National Cancer Institute®
Last Modified: March 1, 2002
UI - 11823498
AU - Ma YQ; Geng JG
TI - Obligatory requirement of sulfation for P-selectin binding to human salivary gland carcinoma Acc-M cells and breast carcinoma ZR-75-30 cells.
SO - J Immunol 2002 Feb 15;168(4):1690-6
AD - Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Stimulated endothelial cells and activated platelets express P-selectin, which reacts with P-selectin glycoprotein ligand-1 (PSGL-1) for leukocyte rolling on the stimulated endothelial cells and heterotypic aggregation of the activated platelets on leukocytes. P-selectin also binds to several cancer cells in vitro and promotes the growth and metastasis of human colon carcinoma in vivo. The P-selectin/PSGL-1 interaction requires tyrosine sulfation. However, it is unknown whether sulfation is necessary for P-selectin binding to somatic cancer cells. In this study, we show that P-selectin mediated adhesion of Acc-M cells, a cell line derived from a human adenoid cystic carcinoma of salivary gland. These cells had a moderate expression of heparan sulfate-like proteoglycans, but had no detectable expressions of PSGL-1, CD24, Lewis(x), and sialyl Lewis(x). Treatment with sodium chlorate (a sulfation biosynthesis inhibitor), but not 4-methylumbelliferyl-beta-D-xyloside (a proteoglycan biosynthesis inhibitor) or heparinases, reduced adhesion of these cells to P-selectin. Sodium chlorate also inhibited the P-selectin precipitation of the 160-, 54-, and 36-kDa molecules from the cell surface of Acc-M cells. Furthermore, P-selectin could bind to human breast carcinoma ZR-75-30 cells in a sulfation-dependent manner. Our results thus indicate that sulfation is essential for adhesion of nonblood-borne, epithelial-like human cancer cells to P-selectin.
UI - 9065618
AU - Ozdzinski W; Kuczkowski J; Debniak E; Zoltowska A
TI - Clinical and immunohistochemical analyses of parotid gland tumors.
SO - Eur Arch Otorhinolaryngol 1997;254 Suppl 1():S20-2
AD - Department of Otorhinolaryngology, Medical University of Gdansk, Poland.
Clinical, histological and immunohistochemical data on 71 parotid gland tumors were analyzed. Benign neoplasms accounted for 71.8% of the case material and malignant tumors 22.6%. Chronic parotitis occurred in 5.6% of the total case number. Pleomorphic adenomas and mucoepidermoid carcinomas were the most frequently occurring benign and malignant neoplasms. Pleomorphic adenomas stained positive for S-100 protein, tenascin, smooth muscle actin, synaptophysin and chromogranin A. This immunohistochemical, histological and clinical analysis was believed to be of potential assistance in the diagnosis, treatment and prognosis of parotid gland tumors.
UI - 10774375
AU - Fernandez E; Pallini R; Lauretti L
TI - Microsurgical selective removal of benign neoplasms of the parotid gland.
SO - Eur Arch Otorhinolaryngol 1994 Dec;():S290-2
AD - Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy.
UI - 10774378
AU - Diard JP; Borsik M; Wassef M; Freyss G
TI - Facial paralysis induced by tumors.
SO - Eur Arch Otorhinolaryngol 1994 Dec;():S297-8
AD - Medical Aircrew Examination Center, Armees, France.
UI - 11780493
AU - Yu G; Ussmueller J; Donath K
TI - [A clinicopathologic study on membranous basal cell adenoma]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 Mar;35(2):88-90
AD - Department of Oral Maxillofacial Surgery, School of Stomatology, Beijing Medical University, Beijing 100081, China.
OBJECTIVE: To investigate the clinicopathologic features and behaviour of membranous basal cell adenoma. METHODS: Twelve cases with membranous basal cell adenoma of salivary gland were analysed clinicopathologically. RESULTS: The tumors were composed of epithelial islands of various sizes and shapes. Its histologic finding was characterized by palisading of peripheral cells and excessive hyaline basal membrane. Four cases had co-existing dermal cylindromas of the scalp. In 8 cases, the tumors demonstrated multiple origin. One case showed malignant transformation and cervical lymph node metastasis. CONCLUSIONS: The differential diagnosis involved the solid variant of basal cell adenoma, basal cell adenocarcinoma, solid subtype of adenoid cystic carcinoma and basal squamous cell carcinoma. Total parotidectomy rather than superficial parotidectomy is suggested to avoid the recurrence of the tumor. A close follow up after treatment is necessary.
