National Cancer Institute®
Last Modified: April 1, 2002
UI - 11534406
AU - Conde Sanchez JM; Espinosa Olmedo J; Rico Lopez J; Camacho Martinez E;
TI - Blasco Hernandez P; Lara Lara I; Miralles Sanchiz EJ; Garcia Perez M [Squamous cell carcinoma of the renal pelvis. A clinical case]
SO - Actas Urol Esp 2001 Jul-Aug;25(7):513-8
AD - Servicio de Urologia, Hospital Universitario de Valme, Sevilla.
Squamous cell carcinoma of the renal pelvis is uncommon, accounting for approximately 10% of all renal pelvic tumours. It's often associated with chronic renal calculi or infection and it usually presents at an advanced stage with pain or a palpable mass. We report an incidental case of squamous cell carcinoma of the renal pelvis, associated with chronic renal calculi and infection, and weight loss. The prognosis of patients with advanced squamous cell carcinoma of genitourinary origin is poor. In patients with chronic stones or infection squamous cell carcinoma of renal pelvis must be suspected if survival is to be affected.
UI - 11705569
AU - Lord GM; Cook T; Arlt VM; Schmeiser HH; Williams G; Pusey CD
TI - Urothelial malignant disease and Chinese herbal nephropathy.
SO - Lancet 2001 Nov 3;358(9292):1515-6
We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) in two patients in the UK. These cases highlighted the role of aristolochic acid in causing this nephropathy, which was first described in a Belgian cohort. We now report development of invasive transitional cell carcinoma of the urinary tract associated with the presence of aristolochic acid-DNA adducts in one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid in this new type of nephropathy.
UI - 11905911
AU - Lyon ES; Kyker JS; Schoenberg HW
TI - Transurethral ureteroscopy in women: a ready addition to the urological armamentarium. 1978.
SO - J Urol 2002 Feb;167(2 Pt 2):859-60; discussion 861
UI - 11706066
AU - Nakanishi K; Hiroi S; Kawai T; Aida S; Kasamatsu H; Aurues T; Ikeda T
TI - Expression of telomerase catalytic subunit (hTERT) mRNA does not predict survival in patients with transitional cell carcinoma of the upper urinary tract.
SO - Mod Pathol 2001 Nov;14(11):1073-8
AD - Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa 359-8513, Japan. email@example.com
Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric repeats onto chromosomal ends using a segment of its RNA component as a template. Its activity has become an established indicator of the diagnosis, biological behavior, and prognosis of several tumors. However, few studies have investigated the diagnostic and prognostic importance of the expression of telomerase catalytic subunit (hTERT) mRNA in transitional cell carcinoma of the upper urinary tract (TCC-UUT). We investigated the expression of hTERT mRNA using in situ hybridization in 125 cases of TCC-UUT, and also its relation with the expression of telomerase RNA component (hTERC), proliferating cell nuclear antigen (PCNA) immunoreactivity, clinicopathologic parameters, and clinical outcome. A positive expression of hTERT mRNA was recognized in 93.6% of the samples and was apparent within the cytoplasm of tumor cells. In the normal urothelium examined in a few cases, its expression was barely detected. hTERT mRNA scores showed a significant association with hTERC score. However, no relationship was found between the expression of hTERT mRNA and clinicopathologic findings, PCNA index, or prognosis. These results suggest that the expression of hTERT mRNA does not predict prognosis in TCC-UUT.
UI - 11911292
AU - Hirano Y; Kageyama S; Ushiyama T; Suzuki K; Fujita K
TI - Clinical usefulness of chemotherapy based on an in vitro chemosensitivity test in urothelial cancer patients.
SO - Anticancer Res 2001 Nov-Dec;21(6A):4061-6
AD - Department of Urology, Hamamatsu University School of Medicine, Hamamatsu City, Japan. firstname.lastname@example.org
BACKGROUND: We evaluated the clinical usefulness of individualized chemotherapy based on an in vitro chemosensitivity test, i.e., the histoculture drug response assay (HDRA), for urothelial cancer. MATERIALS AND METHODS: 62 clinically obtained cancer specimens were studied. Each specimen was tested for sensitivity to nine anticancer drugs. The antitumor effect was calculated as the inhibition rate to their control values. The HDRA effective cytotoxic drugs were selected for clinical treatment. RESULTS: HDRA was possible in 58 out of 62 specimens (93.5%). Their chemosensitivity showed a wide variety even among the same histological category. No correlation was seen between histological grade and chemosensitivity. The effect of chemotherapy on the measurable lesions was studied in 12 patients and good clinical responses were obtained in 7 of them (58.3%). All 7 responders were the patients who received drugs predicted to be effective by HDRA. In 8 out of the 12 patients (66.7%), including 7 true-positive and 1 true-negative, HDRA correctly predlicted the clinical effect of chemotherapy. CONCLUSION: The HDRA might be feasible for predicting the efficacy and, therefore, selecting the proper anticancer drug for individual patients.
UI - 11847585
AU - Chan V; Pantanowitz L; Vrachliotis TG; Rabkin DJ
TI - CT demonstration of a rapidly growing transitional cell carcinoma of the ureter and renal pelvis.
SO - Abdom Imaging 2002 Mar-Apr;27(2):222-3
AD - Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA.
Transitional cell carcinoma (TCC) is the most common urothelial malignancy. We present a case of an exceptionally aggressive TCC involving the renal pelvis and ureter. To our knowledge, an upper tract TCC of such rapid growth has not been reported.
UI - 11555017
AU - Yagi S; Kawano Y; Gotanda T; Kitagawa T; Kawahara M; Nakagawa M; Higashi
TI - Y Endoscopic treatment of a long fibroepithelial ureteral polyp.
SO - Int J Urol 2001 Aug;8(8):467-9
AD - Department of Urology, Kagoshima University Hospital, Kagoshima, Japan. email@example.com
A case is reported of a 30-year-old woman with a long fibroepithelial polyp in the middle ureter treated with the Ho-YAG laser endoscopically. She presented with an intermittent macroscopic hematuria and lower abdominal pain lasting for 1 year. The filling defect on urography occupying one-third of the ureter was migratory depending on the patient position. Transurethral flexible ureterorenoscopy showed a large pedunculated tumor with a small base at the middle ureter. About 1 month after the endoscopic irradiation of the Ho-YAG laser to the base of tumor, the tumor was spontaneously discharged and pathologic examination revealed it to be a fibroepithelial polyp without malignant component. Postoperatively, the patient remained asymptomatic and follow-up excretory urographs showed no abnormal findings.
UI - 11901541
AU - VanderMolen LA; Sheehy PF; Dillman RO
TI - Successful treatment of transitional cell carcinoma of the urethra with chemotherapy.
SO - Cancer Invest 2002;20(2):206-7
AD - Hoag Cancer Center, Newport Beach, CA 92658, USA.
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