National Cancer Institute®
Last Modified: May 1, 2002
UI - 11914950
AU - Scheer M; Drebber U; Kubler A; Zoller JE
TI - [The monthly interesting case No. 52. Plexiform ameloblastoma of the maxillary sinus]
SO - Laryngorhinootologie 2002 Feb;81(2):122-5
AD - Klinik und Poliklinik fur Zahnarztliche Chirurgie und fur Mund-, Kiefer- und Gesichtschirurgie, Universitat zu Koln. m.scheer@uni-koeln-de
UI - 11914946
AU - Issing PR; Hemmanouil I; Wilkens L; Karstens H; Lenarz T
TI - [Long term results in adenoidcystic carcinoma]
SO - Laryngorhinootologie 2002 Feb;81(2):98-105
AD - Klinik fur Hals-Nasen-Ohrenheilkunde, Medizinische Hochschule Hannover. email@example.com
BACKGROUND: Due to the discreet initial symptoms and the locally aggressive infiltration with perineural spread the adenoidcystic carcinoma (ACC) presents a special diagnostical and therapeutical challenge. PATIENTS:: In a retrospective study the forms of 54 patients were analysed, whose average age was 55.5 (24 - 77) years. RESULTS: The sex ratio showed a slight female preponderance with 57 % to 43 %. The major salivary glands were affected in 26 cases. The exact distribution of the ACC was: parotid gland (n = 18), submandibular gland (n = 8), oral cavity (n = 10), paranasal sinuses (n = 11), nasopharynx (n = 4) and larynx (n = 3). The most common symptoms were a tumor-related swelling and pain which persisted for a duration of several months after final diagnosis could be established. Facial palsy was observed in 4 patients. Histological examination revealed a tubular subtype in 4 cases, in 28 cases a cribriforme and in 12 cases a solid subtype. No definitive differentiation was possible in 10 specimens. The skull base was infiltrated in 16 patients. Except one patient all 54 underwent surgical therapy. Postoperative radiotherapy was additionally given in 25 cases which was combined with a chemotherapy in 6 patients. Nevertheless ACC recurred in 60 % of our patients. Lymphnode metastases were observed in 13 patients after a latency of 3.3 years in average, but predominantly pulmonary metastases as distant spread developed in 18 patients after 5.8 years significantly later. The overall survival rate was 84.38 % after 2 years, 75.90 % after 5 years, 50.49 % after 10 years and 20.11 % after 20 years. Male sex, infiltration of the skull base and histological evidence of perineural and perivascular spread proved to be statistically significant factors for an unfavourable prognosis. CONCLUSIONS: Due to the uncommon biological behaviour with a slow growth on the one hand side and an aggressive local invasion on the other hand side the ACC can be regarded as a challenging malignant disease for the clinician whose adequate therapy does not allow any standardized regime. The tendency for recurrence even after a period clinically free of symptoms makes a life long follow-up mandatory.
UI - 11771047
AU - Yoskovitch A; Frenkiel S; Franco E; Coutlee F; Nachtigal D; Rochon L
TI - Analysis of human papillomavirus in schneiderian papillomas as compared to chronic sinusitis and normal nasal mucosa.
SO - J Otolaryngol 2001 Jun;30(3):167-72
AD - Department of Otolaryngology, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec.
Schneiderian papillomas (SPs) are tumours arising from the surface epithelium (schneiderian epithelium) of the nasal cavity and paranasal sinuses. Evidence points toward a viral etiology, specifically human papillomavirus (HPV). Although substantial data indicate HPV as a likely etiology, little is known about the role of HPV in benign nasal pathologies or in normal nasal mucosa. The objective of this study was to characterize the relationship between HPV and SP, chronic sinusitis (CS), and normal nasal mucosa. A case-control study was undertaken, matching patients with SP to patients with CS. Patients with normal nasal mucosa served as a control group. All patients had their tissues analyzed for the presence of various HPV subtypes using line blot assay. A total of 168 patients were identified (74 SP, 74 CS, 20 control). Of these, 70 (41.7%) had detectable deoxyribonucleic acid and 9 of 70 (12.9%) had detectable HPV of subtypes 6, 11, and 16. None had detectable HPV type 18. Significant differences were detected in the presence of HPV in the CS, SP, and control groups, as well as in the presence of low- versus high-risk subtypes among investigation and control groups. Significant differences exist in HPV infectivity among SP, benign nasal pathologies such as CS, and normal nasal mucosa. Human papillomavirus plays an important role, at least in part, in the development of SP, with types 6, 11, and 16 being more pivotal than other types. Line blot assay is a useful technique in identifying HPV in SP.
