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Abramson Cancer CenterNCI CANCERLIT® Search: Small Intestine Cancer - June 2002
National Cancer Institute®
Last Modified: June 1, 2002
- Ewing sarcoma of the small intestine.
- Duodenal cancer in patients with familial adenomatous polyposis (FAP): results of a 10 year prospective study.
- Bowel obstruction due to extrinsic compression by metastatic lobular carcinoma of the breast.
- Adenocarcinoma of the small intestine mistaken as a primary ovarian cancer.
- Endoscopic removal of a pedunculated early duodenal cancer: diagnostic value of endoscopic ultrasound.
- [Stromal tumors of the small intestine. Retrospective analysis of 9 cases surgically treated]
- [Treatment of adenocarcinoma of the duodenum: presentation of 4 clinical cases and review of the literature]
- Transitional cell carcinoma in the ileal conduit following radical cystectomy and nephroureterectomy.
- A case of duodenal involvement of multiple myeloma imaged by positron emission tomography with 18F-fluorodeoxyglucose.
- Pancreas-preserving duodenectomy in the management of duodenal familial adenomatous polyposis.
- Duodenal leiomyoma--a rare cause of haematemesis.
- Hemoclip-assisted endoscopic polypectomy of large superior duodenal angle polyp using a needle knife.
- [Lymphoma as a cause of ileocecal invagination in children]
- [Leiomyosarcoma of the small intestine in a patient after previous radical surgery for cancer of the stomach and sigmoid]
- Ileal intussusception due to intestinal metastases from primary malignant melanoma of the lung.
- Primary adenocarcinoma of the jejunum--a case report.
- The value of laparoscopy in the management of ampullary, duodenal, and distal bile duct tumors.
- CT diagnosed jejunal intussusception revealing metastatic renal cell carcinoma.
- [Small intestine obstruction caused by primary malignant neoplasms]
- A novel duodenal elevated lesion mimicking an intraluminal protrusion.
- Isolated metastatic myocardial carcinoid tumor in a 48-year-old man.
- Successful treatment of gastrointestinal follicular lymphoma with rituxan and combination chemotherapy.
- Mixed neuronal-glial tumor of the digestive tract: distinctive entity from gastrointestinal stromal tumor?
- [Adenomas of Vater's ampulla and of the duodenum. Presentation of diagnosis and therapy by endoscopic interventional and surgical methods]
Table of Contents
1
UI - 11878783
AU - Shek TW; Chan GC; Khong PL; Chung LP; Cheung AN
TI -
Ewing sarcoma of the small intestine.
SO - J Pediatr Hematol Oncol 2001 Nov;23(8):530-2
AD - Department of Pathology, The University of Hong Kong, Queen Mary
Hospital, Pokfulam. whshek@hkucc.hku.hk
This report describes a rare case of Ewing sarcoma (ES) of the small
intestine. The patient was a 9-year-old girl with progressive abdominal
distension. Computed tomography showed a large mass in the small bowel.
Histopathologic examination of the resected tumor showed ES with typical
histologic, immunohistochemical, and ultrastructural features. The tumor
recurred in the pelvic cavity 18 months after the original surgery.
Molecular study of the recurrent tumor confirmed a diagnostic EWS-FLI1
gene fusion. This patient illustrates the unique occurrence of ES in the
small intestine.
2
UI - 11950808
AU - Groves CJ; Saunders BP; Spigelman AD; Phillips RK
TI -
Duodenal cancer in patients with familial adenomatous polyposis (FAP):
results of a 10 year prospective study.
SO - Gut 2002 May;50(5):636-41
AD - St Mark's Hospital, Northwick Park, Watford Rd, Harrow HA1 3UJ, UK.