UI - 11776872
AU - Wu X; Lin G; Zhang Q
TI - [Evaluation of clinical value of technetium-99m(V) dimercaptosuccinic acid SPECT in diagnosis of parotid lump]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Nov;34(6):334-6
AD - Department of Stomatology, First Affiliated Hospital, Fujian Medical University, Fuzhou 350000.
OBJECTIVE: To evaluate the clinical value of single photon emission computed tomography (SPECT) on classifying parotid lump as benign or malignant before treatment. METHODS: SPECT images of the parotid region were obtained in forty-five patients with parotid lump before surgery. We used technetium-99m(V) dimercaptosuccinic acid as imaging agent. The results were compared with their pathological diagnoses, clinical examination, and ultrasonography. RESULTS: The sensitivity, specificity and accuracy of Tc-99m(V)-DMSA SPECT imaging in determining malignancy of parotid lump were 93.7%, 72.4%, 80.0%, respectively. The uptake ratios of parotid lesions were higher in malignant tumors than benign tumors, cysts, and inflammatory lumps (P < 0.05). CONCLUSION: It is suggested that Tc-99m (V)-DMSA SPECT can be a useful aided method of preoperative diagnosis of parotid lumps. The uptake ratios can help increase the accuracy of diagnoses. For the benign tumors and inflammatory masses of parotid gland, the diagnoses had some false positives which may be reduced by combined clinical examination and ultrasonography.
UI - 11776890
AU - Yu G; Gao Y; Ma D
TI - [Basal cell adenocarcinoma of the salivary gland: a clinicopathologic study of 14 cases]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):275-7
AD - School of Stomatology, Beijing Medical University, Beijing 100081.
OBJECTIVE: To study clinicopathologic features and behaviour of the basal cell adenocarcinoma of salivary gland tumor and prognosis of the patients, METHODS: 14 cases with basal cell adenocarcinoma were studied clinicopathologically. RESULTS: The clinical features were as follows: females more than males; most frequently in the minor salivary glands; 21.4% of cervical lymph node metastasis and 14.3% of distant metastasis; and rather poor prognosis. The histopathologic appearances were similar to those of basal cell adenoma, but with more mitotic figures and infiltrating growth. CONCLUSION: This tumor was of moderate grade malignancy. It must be treated radically. The elective neck dissection could be considered for the patients with extensive tumors.
UI - 11776893
AU - Sun K; Yu G; Wang J
TI - [The ultrastructure of membrane component in adenoid cystic carcinoma of salivary gland]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):284-5
AD - School of Stomatology, Beijing Medical University, Beijing 100081.
OBJECTIVE: To study morphological variations of basment membrane component (BMC) for determination of invasion and vascular metastasis in adenoid cystic carcinoma (ACC). METHODS: The BMC of 8 cases in ACC and 2 cases of normal parotid gland were observed by LM and EM. RESULTS: The BMC surrounding tumor mass and strands showed multi-layered or dissolution, pseudopodia were seen extended from tumor cells, and contained numerous microvesicles. If the tumor cell attached blood vessels, the collagenous fibril were dissoluted and BMC were lost. CONCLUSION: The tumor cell may release some digestive enzymes which may be able to dissolve BMC and collagenous fibrils and invade into blood vessels and metastasis take place.
UI - 11776895
AU - Sun H; Wu S; Ouyang J
TI - [Expression of C-erbB-2 oncogene mRNA in salivary gland tumors]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):289-91
AD - School of Stomatology, Norman Bethune University of Medical Sciences, Changchun 130041.
