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Abramson Cancer CenterNCI CANCERLIT® Search: Small Intestine Cancer - October 2001
National Cancer Institute®
Last Modified: November 21, 2001
Table of Contents
1
UI - 21254743
AU - Kadmon M; Tandara A; Herfarth C
TI -
Duodenal adenomatosis in familial adenomatous polyposis coli. A review
of the literature and results from the Heidelberg Polyposis Register.
SO - Int J Colorectal Dis 2001 Apr;16(2):63-75
AD - Department of General Surgery, Heidelberg University, Im Neuenheimer
Feld 110, 69120 Heidelberg, Germany. martinakadmon@web.de
Familial adenomatous polyposis coli (FAP) is an autosomal dominant
genetic disorder caused by mutations of the APC gene on the long arm of
chromosome 5. While multiple colorectal adenomas usually developing in
early adolescence represent the most conspicuous phenotypic feature, the
disease represents a generalized hyperproliferative disorder with
various extracolonic manifestations. Duodenal cancer and desmoids are
the leading causes of death in FAP patients after prophylactic
colectomy. The prevalence of duodenal adenomatosis among FAP patients
varies from 50% to greater than 90%, while only few patients (3-5%)
develop duodenal cancer. Periampullary adenomas seem to carry a high
risk of malignant transformation. The sensitivity of endoscopic
procedures for early detection of severely dysplastic or malignant
duodenal lesions is low, and the prognosis of duodenal cancer is poor.
Thus the question arises whether it is possible to define a subgroup of
high-risk patients for duodenal malignancy, and whether severe duodenal
adenomatosis should lead to an aggressive prophylactic surgical
approach. This contribution discusses the current literature and
presents the experience of the Heidelberg Polyposis Register based on
gastroduodenoscopy findings in 231 FAP patients. In 135 cases (58.4%)
macroscopic duodenal adenomas were observed. The majority of patients
displayed numerous lesions throughout the duodenum, while adenomas were
restricted to the periampullary region in ten. Four patients suffered
from duodenal cancer. Twenty-two required an endoscopic or operative
intervention. Five were treated by laparotomy and duodenotomy, while
ampullary excision was indicated in six cases. Eight patients underwent
partial pancreaticoduodenectomy for severe duodenal adenomatosis.
2
UI - 21346305
AU - Asano Y; Ishii K; Sagiuchi T; Aoki Y; Yanaihara H; Hayakawa K
TI -
[Gastrointestinal bleeding from capillary hemangioma of the ileum
detected by 99mTc-HSAD scintigraphy]
SO - Kaku Igaku 2001 May;38(3):219-22
AD - Department of Radiology, Kitasato University School of Medicine.
It has been well-known that technetium-99m-human serum
albumin-diethylenetriaminepenta-acetic acid (99mTc-HSAD) scintigraphy is
useful for diagnosis of the localization of the gastrointestinal
arterial or venous bleeding. In this report, we describe a case of
venous bleeding from capillary hemangioma of the ileum end detected by
99mTc-HSAD scintigraphy. This patient was a 9-year-old girl with severe
anemia. Gastrointestinal bleeding was suspected from her clinical course
and laboratory tests. Immediately after melena occurred, 99mTc-HSAD
scintigraphy showed the extravasation of RI suggesting gastrointestinal
bleeding in the ileum end. Abdominal angiography immediately after
99mTc-HSAD scintigraphy, however, could not show the extravasation of
contrast agent. Because the condition of the patient became worse,
laparotomy was performed on the basis of 99mTc-HSAD scintigraphy
findings. At surgery, venous bleeding from capillary hemangioma in the
ileum end was observed. It was suggested that 99mTc-HSAD scintigraphy
was very useful for identifying the gastrointestinal venous bleeding.
3
UI - 21375988
AU - Ferrozzi F; Armaroli S; Pedrazzini M; Tognini G; Pavone P
TI -
Duodenal hemangiopericytoma: CT and MRI findings.
