National Cancer Institute®
Last Modified: July 1, 2002
UI - 11908172
AU - Carpentier O; Cottencin-Charriere AC; Patenotre P; Piette F
TI - [Tumor of the nose]
SO - Ann Dermatol Venereol 2001 Nov;128(11):1245-6
AD - Clinique Dermatologique, Hopital Claude Huriez.
UI - 12024680
AU - Raikov S; Avramov T; Despotov O
TI - [Primary melanoma of the nasal and paranasal sinus mucosa]
SO - Khirurgiia (Sofiia) 2001;57(3-4):65-6
The authors make short review on the one of most malignant neoplasms in human pathology--its incidence, ethiology, pathogenesis, clinical characteristics, diagnosis, treatment and prognostic features. We present a clinical case from our practice--a melanoma of the nasal cavity and paranasal sinuses--a rare localization. Melanocarcinomas of the mucous membranes of the nasal cavity and paranasal sinuses are almost uniformly fatal. Undoubtedly some of the contributory reasons for their grave prognosis are the delay in detection and in accurate histologic diagnosis, the frequent injudicious therapy, the difficulties in adequate operative removal. Melanomas o mucous membranes may arise in mucosa lined by either normally present, or metaplastic stratified squamous epithelium.
UI - 12021905
AU - Hirata S; Yamaguchi K; Bandai S; Izumo A; Chijiiwa K; Tanaka M
TI - Secondary extramedullary plasmacytoma involving the pancreas.
SO - J Hepatobiliary Pancreat Surg 2002;9(1):111-5
AD - Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Extramedullary plasmacytoma is a rare variant of plasma cell tumor involving organs outside the bone marrow. The vast majority of extramedullary plasmacytomas present as a secondary tumor of systemic myelomatosis of the bone marrow. We experienced a patient with extramedullary plasmacytomas of the head and tail of the pancreas presenting as secondary masses from extramedullary plasmacytoma of the maxillary sinus that had been treated 5 years previously. A 38-year-old Japanese man had undergone radiation therapy for an extramedullary plasmacytoma of the maxillary sinus 5 years before the current presentation. He experienced severe upper abdominal pain in November 1999, when laboratory data showed elevation of the serum amylase level. Computed tomography showed two isodensity masses, in the head and tail of the pancreas. Angiography showed two hypervascular masses, one in the head and the other in the tail of the pancreas, and encasement of the portal vein trunk junction. Laparotomy was performed, with the tentative diagnosis of extramedullary plasmacytoma of the pancreas, in order to obtain a definite diagnosis. Intraoperative biopsy revealed that the two pancreatic masses were extramedullary plasmacytomas. External radiation therapy was performed after the operation. When a pancreatic mass is noticed in patients with a history of plasmacytoma, secondary extramedullary plasmacytoma of the pancreas should be considered as a differential diagnosis.
UI - 11955607
AU - Wei JL; Scheithauer BW; Smith JS; Jenkins RB; Passe SM; Arndt CA; Strome
TI - SE Primary neuroblastoma of the maxillary sinus.
SO - Int J Pediatr Otorhinolaryngol 2002 Apr 25;63(2):155-62
AD - Department of Otorhinolaryngology, c/o Section of Scientific Publications, Mayo Clinic, Rochester, MN, USA.
Although neuroblastoma is the most common of extracranial solid tumors of childhood and infancy, we report the first case of an isolated neuroblastoma of a paranasal sinus. A 15-year-old girl with a right maxillary sinus mass was asymptomatic except for persistent epiphora. Computed tomography and magnetic resonance imaging scans showed that the mass extended into the nasal cavity, encroached on the lamina papyracea, and obstructed the nasofrontal duct. An extensive workup revealed no evidence of systemic disease. The patient underwent right craniofacial resection. Immunohistochemistry and electronmicroscopic findings were consistent with conventional neuroblastoma. Fluorescence in situ hybridization analysis was performed with probes selected to demonstrate genetic alterations associated with neuroblastoma. Studies revealed deletion of chromosome arm 1p, gain of chromosome 17, and normal N-myc gene copy number. In summary, the tumor exhibited morphologic features and genetic alterations more consistent with those of neuroblastoma than with those of esthesioneuroblastoma.
UI - 12037401
AU - Silvestri M; Sabatini F; Scarso L; Cordone A; Dasic G; Rossi GA
TI - Fluticasone propionate downregulates nasal fibroblast functions involved in airway inflammation and remodeling.
