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Abramson Cancer CenterNCI CANCERLIT® Search: Salivary Gland Cancer - March 2002
National Cancer Institute®
Last Modified: March 1, 2002
Table of Contents
1
UI - 11823498
AU - Ma YQ; Geng JG
TI -
Obligatory requirement of sulfation for P-selectin binding to human
salivary gland carcinoma Acc-M cells and breast carcinoma ZR-75-30
cells.
SO - J Immunol 2002 Feb 15;168(4):1690-6
AD - Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell
Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences, Shanghai, China.
Stimulated endothelial cells and activated platelets express P-selectin,
which reacts with P-selectin glycoprotein ligand-1 (PSGL-1) for
leukocyte rolling on the stimulated endothelial cells and heterotypic
aggregation of the activated platelets on leukocytes. P-selectin also
binds to several cancer cells in vitro and promotes the growth and
metastasis of human colon carcinoma in vivo. The P-selectin/PSGL-1
interaction requires tyrosine sulfation. However, it is unknown whether
sulfation is necessary for P-selectin binding to somatic cancer cells.
In this study, we show that P-selectin mediated adhesion of Acc-M cells,
a cell line derived from a human adenoid cystic carcinoma of salivary
gland. These cells had a moderate expression of heparan sulfate-like
proteoglycans, but had no detectable expressions of PSGL-1, CD24,
Lewis(x), and sialyl Lewis(x). Treatment with sodium chlorate (a
sulfation biosynthesis inhibitor), but not
4-methylumbelliferyl-beta-D-xyloside (a proteoglycan biosynthesis
inhibitor) or heparinases, reduced adhesion of these cells to
P-selectin. Sodium chlorate also inhibited the P-selectin precipitation
of the 160-, 54-, and 36-kDa molecules from the cell surface of Acc-M
cells. Furthermore, P-selectin could bind to human breast carcinoma
ZR-75-30 cells in a sulfation-dependent manner. Our results thus
indicate that sulfation is essential for adhesion of nonblood-borne,
epithelial-like human cancer cells to P-selectin.
2
UI - 9065618
AU - Ozdzinski W; Kuczkowski J; Debniak E; Zoltowska A
TI -
Clinical and immunohistochemical analyses of parotid gland tumors.
SO - Eur Arch Otorhinolaryngol 1997;254 Suppl 1():S20-2
AD - Department of Otorhinolaryngology, Medical University of Gdansk, Poland.
Clinical, histological and immunohistochemical data on 71 parotid gland
tumors were analyzed. Benign neoplasms accounted for 71.8% of the case
material and malignant tumors 22.6%. Chronic parotitis occurred in 5.6%
of the total case number. Pleomorphic adenomas and mucoepidermoid
carcinomas were the most frequently occurring benign and malignant
neoplasms. Pleomorphic adenomas stained positive for S-100 protein,
tenascin, smooth muscle actin, synaptophysin and chromogranin A. This
immunohistochemical, histological and clinical analysis was believed to
be of potential assistance in the diagnosis, treatment and prognosis of
parotid gland tumors.
3
UI - 10774375
AU - Fernandez E; Pallini R; Lauretti L
TI -
Microsurgical selective removal of benign neoplasms of the parotid
gland.
SO - Eur Arch Otorhinolaryngol 1994 Dec;():S290-2
AD - Department of Neurosurgery, Catholic University School of Medicine,
Rome, Italy.
4
UI - 10774378
AU - Diard JP; Borsik M; Wassef M; Freyss G
TI -
Facial paralysis induced by tumors.
SO - Eur Arch Otorhinolaryngol 1994 Dec;():S297-8
AD - Medical Aircrew Examination Center, Armees, France.
5
UI - 11780493
AU - Yu G; Ussmueller J; Donath K
TI -
[A clinicopathologic study on membranous basal cell adenoma]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 Mar;35(2):88-90
AD - Department of Oral Maxillofacial Surgery, School of Stomatology, Beijing
Medical University, Beijing 100081, China.
OBJECTIVE: To investigate the clinicopathologic features and behaviour
of membranous basal cell adenoma. METHODS: Twelve cases with membranous
basal cell adenoma of salivary gland were analysed
clinicopathologically. RESULTS: The tumors were composed of epithelial
islands of various sizes and shapes. Its histologic finding was
characterized by palisading of peripheral cells and excessive hyaline
basal membrane. Four cases had co-existing dermal cylindromas of the
scalp. In 8 cases, the tumors demonstrated multiple origin. One case
showed malignant transformation and cervical lymph node metastasis.