OBJECTIVE: To study relationship of C-erb-2 oncogene mRNA expression and histotype, tumorigenesis and biological behavior of salivary gland neoplasms. METHODS: Using 32P labeled oligonucleotide as probe, the dot blot technique was used to study the expression of C-erbB-2 oncogene mRNA in salivary gland neoplasm with normal salivary gland as control. RESULTS: With the expression in normal salivary gland as a standard, low C-erbB-2 mRNA expression was seen in adenolymphoma, basal cell adenoma. However, various degrees of over-expression of C-erbB-2 oncogene mRNA were detected in pleomorphic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma, papillary cystic carcinoma, and myoethelial cell carcinoma. CONCLUSION: C-erbB-2 oncogene mRNA over-expression in salivary gland neoplasm is related to biological behavior of salivary gland carcinoma.
UI - 11776898
AU - Wang J; Dong F; Yong P
TI - [p53 gene mutation determined by single-strand conformational polymorphism and DNA sequencing analysis in pleomorphic adenoma of salivary gland]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 Sep;34(5):298-300
AD - School of Stomatology, Hebei Medical University, Shijiazhuang 050017.
OBJECTIVE: To detect p53 exon 6 mutation pattern in pleomorphic adenoma of salivary gland. METHODS: Single-strand conformational polymorphism (SSCP) and DNA sequecing were used. RESULTS: SSCP analysis showed that 6 of 11 cases with SSCP positive were exon 6 abnormal. Comparison of the SSCP results with DNA sequecing, 4 cases with p53 exon 6 mutations were SSCP positive. Mutation pattern included base substitution (point mutation, G-->T, T-->G) and frame-shift mutation (base insertion and base loss). CONCLUSION: Poly-codon and poly-pattern mutations appeared in p53 exon 6. PCR-SSCP was a convenient method to detecte gene mutation.
UI - 11793273
AU - Jaehne M; Ussmuller J; Jakel KT; Zschaber R
TI - [Clinical presentation, therapy and prognosis of non-Hodgkin lymphomas of the major salivary glands]
SO - Laryngorhinootologie 2001 Dec;80(12):743-7
AD - Hals-Nasen-Ohren-Klinik des Universitatsklinikums Hamburg-Eppendorf, Germany. firstname.lastname@example.org
INTRODUCTION: About 5 - 10 % of all Non-Hodgkin-Lymphomas (NHL) present within the major salivary glands. Two etio-pathologically different groups, the (extranodal)-parenchymal NHL and NHL of intra- or periglandular lymphnodes (nodal lymphomas) have to be distinguished. It was the aim of this study to evaluate the clinical presentation, therapy and biological behaviour of these etiopathologically different lymphoma-groups. MATERIAL AND METHOD: In a retrospective study, therapy and course of disease of 26 patients with a NHL of the major salivary glands were examined (diagnosis and treatment between 1988 and 1996). RESULTS: Staging results in the group of parenchymal lymphoma always showed the disease limited to the effected gland, whereas nodal NHL presented with a stadium II to IV (Ann-Arbor) at time of diagnosis. Local recurrencies were five times higher in nodal NHL compared to parenchymal NHL. In only one case (7.7 %) of the patients with parenchymal NHL, dissemination was observed. In the group of nodal NHL, a dissemination was observed in 6 patients (46.2 %). 7 of 13 patients (53.8 %) with a nodal NHL died due to lymphoma dissemination, compared to one patient (7.7 %) with a parenchymal NHL. CONCLUSION: Based on the presented data, the histopathological diagnosis, under special recognition of the particular lymphoma-pathogenesis, constitutes an important prognostic factor in patients with NHL of the major salivary glands.
UI - 11780221
AU - Huang J
TI - [Expression of S-100 proteins and intermediate filament proteins in pleomorphic adenoma]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 May;35(3):191-3
AD - Department of Pathology, Fujian Medical University, Fuzhou 350004, China.