SO - Int Arch Allergy Immunol 2002 May;128(1):51-8
AD - Pulmonary Department, Giannina Gaslini Institute, Genoa, Italy.
BACKGROUND: Besides being highly effective in the treatment of allergic and nonallergic rhinitis with eosinophilia, intranasal corticosteroids appear to be useful in reducing nasal polypoid lesions and the likelihood of polyp recurrence after surgery. We evaluated the ability of fluticasone propionate to downregulate fibroblast functions related to nasal inflammation and remodeling. METHODS: Primary nasal polyp tissue-derived fibroblasts were stimulated with tumor necrosis factor (TNF)-alpha or interleukin (IL)-4 or basic fibroblast growth factor (bFGF) in the presence of fluticasone propionate (0.1-100 nM). Fibroblast proliferation, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression and eotaxin release were then evaluated. RESULTS: As compared with unstimulated cultures, a significant increase in fibroblast proliferation was observed when the cells were stimulated with bFGF (p < 0.05), but not with TNF-alpha or IL-4 (p > 0.05). TNF-alpha induced an upregulation of ICAM-1 expression (p < 0.05), which was not seen in fibroblasts cultured in the presence of IL-4 or bFGF. No changes in VCAM-1 expression were induced by TNF-alpha, IL-4 or bFGF, whereas both TNF-alpha and IL-4 increased eotaxin release (p < 0.05). Both bFGF-induced fibroblast proliferation and TNF-alpha-induced ICAM-1 expression were significantly reduced by fluticasone, starting at the dose of 1 and 10 nM, respectively (p < 0.05). Fluticasone at concentrations of 1-100 nM effectively inhibited eotaxin release by TNF-alpha- or IL-4-stimulated fibroblasts (p < 0.05). CONCLUSIONS: The pharmacologic activity of fluticasone in patients with chronic upper airway inflammatory disease may include inhibition of resident fibroblast functions involved in airway inflammation and remodeling. Copyright 2002 S. Karger AG, Basel
UI - 11816378
AU - Yanagisawa K; Yanagisawa E
TI - Epidermal inclusion cyst in the nasal vestibule.
SO - Ear Nose Throat J 2002 Jan;81(1):10
AD - Southern New England Ear, Nose, Throat, and Facial Plastic Surgery Group, New Haven, Conn., USA.
UI - 11816380
AU - Roth J; Friedlander PL; Palacios E
TI - Primary adenocarcinoma of the maxillary sinus simulating an osteosarcoma.
SO - Ear Nose Throat J 2002 Jan;81(1):14
AD - Department of Otorhinolaryngology, Louisiana State University Health Sciences Center, New Orleans, USA.
UI - 11998524
AU - Llorente JL; Martinez-Farreras A; Rodrigo JP; Perez P; Munoz C; Baragano
TI - L; Suarez C [Nasal polyposis: postoperative long term results (5 years) after endoscopic sinus surgery]
SO - Acta Otorrinolaringol Esp 2002 Feb;53(2):102-9
AD - Servicio de ORL, Hospital Central Universitario de Asturias, Oviedo, Asturias, Universidad de Oviedo.
The purpose of this study is to evaluate the results after endoscopic sinus surgery in cases of nasal polyposis. We include 54 patients with diffuse nasal polyposis suffering from nasal obstruction. An endoscopic sinus surgery under general anesthesia with excision of the polyposis was performed. There were no complications. The patients were followed closely and treated with local and systemic steroids. After 5 years, the 75% of these patients were free of nasal symptoms and in the 67% the mucosa appeared normal. We also review the influence of some factors (ASA triad, anosmia, allergy...) in the recurrence of the disease.
UI - 11969359
AU - Marx D; Tassabehji M; Heer S; Huttenbrink KB; Szelenyi I
TI - Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and glucocorticoids.