UI - 11904043
AU - Johnson D; Tan L
TI - Intraparenchymal tension pneumatocele complicating frontal sinus osteoma: case report.
SO - Neurosurgery 2002 Apr;50(4):878-9; discussion 880
AD - Department of Neurosurgery, Gold Coast Hospital, Southport, Queensland, Australia. firstname.lastname@example.org
OBJECTIVE AND IMPORTANCE: A relatively rare condition of intraparenchymal tension pneumatocele secondary to a frontal sinus osteoma eroding posteriorly and breaching dura mater is described. The scanty body of literature on this subject is briefly summarized, and the importance of this condition as a result of its life-threatening but readily treatable intracranial mass effect is outlined. CLINICAL PRESENTATION: The patient presented with acute deterioration in conscious state and lateralizing signs from the mass effect of gas under tension. Two weeks earlier, he had experienced vague and subtle changes in personality noticeable only to his family. INTERVENTION: The patient was cured by a frontal craniotomy, partial excision of the osteoma, and suture repair of the dural defect after evacuation of the pressurized air cavity. CONCLUSION: This rare condition should be urgently treated in the event of acute deterioration. To prevent a life-threatening situation from arising, elective surgery should be considered for patients known to have air sinus osteomas that are at risk of erosion into the cranial cavity.
UI - 11950664
AU - Chen CC; Hsu L; Hecht JL; Janecka I
TI - Bimaxillary chondrosarcoma: clinical, radiologic, and histologic correlation.
SO - AJNR Am J Neuroradiol 2002 Apr;23(4):667-70
AD - Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
In this report, we describe an unusual case of chondrosarcoma that involved the entire bimaxillary and nasal skeleton. The pathogenesis, correlation of histopathology with radiology, and management of chondrosarcoma are reviewed.
UI - 11966793
AU - Carucci JA; Kolenik SA 3rd; Leffell DJ
TI - Human cadaveric allograft for repair of nasal defects after extirpation of Basal cell carcinoma by Mohs micrographic surgery.
SO - Dermatol Surg 2002 Apr;28(4):340-3
AD - Department of Mohs Micrographic and Dermatologic Surgery, Weil Medical College, Cornell University, New York, New York, USA.
BACKGROUND: Immediate reconstruction after removal of skin cancer by Mohs micrographic surgery (MMS) may not be feasible in patients unwilling or unable to undergo an extensive procedure. Human cadaveric allograft (HCA) may offer a useful alternative to granulation. OBJECTIVE: To examine the usefulness of HCA in resurfacing nasal defects after extirpation of basal cell carcinoma (BCC) by MMS. METHODS: Case histories of seven patients treated with HCA were reviewed with respect to primary skin cancer histology, defect size, medical status, healing time, and cosmesis. RESULTS: Five of seven tumors were infiltrative BCCs. Defects ranged from 2.7 to 20 cm2. Average healing times for wounds with and without exposed cartilage were 42 and 35 days, respectively. There were no wound infections. Hypergranulation tissue was noted in three patients and had no effect on cosmesis, which was adequate in five patients and poor in two patients. CONCLUSION: HCA may be a useful alternative to granulation following MMS for treatment of skin cancers involving the nose.
UI - 11859210
AU - Jeng YM; Sung MT; Fang CL; Huang HY; Mao TL; Cheng W; Hsiao CH
TI - Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities.
SO - Am J Surg Pathol 2002 Mar;26(3):371-6
AD - Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive neoplasm arising in the nasal cavity and paranasal sinuses. Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is an even rarer tumor that has not been adequately reported. Both tumors have been reported to be associated with Epstein-Barr virus (EBV). We studied the clinicopathologic features and EBV status of 36 SNUC and 13 PSNPC patients from Taiwan, an EBV endemic area. The median age of SNUC patients was 53 years (range 20-76 years), with a male/female ratio of approximately 2:1. Five patients had histories of previous nasopharyngeal carcinoma treated with irradiation 6-26 years earlier. The most common locations were nasal cavity and ethmoid sinus. Orbital and intracranial invasion and distant metastasis were frequent findings. The median survival was 10 months. All 36 tumors were negative for EBER-1 by in situ hybridization. The median age of PSNPC patients was 58 years (range 36-75 years), with a male/female ratio of approximately 2:1. The most common location is nasal cavity. Eight patients achieved disease-free survival. Eight tumors had the morphology of lymphoepithelioma, whereas significant inflammatory infiltrate was not detected in the other five tumors. All 13 tumors were positive for EBER-1 by in situ hybridization. Because of the difference in the relation with EBV, prognosis, and response to radiotherapy, SNUC and PSNPC should be considered as two entirely different entities. The most important criteria for PSNPC are vesicular nuclei, syncytial pattern, spindle cells, and absence of necrosis.