BACKGROUND: Duodenal cancer is one of the leading causes of death in
familial adenomatous polyposis (FAP) patients. An endoscopic
surveillance programme was therefore initiated in 1988, the outcome of
which is described in this paper. METHODS: We report the 10 year follow
up of 114 patients with FAP who were prospectively screened for the
presence and severity of duodenal adenomas. RESULTS: Six of 114 patients
(median age 67 years) developed duodenal adenocarcinoma. Four of these
were from 11 patients who originally had Spigelman stage IV disease
(advanced duodenal polyposis), which gives a 36% risk within this group
of developing cancer. One case of duodenal cancer arose from 41 patients
who originally had stage III disease (2%) and one cancer arose from 44
patients with original stage II disease (2%). All six patients have
died: five were inoperable and one had recurrence three years after a
pancreaticoduodenectomy. There was no association between duodenal
cancer and site of germline mutation of the APC gene. CONCLUSIONS:
Surveillance for duodenal adenocarcinoma and subsequent early referral
for curative surgery has not been effective. Selection of patients with
advanced but benign (Spigelman stage IV) duodenal polyposis for
prophylactic pancreaticoduodenectomy should therefore be considered and
can now be justified on the basis of these results. More comprehensive
endoscopic surveillance of high risk (stage III and IV) patients is
needed in an attempt to avoid underestimating the severity of duodenal
polyposis, and to evaluate the role of endoscopic therapy in preventing
advanced disease.
3
UI - 11989148
AU - Daniels IR; Layer GT; Chisholm EM
TI -
Bowel obstruction due to extrinsic compression by metastatic lobular
carcinoma of the breast.
SO - J R Soc Health 2002 Mar;122(1):61-2
AD - Department of Surgery, St Peter's Hospital, Chertsey, Surrey, England.
irdaniels@dorkingrh4.freeserve.co.uk
The commonest sites for breast cancer metastases are the bones, lungs,
liver, pleura, adrenals and central nervous system. However, although
other sites have been reported, solitary metastases to the
gastrointestinal tract are extremely uncommon. Widely disseminated
gastrointestinal metastases may be found in up to 20% of patients.
Although only 15% of patients with breast cancer will have the lobular
variety, these make up the majority of patients with solitary
gastrointestinal metastases. Here we present three cases where solitary
lobular breast cancer metastases have been demonstrated to be the cause
of bowel obstruction. In two cases of duodenal obstruction was
demonstrated and in the third colonic obstruction. In all cases a focal
extrinsic compression was found.
4
UI - 11789749
AU - Andresen DM; Pedersen FH; Rasmussen KL
TI -
Adenocarcinoma of the small intestine mistaken as a primary ovarian
cancer.
SO - Arch Gynecol Obstet 2001 Nov;265(4):214-5
AD - Department of Gynecology & Obstetrics, Herning Central Hospital,
Denmark.
A case of primary adenocarcinoma of the small intestine metastazing to
the ovary is described. The patient was erroneously thought to suffer
from a primary ovarian malignancy. To avoid unnessessary surgery, severe
gastrointestinal symptoms in a patient thought to have an ovarian cancer
should warn the surgeon against a possible gastrointestinal cancer.
5
UI - 12014317
AU - Yoshimoto T; Akahoshi K; Nakanishi K; Nawata H
TI -
Endoscopic removal of a pedunculated early duodenal cancer: diagnostic
value of endoscopic ultrasound.
SO - Acta Gastroenterol Belg 2002 Jan-Mar;65(1):52-4
AD - First Department of Internal Medicine, Aso Iizuka Hospital, Iizuka,
Japan.
A 79-year-old Japanese woman was admitted to our hospital for evaluation
of a polypoid lesion in the second portion of the duodenum. Radiographic
and endoscopic examinations of the upper gastrointestinal tract
indicated that this mass was pedunculated and had a nodular surface.
Endoscopic ultrasonography demonstrated a hypoechoic tumor limited to
the mucosa without lymph node involvement. Endoscopic polypectomy was
performed. Histologic examination showed a tubular adenocarcinoma
arising in an adenoma with invasion limited to the mucosa. Findings were
consistent with complete endoscopic resection. Follow-up over a 12-month
period has disclosed no evidence of tumor recurrence. Endoscopic
polypectomy using information from endoscopic ultrasonography would
appear to be a safe and effective method for diagnosis and treatment of
pedunculated early duodenal cancers.
6
UI - 12038103
AU - Mosca F; Stracqualursi A; Persi A; Zappala O; Latteri F; Latteri S
TI -
[Stromal tumors of the small intestine. Retrospective analysis of 9
cases surgically treated]
SO - Chir Ital 2002 Mar-Apr;54(2):133-40
AD - Dipartimento di Chirurgia Sezione di Chirurgia Generale Universita degli
Studi di Catania.