SO - Pulm Pharmacol Ther 2002;15(1):7-15
AD - Pulmonary Pharmacology, Corporate Research ASTA Medica AG, Arzneimittelwerk Dresden GmbH, Radebeul, Germany. firstname.lastname@example.org
The aim of this study was to investigate the role of the inhibitors of different PDE isoenzymes (PDE 1-5) on the production of two pro-inflammatory cytokines - tumor necrosis factor alpha (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Two in vitro models were used to compare the antiinflammatory properties of PDE inhibitors with that of glucocorticoids. The effect on TNF release from diluted human blood following lipopolysaccharide (LPS from Salmonella abortus equi) stimulation as well as the GM-CSF and TNF release from human nasal polyp cells following allergic stimulation were investigated. Both models proofed to be well suited for the characterisation of the antiinflammatory properties of new chemical entities.In diluted human blood and dispersed human nasal polyp cells the induced TNF release was most potently suppressed by selective PDE4 inhibitors. Amrinone and milrinone, selective PDE3 inhibitors, suppressed TNF secretion to a lesser extent. The effects of theophylline (unspecific PDE inhibitor), vinpocetine (PDE1 inhibitor), EHNA (PDE2 inhibitor) and the PDE5 inhibitors zaprinast and E 4021 were weak. In human blood, the tested glucocorticoids beclomethasone, dexamethasone and fluticasone inhibited the LPS induced TNF release potently in a concentration dependent manner, whereas in dispersed human nasal polyp cells, the effect of the glucocorticoids on allergically induced TNF release, with the exception of dexamethasone, was much less pronounced. Glucocorticoids were the most potent inhibitors of GM-CSF release and the effect correlates well with the affinity to the glucocorticoid receptor. The selective PDE 4 inhibitors, and to a certain extent the PDE3 inhibitors amrinone and milrinone, reduced the GM-CSF release in a concentration dependent manner. In all investigations selective PDE4 inhibitors reduced TNF release to a much higher degree (4-10 fold) than GM-CSF release. Copyright 2002 Elsevier Science Ltd.
UI - 12051022
AU - Hsu MC; Shun CT; Liu CM
TI - Increased epithelial cell proliferation in nasal polyps.
SO - J Formos Med Assoc 2002 Mar;101(3):227-9
AD - Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan.
BACKGROUND AND PURPOSE: The mucociliary function of the sinonasal mucosa is an innate defense mechanism of the human nasal airway. Epithelial cell proliferation is required for cell renewal and repair of the sinonasal mucosa. In this study, the MIB-1 monoclonal antibody, which can detect the S-phase nuclear protein Ki-67, was used to evaluate the proliferation of the sinonasal mucosa in patients with various inflammatory conditions of the sinonasal mucosa. METHODS: Specimens from the inferior turbinates of patients with nasal allergy (n = 12), vasomotor rhinitis (n = 20), nasal polyps (n = 22), and control subjects undergoing rhinoplasty (n = 5) and mucosa of chronic sinusitis patients [inferior turbinates (n = 10), middle turbinates (n = 10), and maxillary sinus (n = 9)] were fixed in neutral formalin and embedded in paraffin. MIB-1 monoclonal antibody was used to detect proliferation of epithelial cells. RESULTS: Significantly increased epithelial cell proliferation was noted in nasal polyps compared to sinonasal mucosa. There was no difference among various sinonasal inflammatory conditions between patients and controls. CONCLUSIONS: Increased epithelial cell proliferation in nasal polyps may play an important role in covering the epithelial defects caused by the rupture of the epithelium and prolapse of connective tissue in nasal polyps.
UI - 12049564
AU - Kim J; Hanley JA
TI - The role of woodstoves in the etiology of nasal polyposis.
SO - Arch Otolaryngol Head Neck Surg 2002 Jun;128(6):682-6
AD - Centre Hospitalier l'Hotel Dieu de Gaspe, Quebec, Canada. email@example.com
OBJECTIVE: To determine the role of environmental pollutants in the etiology of nasal polyposis. DESIGN: Case-control study. SETTING: A community-based hospital practice in the Gaspesian peninsula in rural northeastern Quebec. PATIENTS: Fifty-five case patients with nasal polyposis and 55 age-matched control subjects without nasal polyposis who were seen at one physician's practice (J.K.) from March 1, 1998, to December 19, 1998. INTERVENTIONS: Exposure to woodstoves, indoor tobacco smoke, and pets and occupational exposures to noxious inhalant compounds. RESULTS: Forty-five (82%) of the cases, but only 14 (25%) of the controls, reported using woodstoves, yielding a crude odds ratio (OR) of 13.1. The corresponding risk associated with occupational exposure to noxious inhalant compounds was also high (OR, 6.1). When adjusted in various ways for the presence of other factors, these ORs remained high and statistically significant. For woodstove use, the point estimates of the ORs were consistently above 10, with the lower limits of 95% confidence intervals above 5. For occupational exposures to noxious inhalant compounds, the various adjusted OR estimates were above 6, with the lower limits above 1.5. CONCLUSIONS: There is a strong association between the use of woodstoves as a principal source of heating and the development of nasal polyposis. Occupational exposures to noxious inhalant compounds (other than tobacco smoke) also play an important role in its etiology.
UI - 12049572
AU - Roy S; Gungor A
TI - Pathology quiz case. Heterotopic neuroglial tissue (nasal glioma).