OBJECTIVE: To observe immunohistochemical expression of S-100A1, S-100A2, S-100A4, S-100A6, S-100B, K8.12, KL1, Vimentin, GFAP and NSE in pleomorphic adenoma of salivary gland, and to evaluate the differential localization of S-100 proteins and biological behaviour of neoplastic myoepithelial cells. METHODS: 23 cases of normal salivary gland and 60 cases of pleomorphic adenoma were embedded, in paraffin and were routinely diagnosed on the basis of hematoxylin and eosin-stained sections. Serial sections at 4 microns from the paraffin embedded blocks were used for the immunohistochemical studies. RESULTS: Normal salivary glands had positive immunoreactivity for S-100A families, K8.12 and KL1 in the ductal cells, while S100B, GFAP and NSE were observed in peripheral nerve fibers innervating the gland. In pleomorphic adenomas, luminal tumor cells in duct-like structures had positive immunoreactivity for S-100A subfamilies and keratin. Nonluminal tumor cells had positive immunoreactivity for S-100B, as well as Vimentin, keratins detected by monoclonal K8.12 and KL1, GFAP and NSE. CONCLUSIONS: These findings may suggest that the neoplastic myoepithelial cells contain Ca2+ binding proteins which may have a role in the regulation of calcium ions or calcium signaling mechanisms in the modulation of extracellular matrix deposition in pleomorphic adenoma which may in turn affect the extracellular matrix synthesis as well as histomorphology of the tumor.
UI - 11780226
AU - Peng X; Yu G; Gao Y
TI - [The expression of cathepsin-D in salivary adenoid cystic carcinoma]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 May;35(3):206-8
AD - Department of Oral Maxillofacial Surgery, School of Stomatology, Beijing Medical University, Beijing 100081, China.
OBJECTIVE: To investigate the relationship between Cathepsin-D(Cath-D) and the prognosis of patients with salivary adenoid cystic carcinoma (SACC). METHODS: The immunoactivity of Cath-D of 52 cases with SACC was determined by immunohistochemistry method (Streptavidin-Biotin method). The relationship between Cath-D and the histological type, clinical stage, local recurrence, distant metastasis of the tumor and survival rate of the patients with SACC were analysed. RESULTS: Statistical analysis showed that the expression levels of Cath-D were correlated positively with distant metastasis potential and clinical stage (P < 0.05), and had no significant relation with histological type, local recurrence and survival rate (P > 0.05). CONCLUSIONS: Cath-D can facilitate invasiveness and distant metastasis of SACC; evaluation of Cath-D can act as a predictor of distant metastasis of SACC and direct the clinical treatment.
UI - 11857983
AU - Morimoto H; Hashida H; Honda T; Aibara Y
TI - [An elderly case of cytomegalovirus enterocolitis associated with a malignant tumor]
SO - Nippon Ronen Igakkai Zasshi 2002 Jan;39(1):97-100
AD - Department of Internal Medicine, Ehime Prefectural Iyomishima Hospital.
An 83-year-old man was given a diagnosis of left parotid cancer in our because of his advanced age. Therefore chemotherapy and radiotherapy were used. Chemotherapy with CAP (Cyclophosphamide, Adriacin, and CDDP) Prednisolone (15 mg) was administered daily from July 15, 2000. The patient started suffering from diarrhea on August 2, 2000. As the patient also began to suffer high grade fevers and stomachaches, he was admitted on a diagnosis of acute enterocolitis. He had bloody stool on August 11. On emergency colonoscopy, an ulceration with bleeding was located in the lower rectum. The biopsy specimen revealed intranuclear inclusion bodies and positively staining cells for monoclonal antibody to cytomegalovirus through the immunohistochemical technique, and it was diagnosed as cytomegalovirus enterocolitis. He was treated with ganciclovir. One month later, his clinical symptoms had improved. Cytomegalovirus enterocolitis is an opportunistic infection, so immunocompromised hosts (such as cancer patients, patients using immunosuppressants, old people) have a greater probability of contracting cytomegalovirus infection. A ganciclovir is an effective treatment. A cytomegalovirus enterocolitis should considered in the differential diagnosis of enterocolitis, when alimentary symptoms like diarrhea or bloody stool are found in immunocompromised hosts.
