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NCI CANCERLIT® Search: Laryngeal Cancer - February 2002
National Cancer Institute®
Last Modified: February 1, 2002
Table of Contents
1
UI - 11778284
AU - Li S
TI -
[Long-term results of total versus partial laryngectomy for the
treatment of squamous-cell carcinoma of the larynx]
SO - Zhonghua Zhong Liu Za Zhi 2000 Sep;22(5):426-8
AD - Liaoning Tumor Hospital, Shenyang 110042, China.
OBJECTIVE: To analyze the long-term effects of total versus partial
laryngectomy for the treatment of squamous-cell carcinoma of the larynx.
METHOD: Of 423 patients with laryngeal carcinoma surgically treated, 327
had supraglottic cancer and 96 had glottic cancer. Total laryngectomy
was performed in 243 patients (210 supraglottic and 33 glottic cancers)
and partial laryngectomy in 180 patients (117 supraglottic and 63
glottic cancers). RESULTS: The overall 5-year survival rate of patients
with supraglottic carcinoma was 72.9%. That of patients treated by total
and partial laryngectomy was 70.1% and 77.4%, respectively (P > 0.05).
The overall 5-year survival rate of patients with glottic carcinoma was
86.0%. That of patients treated with total and partial laryngectomy was
72.2% and 92.3%, respectively (P < 0.05). CONCLUSION: The long-term
result of partial laryngectomy for glottic carcinoma is as good as total
laryngectomy, and for supraglottic carcinoma, partial laryngectomy is
superior to total laryngectomy. Partial laryngectomy is recommended to
treat patients with squamous-cell carcinoma of the larynx. Patients so
treated have a better quality of life.
2
UI - 11774398
AU - Franchi A; Gallo O; Paglierani M; Sardi I; Magnelli L; Masini E;
TI -
Santucci M
Inducible nitric oxide synthase expression in laryngeal neoplasia:
correlation with angiogenesis.
SO - Head Neck 2002 Jan;24(1):16-23
AD - Department of Human Pathology and Oncology, University of Florence,
Viale G. B. Morgagni 85, 50134 Florence, Italy. Franchi@UNIFI.IT
BACKGROUND: The nitric oxide (NO) pathway plays a relevant role in
angiogenesis and tumor progression in squamous cell carcinoma (SCC) of
the head and neck. The aim of this study was to assess whether the NO
pathway may be correlated with angiogenesis in the transition from
laryngeal dysplasia to invasive carcinoma. METHODS: We investigated the
expression of the inducible NO synthase (iNOS) in 26 laryngeal
precancerous lesions and 35 squamous cell carcinomas with respect to
microvessel density. In addition, we determined iNOS activity and cGMP
levels in specimens from SCCs. RESULTS: There was a significant increase
of iNOS levels detected immunohistochemically passing from
hyperplastic/mild dysplastic to moderate/severe dysplastic lesions to
SCC (p =.04). Accordingly, Northern and Western analyses demonstrated
higher iNOS mRNA and protein levels in SCCs than dysplastic mucosa. iNOS
expression was significantly correlated with microvessel counts both in
the group of preneoplastic lesions (p =.02) and in the group of SCCs (p
=.01). In addition, iNOS activity was correlated with iNOS
immunohistochemical expression (p =.1) and was significantly associated
with increased vascularization (p =.03) in SCCs. Similarly, iNOS
expression was significantly correlated with cGMP levels in SCC (p =.02)
and increased tumor vascularization correlated with higher cGMP levels
(rs =.4; p =.01). CONCLUSIONS: Our data indicate that the NO pathway may
play a relevant role in the angiogenesis associated with the progression
from laryngeal dysplasia to laryngeal SCC. Copyright 2002 John Wiley &
Sons, Inc.
3
UI - 11730998
AU - Claus F; De Gersem W; Vanhoutte I; Duthoy W; Remouchamps V; De Wagter C;
TI -
De Neve W
Evaluation of a leaf position optimization tool for intensity modulated
radiation therapy of head and neck cancer.
SO - Radiother Oncol 2001 Dec;61(3):281-6
AD - Division of Radiotherapy, Ghent University Hospital (GUH), De Pintelaan
185, 9000 Ghent, Belgium.