SO - Clin Imaging 2001 Mar-Apr;25(2):101-3
AD - Istituto di Scienze Radiologiche, Universita degli Studi di Parma, Viale
Gramsci 14, Parma I-43100, Italy. ferrozzi@unipr.it
Hemangiopericytoma (HPC) is a rare mesenchymal tumor generally occurring
in adults and originating from the pericytes. The tumor more commonly
affects the soft tissues of the extremities, the pelvis, and the
retroperitoneum. We describe the computed tomographic and magnetic
resonance appearance of a patient affected by HPC of the duodenum.
4
UI - 21435100
AU - Rymarczyk G; Hartleb M; Boldys H; Kajor M; Wodolazski A
TI -
Neurogenic tumors of the digestive tract: report of two cases.
SO - Med Sci Monit 2000 Mar-Apr;6(2):383-5
AD - Department of Gastroenterology, Silesian Medical University, ul. Medykow
14, 40-752 Katowice, Poland.
We report two female patients with neurogenic tumors of the digestive
tract. In the first patient, the tumor of 10 cm diameter originated in
the stomach and at preoperative CT imitated a peripancreatic cyst. In
the second patient, the tumor of 6 cm diameter originated in the
duodenum. Despite large size, the tumors were clinically indolent and
escaped detection at routine endoscopic evaluation. In both cases the
neoplasm was removed and postoperative histopathology combined with
immunohistochemistry was consistent with diagnosis of digestive
Schwannoma.
5
UI - 21393535
AU - Ishida H; Konno K; Sato M; Naganuma H; Komatsuda T; Yamada N; Hamashima
TI -
Y; Ishida J; Segawa D; Watanabe S
Duodenal carcinoma: sonographic findings.
SO - Abdom Imaging 2001 Sep-Oct;26(5):469-73
AD - First Department of Internal Medicine, Akita University School of
Medicine, 1-1-1 Hondo, Akita City, Japan.
BACKGROUND: Duodenal carcinoma is a relatively rare tumor and its
sonographic (US) findings have rarely been reported. METHODS: We
reviewed the clinical data and US results of 15 patients with
histologically proven duodenal carcinoma to pinpoint the contribution of
US to the diagnosis. RESULTS: US was useful for not only detecting the
duodenal carcinoma (13 of 15, 86.7%), which altered the endoscopic
procedure in nine patients, but also for evaluating vascular involvement
(marked portal invasion in four cases and inferior vena cava invasion in
two cases). Four of the eight carcinomas arising from the second or
third portion showed this vascular invasion. CONCLUSION: After reviewing
the clinical data and US results of 15 cases of duodenal carcinoma, we
found that US was useful for detecting duodenal carcinoma and
determining vascular invasion. Thus, US contributed significantly to
alter the endoscopic procedure and patient management.
6
UI - 21416562
AU - Kanamori A; Okamura S; Ohashi S; Urano F; Kanamori S; Hosoi T; Ishikawa
TI -
H; Kitabatake S; Sano H; Segawa K
[A case of carcinoma of the ileum invading proper muscular layer]
SO - Nippon Shokakibyo Gakkai Zasshi 2001 Aug;98(8):959-63
AD - Department of Gastroenterology, Toyohashi Municipal Hospital.
7
UI - 21420067
AU - Mahachai V; Vilaichone RK; Wisedopas N
TI -
Malignant duodenal stromal tumor: the first case report in Thailand and
review of the literature.
SO - J Med Assoc Thai 2001 Jun;84 Suppl 1():S481-4
AD - Department of Medicine, Faculty of Medicine, Chulalongkorn University,
Bangkok, Thailand.
The authors presented a middle aged Thai patient with malignant duodenal
stromal tumor identified at a tertially care centre in Thailand. The
patient presented with obscure gastrointestinal bleeding and the small
bowel endoscopy revealed a bleeding tumor mass at the fouth part of the
duodenum. The patient underwent segmental duodenectomy with end to end
anstosomis. The histopathology of the tumor composed of interlacing
bundles of spindle cells with oval to elongated pleomorphic nuclei and
eosinophilic cytoplasm. The immunohistochemistrical study confirmed the
diagnosis of malignant stromal tumor with smooth muscle differentiation.