UI - 11604993
AU - Hoque MO; Kawamata H; Nakashiro KI; Omotehara F; Shinagawa Y; Hino S;
TI - Begum NM; Uchida D; Yoshida H; Sato M; Fujimori T Dihydropyrimidine dehydrogenase mRNA level correlates with the response to 5-fluorouracil-based chemo-immuno-radiation therapy in human oral squamous cell cancer.
SO - Int J Oncol 2001 Nov;19(5):953-8
AD - Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.
The measurement of the intra-tumoral level of thymidylate synthetase (TS), and dihydropyrimidine dehydrogenase (DPD), may be useful in predicting tumor sensitivity to 5-fluorouracil (5-FU). In this study, we examined the mRNA levels of DPD and TS in 28 oral squamous cell carcinomas (SCC), and 22 salivary gland tumors by semi-quantitative reverse transcription polymerase chain reaction. Then we examined the correlation of the responsiveness of the patients with oral SCC to 5-FU with the intra-tumoral levels of DPD and TS mRNA. All specimens were obtained at the biopsy before treatment, and then the patients were treated by oral administration of a 5-FU compound (UFT), the irradiation of cobalt-60 (upto 60 Gy) and injection of an immuno-potentiator (OK-432). Intra-tumoral levels of DPD mRNA in the patients who showed CR (complete response) and PR (partial response) were significantly lower than those in the patients who showed NC (no change). However, intra-tumoral levels of DPD mRNA did not correlate with the local recurrence of the tumor during the observation period after initial treatment with or without surgical resection of the residual tumors. On the other hand, TS mRNA levels in the tumors did not correlate with any clinico-pathological parameters. These observations suggest that intra-tumoral levels of DPD mRNA may predict the tumor response to 5-FU-based chemo-immuno-radiation therapy in the patients with oral SCC.
UI - 11836700
AU - Chhieng DC; Paulino AF
TI - Cytology of myoepithelial carcinoma of the salivary gland.
SO - Cancer 2002 Feb 25;96(1):32-6
AD - Department of Pathology, University of Alabama at Birmingham, Birmingham Alabama 35249-6823, USA. email@example.com
BACKGROUND: Myoepithelial carcinoma, also know as malignant myoepithelioma, is rare in the salivary gland, and its cytologic features have rarely been reported. DESIGN: Four cases of myoepithelial carcinoma with cytology were retrieved from the archives of the Pathology Departments of two academic institutes. In three cases, the specimens were obtained by fine needle aspiration biopsy (FNA); the remaining case was a bench aspiration performed on the surgically resected specimen at the time of intra-operative consultation. The cytologic features were reviewed and correlated with the histology. RESULTS: The four patients with myoepithelial carcinoma (two men and two women) ranged in age from 48 to 64 years. Three cases arose from the parotid gland, and the remaining case was a recurrent tumor in the minor salivary glands of the hard palate. The aspirates of two cases consisted of predominantly spindle cells, one predominantly epithelioid/plasmacytoid cells, and one with a mixture of both spindle and epithelioid/plasmacytoid cells. Cellular pleomorphism was noted in two cases and mitotic figures in three cases. Two cases were cytologically diagnosed as malignant spindle cell neoplasm, not otherwise specified. The FNA of the recurrent tumor was diagnosed as consistent with the previous malignancy. The remaining case was interpreted as a pleomorphic adenoma with atypia. CONCLUSIONS: The cytologic features of myoepithelial carcinoma are diverse and may lack overt features of malignancy. Pathologists should be aware of this entity when evaluating cytologic specimen of salivary gland mass.
UI - 11849796
AU - Bragg CM; Conway J; Robinson MH
TI - The role of intensity-modulated radiotherapy in the treatment of parotid tumors.