CONCLUSIONS: The differential diagnosis involved the solid variant of
basal cell adenoma, basal cell adenocarcinoma, solid subtype of adenoid
cystic carcinoma and basal squamous cell carcinoma. Total parotidectomy
rather than superficial parotidectomy is suggested to avoid the
recurrence of the tumor. A close follow up after treatment is necessary.
6
UI - 11776872
AU - Wu X; Lin G; Zhang Q
TI -
[Evaluation of clinical value of technetium-99m(V) dimercaptosuccinic
acid SPECT in diagnosis of parotid lump]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Nov;34(6):334-6
AD - Department of Stomatology, First Affiliated Hospital, Fujian Medical
University, Fuzhou 350000.
OBJECTIVE: To evaluate the clinical value of single photon emission
computed tomography (SPECT) on classifying parotid lump as benign or
malignant before treatment. METHODS: SPECT images of the parotid region
were obtained in forty-five patients with parotid lump before surgery.
We used technetium-99m(V) dimercaptosuccinic acid as imaging agent. The
results were compared with their pathological diagnoses, clinical
examination, and ultrasonography. RESULTS: The sensitivity, specificity
and accuracy of Tc-99m(V)-DMSA SPECT imaging in determining malignancy
of parotid lump were 93.7%, 72.4%, 80.0%, respectively. The uptake
ratios of parotid lesions were higher in malignant tumors than benign
tumors, cysts, and inflammatory lumps (P < 0.05). CONCLUSION: It is
suggested that Tc-99m (V)-DMSA SPECT can be a useful aided method of
preoperative diagnosis of parotid lumps. The uptake ratios can help
increase the accuracy of diagnoses. For the benign tumors and
inflammatory masses of parotid gland, the diagnoses had some false
positives which may be reduced by combined clinical examination and
ultrasonography.
7
UI - 11776890
AU - Yu G; Gao Y; Ma D
TI -
[Basal cell adenocarcinoma of the salivary gland: a clinicopathologic
study of 14 cases]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):275-7
AD - School of Stomatology, Beijing Medical University, Beijing 100081.
OBJECTIVE: To study clinicopathologic features and behaviour of the
basal cell adenocarcinoma of salivary gland tumor and prognosis of the
patients, METHODS: 14 cases with basal cell adenocarcinoma were studied
clinicopathologically. RESULTS: The clinical features were as follows:
females more than males; most frequently in the minor salivary glands;
21.4% of cervical lymph node metastasis and 14.3% of distant metastasis;
and rather poor prognosis. The histopathologic appearances were similar
to those of basal cell adenoma, but with more mitotic figures and
infiltrating growth. CONCLUSION: This tumor was of moderate grade
malignancy. It must be treated radically. The elective neck dissection
could be considered for the patients with extensive tumors.
8
UI - 11776893
AU - Sun K; Yu G; Wang J
TI -
[The ultrastructure of membrane component in adenoid cystic carcinoma
of salivary gland]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):284-5
AD - School of Stomatology, Beijing Medical University, Beijing 100081.
OBJECTIVE: To study morphological variations of basment membrane
component (BMC) for determination of invasion and vascular metastasis in
adenoid cystic carcinoma (ACC). METHODS: The BMC of 8 cases in ACC and 2
cases of normal parotid gland were observed by LM and EM. RESULTS: The
BMC surrounding tumor mass and strands showed multi-layered or
dissolution, pseudopodia were seen extended from tumor cells, and
contained numerous microvesicles. If the tumor cell attached blood
vessels, the collagenous fibril were dissoluted and BMC were lost.
CONCLUSION: The tumor cell may release some digestive enzymes which may
be able to dissolve BMC and collagenous fibrils and invade into blood
vessels and metastasis take place.
9
UI - 11776895
AU - Sun H; Wu S; Ouyang J
TI -
[Expression of C-erbB-2 oncogene mRNA in salivary gland tumors]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):289-91
AD - School of Stomatology, Norman Bethune University of Medical Sciences,
Changchun 130041.
OBJECTIVE: To study relationship of C-erb-2 oncogene mRNA expression and
histotype, tumorigenesis and biological behavior of salivary gland
neoplasms. METHODS: Using 32P labeled oligonucleotide as probe, the dot
blot technique was used to study the expression of C-erbB-2 oncogene
mRNA in salivary gland neoplasm with normal salivary gland as control.