The computer tomography scan (CT scan) of the abdomen showed no evidence
of metastasis. Postoperatively, the patient's clinical condition showed
continuous improvement without further gastrointestinal bleeding. The
patient has remained healthy up to present (six months of follow-up). A
high level of suspicion to detect this malignant tumor especially in a
patient presenting with obscure gastrointestinal bleeding and effective
surgical treatment allow better clinical outcome in this rare and fatal
malignancy.
8
UI - 21441830
AU - Abrahams NA; Vesoulis Z; Petras RE
TI -
Angiogenic polypoid proliferation adjacent to ileal carcinoid tumors: a
nonspecific finding related to mucosal prolapse.
SO - Mod Pathol 2001 Sep;14(9):821-7
AD - Department of Anatomic Pathology, The Cleveland Clinic Foundation,
Cleveland, Ohio 44195, USA.
Case reports have highlighted angiogenic polypoid proliferation in the
mucosa adjacent to ileal carcinoid tumors, describing them as
granulation tissue polyposis and florid angiogenesis. Some authors have
proposed that the ileal carcinoid tumors themselves produce growth
factors that cause the change. The purpose of this study was to
determine the frequency of angiogenic polypoid proliferation in a large
cohort of resected ileal carcinoid tumors compared with control groups.
Search of the Cleveland Clinic and Summa Health System pathology files
(1985 to 1999) yielded 65 resected ileal carcinoid tumors. Mucosal
abnormalities adjacent to the ileal carcinoid tumors were graded 0 to
4+. Twenty ileal resection margins from colonic carcinoma cases served
as normal controls. Ileal mucosa adjacent to 22 noncarcinoid neoplasms
were also examined. The mucosa adjacent to 54/65 ileal carcinoid tumors
(83%) showed mucosal abnormalities (vs. 3/20 normal controls), including
mucosal edema, capillary ectasia, muscularis mucosae hypertrophy,
fibrosis/smooth muscle proliferation within the lamina propria,
club-shaped villi, and intramucosal capillary proliferation. Forty ileal
carcinoid tumor cases (61%) showed some degree of angiogenic polypoid
proliferation characterized by club-shaped villi and prominent
intramucosal capillaries, with 17 (26%) graded as 3+ or 4+. Angiogenic
polypoid proliferation was associated with hypertrophy of the muscularis
mucosae, lamina proprial fibrosis/smooth muscle proliferation, and
capillary ectasia similar to that described with gastrointestinal
mucosal trauma/prolapse. This trauma/prolapse change was identified in
45 cases (69%) and was graded 3+ or 4+ in 23 (35%). Seventeen (77%) of
the noncarcinoid neoplasms showed trauma/prolapse changes, with 7 (32%)
graded as 3+ or 4+. Angiogenic polypoid proliferation also correlated
with trauma/prolapse change in the noncarcinoid neoplasm controls.
Neither APP (P =.24) nor the prolapse changes (P =.33) were found to be
statistically different between the two tumor groups. Angiogenic
polypoid proliferation of the adjacent ileal mucosa is common in
patients with ileal carcinoid tumors and with noncarcinoid neoplasms.
Angiogenic polypoid proliferation almost invariably coexists with
fibromuscular change and capillary ectasia within the lamina propria,
suggesting that mucosal trauma/prolapse plays a role in the
histogenesis. The association of angiogenic polypoid proliferation with
a variety of different neoplasms makes it unlikely that the tumors
themselves secrete growth factors.
9
UI - 21454843
AU - Strobel K
TI -
[Small intestine invagination in metastatic intestinal malignant
melanoma]
SO - Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 2001 Aug;173(8):768-9
10
UI - 21453173
AU - Capirci C; Polico C; Mandoliti G
TI -
Dislocation of small bowel volume within box pelvic treatment fields,
using new "up down table" device.