BACKGROUND AND PURPOSE: Since 1996, patients are treated at Ghent
University Hospital with a multi-segment technique using MultiLeaf
Collimators. The segments were obtained by using the Beam's eye view
projections of the planning target volume (PTV) and the organs at risk
(OARs), after which the segments weights were optimized. To investigate
if optimization of the leaf positions would further improve the
intensity modulated radiation therapy (IMRT) plans, a tool optimizing
leaf positions and segment weights simultaneously, was developed. This
tool is called SOWAT, which is the acronym for segment outline and
weight adapting tool. MATERIAL AND METHODS: The tool evaluates the
effects of changing the position of each collimating leaf of all
segments on the value of the objective function. Only changes that
improve the value of the objective function are retained. Between
with IMRT. Two patient groups were distinguished: pharyngeal and
laryngeal tumors (n=17) and sinonasal tumors (n=13). A specific set of
physical endpoints was evaluated for each group. Dose statistics of the
treatment plans without and with SOWAT were analyzed. RESULTS: When
using SOWAT for the pharyngeal and laryngeal cases, the PTV dose
homogeneity increased with a median of 11% (range 2-27%), while the
maximum dose to the spinal cord was decreased for 14 of the 17 patients.
In four plans where parotid function preservation was a goal, the
parotid mean dose was lower than 26 Gy in one plan without SOWAT, and in
four plans with SOWAT. For the sinonasal tumors, the PTV dose
homogeneity increased with a median of 7% (range 1-14%). SOWAT lowered
the mean dose to 53 of the 63 optic pathway structures (retina, optic
nerve and optic chiasm). SOWAT leaves the number of segments unchanged
and has little or no effect on the delivery time. CONCLUSIONS: SOWAT is
a powerful tool to perform the final optimization of IMRT plans, without
increasing the complexity of the plan or the delivery time.
4
UI - 11730999
AU - Cozzi L; Fogliata A; Lomax A; Bolsi A
TI -
A treatment planning comparison of 3D conformal therapy, intensity
modulated photon therapy and proton therapy for treatment of advanced
head and neck tumours.
SO - Radiother Oncol 2001 Dec;61(3):287-97
AD - Oncology Institute of Southern Switzerland, Medical Physics Unit,
Bellinzona, Switzerland.
BACKGROUND AND PURPOSE: In this work, the potential benefits and
limitations of different treatment techniques, based on mixed
photon-electron beams, 3D conformal therapy, intensity modulated photons
(IM) and protons (passively scattered and spot scanned), have been
assessed using comparative treatment planning methods in a cohort of
patients presenting with advanced head and neck tumours. MATERIAL AND
METHODS: Plans for five patients were computed for all modalities using
CT scans to delineate target volume (PTV) and organs at risk (OAR) and
to predict dose distributions. The prescribed dose to the PTV was 54 Gy,
whilst the spinal cord was constrained to a maximum dose of 40.5 Gy for
all techniques. Dose volume histograms were used for physical and
biological evaluation, which included equivalent uniform dose (EUD)
calculations. RESULTS: Excluding the mixed photon-electron technique,
PTV coverage was within the defined limits for all techniques, with
protons providing significantly improved dose homogeneity, resulting in
correspondingly higher EUD results. For the spinal cord, protons also
provided the best sparing with maximum doses as low as 17 Gy. Whilst the
IM plans were demonstrated to be significantly superior to non-modulated
photon plans, they were found to be inferior to protons for both
criteria. A similar result was found for the parotid glands. Although
they are partially included in the treated volume there is a clear
indication that protons, and to a lesser extent IM photons, could play
an important role in preserving organ functionality with a consequent
improvement of the patient's quality of life. CONCLUSIONS: For advanced
head and neck tumours, we have demonstrated that the use of IM photons
or protons both have the potential to reduce the possibility of spinal
cord toxicity. In addition, a substantial reduction of dose to the
parotid glands through the use of protons enhances the interest for such
a treatment modality in cases of advanced head and neck tumours.
However, in terms of target coverage, the use of 3D conformal therapy,
although somewhat inferior in quality to protons or IM photons, has been
shown to be a reasonable alternative to the more advanced techniques. In
contrast, the conventional technique of mixed photon and electron fields
has been shown to be inferior to all other techniques for both target
coverage and OAR involvement.
