National Cancer Institute®
Last Modified: June 1, 2002
UI - 11974900
AU - Naniwa T; Kakihara H; Zen-nami S; Tomita H; Sugiura Y; Yoshinouchi T;
TI - Sato S; Ueda R [Recurrence of thymoma accompanied with hypogammaglobulinemia 20 years after surgery: a case report]
SO - Nihon Kokyuki Gakkai Zasshi 2002 Mar;40(3):241-4
AD - Second Department of Internal Medicine, Nagoya City University Medical School.
We reported a case of recurrence of localized thymoma accompanied with hypogammaglobulinemia (Good's syndrome) 20 years after surgery. A 74-year-old man was admitted to this hospital because of mediastinal tumor and chronic pulmonary infection. He had been thymectomised at the age of 55 because of spindle cell thymoma. After that, he had been productive cough, and low-grade fever. Laboratory findings revealed hypogammaglobulinemia. Percutaneous needle biopsy of the mediastinal tumor revealed spindle cell thymoma. Therefore, hypogammaglobulinemia with thymoma (Good's syndrome) accompanied with a chronic lower respiratory tract infection was diagnosed. Immunologic studies revealed a marked decrease of CD 20 positive cells and decreased lymphocyte activation under the stimuli of phytohemagglutinin and concanavalin A. The thymoma was resected in Dec 1997, but the serum immunoglobulin showed no increase at al.
UI - 12048910
AU - Okumura M; Ohta M; Miyoshi S; Mori T; Yasumitsu T; Nakahara K; Iuchi K;
TI - Tada H; Maeda H; Matsuda H Oncological significance of WHO histological thymoma classification. A clinical study based on 286 patients.
SO - Jpn J Thorac Cardiovasc Surg 2002 May;50(5):189-94
AD - Thoracic Surgery Study Group, Division of General Thoracic Surgery, Department of Surgery, Interventional Medicine (E-1), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-City, Osaka 565-0871, Japan.
OBJECTIVES: The clinical significance of thymoma histology remains controversial because of the numerous histological classifications of thymic epithelial tumors. Universal classification of such tumors was achieved by the World Health Organization (WHO) in 1999. We studied the prognostic significance of this classification. METHODS: We studied clinical features and postoperative survival in cases of thymoma, but not thymic carcinoma, based on WHO histological classification in 286 patients undergoing surgery between 1958 and 2001. RESULTS: Tumors were 19 type A, 79 type AB, 59 type B1, 102 type B2, and 27 type B3. The proportion of invasive tumors increased by type--from A to AB, B1, B2, and B3. The great vessels were involved more frequently in type B2 and B3 tumors than in type A, AB, and B1 tumors. The 20-year survival was 100% in type A, 87% in type AB, 91% in type B1, 65% in type B2, and 38% in type B3 tumors. Multivariate analysis showed Masaoka staging and WHO histological classification to be significant independent prognostic factors, while age, gender, myasthenia gravis association, resection completeness and great vessel involvement were not. In stage III patients, 13 of 45 patients with type B2 and B3 tumor died of their tumors, while no tumor deaths occurred in 11 patients with type A, AB, and B1 tumors. CONCLUSION: WHO histological classification realistically reflects the oncological behavior of thymoma.
UI - 11557903
AU - Forterre O; Houze JP; Picard A
TI - [Malignant thymoma: a strange goiter]
SO - J Chir (Paris) 2001 Aug;138(4):232
AD - Service de Chirurgie Digestive, Endocrinienne et Thoracique, Centre Hospitalier, Belfort, France.
UI - 12048906
AU - Sugihara M; Gomyo Y; Sumii K; Tadehara F; Yoshida Y
TI - [A 42-year-old man with cardiac systolic murmur and a mediastinal tumor. Invasive thymoma (predominantly epithelial type, clinical stage IVa)]
SO - J Cardiol 2002 May;39(5):281-3
AD - Division of Cardiology, Mazda Hospital, Aosaki, Minami 2-15, Fuchu-cho, Akigun, Hiroshima 735-8585.
UI - 11462204
AU - Tarr PE; Lucey DR; Infectious Complications of Immunodeficiency with
TI - Thymoma (ICIT) Investigators Good's syndrome: the association of thymoma with immunodeficiency.
SO - Clin Infect Dis 2001 Aug 15;33(4):585-6
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