The authors report on their experience with 9 patients with small bowel
stromal tumours who underwent surgical treatment over the period
1974-2001. Seven were males and 2 females, with an average age of 63.1
years (range: 49-72 years). Histologically, 4 tumours showed evidence of
differentiation towards smooth muscle elements (1 benign and 3
malignant), 4 towards neural elements (all malignant) and 1 lacked
differentiation towards either cell type. Five tumours were located in
the ileum, 3 in the jejunum and 1 in the duodenum. The main symptoms
were abdominal pain and an abdominal mass, and the most sensitive
diagnostic technique was abdominal CT scan. In the 8 jejunal or ileal
stromal tumours we performed a typical intestinal resection, while
undifferentiated duodenal stromal tumours were managed by
pancreaticoduodenectomy. The diagnosis was only histological. There was
no operative mortality, while 2 postoperative complications (1
pancreatic fistula and 1 myocardial infarction) occurred. The patient
with jejunal benign muscular stromal tumour is still alive and in good
health 73 months after the operation. Of the 3 patients with malignant
muscular ileal stroma tumours, 1 is alive and free from disease 63
months after the operation, while the other 2 died of metastatic disease
39 and 29 months after surgery. Of the 4 patients with malignant neural
stromal tumours (2 jejunal and 2 ileal) 1 with jejunal and 1 with ileal
tumour were lost to follow-up, while 1 is still alive and in good health
101 months postoperatively; the 4th patient, with jejunal disease,
developed liver metastasis 14 months after small bowel resection and
died 12 months later. The patient with undifferentiated duodenal stromal
tumour died of liver metastases 38 months after pancreaticoduodenectomy.
Small bowel stromal tumours are more often than not malignant. The most
frequent symptoms are abdominal pain and a palpable mass, but no
specific signs have been detected. Abdominal CT scan is the most
sensitive diagnostic technique in the evaluation of the location, size,
invasion of adjacent organs and metastases. The treatment must be
intestinal resection, and prognostic prediction on the basis of
histological findings is difficult.
7
UI - 12038110
AU - Pozzetto B; Guarino G; Tonello C; Liguori G
TI -
[Treatment of adenocarcinoma of the duodenum: presentation of 4 clinical
cases and review of the literature]
SO - Chir Ital 2002 Mar-Apr;54(2):195-201
AD - U.C.O. di Clinica Chirurgica Generale e Terapia Chirurgica Dipartimento
Universitario Clinico di Scienze Chirurgiche Generali, Anestesiologiche
e Medicina Intensiva, Universita degli Studi di Trieste.
The Authors comment on the difficulty of diagnosing and treating
duodenal tumours. The most appropriate indications and extent of
resection of these neoplasms are discussed. The Authors report 4 cases
of primitive adenocarcinoma of the duodenum treated by
pancreaticoduodenectomy (2 cases), segmental resection (1 case) and
palliative surgery (1 case) for the presence of omental and lymph-node
metastases. Survival was 18 and 14 months in the patients who underwent
pancreaticoduodenectomy and 9 months for the patient receiving
palliative treatment; the patient who underwent segmental resection is
still alive and healthy after 12 months. The Authors point out that
adenocarcinoma of the duodenum is an uncommon neoplasm and stress the
difficulty encountered in establishing an accurate diagnosis and
appropriate surgical management. Better results can be obtained only
with an early diagnosis. Chemotherapy and radiotherapy do not
significantly improve survival.
8
UI - 11771870
AU - Shioji Y; Morita T; Tokue A
TI -
Transitional cell carcinoma in the ileal conduit following radical
cystectomy and nephroureterectomy.
SO - Scand J Urol Nephrol 2001 Oct;35(5):416-7
AD - Department of Urology, Jichi Medical School, Tochigi, Japan.
urology@jichi.ac.jp
We report a case of transitional cell carcinomas (TCCs) at the terminal
of ileal conduit and right ureteroileal junction after cystectomy and
left nephroureterectomy. When upper urinary tract tumor occurs after
cystectomy with ileal conduit, it is necessary to beware of the
recurrence of TCC in the ileal conduit.
