Recurrent Desmoid Tumors

John Han-Chih Chang, MD and Kenneth Blank, MD
Last Modified: November 1, 2001

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Question
Dear Oncolink:  
Is it possible for an extra abdominal desmoid in the leg to recur five times? Have you ever heard of this happening?


Answer
Kenneth Blank, MD and John Han-Chih Chang, MD, Editorial Assistants for Oncolink, respond:

Thank you for your question.  
Desmoid tumors are also called aggressive fibromatosis. These tumors never metastasize (spread to other parts of the body) but are known to be very locally aggressive. Surgery is the treatment of choice but even after radical resection in which the surgeon takes wide margins around the visible tumor, these tumors can come back. For this reason, radiotherapy is often recommended following surgery.

We are not personally aware of a patient with a history of five recurrences but given the local aggressive nature of these tumors it is not surprising.



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ROR2 ID'd As Novel Biomarker of Soft-Tissue Sarcomas

Jan 18, 2012 - ROR2 gene mutations are expressed in a subset of soft-tissue sarcomas, including leiomyosarcoma, gastrointestinal stromal tumors, and desmoid-type fibromatosis, and expression may be indicative of poor prognosis, according to a study published online Jan. 4 in The Journal of Pathology.



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