UI - 11893980
AU - Fusconi M; Magliulo G; Rocca CD; Marcotullio D; Suriano M; de Vincentiis
TI - M Leiomyosarcoma of the sinonasal tract: a case report and literature review.
SO - Am J Otolaryngol 2002 Mar-Apr;23(2):108-11
AD - ENT Department, "La Sapienza" University, Rome, Italy.
Leiomyosarcoma of the paranasal sinuses is uncommon and has an aggressive clinical behavior. Only 28 cases have been described in the literature, and, of these, only 3 patients treated with surgery had a disease-free survival. In this report, we describe the clinical history of a 57-year-old woman with a leiomyosarcoma of the paranasal sinuses successfully treated with a combination of surgery, radiation therapy, and chemotherapy. We obtained a total response with ifosfamide, doxorubicin, dacarbazine, and epirubicin. This case report emphasizes the possibility of treating this aggressive tumor with chemotherapy in accordance with the same therapy used in the treatment of uterine leiomyosarcomas. Copyright 2002, Elsevier Science (USA). All rights reserved.)
UI - 11900583
AU - Omeroglu A; Petruzzelli GJ; Husain AN; Ciesla MC
TI - Pathologic quiz case. A sinonasal mass in a 79-year-old African American woman.
SO - Arch Pathol Lab Med 2002 Apr;126(4):493-4
AD - Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
UI - 11798962
AU - Yong W; Zheng W; Zhang Y
TI - [Clinical characteristics and treatment of midline nasal and nasal type NK/T cell lymphoma]
SO - Zhonghua Yi Xue Za Zhi 2001 Jul 10;81(13):773-5
AD - Clinical Oncology School, Peking University, Beijing 100036, China.
OBJECTIVE: To study the clinical characteristics and treatment of midline nasal and nasal type T/Nk cell non-Hodgkin lymphoma. METHODS: A retrospective study was made on the clinical characteristics, treatment, short-term effect, and two-year survival rate of 37 patients with midline nasal and nasal type T/NK non-Hodgkin lymphoma. RESULTS: All of the patients were primarily treated with 2 cycles of CHOP chemotherapy. Ten of them were with good effect (common group). Then they were given 6 cycles of chemotherapy followed by focal radiotherapy and reached complete remission (CM). The other 27 patients failed to reach partial remission (PM) or even with their condition worsened after 2 cycles of CHOP regimen and were included into the refractory group. Fourteen of them received L-asparaginase-based salvage chemotherapy followed by focal radiotherapy (L-ASP group), and salvage therapy without L-ASP and followed by focal radiotherapy was given to the other 13 patients (non-L-ASP group). Continuous fever, angioinvasive growth and necrotic lesion could not be found among the patients in the common group. Their international prognostic indexes (IPI) were 0 approximately 1. Seventy percent of them were at the stages I or II. Continuous fever, angioinvasive growth and necrotic lesion could be found in the patients in refractory group. The IPIs among 85% of them were > 2, and 82% of them were at the stages III and IV. The CR rate was 46% for all patients as a whole, 100% for the common group, 26% for the refractory group (P < 0.005); and was 50% for the L-ASP group and 0% for the non-L-ASP group (P < 0.005). The 2-year survival rate was 43% for all patients as a whole, 100% for the common group, 20% for the refractory group (P < 0.005); and was 50.8% for the L-ASP group and 0% for the non-L-ASP group (P < 0.005). CONCLUSION: Patients with midline nasal and nasal type T/NK non-Hodgkin lymphoma can be treated primarily by CHOP regimen and local radiotherapy. Refractory patients can be treated by salvage therapy based on L-ASP chemotherapy with a rather good effect. The clinical characteristics of most of the refractory patients include continuous fever, angioinvasive growth, necrotic lesion, being at stage III and IV, and with an IPI > 2.