9
UI - 12030445
AU - Yasuda S; Hoshikawa T; Yazawa N; Fukumitsu H; Ishikawa K; Suzuki T;
TI -
Sadahiro S; Shimakura Y; Shibuya M; Nasu S; Tajima T; Makuuchi H
A case of duodenal involvement of multiple myeloma imaged by positron
emission tomography with 18F-fluorodeoxyglucose.
SO - Tokai J Exp Clin Med 2001 Dec;26(4-6):147-51
AD - Department of Surgery, Tokai University School of Medicine, Isehara,
Kanagawa, Japan. yasuda@is.icc.u-tokai.ac.jp
A 61-year-old woman had been treated for multiple myeloma for 4 years
when she developed abdominal pain. Ultrasonography and computed
tomography revealed a tumor in the abdomen. Positron emission tomography
(PET) with 18F-fluorodeoxyglucose (FDG) showed increased FDG uptake in
the tumor. In previous bone marrow lesions, which were in clinical
remission after chemotherapy and radiotherapy, abnormal FDG uptake was
not recognized. Pathological examination after surgery revealed the
tumor to be a plasmacytoma of the duodenum. Plasmacytoma of the duodenum
is rare but can be seen during the clinical course of multiple myeloma.
A few reports have described FDG PET findings of plasmacytoma. Those
previous reports and our present case suggest a potential value of FDG
PET in the evaluation of multiple myeloma.
10
UI - 11986022
AU - Kalady MF; Clary BM; Tyler DS; Pappas TN
TI -
Pancreas-preserving duodenectomy in the management of duodenal familial
adenomatous polyposis.
SO - J Gastrointest Surg 2002 Jan-Feb;6(1):82-7
AD - Department of General Surgery, Duke University Medical Center, and the
Veterans Administration Medical Center, Durham, NC 27710, USA.
Most patients with familial adenomatous polyposis (FAP) develop disease
in the duodenum. The duodenal lesions mostly occur in the periampullary
region, but some patients develop diffuse polyposis involving all parts
of the duodenum. These neoplastic polyps have malignant potential, and
thus warrant surveillance and timely intervention. We reviewed our
experience with management of FAP over a 10-year period, focusing on
patients who had diffuse polyposis of the duodenum and their subsequent
management. Three patients with FAP had diffuse duodenal involvement,
documented by upper gastrointestinal endoscopy. Neoplasia was confirmed
by endoscopic biopsy, but no patients had histologic evidence of
carcinoma. The patients underwent resection of the entire duodenum from
the pylorus to the ligament of Treitz with preservation of the pancreas.
Our surgical technique is described. One patient had a postoperative
wound infection and one patient had a biliary leak that resolved with
closed suction drainage for 5 days. Long-term follow-up in these
patients revealed excellent functional status. One patient had polyp
recurrence in the jejunum at 5-year follow-up, but no patients have
developed adenocarcinoma. We conclude that patients with duodenal polyps
associated with FAP may be safely and effectively treated by
pancreas-preserving duodenectomy.
11
UI - 11868869
AU - Shetty SM; Kalokhe S; Rathi P; Desai N; Sethna KS; Rajyadhyaksha G;
TI -
Sawant P
Duodenal leiomyoma--a rare cause of haematemesis.
SO - J Assoc Physicians India 2001 Nov;49():1114-5
AD - Department of Gastroenterology, LTMM College and LTMG Hospital, Sion,
Mumbai.
Leiomyoma of the duodenum is a rare tumour. Small intestinal tumours
contributing to upper gastrointestinal bleed is still rare. They usually
present with malena and anaemia, rarely hematemesis. We report a case of
leiomyoma of duodenum diagnosed on endoscopic ultrasound that presented
with massive haematemesis.
12
UI - 11922495
AU - Lin LF; Siauw CP; Ho KS; Tung JC
TI -
Hemoclip-assisted endoscopic polypectomy of large superior duodenal
angle polyp using a needle knife.
