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NCI CANCERLIT^® Search: Gastrointestinal Carcinoid Tumor - September 2001

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Last Modified: November 1, 2001

• Endoscopic appendectomy for a carcinoid tumor of the appendix.

• Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.

• MRI of carcinoid tumors: spectrum of appearances in the gastrointestinal tract and liver.

• Ileal carcinoid tumor with a rose-shaped appearance by dye spraying: diagnosis at colonoscopy.

CancerMail from the National Cancer Institute

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UI - 21174792
AU - Cipolletta L; Bianco MA; Rotondano G
TI - Endoscopic appendectomy for a carcinoid tumor of the appendix.
SO - Am J Gastroenterol 2001 Mar;96(3):929-30

2
UI - 21329006
AU - Mandai M; Konishi I; Tsuruta Y; Suginami N; Kusakari T; Iwasaki T; Fujii S
TI - Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
SO - Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5
AD - Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Kyoto, Japan.
Appendiceal neoplasms with ovarian metastasis are rare. A 35-year-old woman with a left ovarian tumor underwent left salpingo-oophorectomy, partial resection of the right ovary, and a total hysterectomy. Pathological diagnosis of both ovaries was typical, Krukenberg tumor with signet-ring cells, and the second laparotomy revealed an occult appendiceal tumor to be the primary lesion. The appendix showed no evidence of malignant change of the mucosa, but the tumor cells were observed infiltrating from the basiglandular region into the underlying stroma, associated with mucocele. Although, argentaffin and argyrophil staining were negative, a few tumor cells showed immunohistochemical positivity for Chromogranin A. Accordingly, the tumor was diagnosed as adenocarcinoid rather than adenocarcinoma of the appendix. A review of the literature showed less than 40 cases of metastatic ovarian tumor from appendiceal primary, one-third of which were occult and could be detected at the second laparotomy. Cisplatin-based chemotherapy may have partial effect in the treatment of patient with adenocarcinoid tumor.

3
UI - 21427090
AU - Bader TR; Semelka RC; Chiu VC; Armao DM; Woosley JT
TI - MRI of carcinoid tumors: spectrum of appearances in the gastrointestinal tract and liver.
SO - J Magn Reson Imaging 2001 Sep;14(3):261-9
AD - Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7510, USA.
The purpose of this study was to evaluate the spectrum of appearances of gastrointestinal carcinoid tumors at magnetic resonance imaging (MRI) and to elucidate patterns of appearances of carcinoid liver metastases on precontrast and postgadolinium images. The MR examinations of 29 patients (11 men, 18 women; age range, 33-87 years) with histologically confirmed gastrointestinal carcinoid tumors, representing our complete 9.5 years of experience with this entity, were retrospectively reviewed. Twelve patients had MR examinations prior to resection or biopsy of the primary tumor (preoperative group); 17 patients were imaged postsurgically (postoperative group). All MR studies were performed at 1.5 T and comprised T1-weighted spoiled gradient echo (SGE), T2-weighted fat-suppressed turbo spin echo, HASTE, and serial postgadolinium T1-weighted SGE sequences without and with fat suppression. Morphology, signal intensity, and contrast enhancement of primary tumors and of metastases to the mesentery, peritoneum, and liver were evaluated. Primary tumors were visualized in 8 of 12 patients and best demonstrated on postgadolinium T1-weighted fat-suppressed images. The appearance of primary tumors was a nodular mass originating from the bowel wall (4 of 12 patients) or regional uniform bowel wall thickening (4 of 12 patients) with moderate intense enhancement on postgadolinium images. In 4 of 12 patients the primary tumor was prospectively not seen. Mesenteric metastases, seen in eight patients, presented as nodular masses and were associated with mesenteric stranding in seven patients. A total of 156 liver metastases were evaluated in 16 patients. On precontrast T1- and T2-weighted images, 117 metastases (75%) were hypointense and hyperintense, respectively. A total of 146 metastases (94%) were hypervascular, showing moderate intense enhancement during the hepatic arterial phase, and 9 metastases (6%) were hypovascular. Twenty-three metastases (15%) were visible only on immediate postgadolinium images. MRI is able to demonstrate findings in carcinoid tumors, including the primary tumor, mesenteric metastases, and liver metastases. Liver metastases are commonly hypervascular and may be demonstrable only on immediate postgadolinium images. Copyright 2001 Wiley-Liss, Inc.

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UI - 21367722
AU - Yamauchi H; Hirata I; Sasaki S; Egashira Y; Hamamoto N; Murano M; Toshina K; Ueda S; Maemura K; Katsu K
TI - Ileal carcinoid tumor with a rose-shaped appearance by dye spraying: diagnosis at colonoscopy.
SO - Gastrointest Endosc 2001 Aug;54(2):267-8
AD - Second Department of Internal Medicine, the First Department of Pathology, and the Second Department of Anatomy, Osaka Medical College, Takatsuki City, Osaka, Japan.