RESULTS: With the expression in normal salivary gland as a standard, low
C-erbB-2 mRNA expression was seen in adenolymphoma, basal cell adenoma.
However, various degrees of over-expression of C-erbB-2 oncogene mRNA
were detected in pleomorphic adenoma, mucoepidermoid carcinoma, acinic
cell carcinoma, adenoid cystic carcinoma, papillary cystic carcinoma,
and myoethelial cell carcinoma. CONCLUSION: C-erbB-2 oncogene mRNA
over-expression in salivary gland neoplasm is related to biological
behavior of salivary gland carcinoma.
10
UI - 11776898
AU - Wang J; Dong F; Yong P
TI -
[p53 gene mutation determined by single-strand conformational
polymorphism and DNA sequencing analysis in pleomorphic adenoma of
salivary gland]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):298-300
AD - School of Stomatology, Hebei Medical University, Shijiazhuang 050017.
OBJECTIVE: To detect p53 exon 6 mutation pattern in pleomorphic adenoma
of salivary gland. METHODS: Single-strand conformational polymorphism
(SSCP) and DNA sequecing were used. RESULTS: SSCP analysis showed that 6
of 11 cases with SSCP positive were exon 6 abnormal. Comparison of the
SSCP results with DNA sequecing, 4 cases with p53 exon 6 mutations were
SSCP positive. Mutation pattern included base substitution (point
mutation, G-->T, T-->G) and frame-shift mutation (base insertion and
base loss). CONCLUSION: Poly-codon and poly-pattern mutations appeared
in p53 exon 6. PCR-SSCP was a convenient method to detecte gene
mutation.
11
UI - 11793273
AU - Jaehne M; Ussmuller J; Jakel KT; Zschaber R
TI -
[Clinical presentation, therapy and prognosis of non-Hodgkin lymphomas
of the major salivary glands]
SO - Laryngorhinootologie 2001 Dec;80(12):743-7
AD - Hals-Nasen-Ohren-Klinik des Universitatsklinikums Hamburg-Eppendorf,
Germany. jaehne@uke.uni-hamburg.de
INTRODUCTION: About 5 - 10 % of all Non-Hodgkin-Lymphomas (NHL) present
within the major salivary glands. Two etio-pathologically different
groups, the (extranodal)-parenchymal NHL and NHL of intra- or
periglandular lymphnodes (nodal lymphomas) have to be distinguished. It
was the aim of this study to evaluate the clinical presentation, therapy
and biological behaviour of these etiopathologically different
lymphoma-groups. MATERIAL AND METHOD: In a retrospective study, therapy
and course of disease of 26 patients with a NHL of the major salivary
glands were examined (diagnosis and treatment between 1988 and 1996).
RESULTS: Staging results in the group of parenchymal lymphoma always
showed the disease limited to the effected gland, whereas nodal NHL
presented with a stadium II to IV (Ann-Arbor) at time of diagnosis.
Local recurrencies were five times higher in nodal NHL compared to
parenchymal NHL. In only one case (7.7 %) of the patients with
parenchymal NHL, dissemination was observed. In the group of nodal NHL,
a dissemination was observed in 6 patients (46.2 %). 7 of 13 patients
(53.8 %) with a nodal NHL died due to lymphoma dissemination, compared
to one patient (7.7 %) with a parenchymal NHL. CONCLUSION: Based on the
presented data, the histopathological diagnosis, under special
recognition of the particular lymphoma-pathogenesis, constitutes an
important prognostic factor in patients with NHL of the major salivary
glands.
12
UI - 11780221
AU - Huang J
TI -
[Expression of S-100 proteins and intermediate filament proteins in
pleomorphic adenoma]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 May;35(3):191-3
AD - Department of Pathology, Fujian Medical University, Fuzhou 350004,
China.