5
UI - 11731000
AU - de Boer HC; van Sornsen de Koste JR; Creutzberg CL; Visser AG; Levendag
TI -
PC; Heijmen BJ
Electronic portal image assisted reduction of systematic set-up errors
in head and neck irradiation.
SO - Radiother Oncol 2001 Dec;61(3):299-308
AD - Department of Radiation Oncology, Division of Clinical Physics, Daniel
den Hoed Cancer Center/University Hospital Rotterdam, Groene Hilledijk
301, P.O. Box 5201, 3008 Rotterdam, The Netherlands.
PURPOSE: To quantify systematic and random patient set-up errors in head
and neck irradiation and to investigate the impact of an off-line
correction protocol on the systematic errors. MATERIAL AND METHODS:
Electronic portal images were obtained for 31 patients treated for
primary supra-glottic larynx carcinoma who were immobilised using a
polyvinyl chloride cast. The observed patient set-up errors were input
to the shrinking action level (SAL) off-line decision protocol and
appropriate set-up corrections were applied. To assess the impact of the
protocol, the positioning accuracy without application of set-up
corrections was reconstructed. RESULTS: The set-up errors obtained
without set-up corrections (1 standard deviation (SD)=1.5-2mm for random
and systematic errors) were comparable to those reported in other
studies on similar fixation devices. On an average, six fractions per
patient were imaged and the set-up of half the patients was changed due
to the decision protocol. Most changes were detected during weekly check
measurements, not during the first days of treatment. The application of
the SAL protocol reduced the width of the distribution of systematic
errors to 1mm (1 SD), as expected from simulations. A retrospective
analysis showed that this accuracy should be attainable with only two
measurements per patient using a different off-line correction protocol,
which does not apply action levels. CONCLUSIONS: Off-line verification
protocols can be particularly effective in head and neck patients due to
the smallness of the random set-up errors. The excellent set-up
reproducibility that can be achieved with such protocols enables
accurate dose delivery in conformal treatments.
6
UI - 11776620
AU - Fu W; Wu D; Zhang X
TI -
[FHIT gene is abnormal in laryngeal carcinoma]
SO - Zhonghua Zhong Liu Za Zhi 1999 Nov;21(6):436-8
AD - Department of Medical Genetics, China Medical University, Shenyang
110001.
OBJECTIVE: To determine the role of FHIT gene in laryngeal
carcinogenesis. METHODS: Laryngeal cancer cell line Hep-2, HeLa cell
line and 80 primary tumors from patients with laryngeal cancer were
studied by means of RT-PCR, sequencing and microsatellite analysis.
RESULTS: Abnormal transcripts of FHIT gene were found in the two cell
lines and 70% (14/20) of primary laryngeal carcinomas. Aberrant
laryngeal tumor transcripts often lack more than two exons of FHIT gene.
Microsatellite analysis showed that both loss of heterozygosity and
microsatellite instability of FHIT gene existed in laryngeal carcinoma
and the former was more common. CONCLUSION: FHIT gene participates in
the laryngeal carcinogenesis and may be one of the candidate tumor
suppressor genes.
7
UI - 11801959
AU - Zeitels SM; Jarboe J; Franco RA
TI -
Phonosurgical reconstruction of early glottic cancer.
SO - Laryngoscope 2001 Oct;111(10):1862-5
AD - Department of Otology and Laryngology, Harvard Medical School, and the
Division of Laryngology, Massachusetts Eye and Ear Infirmary, Boston,
Massachusetts 02114, USA. smzeitels.mcci.harvard.edu
8
UI - 11801970
AU - Fung K; Yoo J; Leeper HA; Hawkins S; Heeneman H; Doyle PC; Venkatesan VM
TI -
Vocal function following radiation for non-laryngeal versus laryngeal
tumors of the head and neck.
SO - Laryngoscope 2001 Nov;111(11 Pt 1):1920-4
AD - Department of Otolaryngology, London Health Sciences Centre, University
of Western Ontario, London, Ontario, Canada.
