Last Modified: November 1, 2001
Table of Contents
CancerMail from the National Cancer Institute
UI - 21134197
AU - Clement P; Rondet P; Marlier F; Gros P; Dumas B; Gouteyron JF
TI - [Isolated facial palsy and occult adenoid cystic carcinoma of the parotid]
SO - Ann Otolaryngol Chir Cervicofac 2001 Feb;118(1):61-3
AD - Service d'Oto-Rhino-Laryngologie et de Chirurgie de la Face et du Cou, Hopital d'Instruction des Armees PERCY, 101, avenue Henri Barbusse, 92140 Clamart.
We report a case of adenoid cystic carcinoma of the parotid disclosed by facial palsy alone. No tumefaction could be detected clinically or at imaging. The diagnosis was established at surgical exploration of the facial nerve. Total extended parotidectomy was completed by radiotherapy of the tumor site.
UI - 21384658
AU - Gibbons PJ; Powers CN; Reiter ER
TI - Pathology quiz case: plasmacytoid variety of myoepithelioma of minor salivary gland.
SO - Arch Otolaryngol Head Neck Surg 2001 Aug;127(8):1003-4
UI - 21232095
AU - McCutcheon IE; Kitagawa RH; Sherman SI; Bruner JM
TI - Adenocarcinoma of the salivary gland metastatic to the pituitary gland: case report.
SO - Neurosurgery 2001 May;48(5):1161-5; discussion 1165-6
AD - Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. firstname.lastname@example.org
OBJECTIVE AND IMPORTANCE: A case of metastasis to the pituitary gland from a ductal adenocarcinoma of the salivary gland is presented. Metastasis to this site is rare, and a salivary gland source has never previously been described. CLINICAL PRESENTATION: This patient presented with hypopituitarism, including diabetes insipidus. INTERVENTION: A craniotomy was performed to alleviate visual loss. The histological features of the sellar tumor were identical to those of a tumor removed from the parotid gland 18 months earlier. CONCLUSION: Although intrasellar tumors originating from embryonic rests of salivary gland tissue have been reported, metastasis from a malignant neoplasm arising within a true salivary gland is also possible and should not be excluded from consideration for patients in whom a salivary gland-like tumor is discovered in the sella turcica.
UI - 21225876
AU - Huber PE; Debus J; Latz D; Zierhut D; Bischof M; Wannenmacher M; Engenhart-Cabillic R
TI - Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam?
SO - Radiother Oncol 2001 May;59(2):161-7
AD - Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.
PURPOSE: To compare retrospectively radiotherapy with neutrons, photons, and a photon/neutron mixed beam in patients with advanced adenoid cystic carcinoma of the head and neck. Local control, survival, distant failure, and complications were analyzed. MATERIALS AND METHODS: Between 1983 and 1995, 75 patients with inoperable, recurrent, or incompletely resected adenoid cystic carcinoma of the head and neck received radiotherapy that consisted of either fast 14.1 MV DT neutrons (median dose 16 neutron Gy), linac-based photon irradiation (median dose 64 photon Gy), or both (median dose 8 neutron Gy and 32 photon Gy). Follow-up ranged from 1 to 160 months (median 51 months), and the surviving patients had a minimum follow-up of 3 years at the time of analysis. RESULTS: The actuarial 5-year local control was 75% for neutrons, and 32% for both mixed beam and photons (P = 0.015, log-rank). This advantage for neutrons in local control was not transferred to significant differences in survival (P > 0.1). The survival is dictated by the tumor diseases due to distant metastases occurring in 29 (39%) of the 75 patients. Positive lymph nodes were the only significant factor (P = 0.001) associated with the development of distant metastases although negative lymph nodes did not predict absence of distant metastases, but predicted a delay of occurrence. In multivariate analysis postoperative radiotherapy (P = 0.003) and small tumor size (P = 0.01) were associated with high local control, while primary therapy (P = 0.006) and negative lymph nodes (P = 0.01) were associated with longer survival. While acute toxicity was similar in all three radiotherapy groups, severe late grade 3 and 4 toxicity tended to be more prevalent (P > 0.1) with neutrons (19%) than with mixed beam (10%) and photons (4%). CONCLUSION: Fast neutron radiotherapy provides higher local control rates than a mixed beam and photons in advanced, recurrent or not completely resected adenoid cystic carcinoma of the major and minor salivary glands. Neutron radiotherapy can be recommended in patients with bad prognosis with gross residual disease (R2), with unresectable tumors, or inoperable tumors. The type of radiation does not impact survival, which is dominated by the high number of distant metastases.
