National Cancer Institute®
Last Modified: March 1, 2002
UI - 11872307
AU - Vordermark D; Koelbl O
TI - In regard to Kapp et al.: experience with split-course external beam irradiation +/- chemotherapy and integrated (192)Ir high-dose-rate brachytherapy in the treatment of primary carcinomas of the anal canal. IJROBP 2001;49:997--1005.
SO - Int J Radiat Oncol Biol Phys 2002 Feb 1;52(2):580-1
UI - 11793263
AU - Zbar AP; Nishikawa H; BeerGabel M
TI - Vertical rectus abdominis myocutaneous transposition flap for total pelvic exenteration in recurrent vulvar carcinoma invading the anus.
SO - Tech Coloproctol 2001 Apr;5(1):66
AD - Kaplan Medical Center, Rehovot, 76100 Israel. email@example.com
UI - 11824234
AU - Geile D; Osterholzer G; Muller J
TI - [Precancerous conditions and neoplasms of the anal area]
SO - Kongressbd Dtsch Ges Chir Kongr 2001;118():141-6
AD - Proktologisches Institut Munchen-Ost, Chirurgische Privatklinik Bogenhausen, Denninger Strasse 44, 81679 Munchen.
Classification of this lesions could be done concerning localisation and histological type. Squamous cell carcinoma of the anal canal are the most often to be found, but overall neoplasias in this region are very seldom. The most important role in pathogenesis seems to play infection with HPV viruses. Symptoms are in the beginning unspecific and similar to other common proctological diseases. Proctological diagnostic procedures are to be combined with cytological methods. Therapeutic management depends on malignant potential of the lesions and contains local excision, total operation and combined radiochemotherapy, which is today considered standard therapy of squamous cell carcinoma of the anal canal.
UI - 11824250
AU - Raulf F
TI - [Benign tumors--surgical indication?]
SO - Kongressbd Dtsch Ges Chir Kongr 2001;118():218-20
AD - Abteilung Chirurgie II/Koloproktologie, Raphaelsklinik Munster, Klosterstrasse 75, 48143 Munster.
Diagnostic and therapeutic options of the benign tumors in the anal region will be discussed. There is no systematic scheme for these tumors depending on the polymorph aspects and different matrices in the borderline between ecto- and entoderma. Because of the localisation either in perianal skin, fossa ischiorectalis or in the retrorectal space there is a need of different therapeutic options and approaches.
UI - 11824363
AU - Jongen J; Reh M; Bock JU; Rabenhorst G
TI - [Perianal precancerous conditions (Bowen disease, Paget disease, Carcinoma in situ, Buschke-Lowenstein tumor)]
SO - Kongressbd Dtsch Ges Chir Kongr 2001;118():79-86
AD - Proktologische Praxis und Abteilung Chirurgische Proktologie, Park-Klinik, Goethestrasse 11, 24116 Kiel.
Perianal premalignant lesions are rare. Any suspicious perianal lesion or any perianal exanthema, that does not heal by non-surgical treatment has to be biopsied for histology. Many premalignant lesions are diagnosed as an incidental finding after anorectal surgery: any anorectal specimen must be examined by the pathologist. Leukoplakia is a facultative premalignant condition. High-grade anal intraepithelial neoplasia (AIN) is an in situ squamous cell carcinoma, associated with papillomavirus infection. Bowen's disease and Bowenoid papulosis are clinical variations of high-grade AIN. Buschke-Lowenstein tumour (giant condyloma) is a locally destructive tumour, that does not infiltrate or cause metastases. Paget's disease is a premalignant lesion like AIN, associated with other malignancies.
UI - 11713581
AU - Zucchini C; Biolchi A; Strippoli P; Solmi R; Rosati G; Del Governatore
TI - M; Milano E; Ugolini G; Salfi N; Farina A; Caira A; Zanotti S; Carinci P; Valvassori L Expression profile of epidermal differentiation complex genes in normal and anal cancer cells.
SO - Int J Oncol 2001 Dec;19(6):1133-41
AD - Institute of Histology and Embriology, Fondazione CARISBO Center for Research into Molecular Genetics, Bologna, Italy.
Anal cancer originates from a peculiar histological region and provides a useful model for investigating alterations in proliferation and/or differentiation of neoplastic keratinocytes. Epidermal differentiation complex (EDC) genes, which form one of the major gene clusters in the human genome, are involved in the terminal differentiation of epithelial cells and in many instances have been implicated in epithelial tumours. We constructed a DNA macroarray capable of characterising the expression profiles of the entire EDC gene complex in normal mucosa and anal cancer biopsies of seven unrelated patients. Brain tissue and cultured keratinocytes were used as controls. All anal cancer samples showed expression profiles in which none of the EDC genes was silent, as evaluated by phosphor-imager analysis. Variance analysis showed significantly lower expression of SPRR2 with respect to SPRR1 or SPRR3, and significantly higher expression of S100A8 than of other S100A subfamily members. At hierarchical clustering analysis, the four basaloid anal cancer cases conglomerated in the top five positions. The macroarray method used by us provides the first demonstration of the expression profile of the EDC gene family in anal cancer, and is capable of producing significant information on the subgrouping of epithelial tumours such as anal cancer.
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