhound
|
8 | 0.0008 | 4.2 | 2.09 | 8.51 |
|
American Pit Bull Terrier
|
11 | 0.0001 | 4.2 | 2.30 | 7.6 4 |
|
Great Dane
|
13 | <0.0001 | 4.1 | 2.33 | 7.0 5 |
|
Jack Russel Terrier
|
9 | 0.0006 | 4.0 | 2.09 | 7.8 4 |
|
Beagle
|
16 | 0.0507 | 1.7 | 1.01 | 2.74 |
|
Labrador Retriever
|
51 | 0.0331 | 1.4 | 1.04 | 1.87 |
| Breeds at Decreased Risk |
N | Probability | OR | 95% Confidence Interval |
|
|
Mixed Breed
|
75 | <0.0001 | 0.6 | 0.47 | 0.78 |
|
Cocker Spaniel
|
8 | 0.0022 | 0.4 | 0.19 | 0.75 |
|
Miniature Poodle
|
3 | 0.0046 | 0.2 | 0.08 | 0.78 |
|
Shetland Sheepdog
|
1 | 0.0021 | 0.1 | 0.02 | 0.78 |
| Site | Percent |
|
Head
|
52.1% |
|
Forelimb
|
12.5% |
|
Hindlimb
|
11.2% |
|
Multiple Sites
|
10.6% |
|
Abdomen
|
2.9% |
|
Thorax
|
1.6% |
|
Neck
|
1.3% |
|
Perianal Region
|
0.8% |
|
Tail
|
0.5% |
|
Back
|
0.3% |
 |