SO - Int J Radiat Oncol Biol Phys 2001 Oct 1;51(2):465-73
AD - Department of Radiation Oncology, Rovigo's State Hospital, Rovigo,
Italy.
PURPOSE: To present the impact of a novel minimization device, the up
down table (UDT), on the volume of small bowel included within a 4-field
pelvic irradiation plan. METHODS: A polystyrene bowel displacement
standard mold was created and added to a customized vacuum cushion (Vac
Lok) formed around the abdomen and legs of each patient in the prone
position. Two hundred seventy-seven consecutive patients with pelvic
malignancies treated with the UDT device were compared with 1 historic
series (68 cases) treated at our division. Small bowel contrast dyes at
the time of simulation were used in all patients. RESULTS: The average
volume of small bowel within the planning target volume (high-dose
volume, calculated with Gallagher method) was 100 cm(3) (median 49 +/-
114) in the series treated with standard box technique and 23 cm(3)
(median 0 +/- 64) in the series treated with the UDT (p < 0.001). The
average volume of small bowel included in any isodose (any-dose volume)
was 505 cm(3) (median 447 +/- 338) and 158 cm(3) (median 69 +/- 207),
respectively (p < 0.001). The incidence of G1, G2, and G3 acute enteric
toxicity (Radiation Therapy Oncology Group criteria) in the UDT series
was 16%, 15%, and 1.5%; in the standard box technique, it was 28%, 25%,
and 3%, respectively (p < 0.05). The incidence of acute enteric toxicity
directly correlated with the irradiated small bowel volume. In the UDT
series, the 5-year actuarial incidence of G3 chronic enteric toxicity
was 1.8%. The setup procedures, analyzed in 18 cases, revealed no
systematic errors and a standard deviation equal to +/-5 mm for random
errors. CONCLUSIONS: The UDT technique is comfortable, inexpensive,
highly reproducible, and permits an almost full bowel displacement from
standard radiotherapy fields.
11
UI - 21290106
AU - Rizzo S; Bonomo S; Moser A; Bottura D; Castellini C; Mazzola F; Lauro E;
TI -
Vicenzi L; Betresini B; Angeli G; Brazzarola P; D'Azzo G; Rosa G
[Bilateral pheochromocytoma associated with duodeno-jejunal GIST in
patient with von Recklinghausen disease: report of a clinical case]
SO - Chir Ital 2001 Jan-Feb;53(2):243-6
AD - Dipartimento di Scienze Chirurgiche e Gastroenterologiche Cattedra di
Semeiotica e Metodologia Chirurgica, Universita degli Studi di Verona.
The authors present the case of a 60-year-old male patient suffering
from von Recklinghausen's disease (neurofibromatosis type I, NF1) with
bilateral pheochromocytoma and occasional intraoperative reports of
duodenojejunal GIST (GastroIntestinal Stromal Tumour). Through a review
of the literature the authors analyze the frequency and the features of
bilateral pheochromocytoma and its rare histological variant, the
so-called composite pheochromocytoma, characterized by the combination
of pheochromocytoma and ganglioneuroma or ganglioneuro-blastoma.
Bilaterality of pheochromocytoma is more frequent in patients with
familiarity for pheochromocytoma without NF1. Composite pheochromocytoma
accounts for about 3% of total pheochromocytomas. In addition, the
authors summarize the present knowledge about gastrointestinal stromal
tumours and investigate the possible association between them and NF1 or
pheochromocytoma, concluding that any such association is purely casual,
while confirming the well known, genetically determined association
between NF1 and pheochromocytoma.
12
UI - 21384119
AU - Fleisch MC; Schmidt J; Zirngibl H
TI -
[Jejunum interposition as replacement of the pars descendens duodeni in
extensive tubulovillous adenoma]
SO - Chirurg 2001 Jul;72(7):832-5
AD - Lehrstuhl fur Chirurgie II, Universitat Witten/Herdecke.