SO - Zhonghua Yi Xue Za Zhi (Taipei) 2001 Dec;64(12):731-4
AD - Department of internal Medicine, Shalu Tungs Memorial Hospital,
Taichung, Taiwan, ROC. lienfu42@ms10.hinet.net
Endoscopic polypectomy of a large polyp can be difficult due to
inability to snare the polyp. The difficulty may increase when the polyp
is located at turning corner of the bowel. We presented a case of a 3
cm-sized large pedunculated polyp located at the superior duodenal angle
that was not amenable to conventional snare polypectomy, but was instead
successfully resected by hemoclip-assisted and needle knife method. Such
experience has not been reported in the English literature.
13
UI - 12030051
AU - Krikava K Jr; Poncakova I; Rod Z
TI -
[Lymphoma as a cause of ileocecal invagination in children]
SO - Rozhl Chir 2002 Apr;81(4):192-5
AD - Chirurgicke oddeleni Okresni nemocnice, Pelhrimov.
kkrikavaml@hospital-pe.cz
The authors describe the case-history of two ileocaecal invaginations in
young children caused by a tumour of the lymphatic system. Rapid
diagnosis, using sonography, contributed to a successful surgical
solution of the acute abdomen as a prerequisite of early antitumourous
treatment. The authors analyze possible causes of invagination focused
on the tumourous etiology of this disease so serious in child age.
14
UI - 11810946
AU - Trenin SO; Gel'fenbein LS; Shishkov AV
TI -
[Leiomyosarcoma of the small intestine in a patient after previous
radical surgery for cancer of the stomach and sigmoid]
SO - Khirurgiia (Mosk) 2001;(12):61-2
15
UI - 11952250
AU - Testini M; Trabucco S; Di Venere B; Piscitelli D
TI -
Ileal intussusception due to intestinal metastases from primary
malignant melanoma of the lung.
SO - Am Surg 2002 Apr;68(4):377-9
AD - Institute of 2nd General Surgery, Faculty of Medicine, University of
Bari, Italy.
Primary malignant melanoma of the lung (PMML) is an uncommon tumor with
very few cases reported in the literature that satisfy the required
criteria to establish a primary bronchial origin. We report a case of a
44-year-old man with acute abdominal distress and a right pulmonary
roentgenographic opacity. A cranial-thoracic-abdominal CT scan confirmed
the presence of a pulmonary nodule with bilateral cerebral metastases
and marked dilatation of intestinal loops. At laparotomy an ileal
intussusception was noted and an ileal resection was done. The resected
intestinal segment contained three endoluminal polypoidal formations.
Histological and immunohistochemical analyses showed the presence of
multiple sites of melanoma. These lesions as well as the brain lesions
clearly appeared metastatic. The patient underwent further evaluation to
identify a primary site of melanoma; bronchoscopy was performed with
biopsy of the pulmonary nodule. Pathology revealed a neoplastic process
of fusiform cells, with focal presence of melanic inter- and
extracellular pigment. The immunohistochemical analysis confirmed the
diagnosis of PMML. We discuss the criteria for diagnosis and
histogenesis of PMML along with this unusual presentation.
16
UI - 11977319
AU - Rozylo-Kalinowska I; Karski J; Woznica J; Zlomaniec J
TI -
Primary adenocarcinoma of the jejunum--a case report.
SO - Ann Univ Mariae Curie Sklodowska [Med] 2001;56():249-52
AD - 2nd Department of Medical Radiology, Medical University of Lublin.
A case of adenocarcinoma of jejunum is reported. Although survival
figures in adenocarcinoma of the small bowel appear to correlate with
early presentation, due to poor specificity of the symptoms a
preoperative diagnosis is very seldom. Therefore, in order to improve
the treatment outcome, the diagnosis must be done at an early stage.
Thus there are discussed imaging modalities applied in diagnostics of
this rare pathology.
17
UI - 11992798
AU - Brooks AD; Mallis MJ; Brennan MF; Conlon KC
TI -
The value of laparoscopy in the management of ampullary, duodenal, and
distal bile duct tumors.
SO - J Gastrointest Surg 2002 Mar-Apr;6(2):139-45; discussion 145-6
AD - Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York,
NY 10021, USA.
