National Cancer Institute®
Last Modified: May 1, 2002
UI - 11993209
AU - Okada T; Tsukazaki H; Itoh M; Nishio Y; Muro H
TI - [Renal pelvic cancer representing G-CSF production and hypercalcemia simultaneously: a case report]
SO - Hinyokika Kiyo 2002 Mar;48(3):155-8
AD - Department of Urology, Shizuoka General Hospital.
A 73-year-old man was admitted to the hospital complaining of gross hematuria and left flank pain. Abdominal ultrasonography and computed tomography revealed a left renal tumor with extracapsular extension. Laboratory data showed marked leukocytosis of 121,000/mm3 and hypercalcemia of 12.3 mg/dl without any findings of inflammatory disease or bone metastasis. Enzyme immunoassay of the serum demonstrated a high level of granulocyte colony-stimulating factor (250 pg/ml) and parathyroid hormone-related protein (1,069 pmol/l). Pathological diagnosis of needle biopsy specimen of the primary tumor was transitional cell carcinoma which was suspected to have originated from renal pelvis. Immunohistochemical examination with anti-granulocyte colony-stimulating factor monoclonal antibody demonstrated granulocyte colony-stimulating factor production in cancer cells. The patient underwent a course of systemic chemotherapy, but died two months after diagnosis. To our knowledge, this is the first report of renal pelvic cancer representing granulocyte colony-stimulating factor production and hypercalcemia simultaneously.
UI - 11993213
AU - Hasumi H; Mokuo Y; Sano K; Miura K
TI - [Ureteral inverted papilloma: a case report]
SO - Hinyokika Kiyo 2002 Mar;48(3):171-3
AD - Department of Urology, Hamaoka Municipal Hospital.
A 43-year-old man presented with left hydronephrosis, incidentally found by ultrasonography. He had undergone transurethral bladder tumor resection when he was 29 years old. Cystoscopy revealed a tumor protruding from the left ureteral orifice. Left partial ureterectomy was performed, and its histopathological diagnosis was ureteral inverted papilloma. He has remained free of disease for 18 months after the surgery.
UI - 11993217
AU - Ueda T; Okumi M; Ichimaru N; Itoh K; Matsuoka Y; Fujimoto N
TI - [Mucinous adenocarcinoma of the renal pelvis in the horseshoe kidney: a case report]
SO - Hinyokika Kiyo 2002 Mar;48(3):187-9
AD - Department of Urology, Osaka Prefectural General Hospital.
A 41-year-old man with macroscopic hematuria and abdominal fullness was referred to our hospital. Computed tomography (CT) revealed a left renal pelvic tumor in the horseshoe kidney. We performed left heminephrectomy and ureterectomy. The pathological diagnosis was the mucinous adenocarcinoma in the renal pelvis. He received postoperative adjuvant chemotherapy (CAP therapy). He died of retroperitoneal recurrence 8 months postoperatively. In the literature we found 95 cases of primary adenocarcinoma in the renal pelvis including our case.
UI - 11957151
AU - Seibel JL; Prasad S; Weiss RE; Bancila E; Epstein JI
TI - Villous adenoma of the urinary tract: a lesion frequently associated with malignancy.
SO - Hum Pathol 2002 Feb;33(2):236-41
AD - Department of Urology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.