M.Fleisch@t-online.de
Reconstruction after partial duodenectomy with resection of the ampulla
of Vater is often troublesome. We report the case of a 70-year-old
patient with endoscopically non-resectable tubulo-villous adenoma of the
descending duodenum including the ampulla of Vater in which subsequent
biopsies revealed dysplastic areas. A partial resection of the
descending duodenum including the ampulla of Vater was performed.
Reconstruction was achieved by the interposition of a jejunal limb in
which the ampulla could be reinserted to the posterior wall. The
postoperative course was uneventful; a carcinoma was not found within
the specimen. In cases of widespread adenomas of the ampulla of Vater,
duodenum-preserving resection by interposition of a jejunal limb with
reinsertion of the ampulla into the posterior wall may be used as an
alternative to Roux-Y reconstruction and to Whipple's procedure.
13
UI - 21419020
AU - Scintu F; Giordano M; Mascia R; Comella D; Casula G
TI -
Neuromuscular and vascular hamartoma of the small intestine.
SO - Dig Surg 2001;18(4):331-3
AD - Chirurgia Generale II, University of Cagliari, Cagliari, Italy.
scintu@unica.it
Neuromuscular and vascular hamartoma is an extremely rare stricturing
condition of the small bowel. It consists of abnormal mixtures of
intestinal tissues: disorganized fascicles of smooth muscle derived from
the submucosa, bundles of nonmyelinated nerve fibers with scattered
abnormal ganglion cells and hemangiomatous vessels, occurring focally
and causing recurrent obstructive symptoms or occult chronic
gastrointestinal bleeding. In this paper we report our experience with
this tumor. Copyright 2001 S. Karger AG, Basel
14
UI - 21456740
AU - van Ruth S; de Vos tot Nederveen Cappel WH; van Laarhoven CJ; Vasen HF
TI -
[Frequency of duodenal adenomas in patients with familiar adenomatous
polyposis]
SO - Ned Tijdschr Geneeskd 2001 Sep 8;145(36):1744-8
AD - Universitair Medisch Centrum, afd. Heelkunde, Utrecht.
OBJECTIVE: To estimate the prevalence of polyps in the stomach and
duodenum in patients with familial adenomatous polyposis (FAP), and to
examine the relationship between age and severity of duodenal
adenomatosis. DESIGN: Retrospective. METHOD: Using the FAP-registry of
the Netherlands Foundation for the Detection of Hereditary Tumours, data
were obtained from patients who had undergone a gastroduodenoscopy
to classify the duodenal adenomas according to the Spigelman
classification. RESULTS: 224 patients had undergone at least one
gastroduodenoscopy: 117 men and 107 women with a mean age at the time of
the first endoscopy of 37 years (range: 13-78). Fundic gland polyposis
was detected in 79 patients (35%), stomach adenomas in 6 patients (3%)
and duodenal adenomas in 92 patients (41%). A total of 21 patients (9%)
had severe duodenal adenomatosis (Spigelman III or IV). Duodenal
adenomatosis was often more severe if the patient was older. Ten
patients were known to have duodenal cancer; the mean age at diagnosis
was 50.3 years (range: 39-67). CONCLUSION: Nearly 10% of the patients
with FAP had developed severe duodenal adenomatosis. The severity of
duodenal adenomatosis was related to the patient's age.
15
UI - 21467940
AU - Danikas D; Sachs R; Dressner RM; Arvanitis ML
TI -
Testicular metastasis from ileal carcinoid: report of a case.
SO - Dis Colon Rectum 2001 Sep;44(9):1365-6
AD - Department of Surgery, Monmouth Medical Center, Long Branch, New Jersey,
USA.
PURPOSE: This report presents a patient with testicular metastasis from
an ileal carcinoid. METHODS: This was a retrospective case review with
literature review. RESULTS: The patient underwent right orchiectomy for
a solid mass. Pathology revealed carcinoid tumor. Octreotide scan showed
increased concentration in the right lower quadrant of the abdomen.