OBJECTIVE: The larynx may receive high doses of radiation even in the
absence of disease. Preliminary investigation has provided evidence that
significant voice alterations exist in patients who received
radiotherapy (RT) for non-laryngeal tumors of the head and neck. This
study evaluates subjective and objective parameters of vocal function in
this patient population compared with a control group of patients
irradiated for early glottic tumors. STUDY DESIGN: Retrospective cohort
study. METHODS: Vocal function in patients irradiated for non-laryngeal
and early glottic tumors was assessed in a comprehensive manner and
compared. Microanalytical and macroanalytical acoustic analyses,
aerodynamic measurements, and videostroboscopy were performed on vowel
production data. The Voice Handicap Index was administered for
self-assessment of voice quality. All subjects were male, smokers, and
greater than 12 months post-RT. RESULTS: Seventeen patients with
non-laryngeal tumors and 13 patients with early glottic tumors were
evaluated. Microanalytical acoustic parameters were worse for 75% (6 of
8) of the acoustic measures of vowel production in the non-laryngeal
group. These include jitter, relative amplitude perturbation, amplitude
perturbation quotient, normalized noise energy, pitch amplitude, and
spectral flatness ratio. Macroanalytical acoustic analyses revealed no
difference in fundamental frequency but numerically smaller phonational
frequency range in the non-laryngeal group. All aerodynamic measures,
including mean phonation time, mean airflow, and vocal fold
diadochokinetic rate, were decreased in the non-laryngeal group.
Videostroboscopy demonstrated increased supraglottic activity in the
non-laryngeal group. Voice handicap was significantly greater in the
non-laryngeal group. CONCLUSIONS: When compared with patients receiving
RT for early glottic tumors, there is objective and subjective evidence
of vocal dysfunction in patients treated with wide-field RT for
non-laryngeal tumors.
9
UI - 11773428
AU - Vancurova I; Wu R; Miskolci V; Sun S
TI -
Increased p50/p50 NF-kappaB activation in human papillomavirus type 6-
or type 11-induced laryngeal papilloma tissue.
SO - J Virol 2002 Feb;76(3):1533-6
AD - Department of Pediatrics, Long Island Jewish Medical Center, New Hyde
Park, New York, USA.
We have observed elevated NF-kappaB DNA-binding activity in nuclear
extracts from human papillomavirus type 6- and 11-infected laryngeal
papilloma tissues. The predominant DNA-binding species is the p50/p50
homodimer. The elevated NF-kappaB activity could be correlated with a
reduced level of cytoplasmic IkappaBbeta and could be associated with
the overexpression of p21(CIP1/WAF1) in papilloma cells. Increased
NF-kappaB activity and cytoplasmic accumulation of p21(CIP1/WAF1) might
counteract death-promoting effects elicited by overexpressed PTEN and
reduced activation of Akt and STAT3 previously noted in these tissues.
10
UI - 11779436
AU - Wang D; Zhang W; Xiong M; Xu J
TI -
Laryngeal and hypopharyngeal carcinoma: comparison of helical CT
multiplanar reformation, three-dimensional reconstruction and virtual
laryngoscopy.
SO - Chin Med J (Engl) 2001 Jan;114(1):54-8
AD - Department of Radiology, Air Force General Hospital, Beijing 100036,
China. dongwang66@263.net
OBJECTIVE: To evaluate the clinical application of helical CT
multiplanar reformation (MPR) three-dimensional reconstruction (3D) and
virtual laryngoscopy (CTVL) in laryngeal and hypopharyngeal carcinoma.
METHODS: Axial helical CT scans were performed in 22 patients with
laryngeal or hypopharyngeal carcinoma, along with MPR, 3D and CTVL.
These results were compared with the findings of fiber optic
laryngoscopy and surgery. RESULTS: Combining axial and MPR images, both
the accuracy in preoperative tumor staging and the diagnosis of
metastatic lymph nodes were 95%. MPR demonstrated more information about
the extent of tumor than axial images in 23% cases; 3D image displayed
clearly the extension of tumor, the vessels and airway from multiple
views. The location, size and extent of tumors found in cranio-caudal
CTVL corresponded well with that of laryngoscopy, and CTVL demonstrated
the relationship between the tumor and vocal cords and anterior
commissure by caudo-cranial approach, which was inaccessible to fiber
optic laryngoscopy in 3 cases. CONCLUSIONS: Axial images of helical CT
clearly demonstrate the location, size and extent of laryngeal and
hypopharyngeal carcinoma, while MPR and 3D images are useful in
displaying the three-dimensional images and anatomical relation of the
tumor. CTVL can clearly display the mucosal surface structures of the
larynx and hypopharynx and is a good complementary method of
laryngoscopy.