UI - 11915613
AU - Hallacq P; Labrousse F; Roullet B; Orsel S; Bessede JP; Moreau JJ
TI - [Adenoid cystic carcinomas invading the skull base. Apropos of 4 cases and review of the literature]
SO - Neurochirurgie 2001 Dec;47(6):542-51
AD - Service de Neurochirurgie, CHU Dupuytren, 87042 Limoges. email@example.com
Head and neck adenoid cystic carcinomas may invade the adjacent skull base by bone lysis and/or by perinervous and perivascular spread within the skull base foramina. Neurosurgical decision making is not well defined regarding the extent of intracranial tumor component removal, as neurosurgical expertise is limited for this peculiar type of tumors. The issue is to decide whether a radical supposedly locally curative surgery should be attempted, or if a large non disfigurating surgery is mandatory, keeping in mind the frequency of local recurrences and of distant metastases. Over a 13-year period, four adenoid cystic carcinomas invading the skull base were operated on at our institution: two tumors originated in the parotid gland, one in the sphenoid sinus, and one in the ethmoid sinus. Surgical removal was total in one case, subtotal in three cases. Post-operative irradiation was delivered in the four patients (two neutron irradiation, two conventional). One patient with advanced metastatic disease was submitted to chemotherapy. Three patients died from local tumor progression and distant metastases within three years after the intracranial tumor extension has been diagnosed. The patient with an ethmoid tumor is still alive seven years after surgery without any evidence of local tumor progression nor distant metastases. Surgery remains the gold standard treatment for adenoid cystic carcinomas invading the skull base. However, in our opinion a large tumor removal, without or with bone osteotomies, but without sacrifice of cranial nerves, cavernous sinus, internal carotid artery, and of the orbit allows patient survival with an acceptable comfort and absence of psychological distress due to disfigurating surgery nor surgically induced neurological functional deficit. Post-operative irradiation may sometimes stabilize locally the lesions. The place of chemotherapy has, yet, to be determined.
UI - 11775396
AU - Feldweg AM; Horan RF
TI - Aspirin treatment of patients with aspirin intolerance, asthma, and nasal polyps.
SO - Allergy Asthma Proc 2001 Nov-Dec;22(6):377-82
AD - Harvard Medical School, Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Patients with the triad of aspirin (ASA) intolerance, asthma, and nasal polyps present a clinical challenge for the allergist because their polyps generally are refractory to traditional treatments and their asthmatic symptoms may become more difficult to control with time. These patients can be desensitized and treated with ASA with subsequent improvement in their nasal and respiratory symptoms. This article describes one such individual and briefly reviews the literature regarding this triad. The diagnosis of ASA intolerance, mechanistic studies, a desensitization protocol, and new therapies are reviewed.
UI - 11987747
AU - al-Otieschan AT; Manohar MB; Gangopadhyay K; Tulbah A
TI - Cellular schwannoma of the paranasal sinuses: initial report of a case.
SO - Ear Nose Throat J 2002 Apr;81(4):281-4
AD - Department of Otolaryngology-Head and Neck Surgery and Communication Sciences, King Faisal Specialist Hospital and Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Cellular schwannomas are a benign variant of classic schwannomas. Their histologic appearance closely mimics that of malignant peripheral nerve-sheath tumors, which are high-grade sarcomas. In this article, we describe what to our knowledge is the first reported case of a cellular schwannoma of the paranasal sinuses and only the 33rd reported case of any schwannoma at this site. We also discuss the histology and management of cellular schwannomas and review the pertinent literature.
UI - 11884796
AU - Nakajima H; Imanishi N; Aiso S
TI - Facial artery in the upper lip and nose: anatomy and a clinical application.
SO - Plast Reconstr Surg 2002 Mar;109(3):855-61; discussion 862-3
AD - Department of Plastic and Reconstructive Surgery and the Department of Anatomy, School of Medicine, Keio University, Shinanomacji 35, Shinjuku-ku, Tokyo, 160-8582 Japan. firstname.lastname@example.org
Twenty-five facial arteries were examined radiographically in 19 fresh cadavers that had been injected systemically with a lead oxide-gelatin mixture. Major branches of the facial artery in the upper lip and nose were investigated, and the anatomical variations were classified into three types on the basis of the anatomy of the lateral nasal artery, which was determined as an artery running toward the alar base. In 22 cases (88 percent), the facial artery bifurcated into the lateral nasal artery and superior labial artery at the angle of the mouth. In two cases (8 percent), the facial artery became an angular artery after branching off into the superior labial artery and the lateral nasal artery sequentially. In one case (4 percent), the facial artery became an angular artery after branching off into the superior labial artery, and the lateral nasal artery then branched off from the superior labial artery. Branches from the lateral nasal and superior labial arteries were observed stereographically. Vascular anastomoses between those branches were created in the upper lip, columella base, and nasal tip, and an intimate vascular network was formed. With a vascular network in the mucosa of the upper lip, a bilobed upper-lip flap was created for a clinical case with a full-thickness defect of the ala.