SO - Int J Radiat Oncol Biol Phys 2002 Mar 1;52(3):729-38
AD - Department of Clinical Oncology, Weston Park Hospital, Sheffield, South Yorkshire, United Kingdom. Christopher.Bragg@STH.nhs.uk
PURPOSE: To compare intensity-modulated radiotherapy (IMRT) treatment plans with three-dimensional conformal radiotherapy (3D-CRT) plans to investigate the suitability of IMRT for the treatment of tumors of the parotid gland. METHODS AND MATERIALS: One 3D-CRT treatment plan and 10 IMRT treatment plans with differing beam arrangements were produced for each of nine patient data sets. The plans were compared using regret analysis, dose conformity, dose to organs at risk, and uncomplicated tumor control probability (UTCP). RESULTS: The target dose was comparable in the 3D-CRT and IMRT plans, although improvements were seen when seven and nine IMRT fields were used. IMRT reduced the mean dose to the contralateral parotid gland and the maximum doses to the brain and the spinal cord, but increased the ipsilateral lens dose in some cases. Each IMRT arrangement produced a higher UTCP than the 3D-CRT plans; the largest absolute difference was 9.6%. CONCLUSIONS: IMRT is a suitable means for treating cancer of the parotid, and a five-field class solution is proposed. It produced substantial sparing of organs at risk and higher UTCPs than 3D-CRT and should enable dose escalation.
UI - 11839563
AU - Roijer E; Nordkvist A; Strom AK; Ryd W; Behrendt M; Bullerdiek J; Mark
TI - J; Stenman G Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma.
SO - Am J Pathol 2002 Feb;160(2):433-40
AD - Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE-413 45 Goteborg, Sweden.
Carcinoma ex pleomorphic adenoma (CexPA) is a carcinoma developing within a pre-existing benign pleomorphic adenoma (PA). Here we describe the identification and characterization of a series of genetic events leading to translocation, deletion/amplification, and overexpression of the HMGIC and MDM2 genes in a CexPA at an early stage of development. The tumor had a pseudodiploid stemline karyotype with a del(5)(q22-23q32-33) and a t(10;12)(p15;q14-15). In addition, there were several sidelines with double minute chromosomes (dmin) or homogeneously staining regions (hsr). Fluorescence in situ hybridization (FISH) mapping revealed that the 12q14-15 breakpoint was located centromeric to HMGIC and that the entire gene was juxtaposed to the der(10) chromosome. Detailed analysis of cells with dmin and hsr revealed that HMGIC and MDM2 were deleted from the der(10) and that the dmin and hsr were strongly positive for both genes. Southern blot analysis confirmed that both HMGIC and MDM2 were amplified and that no gross rearrangements of the genes had occurred. Immunostaining revealed that the HMGIC protein was highly overexpressed particularly in the large polymorphic cells within the carcinomatous part of the tumor. These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA.
UI - 11878716
AU - Hirokawa M; Tamura M; Horiguchi H; Wakatsuki S; Sano T
TI - Abnormal venous structures in salivary gland tumors: vasculature characteristics of pleomorphic adenoma.
SO - APMIS 2001 Sep;109(9):625-30
AD - Department of Pathology, University of Tokushima School of Medicine, Japan. firstname.lastname@example.org
To clarify the diagnostic significance of abnormal venous structures present in salivary gland tumors, we examined 21 pleomorphic adenomas, 14 Warthin tumors, 1 oncocytic adenoma, 3 myoepitheliomas, 7 basal cell adenomas, 5 mucoepidermoid carcinomas, and 6 adenoid cystic carcinomas. Verhoeffvan Gieson staining was carried out and the morphology of the veins within the tumors was observed microscopically. Branching veins, thickened intima of the veins, discontinuous elastic membrane and multilayered elastic membrane were seen in 71.4%, 76.2%, 47.6% and 85.7% of pleomorphic adenomas, respectively, and were abundant and easily found in most cases. The abnormal venous structures were also found in other salivary gland tumors examined, but they were few in number and lacked variety. Elastic fibers extending radially into the surrounding stroma were seen in 66.7% of pleomorphic adenomas, and were not seen in other salivary gland tumors. Our results showed that a variety of abnormal venous structures are more abundant and more easily found in pleomorphic adenoma compared with other salivary gland tumors, and, in particular, that perivascular radiating elastic fibers are characteristic of pleomorphic adenoma. We emphasize that the presence of perivascular radiating elastic fibers may be helpful in diagnosing pleomorphic adenoma in small biopsy specimens.