UI - 21225877
AU - Rowbottom CG; Nutting CM; Webb S
TI - Beam-orientation optimization of intensity-modulated radiotherapy: clinical application to parotid gland tumours.
SO - Radiother Oncol 2001 May;59(2):169-77
AD - Joint Department of Physics, Institute of Cancer Research & The Royal Marsden NHS Trust, Downs Road, Sutton, SM2 5PT, Surrey, UK.
BACKGROUND AND PURPOSE: An optimization algorithm has been developed to determine the best beam-arrangement for a small number of intensity-modulated radiotherapy (IMRT) fields. The algorithm is designed to avoid, if possible, beam-orientations that pass through organs-at-risk (OARs) with low radiation tolerance. MATERIALS AND METHODS: An independent, fast IMRT algorithm based on the Bortfeld algorithm was developed to determine the profile of the intensity-modulated beams (IMBs) for each beam-arrangement and a fast-simulated-annealing algorithm finds the 'optimal' beam-arrangement. The final beam-arrangement was transferred to the CORVUS (NOMOS Corporation) treatment planning system, and the IMBs were re-optimized for comparison with a standard nine-field, equi-spaced arrangement. The algorithm has been initially tested on a single example patient, with a parotid gland carcinoma. RESULTS: The nine-field, IMRT plan for an example patient with a parotid gland tumour significantly reduced the dose to the cochlea compared with the conformal radiotherapy plan. In addition, the planning-target-volume (PTV) homogeneity was improved, but the plan produced a higher dose to the contralateral parotid (73% of the OAR received more than 6 Gy). The beam-orientation optimization algorithm produced a three-field plan that greatly reduced the dose to the contralateral parotid (maximum dose of 2 Gy), whilst maintaining the PTV dose homogeneity and the reduced cochlear dose of the nine-field plan. Some changes in the dose to the other OARs, namely the brain and the oral cavity, were seen, but were deemed not to be clinically significant. CONCLUSIONS: In conclusion, IMB-orientation optimization for head and neck treatment sites can produce improvements in treatment plans with only a few fields.
UI - 21243394
AU - Galvez-Jimenez N; Hanson MR; Desai M
TI - Unusual causes of hemifacial spasm.
SO - Semin Neurol 2001;21(1):75-83
AD - Parkinson Disease Clinic and Movement Disorders Program, Department of Neurology, The Cleveland Clinic, Florida, Fort Lauderdale 33309, USA.
Hemifacial spasm (HFS) has been defined as consisting of brief clonic jerking movements of the facial musculature, beginning in the orbicularis oculi with downward spreading to other facial muscles. HFS, perhaps the most common of the abnormal involuntary facial movements, has been classically ascribed to vascular loop compression at the root exit zone of the facial nerve. Causes other than such vascular loops are rare in the medical literature. Here we present three case studies in which the phenomenology of the HFS was atypical in onset and evolution. Using these three patients as introduction to the topic, we reviewed the literature of all cases of HFS with causes other than the vascular loop. In these three cases, HFS was caused by (1) a parotid gland tumor, (2) a cerebellopontine angle meningioma, and (3) an acoustic schwannoma. We also discuss the radiological findings as well as possible differences in the genesis of HFS and phenomenology in such cases and present recommendations on how to evaluate these patients.
UI - 99056507
AU - Klijanienko J; Vielh P
TI - Fine-needle sampling of salivary gland lesions. VII. Cytology and histology correlation of five cases of epithelial-myoepithelial carcinoma.
SO - Diagn Cytopathol 1998 Dec;19(6):405-9
AD - Departement de Pathologie, Unite de Cytopathologie et de Cytometrie Clinique, Institut Curie, Paris, France.
Fine-needle sampling (FNS) of five cases of epithelial-myoepithelial carcinoma, three primary tumors, and two local recurrences, was performed preoperatively in five patients. Cytologic diagnoses of malignancy were established in all tumors (three were reported as adenoid cystic carcinoma, two as adenocarcinoma not otherwise specified). Material for cytologic evaluation was satisfactory in all cases. Adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, papillary cystadenocarcinoma and cellular type of pleomorphic adenoma are the main differential diagnoses.
UI - 99456829
AU - Stewart CJ; Walker E; Mowat A
TI - FNA cytology of epithelial-myoepithelial carcinoma.
SO - Diagn Cytopathol 1999 Nov;21(5):363
UI - 21228231
AU - Sun SS; Tsai SC; Shiau YC; Lee JK; Kao CH
TI - Unilateral gallium-67 citrate uptake in mucosa-associated lymphoid tissue lymphoma of the parotid gland.
SO - Semin Nucl Med 2001 Apr;31(2):168-9
AD - Department of Nuclear Medicine, China Medical College Hospital, Taichung, Taipei, Taiwan.