UI - 11989606
AU - Pignataro L; Peri A; Ottaviani F
TI - Breast carcinoma metastatic to the ethmoid sinus: a case report.
SO - Tumori 2001 Nov-Dec;87(6):455-7
AD - Department of Otorhinolaryngology, Ospedale Maggiore (IRCCS), Milan, Italy. email@example.com
We report a rare case of breast carcinoma metastatic to the ethmoid sinus. An 83-year-old female patient with an intraductal breast carcinoma presented the first symptoms of metastasis to the paranasal sinuses four years after radical mastectomy and axillary node dissection. A review of the literature revealed that only three such cases have been described so far. Symptoms and imaging results are not specific and usually similar to those of primary neoplasms in this region. This case underlines the importance of suspecting a metastasis in patients with a history of malignancy.
UI - 11965417
AU - Fobe LP; Melo EC; Cannone LF; Fobe JL
TI - [Surgery of frontal sinus osteoma]
SO - Arq Neuropsiquiatr 2002 Mar;60(1):101-5
AD - Hospital do Servidor Publico, SP, Brasil. firstname.lastname@example.org
Frontal sinus osteomas are 57% of all paranasal sinus osteomas, with an incidence of 00.1 to 3%. Surgical removal of the frontal sinus osteomas is done in symptomatic patients. Asymptomatic patients can be managed conservatively or submitted to surgery in spite of its location or extension. Five patients having the diagnosis of frontal sinus osteoma were operated on between 1995 and 1999. Medium age was 38.4 years (from 12 to 55 years), 3 male and 2 female. Symptoms occurred from 6 months to 3 years, average of 10.5 months. Four patients had previous headache and one had epistaxis. All patients had standard radiological exams and computed tomography with coronal and axial studies of paranasal sinus. In two patients the diameter of the osteoma was larger than 3 cm and in three smaller than 3 cm. The choice between coronal and supraciliar approach was made according to esthetics, supraciliar approach was made in only one bald patient even with the tumor being large and extending to ethmoidal sinus. Any intra operative difficulty was related to the choice of the approach. Naso-frontal ostium was not obstructed in intra operative course. Minimal postoperative follow up was of two years. Osteomas were radically removed in all patients with no recurrence or residual tumor. Clinical findings, radiological exams and surgical approaches are discussed. No postoperative complications occurred.
UI - 11907480
AU - Jensen AA; Young TL
TI - Inferior oblique muscle palsy following maxillectomy for squamous cell carcinoma.
SO - J AAPOS 2002 Feb;6(1):51-3
AD - University of Minnesota Academic Health Center, Department of Ophthalmology, Philadelphia, PA 19104-4399, USA.
UI - 10971562
AU - Carlson-Sweet KL; Weigand DA; MacFarlane DF
TI - Trichoid basal cell carcinoma found in a dilated pore on the nose.
SO - Dermatol Surg 2000 Sep;26(9):874-6
AD - Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
A pore of Winer is a common, benign epidermal appendageal tumor arising from a hair follicle. We present a case where routine removal of a pore of Winer revealed the presence of a trichoid basal cell carcinoma. We describe the history of these lesions, discuss clinical and histologic differential diagnoses, and propose an explanation for the presence of these tumor cells. No prior report of basal cell carcinoma within a pore of Winer has been documented in the literature.
UI - 11991260
AU - Lutz ME
TI - Effective use of the glabella skin as a donor site for nasal tip grafts.
SO - Dermatol Surg 2002 Jan;28(1):101-2
AD - Department of Dermatology, Mayo Clinic, Jacksonville, Florida 32224, USA. lutz.Michael@mayo.edu
UI - 11892390
AU - Chiz GI; Solov'eva MA
TI - [Analysis of nasal and paranasal cancer in the Rostov region for 35 years: problems of early diagnosis]
SO - Vestn Otorinolaringol 2002;(1):31-3
The article contains information on 280 patients with nasal and paranasal cancer of epithelial (85%) and non-epithelial genesis (15%); on diagnosis, spread of the primary tumor, regional and distant metastases; principles of patients grouping according to TNM staging; analysis of causes of late diagnosis and misdiagnosis.
UI - 12018333
AU - Martinez-Manas RM; Rey MJ; Gaston F
TI - Aggressive psammomatoid ossifying fibroma.
SO - Ann Otol Rhinol Laryngol 2002 May;111(5 Pt 1):466-8
AD - Department of Neurosurgery, Hospital Clinic i Provincial, University of Barcelona, Spain.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.