SO - Arch Otolaryngol Head Neck Surg 2002 Jun;128(6):721-2
AD - Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
UI - 11706678
AU - Ortega JM; Gomez-Angulo JC; Aragones P; Jerez P; Alcazar L;
TI - Rodriguez-Barbero JM; Salazar F; del Pozo JM [Leiomyosarcoma of the paranasal sinuses with intracranial involvement: report of a clinical case and review of the literature]
SO - Neurocirugia (Astur) 2001 Aug;12(4):331-7
AD - Servicio de Neurocirugia, Hospital Universitario de Getafe, Getafe, Madrid.
We describe a 53 year old man with a two months history of frontal headache and right visual loss, with complete right blindness at the moment of diagnosis. Neither nasal obstruction nor endocrine symptoms were found. Computerized Tomography showed a neoplasm involving both paranasal sinuses and sellar region, with bilateral orbital extension. The patient underwent a bifrontal craniotomy with apparent complete excision. Histopathologic examination proved smooth muscle cells sarcoma (leiomyosarcoma). Clinical evolution was unfavorable, with rapid local recurrence. The patient died of cerebellar metastasis 4 months after the initial diagnosis and treatment. Leiomyosarcoma of the sinonasal tract is an unusual tumor, and we have found only 63 cases previously reported. The most frequent clinical presentation is nasal obstruction. Surgery is the treatment of choice, as far as radiotherapy or chemotherapy do not appear to slow disease progression. No relationship has been found between the aggressiveness of leiomyosarcoma of the sinonasal tract and morphologic parameters; instead, prognosis is dependent on the distribution of disease at clinical onset. Leiomyosarcoma of the sinonasal tract may be regarded as a locally aggressive neoplasm with only limited metastatic potential.
UI - 11813907
AU - Rinaldo A; Shaha AR; Patel SG; Ferlito A
TI - Primary mucosal melanoma of the nasal cavity and paranasal sinuses.
SO - Acta Otolaryngol 2001 Dec;121(8):979-82
AD - Department of Otolaryngology-Head and Neck Surgery, University of Udine, Italy.
UI - 11826696
AU - Bloom DC; Finley JC Jr; Broberg TG; Cueva RA
TI - Leiomyoma of the nasal septum.
SO - Rhinology 2001 Dec;39(4):233-5
AD - Kaiser Permanente Southern California Region, Department of Head and Neck Surgery, San Diego, CA, USA. DCBloom@hotmail.com
Leiomyoma is a benign myogenic tumor that may develop wherever smooth muscle is present. It occurs commonly in the uterus, skin, and gastrointestinal tract and is rare within the nasal cavity. Only three of twenty-four reported cases of sinonasal leiomyoma have been found to originate from the nasal septum. Treatment of choice for these neoplasms is surgical excision. We present two cases of nasal septal leiomyoma. Unique features discussed include recurrence of one neoplasm and the technique used to endoscopically repair a cerebrospinal fluid leak resulting from resection of the neoplasm.
UI - 12053594
AU - Modrzynski M; Zawisza E; Rapiejko P
TI - [Zafirlukast in treatment of nasal polyps in patients with aspirin intolerant bronchial asthma--preliminary report]
SO - Pol Merkuriusz Lek 2002 Mar;12(69):224-7
AD - Poradnia Alergologiczna N.Z.O.Z. EUROMEDICA-SPEC w Grudziadzu. firstname.lastname@example.org
Aspirin intolerance is characterized by polypous rhinosinusitis, bronchial asthma and adverse reactions to aspirin. The common intolerance to all cyclo-oxygenase inhibitors allows us to focus study of the pathogenesis of AI on the metabolism of arachidonic acid. Nasal polyposis is a chronic inflammatory condition that is mostly characterized by an infiltration of eosinophils. How this eosinophilic inflammation leads to polyp formation remains largely unclear. Eosinophils are the major source of cysteinyl leukotrienes--potent pro-inflammatory mediators they can by responsible for nasal blockade, rhinorrhoea and hyperresponsiveness. A role of prostaglandins (PGs) and leukotrienes (LTs) in the pathogenesis of nasal polyps has been recently suggested and leukotriene levels have been shown to be elevated in patients with asthma as well as in those with sinonasal polyposis and sinusitis. Because leukotriene receptor antagonists inhibit activity of endogenous leukotrienes and decrease tissue eosinophilia it is speculated that these drugs may be useful also in the management of nasal polyps. Our study was designed to determine the efficacy of zafirlukast, a cysteinyl leukotriene receptor antagonist, in nasal polyposis. We conclude that antileukotrienes might play a role in controlling polyposis and their symptoms, and they might be a alternative to long-term steroid therapy and repeated surgical therapy.