OBJECTIVE: To observe immunohistochemical expression of S-100A1,
S-100A2, S-100A4, S-100A6, S-100B, K8.12, KL1, Vimentin, GFAP and NSE in
pleomorphic adenoma of salivary gland, and to evaluate the differential
localization of S-100 proteins and biological behaviour of neoplastic
myoepithelial cells. METHODS: 23 cases of normal salivary gland and 60
cases of pleomorphic adenoma were embedded, in paraffin and were
routinely diagnosed on the basis of hematoxylin and eosin-stained
sections. Serial sections at 4 microns from the paraffin embedded blocks
were used for the immunohistochemical studies. RESULTS: Normal salivary
glands had positive immunoreactivity for S-100A families, K8.12 and KL1
in the ductal cells, while S100B, GFAP and NSE were observed in
peripheral nerve fibers innervating the gland. In pleomorphic adenomas,
luminal tumor cells in duct-like structures had positive
immunoreactivity for S-100A subfamilies and keratin. Nonluminal tumor
cells had positive immunoreactivity for S-100B, as well as Vimentin,
keratins detected by monoclonal K8.12 and KL1, GFAP and NSE.
CONCLUSIONS: These findings may suggest that the neoplastic
myoepithelial cells contain Ca2+ binding proteins which may have a role
in the regulation of calcium ions or calcium signaling mechanisms in the
modulation of extracellular matrix deposition in pleomorphic adenoma
which may in turn affect the extracellular matrix synthesis as well as
histomorphology of the tumor.
13
UI - 11780226
AU - Peng X; Yu G; Gao Y
TI -
[The expression of cathepsin-D in salivary adenoid cystic carcinoma]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 May;35(3):206-8
AD - Department of Oral Maxillofacial Surgery, School of Stomatology, Beijing
Medical University, Beijing 100081, China.
OBJECTIVE: To investigate the relationship between Cathepsin-D(Cath-D)
and the prognosis of patients with salivary adenoid cystic carcinoma
(SACC). METHODS: The immunoactivity of Cath-D of 52 cases with SACC was
determined by immunohistochemistry method (Streptavidin-Biotin method).
The relationship between Cath-D and the histological type, clinical
stage, local recurrence, distant metastasis of the tumor and survival
rate of the patients with SACC were analysed. RESULTS: Statistical
analysis showed that the expression levels of Cath-D were correlated
positively with distant metastasis potential and clinical stage (P <
0.05), and had no significant relation with histological type, local
recurrence and survival rate (P > 0.05). CONCLUSIONS: Cath-D can
facilitate invasiveness and distant metastasis of SACC; evaluation of
Cath-D can act as a predictor of distant metastasis of SACC and direct
the clinical treatment.
14
UI - 11857983
AU - Morimoto H; Hashida H; Honda T; Aibara Y
TI -
[An elderly case of cytomegalovirus enterocolitis associated with a
malignant tumor]
SO - Nippon Ronen Igakkai Zasshi 2002 Jan;39(1):97-100
AD - Department of Internal Medicine, Ehime Prefectural Iyomishima Hospital.
An 83-year-old man was given a diagnosis of left parotid cancer in our
because of his advanced age. Therefore chemotherapy and radiotherapy
were used. Chemotherapy with CAP (Cyclophosphamide, Adriacin, and CDDP)
Prednisolone (15 mg) was administered daily from July 15, 2000. The
patient started suffering from diarrhea on August 2, 2000. As the
patient also began to suffer high grade fevers and stomachaches, he was
admitted on a diagnosis of acute enterocolitis. He had bloody stool on
August 11. On emergency colonoscopy, an ulceration with bleeding was
located in the lower rectum. The biopsy specimen revealed intranuclear
inclusion bodies and positively staining cells for monoclonal antibody
to cytomegalovirus through the immunohistochemical technique, and it was
diagnosed as cytomegalovirus enterocolitis. He was treated with
ganciclovir. One month later, his clinical symptoms had improved.
Cytomegalovirus enterocolitis is an opportunistic infection, so
immunocompromised hosts (such as cancer patients, patients using
immunosuppressants, old people) have a greater probability of
contracting cytomegalovirus infection. A ganciclovir is an effective
treatment. A cytomegalovirus enterocolitis should considered in the
differential diagnosis of enterocolitis, when alimentary symptoms like
diarrhea or bloody stool are found in immunocompromised hosts.
15
UI - 11604993
AU - Hoque MO; Kawamata H; Nakashiro KI; Omotehara F; Shinagawa Y; Hino S;
TI -
Begum NM; Uchida D; Yoshida H; Sato M; Fujimori T
Dihydropyrimidine dehydrogenase mRNA level correlates with the response
to 5-fluorouracil-based chemo-immuno-radiation therapy in human oral
squamous cell cancer.