Computerized tomography results were negative. Colonoscopy with biopsy
revealed carcinoid of the terminal ileum. The patient underwent an
elective resection of the terminal ileum and the right colon. Pathology
revealed carcinoid tumor with vascular and lymphatic invasion present,
and eight lymph nodes were positive. The patient had adjuvant treatment
with octreotide. CONCLUSION: Carcinoid tumors have been reported to
metastasize to numerous areas. This is the first report of testicular
metastasis from ileal carcinoid. Primary carcinoids of the testicle have
been reported also. The clinician should be aware of this rare
metastatic event. When pathology reveals carcinoid of the testicle,
metastatic disease should be excluded before the tumor is identified as
primary.
16
UI - 21263180
AU - Gorsler C; Schier F; Danzer E
TI -
Ciliated epithelium in a midgut enteric duplication: a case report.
SO - Eur J Pediatr Surg 2001 Apr;11(2):136-8
AD - Department of Pediatric Surgery, University Medical Center Jena,
Germany.
We report the case of a 7-year-old male child with a cystic tumour
attached to the caecum close to the ileocaecal valve. The histological
examination showed that the cyst had a ciliated epithelial lining,
containing serous and mucous glands, with surrounding smooth muscle,
inner circular and outer longitudinal layers. The cyst was interpreted
as an intestinal duplication lined with respiratory epithelium. This
structure and its location, originating from the midgut, is not in
accordance with the typical conception of the embryogenesis. The
clinical picture and treatment are described and compared to other
findings in the literature.
17
UI - 21289719
AU - Suzuki H; Ikeda K
TI -
Endoscopic mucosal resection and full thickness resection with complete
defect closure for early gastrointestinal malignancies.
SO - Endoscopy 2001 May;33(5):437-9
AD - Dept. of Endoscopy, Jikei University School of Medicine, Tokyo, Japan.
endosc-taka@jikei.ac.jp
BACKGROUND AND STUDY AIMS: We developed a new endoscopic technique, the
endoscopic full-thickness resection (EFTR) and endoscopic complete
defect closure (ECDC), for the treatment of early gastrointestinal
malignancies. PATIENTS AND METHODS: Two rectal and one duodenal
carcinoid were treated by EFTR with ECDC and resectability,
complications and pathological findings were evaluated. RESULTS: In all
cases, the lesion was completely resected without serious complications.
The histology of the specimen also confirmed complete resection of the
tumor. CONCLUSIONS: This technique has great potential for the treatment
of early gastrointestinal malignancies. Preliminary results have shown
that early malignant gastrointestinal lesions can be safely and
completely resected by EFTR with ECDC.
18
UI - 21300181
AU - Altavilla G; Chiarelli S; Fassina A
TI -
Duodenal periampullary gangliocytic paraganglioma: report of two cases
with immunohistochemical and ultrastructural study.
SO - Ultrastruct Pathol 2001 Mar-Apr;25(2):137-45
AD - Institute of Pathological Anatomy and Histology, University of Padova,
Italy. altavill@ux1.unipd.it
We report two cases of Gangliocytic Paraganglioma (GP) of the ampulla of
Vater occurring in a 63-year-old and a 34-year-old individual. The
patients were both admitted for a long history of intermittent
gastrointestinal bleeding and abdominal discomfort, with no other
symptoms. At endoscopy, the GP appeared as a polypoid, ulcerated mass in
the ampullar region, measuring 2.5x1.8 and 2 cm, respectively.