11
UI - 11779445
AU - Ji W; Yu J; Guan C
TI -
Pathologic features of occult lymphatic metastasis in supraglottic
carcinoma.
SO - Chin Med J (Engl) 2001 Jan;114(1):88-9
AD - Department of Otorhinolaryngology, First Affiliated Hospital, China
Medical University, Shenyang 110001, China.
OBJECTIVE: To study the pathologic features of occult lymphatic
metastasis in supraglottic carcinoma. METHODS: Serial sections of 153
neck dissection specimens in 100 patients with supraglottic carcinoma
were evaluated under the microscope. RESULTS: In 100 patients, 38 had
occult metastatic lymph nodes. 51 metastatic lymph nodes were found in
pathology, and their sizes ranged from 0.5 cm to 2.6 cm (average 1.1
cm). The distribution of 51 lymph nodes was 1 in level I (2%), 37 in
level II (73%), 12 in level III (24%), and 1 in level IV (2%). Among the
51 nodes, 21 (41%) were early stage, 18 (35%) were growth stage, 7 (14%)
were tull stage, and 5 (10%) were extracapsular stage. The
differentiation degree and appearance of supraglottic carcinoma was not
directly related with occult metastasis. CONCLUSION: The occult
metastatic rate of supraglottic carcinoma is high, and selective neck
dissection may be necessary.
12
UI - 11601383
AU - Gheorghe DC; Ardelean C; Anton G
TI -
Virological and immunological aspects in the juvenile laryngeal
papillomatosis.
SO - Rom J Virol 1999 Jan-Dec;50(1-4):85-9
AD - Marie Sklodowska-Curie Children Hospital, Bucharest.
The juvenile laryngeal papillomatosis, a disease which in the absence of
an adequate monitoring may have an invalidating character, represented
for a long time a problem as regards both its treatment and its possible
etiology. The use of monoclonal antibodies, as well as of molecular
biology techniques, permitted to elucidate some aspects, such as the
viral origin of the infection. Twenty five juvenile laryngeal
papillomas, removed intra-operatively, were investigated
immunohistochemically, a significant increase of the epidermal growth
factor (EGF) receptor being found. Ten samples were also analyzed with
the PCR technique, for the purpose of detecting the presence of the
corresponding DNA sequences of human papillomaviruses (HPV): all were
positive. The HPV genotyping showed the presence of only the HPV6 and 11
genotypes.
13
UI - 11699821
AU - Kazkayasi M; Hucumenoglu S; Siriner GI; Hucumenoglu M
TI -
Over-expression of p53 and c-erbB-2 oncoproteins in laryngeal carcinoma.
SO - Eur Arch Otorhinolaryngol 2001 Sep;258(7):329-35
AD - mkazkaya@ttnet.net.tr
An immunohistochemical analysis of over-expression of p53 and c-erbB-2
proteins was performed on 27 biopsies of laryngeal carcinoma. The aim of
this study was to investigate whether there is a correlation between
over-expression of these proteins and the clinicopathological features
of the tumor and to reveal any possible prognostic value. Paraffin
sections of laryngeal carcinoma were studied using immunohistochemical
staining with mouse and rabbit monoclonal antibodies, respectively, for
p53 and c-erbB-2 proteins. The positive controls were paraffin-embedded
specimens from ten breast carcinomas previously shown to express these
proteins. Ten benign laryngeal nodules were immunohistochemically
stained as negative controls. Samples from 74% of 27 patients with
laryngeal carcinomas demonstrated positive nuclear and cytoplasmic (or
membranous) staining for p53 protein and 48% were positive for c-erbB-2
protein. In the present study, while there was a slight difference in
the frequency of p53 over-expression among stage I-II and stage III-IV
tumors, there was no difference in the frequency of p53 over-expression
among primary and recurrent tumors. There was no statistically
significant correlation between over-expression of the p53 and c-erbB-2
proteins and the age of the patients, tumor site, tumor grade, clinical
stage, histopathological grading of the tumor, alcohol consumption, and
clinical outcome. There was a statistically significant correlation
between immunostaining of p53 and c-erbB-2 proteins (P = 0.037). While
it was found that over-expression of p53 was significantly associated
with the presence of lymph node metastasis (P = 0.006), there was no
association between the expression of c-erbB-2 and lymph node status.