SO - Int J Oncol 2001 Nov;19(5):953-8
AD - Second Department of Oral and Maxillofacial Surgery, Tokushima
University School of Dentistry, Tokushima 770-8504, Japan.
The measurement of the intra-tumoral level of thymidylate synthetase
(TS), and dihydropyrimidine dehydrogenase (DPD), may be useful in
predicting tumor sensitivity to 5-fluorouracil (5-FU). In this study, we
examined the mRNA levels of DPD and TS in 28 oral squamous cell
carcinomas (SCC), and 22 salivary gland tumors by semi-quantitative
reverse transcription polymerase chain reaction. Then we examined the
correlation of the responsiveness of the patients with oral SCC to 5-FU
with the intra-tumoral levels of DPD and TS mRNA. All specimens were
obtained at the biopsy before treatment, and then the patients were
treated by oral administration of a 5-FU compound (UFT), the irradiation
of cobalt-60 (upto 60 Gy) and injection of an immuno-potentiator
(OK-432). Intra-tumoral levels of DPD mRNA in the patients who showed CR
(complete response) and PR (partial response) were significantly lower
than those in the patients who showed NC (no change). However,
intra-tumoral levels of DPD mRNA did not correlate with the local
recurrence of the tumor during the observation period after initial
treatment with or without surgical resection of the residual tumors. On
the other hand, TS mRNA levels in the tumors did not correlate with any
clinico-pathological parameters. These observations suggest that
intra-tumoral levels of DPD mRNA may predict the tumor response to
5-FU-based chemo-immuno-radiation therapy in the patients with oral SCC.
16
UI - 11836700
AU - Chhieng DC; Paulino AF
TI -
Cytology of myoepithelial carcinoma of the salivary gland.
SO - Cancer 2002 Feb 25;96(1):32-6
AD - Department of Pathology, University of Alabama at Birmingham, Birmingham
Alabama 35249-6823, USA. dcchieng@path.uab.edu
BACKGROUND: Myoepithelial carcinoma, also know as malignant
myoepithelioma, is rare in the salivary gland, and its cytologic
features have rarely been reported. DESIGN: Four cases of myoepithelial
carcinoma with cytology were retrieved from the archives of the
Pathology Departments of two academic institutes. In three cases, the
specimens were obtained by fine needle aspiration biopsy (FNA); the
remaining case was a bench aspiration performed on the surgically
resected specimen at the time of intra-operative consultation. The
cytologic features were reviewed and correlated with the histology.
RESULTS: The four patients with myoepithelial carcinoma (two men and two
women) ranged in age from 48 to 64 years. Three cases arose from the
parotid gland, and the remaining case was a recurrent tumor in the minor
salivary glands of the hard palate. The aspirates of two cases consisted
of predominantly spindle cells, one predominantly
epithelioid/plasmacytoid cells, and one with a mixture of both spindle
and epithelioid/plasmacytoid cells. Cellular pleomorphism was noted in
two cases and mitotic figures in three cases. Two cases were
cytologically diagnosed as malignant spindle cell neoplasm, not
otherwise specified. The FNA of the recurrent tumor was diagnosed as
consistent with the previous malignancy. The remaining case was
interpreted as a pleomorphic adenoma with atypia. CONCLUSIONS: The
cytologic features of myoepithelial carcinoma are diverse and may lack
overt features of malignancy. Pathologists should be aware of this
entity when evaluating cytologic specimen of salivary gland mass.
17
UI - 11849796
AU - Bragg CM; Conway J; Robinson MH
TI -
The role of intensity-modulated radiotherapy in the treatment of parotid
tumors.
SO - Int J Radiat Oncol Biol Phys 2002 Mar 1;52(3):729-38
AD - Department of Clinical Oncology, Weston Park Hospital, Sheffield, South
Yorkshire, United Kingdom. Christopher.Bragg@STH.nhs.uk
PURPOSE: To compare intensity-modulated radiotherapy (IMRT) treatment
plans with three-dimensional conformal radiotherapy (3D-CRT) plans to
investigate the suitability of IMRT for the treatment of tumors of the
parotid gland. METHODS AND MATERIALS: One 3D-CRT treatment plan and 10
IMRT treatment plans with differing beam arrangements were produced for
each of nine patient data sets. The plans were compared using regret
analysis, dose conformity, dose to organs at risk, and uncomplicated
tumor control probability (UTCP). RESULTS: The target dose was
comparable in the 3D-CRT and IMRT plans, although improvements were seen
when seven and nine IMRT fields were used. IMRT reduced the mean dose to
the contralateral parotid gland and the maximum doses to the brain and
the spinal cord, but increased the ipsilateral lens dose in some cases.
