National Cancer Institute®
Last Modified: June 1, 2002
UI - 11911297
AU - Nilsson A; Janson ET; Eriksson B; Larsson A
TI - Levels of angiogenic peptides in sera from patients with carcinoid tumours during alpha-interferon treatment.
SO - Anticancer Res 2001 Nov-Dec;21(6A):4087-90
AD - Department of Medical Sciences, University Hospital, Uppsala, Sweden.
BACKGROUND: Alpha-interferon, a known inhibitor of angiogenesis and cell proliferation, is used in the standard treatment of patients with carcinoid tumors. We studied the levels of two angiogenic peptides (bFGF and VEGF) in sera from patients with carcinoid tumours before and during treatment with alpha-interferon. The aim was to investigate if the antitumoral effect of alpha-interferon in these patients could be at least in part explained by a reduction in the measured angiogenetic peptides. PATIENTS AND METHODS: Sera from 29 patients with carcinoid tumours were collected before and during alpha-interferon treatment and analyzed using commercially available ELISA-kits. RESULTS: Interferon alpha treatment did not cause reduction of bFGF and VEGF levels in serum from patients with carcinoid tumours. In fact there was no correlation between changes in bFGF or VEGF levels and treatment effect. CONCLUSION: The action of alpha-interferon does not seem to be mediated by bFGF or VEGF in patients with carcinoid tumours. If alpha-interferon has an anti-angiogenic effect in this patient group, it is probably mediated by angiogenic peptides other than bFGF and VEGF.
UI - 11862561
AU - Heah SM; Eu KW; Ooi BS; Ho YH; Seow-Choen F
TI - Tumor size is irrelevant in predicting malignant potential of carcinoid tumors of the rectum.
SO - Tech Coloproctol 2001 Aug;5(2):73-7
AD - Department of Colorectal Surgery, Singapore General Hospital, Outram Road, 169608 Singapore.
The malignant potential and prognosis of rectal carcinoids are said to be related to tumor size. Our study assessed if size could predict the malignant potential and hence its management. All patients in the Department of Colorectal Surgery, Singapore General Hospital, who years (range, 33-77 years) were studied. Median follow-up was 40 months (range, 5-120 months). The median tumor diameter was 2.5 cm (range, 0.1-5.0 cm). Eleven patients underwent radical resection and 9 patients had local resection for a presumed benign tumor. Morbidity was 15% and postoperative death was 5%. Overall median survival was 24 months (range, 5-120 months). One patient had an anterior resection for rectal adenocarcinoma but had an incidental 0.1-cm carcinoid tumor near the resection margin which on histology was found to have carcinoid tumor metastasis to 2 out of 12 lymph nodes. In conclusion, tumor size cannot predict malignant potential as even small tumors (<1 cm) can be malignant. Accurate preoperative staging with radical surgery may be required.
UI - 12059131
AU - Kasi VS; Ahsanudin AN; Gilbert C; Orr L; Moran J; Sorrell VL
TI - Isolated metastatic myocardial carcinoid tumor in a 48-year-old man.
SO - Mayo Clin Proc 2002 Jun;77(6):591-4
AD - Division of Cardiology, Pitt County Memorial Hospital and East Carolina University, Greenville, NC 27858, USA.
This brief report describes an asymptomatic patient with a myocardial mass. Two-dimensional echocardiography, technetium Tc 99m cardiac nuclear scan, and transesophageal echocardiography were performed to define the mass. The mass, which involved the subvalvar right ventricular free wall, was resected and determined to be a metastatic carcinoid tumor by histologic and immunohistochemical analysis. Further investigation revealed the presence of a midgut carcinoid tumor located within the terminal ileum, which was also resected surgically. The patient recovered well after surgery and adjunctive chemotherapy. To our knowledge, this is the first report of comprehensive nuclear and echocardiographic imaging, supplemented by surgical and pathologic findings, in an asymptomatic patient with isolated myocardial metastasis of an ileal carcinoid tumor.
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