The data demonstrated increased expression of p53 and c-erbB-2 proteins,
presumed to be mutant, in laryngeal carcinomas. Hence, we conclude that
p53 and c-erbB-2 over-expression as detected by immunohistochemical
staining in larynx carcinomas is not predictive of poor survival or
disease-free survival.
14
UI - 11699822
AU - Nalbadian M; Nikolaou A; Nikolaidis V; Petridis D; Themelis C;
TI -
Daniilidis I
Factors influencing quality of life in laryngectomized patients.
SO - Eur Arch Otorhinolaryngol 2001 Sep;258(7):336-40
AD - University Department of Otolaryngology, Aristotle University, AHEPA
Hospital, Thessaloniki, Greece.
The aim of this study is to estimate the quality of life
postlaryngectomy. A questionnaire was used. Fifty-six patients were
enrolled answering 26 questions. The mean age was 60.2 (40-76) years and
median post-treatment time 43 (7-120) months. The most frequent
complaints of the patients were increased bronchial discharge (66%) and
reduced olfactory function (63%). Communication problems with strangers
was mentioned by 57% and with their family by 29%. With regard to the
psychological status, 30% were ashamed of their voice, 32% were ashamed
of their appearance, 42% stated that they were rather depressed, and 30%
were feeling lonely. More than 3 out of 4 patients believed that their
everyday life had been altered. Half of the patients experienced
financial difficulties and 37% were not participating in social meetings
outside their house. Statistical analysis was used in order to calculate
the severity of each category of problems which the patient faced using
the scale from 0 to 1. The average grade for functional disorders was
0.31, for communication problems 0.47, for psychological problems 0.29,
for social problems 0.27, and for financial problems 0.51.
15
UI - 11699825
AU - Sieron A; Namyslowski G; Misiolek M; Adamek M; Kawczyk-Krupka A
TI -
Photodynamic therapy of premalignant lesions and local recurrence of
laryngeal and hypopharyngeal cancers.
SO - Eur Arch Otorhinolaryngol 2001 Sep;258(7):349-52
AD - Centre for Laser Diagnostics and Therapy, Department of Internal
Diseases and Physical Medicine, Silesian Medical University, Katowice,
Poland.
The main advantage of photodynamic therapy (PDT) in laryngology seems to
be its non-invasiveness and the possibility of using it despite previous
application of conventional methods. In the study, we gave PDT to two
separate groups of patients, i.e. five patients with advanced tumour
(four of them with local recurrence (squamous cell carcinoma) after
surgery and radiotherapy and one with a primary hypopharyngeal tumour)
and five patients with leucoplakia. In the first group
delta-aminolaevulinic acid (ALA) was administered orally (dose 3 g),
while in the second, an ointment containing 10% ALA was applied locally.
In both groups prior to irradiation, the tissue level of protoporphyrin
IX was verified using an adapted Xillix Life instrument. All treated
lesions were irradiated with an argon-pumped dye laser (dose range
100-250 J/cm2, wavelength 635 nm). In the first group, partial response
was obtained. In these advanced cases, diminution of cancerous
ulcerations was observed. In the leucoplakia group, complete response
was achieved in four out of five treated patients. On the basis of our
preliminary results, PDT may be useful in eradicating premalignant
lesions of the oral cavity and in the palliation of advanced lesions of
the oropharynx and larynx.
16
UI - 11783023
AU - Sun Y; Yang B
TI -
[Microscopic measurement of the surgical resection margins of laryngeal
carcinomas]
SO - Zhonghua Zhong Liu Za Zhi 2001 Mar;23(2):151-3
AD - Department of Otorhinolaryngology, Medical School of Zhejiang
University, Hangzhou 310009, China.
OBJECTIVE: To investigate the relationship between the primary sites of
laryngeal carcinomas and the surgical resection margins, to obtain
quantitative data of the safe distance of surgical margins for
supraglottic and glottic carcinomas. METHODS: In this series, 33 cases
of surgical specimens of laryngeal carcinomas were examined and measured
microscopically by means of cutting strips of tissues adjacent to the
tumor and longitudinal serial sections. RESULTS: The pattern and extent
of invasion of supraglottic carcinoma were quite different from those of
glottic carcinoma. Under microscopic measurement, the tumor invasion
distance in 95% of the supraglottic carcinoma samples was within 10.52
mm, while that of 95% of the glottic carcinoma samples was within 4.41
mm. CONCLUSIONS: The local invasion of laryngeal carcinomas appears to
be primary tumor site-dependent. The safe distance of surgical resection
margins may be set at 12.52 mm and 6.41 mm for supraglottic and glottic
carcinomas, respectively.