Laparoscopy identifies radiologically occult advanced disease in
patients with pancreatic adenocarcinoma. The value of laparoscopy in the
management of peri-ampullary tumors was determined. One hundred
forty-four patients with radiologically resectable nonpancreatic
adenocarcinoma, periampullary tumors were identified from a prospective
laparoscopic unresectability included histologically proved peritoneal
or hepatic metastases, distant nodal involvement, arterial involvement,
and local extension outside the resection field. Median age at operation
was 70 years (range 31 to 87 years) and 56% of the patients were men. An
adequate laparoscopy was performed in 134 cases (93%). Laparoscopy
identified 13 patients (10%) with unresectable disease. Of 121 patients
with laparoscopic resectable disease, 111 (92%) went on to subsequent
resection; CT correctly predicted resectability in 82%. Laparoscopy
spared 36% of unresectable patients a nontherapeutic laparotomy.
Patients with resectable disease were treated by pancreaticoduodenectomy
(n = 91, 76%), ampullectomy (n = 12, 10%), duodenal resection (n = 10,
9%), or bile duct excision (n = 6, 5%). The addition of diagnostic
laparoscopy to dynamic CT scanning in this selected patient population
identifies an additional 10% of patients with unresectable disease. We
believe that laparoscopy should be used in a selective manner for
preoperative staging of patients suspected of having nonpancreatic
periampullary tumors.
18
UI - 11688728
AU - Savoye-Collet C; Thoumas D; Dunet F; Lemercier E; Benozio M; Dacher JN
TI -
CT diagnosed jejunal intussusception revealing metastatic renal cell
carcinoma.
SO - JBR-BTR 2001 Aug;84(4):153-4
AD - Service de Radiologie Centrale, Hjpital Charles Nicolle, Rouen , France.
We report the case of a 77-year-old woman presenting with a jejunal
intussusception as the primary symtom of metastatic renal cell
carcinoma. Both lesions were demonstrated by abdominal CT which detected
also pancreatic metastasis. This case emphasizes the significance of CT
to diagnose intussusception and to characterize its cause.
19
UI - 11957825
AU - Jamski J; Graca M; Orlicki P
TI -
[Small intestine obstruction caused by primary malignant neoplasms]
SO - Przegl Lek 2001;58(10):943-4
AD - III Klinika Chirurgii Ogolnej Collegium Medicum Uniwersytetu
Jagiellonskiego, Krakow.
The authors presented 4 cases of primary malignant neoplasm of the
intestine caused by small intestine obstruction. These patients
underwent emergency surgery. In all cases, a segmental resection of the
intestine was performed. There were two cases of adenocarcinoma and two
cases of carcinoid. Three patients were complementarily treated using
chemotherapeutics. One of them died two years post operation. The last
three patients survived 0.5-5 years post operation.
20
UI - 11979267
AU - Okuyama T; Noda T; Yoshida M; Adachi K; Watanabe M; Kazumori H; Sato H;
TI -
Ishihara S; Kinoshita Y
A novel duodenal elevated lesion mimicking an intraluminal protrusion.
SO - Gastrointest Endosc 2002 May;55(6):750-2
AD - Department of Internal Medicine II, Shimane Medical University, Izumo,
Shimane, Japan.
21
UI - 12059131
AU - Kasi VS; Ahsanudin AN; Gilbert C; Orr L; Moran J; Sorrell VL
TI -
Isolated metastatic myocardial carcinoid tumor in a 48-year-old man.
SO - Mayo Clin Proc 2002 Jun;77(6):591-4
AD - Division of Cardiology, Pitt County Memorial Hospital and East Carolina
University, Greenville, NC 27858, USA.
This brief report describes an asymptomatic patient with a myocardial
mass. Two-dimensional echocardiography, technetium Tc 99m cardiac
nuclear scan, and transesophageal echocardiography were performed to
define the mass. The mass, which involved the subvalvar right
ventricular free wall, was resected and determined to be a metastatic
carcinoid tumor by histologic and immunohistochemical analysis. Further
investigation revealed the presence of a midgut carcinoid tumor located
within the terminal ileum, which was also resected surgically. The
patient recovered well after surgery and adjunctive chemotherapy. To our
knowledge, this is the first report of comprehensive nuclear and
echocardiographic imaging, supplemented by surgical and pathologic
findings, in an asymptomatic patient with isolated myocardial metastasis
of an ileal carcinoid tumor.