Each IMRT arrangement produced a higher UTCP than the 3D-CRT plans; the
largest absolute difference was 9.6%. CONCLUSIONS: IMRT is a suitable
means for treating cancer of the parotid, and a five-field class
solution is proposed. It produced substantial sparing of organs at risk
and higher UTCPs than 3D-CRT and should enable dose escalation.
18
UI - 11839563
AU - Roijer E; Nordkvist A; Strom AK; Ryd W; Behrendt M; Bullerdiek J; Mark
TI -
J; Stenman G
Translocation, deletion/amplification, and expression of HMGIC and MDM2
in a carcinoma ex pleomorphic adenoma.
SO - Am J Pathol 2002 Feb;160(2):433-40
AD - Lundberg Laboratory for Cancer Research, Department of Pathology,
Goteborg University, Sahlgrenska University Hospital, SE-413 45
Goteborg, Sweden.
Carcinoma ex pleomorphic adenoma (CexPA) is a carcinoma developing
within a pre-existing benign pleomorphic adenoma (PA). Here we describe
the identification and characterization of a series of genetic events
leading to translocation, deletion/amplification, and overexpression of
the HMGIC and MDM2 genes in a CexPA at an early stage of development.
The tumor had a pseudodiploid stemline karyotype with a
del(5)(q22-23q32-33) and a t(10;12)(p15;q14-15). In addition, there were
several sidelines with double minute chromosomes (dmin) or homogeneously
staining regions (hsr). Fluorescence in situ hybridization (FISH)
mapping revealed that the 12q14-15 breakpoint was located centromeric to
HMGIC and that the entire gene was juxtaposed to the der(10) chromosome.
Detailed analysis of cells with dmin and hsr revealed that HMGIC and
MDM2 were deleted from the der(10) and that the dmin and hsr were
strongly positive for both genes. Southern blot analysis confirmed that
both HMGIC and MDM2 were amplified and that no gross rearrangements of
the genes had occurred. Immunostaining revealed that the HMGIC protein
was highly overexpressed particularly in the large polymorphic cells
within the carcinomatous part of the tumor. These findings suggest that
amplification and overexpression of HMGIC and possibly MDM2 might be
important genetic events that may contribute to malignant transformation
of benign PA.
19
UI - 11878716
AU - Hirokawa M; Tamura M; Horiguchi H; Wakatsuki S; Sano T
TI -
Abnormal venous structures in salivary gland tumors: vasculature
characteristics of pleomorphic adenoma.
SO - APMIS 2001 Sep;109(9):625-30
AD - Department of Pathology, University of Tokushima School of Medicine,
Japan. hirokawa@basic.med.tokushima-u.ac.jp
To clarify the diagnostic significance of abnormal venous structures
present in salivary gland tumors, we examined 21 pleomorphic adenomas,
14 Warthin tumors, 1 oncocytic adenoma, 3 myoepitheliomas, 7 basal cell
adenomas, 5 mucoepidermoid carcinomas, and 6 adenoid cystic carcinomas.
Verhoeffvan Gieson staining was carried out and the morphology of the
veins within the tumors was observed microscopically. Branching veins,
thickened intima of the veins, discontinuous elastic membrane and
multilayered elastic membrane were seen in 71.4%, 76.2%, 47.6% and 85.7%
of pleomorphic adenomas, respectively, and were abundant and easily
found in most cases. The abnormal venous structures were also found in
other salivary gland tumors examined, but they were few in number and
lacked variety. Elastic fibers extending radially into the surrounding
stroma were seen in 66.7% of pleomorphic adenomas, and were not seen in
other salivary gland tumors. Our results showed that a variety of
abnormal venous structures are more abundant and more easily found in
pleomorphic adenoma compared with other salivary gland tumors, and, in
particular, that perivascular radiating elastic fibers are
characteristic of pleomorphic adenoma. We emphasize that the presence of
perivascular radiating elastic fibers may be helpful in diagnosing
pleomorphic adenoma in small biopsy specimens.
20
UI - 11285621
AU - Valencerina Gopez E; Dauterman J; Layfield LJ
TI -
Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the
parotid: a case report and review of the literature.