17
UI - 11406019
AU - Pedersen M; McGlashan J
TI -
Surgical versus non-surgical interventions for vocal cord nodules.
SO - Cochrane Database Syst Rev 2001;(2):CD001934
AD - Department of Otolaryngology - Head and Neck Surgery, The Medical
Center, Ostergade 18,3, DK-1100 Copenhagen, Denmark.
m.f.pedersen@dadlnet.dk
BACKGROUND: Vocal cord nodules are bilateral swellings of the
mid-portion of the membranous vocal folds. They are of variable size and
are characterised histologically by thickening of the epithelium with a
variable degree of inflammatory action in the underlying superficial
lamina propria. They characteristically produce hoarseness. Treatment of
vocal cord nodules aims to eliminate or reduce this hoarseness.
OBJECTIVES: To assess the effectiveness of surgery versus non-surgical
interventions for vocal cord nodules. SEARCH STRATEGY: We searched the
Cochrane Controlled Trials Register (CCTR) and Medline (1966-2000),
Embase (1974-2000), Biological Abstracts (1970-2000), Biological
Abstracts RRM (Reports, Reviews and Meetings) on CD-ROM (1989-2000) and
review articles. SELECTION CRITERIA: Randomised and quasi-randomised
trials comparing any surgical intervention for vocal cord nodules with
non-surgical treatment or no treatment. DATA COLLECTION AND ANALYSIS: No
suitable trials were identified. MAIN RESULTS: No studies fulfilled the
inclusion criteria. REVIEWER'S CONCLUSIONS: There is a need for high
quality randomised controlled trials to evaluate the effectiveness of
surgical and non-surgical treatment of vocal cord nodules.
18
UI - 11812937
AU - Thompson LD; Wieneke JA; Miettinen M; Heffner DK
TI -
Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic
study of 187 cases.
SO - Am J Surg Pathol 2002 Feb;26(2):153-70
AD - Department of Endocrine and Otorhinolaryngic-Head & Neck Pathology,
Armed Forces Institute of Pathology, Building 54, 6825 16th Street NW,
Washington, DC 20306-6000, U.S.A. thompsonl@afip.osd.mil
Laryngeal spindle cell (sarcomatoid) carcinomas are uncommon tumors,
frequently misdiagnosed as reactive lesions or mesenchymal malignancies.
The records of 187 patients with tumors diagnosed as laryngeal spindle
cell (sarcomatoid) carcinoma were retrieved from the files of the
Otorhinolaryngic Tumor Registry of the Armed Forces Institute of
Pathology. There were 174 men and 13 women, 35-92 years of age (average,
65.6 years). Nearly all patients experienced hoarseness (n = 165 [88%]
patients) for a mean duration of 11.0 months. Patients admitted to
smoking (n = 162 [87%] patients) and/or alcohol use (n = 90 [48%]
patients). Most tumors were glottic (n = 132 [71%]), T1 (n = 111 [59%]),
1 and polypoid (n = 185 [99%]), with a mean tumor size of 1.8 cm.
Histologically, squamous cell carcinoma (n = 157 [84%]) was noted,
ulcerated, and blended with the spindle cell component, which was most
frequently arranged in a storiform pattern (n = 92 [49%] tumors). Foci
of benign or malignant cartilage and/or bone (n = 13 [7%]) were noted in
the spindle cell component. All patients were treated with surgery (n =
90 [48%] patients) or surgery with radiation (n = 97 [52%] patients).
Recurrences developed in 85 (45%) patients. Overall, T1 glottic tumors
managed by complete surgical eradication had the best outcome (mean
follow-up, 7.8 years).
19
UI - 11765438
AU - Szmeja Z; Wojtowicz JG; Leszczynska M; Mielcarek-Kuchta D
TI -
[Laser cordectomy: treatment of precancerous stages of the larynx]
SO - Otolaryngol Pol 2001;55(3):255-7
AD - Katedra i Klinika Otolaryngologii Akademii Medycznej im. K.