22
UI - 11918454
AU - Al-Salman J; Salib H; Boonswang P
TI -
Successful treatment of gastrointestinal follicular lymphoma with
rituxan and combination chemotherapy.
SO - Med Oncol 2001;18(4):277-83
AD - Easton Hospital, PA 18042, USA. jsalman@hotmail.com
The clinical course of follicular lymphoma (FL) is well known. Although
it is a chemosensitive disease, thereby allowing substantial palliation,
recurrence is the rule; only a small subset who presents with limited
stage disease is cured. Multiple attempts have been made over the past
two decades to improve the survival of patients with FL, and a large
number of phase III trials have been reported. These have included a
variety of different therapeutic interventions, such as combination
chemotherapy, recombinant interferons, new cytotoxic drugs, and
immunologic agents. Most studies have not demonstrated that the use of a
particular therapy convincingly prolongs survival. Follicular lymphoma
cells express CD20 and are associated in most cases with the t(14:18)
chromosomal translocation. Rituximab is a chimeric monoclonal antibody
directed against the B-cell CD20 antigen, which has been utilized for
the therapy of B-cell non-Hodgkin's lymphoma. Rituximab was shown to be
active in FL, and studies of its effectiveness in combination with
cytotoxic chemotherapy to increase the response rate are forthcoming.
23
UI - 11940221
AU - Chambonniere ML; Mosnier-Damet M; Cavillon C; Mosnier JF
TI -
Mixed neuronal-glial tumor of the digestive tract: distinctive entity
from gastrointestinal stromal tumor?
SO - Pathol Int 2002 Feb;52(2):153-7
AD - Department of Pathology, Bellevue Hospital, Saint-Etienne, France.
A 53-year-old-woman presenting with pelvic discomfort was found to have
a 9.5 cm tumor located in the wall of the ileon. Light microscopy showed
that the tumor was made of fascicles of plump spindle cells and bizarre
epithelioid cells. A cuff of lymphoid cells was also present at the
tumor margin. The tumor cells strongly expressed tau protein,
neuron-specific enolase, protein green product 9.5 and glial fibrillary
acid protein (GFAP), but did not show positive immunostaining for S-100
protein, CD34 or CD117. The tumor showed unequivocal ultrastructural
evidence of neural differentiation. Skeinoid fibers were scattered
throughout the tumor. This is the first mixed neuronal-glial tumor of
the digestive tract to be described in the literature. Such histological
and immunohistochemical features could be misinterpreted as features of
digestive schwannoma. We suggest that this tumor is distinct from
gastrointestinal stromal tumors in lacking CD34 and CD117 expression.
24
UI - 11963497
AU - Hartenfels IM; Dukat A; Burg J; Hansen M; Jung M
TI -
[Adenomas of Vater's ampulla and of the duodenum. Presentation of
diagnosis and therapy by endoscopic interventional and surgical methods]
SO - Chirurg 2002 Mar;73(3):235-40
AD - St. Hildegardis-Krankenhaus, Abteilung fur Chirurgie, Hildegardstrasse
2, 55131 Mainz.
BACKGROUND: Adenoma of the ampulla of Vater and the duodenum are rare
tumors. The leading symptoms are unspecific; sometimes they are due to
the disturbances of the passage or erosion of the tumor. Early and
correct diagnosis and the appropriate therapy are of decisive importance
because these tumors are precancerous. PATIENTS AND METHODS: We report
the cases of seven patients with periampullary adenoma of the duodenum,
in one case with incorporation of the the distal bile duct. The
diagnostic steps and the surgical treatment are reported and discussed.
In achieving a definitive diagnosis, endoscopic retrograde
cholangiopancreatography is of paramount importance. Three patients
subsequently underwent partial pancreatoduodenectomy (Whipple's
procedure); in three patients transduodenal local tumor excision was
performed. Postoperative course was without complications in each case
and no operative mortality occurred. One patient was treated by
argon-coagulation. RESULTS: The histopathological examination showed a
tubular villous adenoma in six cases and in one case a villous adenoma
(ranging from low to high grade dysplasia). Because there is evidence of
an adenoma-carcinoma-sequence, radical surgical treatment is
recommended, even in adenoma with low grade dysplasia, in spite of the
absence of malignancy.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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