UI - 21377613
AU - Wright JM
TI - Oral and maxillofacial pathology case of the month. Pleomorphic adenoma (PA).
SO - Tex Dent J 2001 Jun;118(6):474, 479
AD - Baylor College of Dentistry, USA.
UI - 21377916
AU - Dolinsky H; Laifook M
TI - Oral pathology quiz #32. Case 1. Malignant salivary gland neoplasm.
SO - J N J Dent Assoc 2001 Spring;72(2):32-3, 36
UI - 21377917
AU - Dolinsky H; Laifook M
TI - Oral pathology quiz #32. Case 2. Benign salivary gland tumor.
SO - J N J Dent Assoc 2001 Spring;72(2):32-3, 36
UI - 21391264
AU - Longuet M; Nallet E; Guedon C; Depondt J; Gehanno P; Barry B
TI - [Diagnostic value of needle biopsy and frozen section histological examination in the surgery of primary parotid tumors]
SO - Rev Laryngol Otol Rhinol (Bord) 2001;122(1):51-5
AD - CHU Bichat Claude Bernard, Service ORL, 46 rue Henri Huchard, F-75877 Paris, France.
The necessity of fine-needle aspiration biopsy (FNAB) in the diagnosis and treatment of parotid gland lesions is still controversial. We examined the accuracy of cytology and histology in a review of 128 parotid gland tumors who underwent surgery with FNAB, n = 102 and/or frozen section examination (FS), n = 94. The diagnostic sensibility and specificity for malignant or benign lesions was respectively 81.5% and 97.5% for FNAB and 75% and 100% for FS as compared with definite histology (110 tumors were benign and 18 malignant). Insufficient material for FNAB evaluation was found in 12 patients mainly with small tumors (p = 0.043) or with tumors located in the deep process of the parotid gland (p = 0.029). Surgery was inappropriate (superficial lobe resection for malignant tumor) because of 4 false negative FS diagnoses. FNAB offers valuable information in the diagnosis of nonsurgical lesions and permits to avoid FS if FNAB identify a benign lesion. FS remains mandatory if FNAB evaluation is not possible or suggests a neoplastic tumor.
UI - 21427062
AU - Timon CI; Dardick I
TI - The importance of dedifferentiation in recurrent acinic cell carcinoma.
SO - J Laryngol Otol 2001 Aug;115(8):639-44
AD - Department of Orolaryngology, Head and Neck Surgery, St James's Hospital, Dublin, Ireland.
The biological activity of acinic cell carcinoma is uncertain. Histological dedifferentiation is one possible reason for recurrent disease, and this study was undertaken to assess its importance in acinic cell carcinoma. The initial and recurrent specimens from five patients with acinic cell carcinoma were assessed histologically and using flow cytometry, AgNOR estimation and morphometric analysis for evidence of dedifferentiation. No objective evidence of a change in biological aggressiveness in recurrent acinic cell carcinoma was identified. In this limited series of a rare salivary gland tumour, it would appear that factors other than dedifferentiation, such as close/involved margins, histological type and stage have a more meaningful effect on the likelihood of recurrence and prognosis.
UI - 21427078
AU - Cain AJ; Goodlad J; Denholm SW
TI - Metachronous bilateral submandibular gland metastases from carcinoma of the breast.
SO - J Laryngol Otol 2001 Aug;115(8):683-4
AD - Department of Otolaryngology, Raigmore Hospital, Inverness, Scotland. email@example.com
Metastases to the salivary glands from distant neoplasms are unusual, with most reported cases involving the parotid gland. Metastatic deposits in the submandibular gland are extremely rare with bilateral involvement not previously reported. We present the case of a patient with advanced breast carcinoma who has had metachronous involvement of both submandibular glands and review the literature on this subject.
UI - 21429780
AU - Kesse KW; Manjaly G; Howlett DC
TI - Pleomorphic adenoma of retropharyngeal space: a rare location.
SO - J Laryngol Otol 2001 Aug;115(8):687
UI - 21393242
AU - Halfpenny W; Bhandari R; Dunkley S
TI - Facial paralysis with an inflammatory parotid mass.
SO - Int J Clin Pract 2001 Jul-Aug;55(6):413-4
AD - Department of Oral and Facial Surgery, Ipswich Hospital NHS Trust, Ipswich, Suffolk.
Facial paralysis in association with a parotid mass is usually associated with a diagnosis of malignancy. Benign parotid neoplasms and inflammatory processes resulting in facial paralysis are extremely rare. This report describes such a case and highlights some of the difficulties surrounding the diagnosis and management of these cases.