Marcinkowskiego w Poznaniu.
Diagnostics and treatments of precancerous states of cancer of larynx
will demand in select chances the multistages treatment AIM: In work one
priced radicality and efficiencies of treatment of precancerous stages
of larynx with method of carbone dioxide laser cordectomy. The
retrospective examination was executed of years 1991-2000 imicrosurgical
interventions of larynx--in talked over period one executed 308 of
surgical interventions with use of laser CO2, in number this 41 of
interventions were partial laser cordectomies in stages with
precancerous changes on the vocal cords. In chances of extensive
precancerous changes of vocal cords in sorted chances not one should
limit oneself to receiving of specimens from several localization, but
change to remove in wholes. Permits this on obtainment radicality of
intervention with possibility of obtainment the large material to
histopathological investigations.
20
UI - 11765439
AU - Sieczka J; Zietek E
TI -
[The problem of cervical metastases in vocal cord carcinoma]
SO - Otolaryngol Pol 2001;55(3):259-61
On the base of 755 cases of glottic cancer, the occurrence and
prognostic importance of lymph node metastases were analysed. Metastases
of the vocal cord cancer to cervical lymph nodes are rare. In our
material amounted 9.13%. Number of metastatic lymph nodes and N factor
influenced the lymph node recurrency. It is not, however, dependence
statistically. Surgical treatment of the glottic cancer with various
degree of advancement secures good oncological results. In our material
3 and 5 years survival rate accounted to 71.33% and 59.31%. The clinical
advancement of the glottic neoplasm does not influence in statistically
essential way the increase of metastases to regional lymph nodes.
21
UI - 11765440
AU - Makowska W; Malejczyk M; Kapiszewska D; Nyckowska J; Wojcikiewicz E;
TI -
Wroblewska B
[Human papillomavirus (HPV) in the laryngeal carcinoma]
SO - Otolaryngol Pol 2001;55(3):263-6
AD - Klinika Otolaryngologii AM w Warszawie.
Epidemiological data and results of molecular studies suggest that human
papillomavirus has been considered a risk factor in upper respiratory
tract cancers. 10 out of 23 studied cases of laryngeal carcinoma
revealed presence of HPV DNA (43.5%). The PCR and Hybrid Capture II test
were used for the detection of viral DNA.
22
UI - 11783123
AU - Gao Y; Wang L; Zhang D
TI -
[Second primary lung cancer in laryngeal cancer patients: report on 36
cases]
SO - Zhonghua Zhong Liu Za Zhi 2001 Jul;23(4):341-3
AD - Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking
Union Medical College, Beijing 100021, China.
OBJECTIVE: To discuss the development, treatment and prognosis of a
second primary lung cancer in laryngeal carcinoma patients. METHODS: A
total of 36 patients with a second primary lung cancer was discovered in
2,182 laryngeal cancer patients. For comparison, a group of 15,541 lung
cancers was also reviewed for the presence of a second primary laryngeal
cancer. All patients have been followed for over five years. RESULTS:
From 1958 to 1999, out of 2,182 laryngeal carcinoma patients, 36
synchronous (3) or metachronous (33) second primary malignancies of the
lung were found. This represented 1.65% of all largngeal cancers
observed or 45.0% of all the second primary cancers developed. Their
pathology was: squamous cell carcinoma (32-88.9%),
adenocarcinoma(2-5.6%), small cell carcinoma(1-2.8%) and large cell
carcinoma (1-2.8%). The c-TNM stages were: stage I (7-19.4%), stage II
(12-33.3%), stage III (9-25.0%) and stage IV (8-22.2%). The 2- and
5-year survival rates were 41.7% and 8.3%, with an average survival of
23 months. The interval from the treatment of the initial laryngeal
carcinoma to the development of the new second primary carcinoma of lung
ranged from 1 to 14 years, with an average of 44 months. CONCLUSION:
Synchronous or metachronous second malignancies of the lung are
sometimes encountered in laryngeal cancer patients while the occurrence
of a laryngeal second primary following a lung cancer is not observed.
The development of the second primary lung cancer is not related to the
treatment of the initial laryngeal malignancies. Surgery plus external
radiotherapy provides better results than surgery or radiotherapy alone.
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