Microscopically, the tumors showed similar features and were composed of
epithelial cells (more than 50%), spindle cells, and ganglion-like
cells. The epithelial cells showed clear cytoplasm and formed nests
(zellballen or paraganglioma-like groups), and less frequently, cords
(carcinoid-like), extending to mucosa and submucosa. Ganglion cells were
sparse, constantly associated with the spindle cells. Both epithelial
and ganglion cells were synaptophysin, chromogranin A, and
anti-neurofilament immunoreactive. The spindle cells were all S-100
positive. Ultrastructural studies revealed dark and light cells, rare
elongated cellular processes, secretory granules, and fine fibrils
resembling neurofilaments. The histogenesis of GP is still a matter of
debate, however its neoplastic nature is supported by the occasionally
reported malignant evolution.
19
UI - 21342885
AU - Hutchins RR; Bani Hani A; Kojodjojo P; Ho R; Snooks SJ
TI -
Adenocarcinoma of the small bowel.
SO - ANZ J Surg 2001 Jul;71(7):428-37
AD - King George Hospital, Essex, UK. rob@rhutchins.fsnet.co.uk
Cancer of the small bowel is a rare entity but its incidence is rising.
Historically, outcome is poor despite apparent curative resection. At
present surgery remains the only treatment modality of proven benefit in
the management of this disease. Recent data would suggest 5-year
survival rates in the order of 40-50% at all sites of small bowel
cancer. To improve upon this, earlier diagnosis with a high index of
suspicion and multicentre adjuvant therapy trials are required.
20
UI - 21462462
AU - Langer P; Wild A; Celik I; Kopp I; Bergenfelz A; Bartsch DK
TI -
Prospective controlled trial of a standardized meal stimulation test in
the detection of pancreaticoduodenal endocrine tumours in patients with
multiple endocrine neoplasia type 1.
SO - Br J Surg 2001 Oct;88(10):1403-7
AD - Department of General Surgery, Philipps-University, Marburg, Germany.
BACKGROUND: Use of a standardized meal stimulation test has been
recommended for the early diagnosis of pancreaticoduodenal endocrine
tumours (PETs) in patients with multiple endocrine neoplasia type 1 (MEN
1). The diagnostic value of this test was re-evaluated. METHODS: In a
prospective, controlled trial 58 standardized meal stimulation tests
(563 kcal) were performed in 12 patients with MEN 1 and histologically,
biochemically and/or radiologically confirmed PETs (group 1), 11
carriers of an MEN 1 mutation with no evidence of PETs (group 2) and in
27 healthy controls (group 3). Serum pancreatic polypeptide (PP) and
gastrin concentrations were measured before and during the test meal.
RESULTS: Patients in group 1 had significantly higher mean basal serum
PP and gastrin concentrations than patients in group 2 and controls (P <
0.05). In all three groups an increase in serum PP was observed after
meal stimulation, but there was no significant difference between the
groups. No increase in gastrin level was found in any of the groups
after meal stimulation. CONCLUSION: The standardized meal stimulation
test does not reliably indicate the presence of PETs in patients with
MEN 1, whereas raised basal serum PP and gastrin levels do. The
expensive and time-consuming meal test can be excluded from MEN 1
screening programmes.
21
UI - 20351099
AU - Block KP; Frick TJ; Warner TF
TI -
Gastrointestinal bleeding from a Brunner's gland hamartoma:
characterization by endoscopy, computed tomography, and endoscopic
ultrasound.
SO - Am J Gastroenterol 2000 Jun;95(6):1581-3
AD - Department of Medicine, University of Wisconsin-Madison, USA.
22
UI - 21398444
AU - Jouini S; Ayadi K; Mokrani A; Wachuku E; Hmouda H; Gourdie R
TI -
[Mediterranean lymphoma mimicking Crohn's disease]
SO - J Radiol 2001 Jul;82(7):855-8
AD - Departement d'Imagerie Medicale, King Khalid Military City Hospital,
Hafal Al Batin 31991 Arabie Saoudite, France.
We report an uncommon localization of mediterranean lymphoma of the
terminal ileum in a 28 year-old male patient. Ultrasound and Computed
Tomography showed moderate regular and symmetrical intestinal wall
thickening simulating Crohn's disease. We highlight the role of computed
tomography in the diagnosis, staging and detection of complications.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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