UI - 11285621
AU - Valencerina Gopez E; Dauterman J; Layfield LJ
TI - Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the parotid: a case report and review of the literature.
SO - Diagn Cytopathol 2001 Apr;24(4):249-52
AD - Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah. email@example.com
The cytologic features of an alveolar rhabdomyosarcoma arising within the parotid gland are described. The occurrence of this neoplasm as a primary malignancy in the parotid gland is very rare, and the tumor is usually not included in the cytologic differential diagnosis of parotid tumors. The diagnosis of the current case was achieved by a combination of fine-needle aspiration biopsy and frozen sections. Realizing the difficulty of recognizing this tumor both histologically and cytologically, we present this case to increase the awareness of this tumor's occurrence within the parotid gland and other salivary glands, and to highlight cytomorphologic features that will aid the pathologist in making the correct diagnosis. Copyright 2001 Wiley-Liss, Inc.
UI - 11793066
AU - Ratan SK; Bhardwaj M; Gambhir A; Sen A
TI - Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal?
SO - Pediatr Surg Int 2002 Jan;18(1):60-1
AD - Department of Pediatric Surgery, Dr. RML Hospital, New Delhi 110 001, India.
A 12-year-old boy with a pleomorphic adenoma of the parotid is reported. The excised gland specimen also showed evidence of chronic sialadenitis. The co-existence of these two entities has not been previously reported in the literature surveyed by us. The authors feel that the two conditions may have a common underlying etiology.
UI - 11857890
AU - Aufdemorte T; Jones AC; McGuff HS; Alderson G
TI - Oral and maxillofacial pathology case of the month. Adenoid cystic carcinoma.
SO - Tex Dent J 2000 Oct;117(10):72, 101
AD - University of Texas Health Science Center at San Antonio, USA.
UI - 11876610
AU - Patil S; Suvarna P; Dayal P K
TI - Central mucoepidermoid carcinoma--a case report.
SO - Indian J Cancer 2000 Jun-Sep;37(2-3):123-6
AD - Department of Oral Medicine and Radiology, College of Dental Surery, Mangalore, Karnataka, India.
The mucoepidermoid carcinoma (MEC) account for approximately 6-8 Percent of all salivary gland tumors. Central mucoepidermoid carcinoma of the jaws is rare. Following is a case report of central mucoepidermoid carcinoma which involves the ramus of the mandible. Origin of the central mucoepidermoid carcinoma is discussed.
UI - 11717913
AU - Cai X; Shi L; Dong P
TI - [Parapharyngeal space neoplasms]
SO - Zhonghua Er Bi Yan Hou Ke Za Zhi 1998 Jun;33(3):178-80
AD - First Affiliated Hospital of Shandong Medical University, Jinan 250012.
OBJECTIVE: To study parapharyngeal space (PPS) neoplasms which are rarely seen clinically. METHODS: A retrospective review was made of 59 patients with PPS neoplasm operated on from 1986 to July, 1997 in our institution. RESULTS: Neurogenic tumors were the most common neoplasms, which constituted about 60 percent in the primary parapharyngeal space neoplasms. High-resolution computed tomography or magnetic resonance imaging was essential for diagnosis and presurgical planning. The transcervical approach was the preferred procedure for 75% benign parapharyngeal tumors. Middle mandibulotomy was used in 3 cases, including 2 small tumors confined to the superior aspect of the PPS and 1 carotid body tumor which extended to the skull base. Lateral skull base approach was utilized for 1 schwannoma originating in the jugular foramen with extension into the PPS. CONCLUSIONS: We believe that transoral approach can be used for small tumors and transparotid approach may be especially indicated for removal of deep lobe parotid tumors with extension to the PPS. Middle mandibulotomy is a safe and efficacious approach for the removal of special PPS neoplasms.
UI - 11870356
AU - Liu CY; Chu PY; Li WY; Chang SY
TI - Sebaceous adenoma in the submandibular gland.
SO - Otolaryngol Head Neck Surg 2002 Feb;126(2):199-200
AD - Department of Otolaryngology, Veterans General Hospital, Taipei, Taiwan.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.