SO - Diagn Cytopathol 2001 Apr;24(4):249-52
AD - Department of Pathology, University of Utah School of Medicine, Salt
Lake City, Utah. evelyn.gopez@hsc.utah.edu
The cytologic features of an alveolar rhabdomyosarcoma arising within
the parotid gland are described. The occurrence of this neoplasm as a
primary malignancy in the parotid gland is very rare, and the tumor is
usually not included in the cytologic differential diagnosis of parotid
tumors. The diagnosis of the current case was achieved by a combination
of fine-needle aspiration biopsy and frozen sections. Realizing the
difficulty of recognizing this tumor both histologically and
cytologically, we present this case to increase the awareness of this
tumor's occurrence within the parotid gland and other salivary glands,
and to highlight cytomorphologic features that will aid the pathologist
in making the correct diagnosis. Copyright 2001 Wiley-Liss, Inc.
21
UI - 11813334
AU - Bedard YC; Kandel R
TI -
Comment on Gopez et al.
SO - Diagn Cytopathol 2002 Feb;26(2):130
22
UI - 11793066
AU - Ratan SK; Bhardwaj M; Gambhir A; Sen A
TI -
Chronic sialadenitis with pleomorphic adenoma of the parotid:
coincidental or causal?
SO - Pediatr Surg Int 2002 Jan;18(1):60-1
AD - Department of Pediatric Surgery, Dr. RML Hospital, New Delhi 110 001,
India.
A 12-year-old boy with a pleomorphic adenoma of the parotid is reported.
The excised gland specimen also showed evidence of chronic sialadenitis.
The co-existence of these two entities has not been previously reported
in the literature surveyed by us. The authors feel that the two
conditions may have a common underlying etiology.
23
UI - 11857890
AU - Aufdemorte T; Jones AC; McGuff HS; Alderson G
TI -
Oral and maxillofacial pathology case of the month. Adenoid cystic
carcinoma.
SO - Tex Dent J 2000 Oct;117(10):72, 101
AD - University of Texas Health Science Center at San Antonio, USA.
24
UI - 11876610
AU - Patil S; Suvarna P; Dayal P K
TI -
Central mucoepidermoid carcinoma--a case report.
SO - Indian J Cancer 2000 Jun-Sep;37(2-3):123-6
AD - Department of Oral Medicine and Radiology, College of Dental Surery,
Mangalore, Karnataka, India.
The mucoepidermoid carcinoma (MEC) account for approximately 6-8 Percent
of all salivary gland tumors. Central mucoepidermoid carcinoma of the
jaws is rare. Following is a case report of central mucoepidermoid
carcinoma which involves the ramus of the mandible. Origin of the
central mucoepidermoid carcinoma is discussed.
25
UI - 11717913
AU - Cai X; Shi L; Dong P
TI -
[Parapharyngeal space neoplasms]
SO - Zhonghua Er Bi Yan Hou Ke Za Zhi 1998 Jun;33(3):178-80
AD - First Affiliated Hospital of Shandong Medical University, Jinan 250012.
OBJECTIVE: To study parapharyngeal space (PPS) neoplasms which are
rarely seen clinically. METHODS: A retrospective review was made of 59
patients with PPS neoplasm operated on from 1986 to July, 1997 in our
institution. RESULTS: Neurogenic tumors were the most common neoplasms,
which constituted about 60 percent in the primary parapharyngeal space
neoplasms. High-resolution computed tomography or magnetic resonance
imaging was essential for diagnosis and presurgical planning. The
transcervical approach was the preferred procedure for 75% benign
parapharyngeal tumors. Middle mandibulotomy was used in 3 cases,
including 2 small tumors confined to the superior aspect of the PPS and
1 carotid body tumor which extended to the skull base. Lateral skull
base approach was utilized for 1 schwannoma originating in the jugular
foramen with extension into the PPS. CONCLUSIONS: We believe that
transoral approach can be used for small tumors and transparotid
approach may be especially indicated for removal of deep lobe parotid
tumors with extension to the PPS. Middle mandibulotomy is a safe and
efficacious approach for the removal of special PPS neoplasms.
26
UI - 11870356
AU - Liu CY; Chu PY; Li WY; Chang SY
TI -
Sebaceous adenoma in the submandibular gland.
SO - Otolaryngol Head Neck Surg 2002 Feb;126(2):199-200
AD - Department of Otolaryngology, Veterans General Hospital, Taipei, Taiwan.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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