Villous adenomas arising in the urinary tract are rare. We identified 18 cases of villous adenomas of the bladder, urachus, and prostatic urethra. Patients ranged in age from 53 to 93 years with an average age of 69.6 years and a male preponderance of 67%. In six cases (33%), the lesion was pure villous adenoma. In three cases (17%), there was villous adenoma with in situ adenocarcinoma. In six cases (33%) there was villous adenoma with in situ and infiltrating adenocarcinoma. One case (6%) had villous adenomas with in situ (noninvasive) papillary urothelial carcinoma. One case (6%) had villous adenomas with in situ adenocarcinoma and in situ papillary (noninvasive) and infiltrating urothelial carcinoma. The remaining case (6%) had villous adenoma with in situ and infiltrating adenocarcinoma and in situ (noninvasive) papillary and infiltrating urothelial carcinoma. Clinical outcome was available in eight of the cases, with a mean follow-up of 4.6 years. No evidence of recurrence was found in two patients with pure villous adenoma or in two patients with villous adenoma and only in situ adenocarcinoma, all of whom were treated by nonradical excision. However, two of three cases with infiltrating cancer developed distant metastases despite radical surgery; the remaining patient was disease-free 11 years after transurethral resection. The case with villous adenoma and in situ urothelial carcinoma progressed to sarcomatoid urothelial carcinoma following partial cystectomy. Eight of 10 villous adenomas cases studied expressed the epitope for mAbDas1, found on colonic epithelium and primary adenocarcinomas of the bladder and urachus but not on normal or neoplastic urothelium. This study expands the spectrum of histologic features accompanying villous adenomas of the urinary tract. Coexisting infiltrating adenocarcinoma is often present, necessitating thorough sampling of any lesion diagnosed by biopsy as villous adenoma. Pure villous adenoma and those well-sampled lesions also containing in situ adenocarcinoma portend a favorable prognosis, even without radical treatment. Coexisting in situ or infiltrating carcinoma suggests a more aggressive course. Histologically, immunohistochemically, and prognostically, these lesions appear analogous to their counterparts in the intestine. Copyright 2002, Elsevier Science (USA). All rights reserved.
UI - 11872045
AU - Christopher N; Arya M; Brown RS; Payne HA; Woodhouse CR; Ralph DJ
TI - Penile preservation in squamous cell carcinoma of the bulbomembranous urethra.
SO - BJU Int 2002 Mar;89(4):464-5
AD - Institute of Urology, University College London, London, UK.
UI - 11992840
AU - Yang MH; Chen KK; Yen CC; Wang WS; Chang YH; Huang WJ; Fan FS; Chiou TJ;
TI - Liu JH; Chen PM Unusually high incidence of upper urinary tract urothelial carcinoma in Taiwan.
SO - Urology 2002 May;59(5):681-7
AD - Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China.
OBJECTIVES: Unusually high incidences of upper urinary tract urothelial carcinoma (UUT-UC) have been reported from the endemic area for "blackfoot disease" of southern Taiwan, and the arsenic-contaminated water was considered to be the reason for this prevalence. In this study, we determined the ratio of UC in different locations, the difference in clinical profiles for UUT-UC and urinary-bladder urothelial carcinoma (UB-UC), and the influence of tumor location on survival in a medical center of northern Taiwan. METHODS: A total of 535 patients with pathologically proven UC were reviewed retrospectively in this study, and clinical data were recorded from pathologic and chart reviews. Statistical analyses to determine the association between tumor location and clinical variables, and stratified survival analyses to determine the effect of tumor location on survival were performed. RESULTS: The incidence of UUT-UC was relatively high (the ratio of renal pelvis/ureter/urinary bladder was 1:2.08:6.72), even though most of the patients did not reside in the endemic "blackfoot disease" area. Young age, female sex, higher T stage, and elevated pretreatment serum lactate dehydrogenase and creatinine level were significantly associated with UUT-UC after multivariate logistic regression analysis. Tumor location influenced survival in patients with early-stage disease or favorable prognostic factors. CONCLUSIONS: Factors other than arsenic water contamination may contribute to the unusually high incidence of UUT-UC in the non-"blackfoot disease" area in Taiwan. UUT-UC carried a more aggressively clinical behavior than UB-UC; tumor location influences patient survival markedly in patients with early-stage disease or favorable prognostic factors.
UI - 11992925
AU - Shalev M; Mistry S; Kernen K; Miles BJ
TI - Squamous cell carcinoma in a female urethral diverticulum.
SO - Urology 2002 May;59(5):773
AD - Department of Urology, Meir General Hospital, Kfar-Saba, Israel.
A 38-year-old woman was found to have a squamous cell carcinoma in a urethral diverticulum after a simple diverticulectomy. The aggressiveness of this histologic subtype of carcinoma, along with this patient's long life expectancy, supported the choice of aggressive therapy. Only nine other cases have been reported. A brief review of the published reports on the presentation, diagnosis, options for treatment, and outcomes is included.
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