UI - 12075712
AU - Hunchaisri N
TI - Myxoma of the nasal cavity and paranasal sinuses: report of a case.
SO - J Med Assoc Thai 2002 Jan;85(1):120-4
AD - Department of Ophthalmology and Otolaryngology, Faculty of Medicine, Srinakharinwirot University, Vajira Hospital, Bangkok, Thailand.
Myxomas are benign connective tissue tumors composed of stellate and spindle-shaped cells with benign-appearing nuclei lying in a myxoid stroma. They are usually found in the heart, soft tissues, and bones. Myxomas of the nasal cavity and paranasal sinuses are very rare. They are benign but of a locally invasive nature. Recurrent rate is high because of the difficulty to excise them completely. This article presents a case of myxoma of the nasal cavity and paranasal sinuses that extensively invaded the brain and orbits causing blindness. After three resections, also with a transbasal craniotomy in the second operation, the patient remains free from the disease.
UI - 11932813
AU - Schmidt T; Thaller-Antlanger H; Klopfer M
TI - [Accidental injury of medial rectus muscle in endoscopic surgery of ethmoidal sinus: case report and survey of literature]
SO - Klin Monatsbl Augenheilkd 2002 Jan-Feb;219(1-2):59-63
AD - Augenklinik und -poliklinik rechts der Isar der Technischen Universitat Munchen, Germany. email@example.com
BACKGROUND: Ophthalmologic complications of endoscopic sinus surgery are rare, consequences may be serious. PATIENTS: Two patients are presented who suffered lesions of the internal rectus muscles during endoscopic ethmoidectomy. The clinical picture of this rare complication resembles that of a paralysis of the medial rectus muscle. THERAPY AND COURSE: In one patient the very thinned medial rectus muscle was tucked in a first surgical step. In the second step the external rectus muscle was recessed. Fusion in primary gaze was possible. In the second patient surgery was planned, he died however. CONCLUSION: Because of the anatomy the medial rectus muscle is endangered in endoscopic ethmoidectomy. Considered to the frequency of this surgery the incidence however is rare.
UI - 11701987
AU - Obata C; Murakami Y; Furue M; Kiryu H
TI - Cutaneous angiomyolipoma.
SO - Dermatology 2001;203(3):268-70
AD - Department of Dermatology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. firstname.lastname@example.org
We report a rare case of angiomyolipoma located in the subcutis on the nose. A 54-year-old female first noticed a small, asymptomatic mass on Histopathological examination revealed a typical form of angiomyolipoma, showing a proliferation of mature adipocytes, smooth muscle fascicles, and small- to medium-sized blood vessels. Copyright 2001 S. Karger AG, Basel
UI - 12075239
AU - Park YW
TI - Nasal granuloma gravidarum.
SO - Otolaryngol Head Neck Surg 2002 May;126(5):591-2
AD - Department of Otolaryngology, Northeastern Universities College of Medicine, and Section of Otolaryngology, Barberton Citizens Hospital, USA.
UI - 12011734
AU - Carton M; Goldberg M; Luce D
TI - [Occupational exposure to wood dust. Health effects and exposure limit values]
SO - Rev Epidemiol Sante Publique 2002 Apr;50(2):159-78
AD - INSERM Unite 88. 14, rue du Val d'Osne. 94415 Saint-Maurice Cedex, France. email@example.com
This article presents a review of the health effects of occupational exposure to wood dusts and of the data that could be used for setting occupational exposure limits for this nuisance. The causal role of wood dust in the onset of sinonasal cancers is solidly established by numerous epidemiological studies, and the magnitude of the risk is particularly high for adenocarcinoma induced by exposure to hardwood dust. However, no current data allows to rule out the carcinogenic role of softwood dusts and, in the view of protecting the health of the workers, it does not seem relevant to distinguish these two types of wood. Various impairments of the lung function have been frequently associated with exposure to both 'allergenic' and 'non-allergenic' wood dusts and may occur at very low concentrations. According to the SUMER 94 and CAREX studies, about 200 000 workers are currently exposed to wood dusts in France (about 1% of the working population between 1990 and 1994). When taking into account full professional careers, the percentage of workers having been occupationally exposed can be estimated to be about 15% for men and 5% for women. Measurements performed in France between 1987 and 2000 show that exposure levels are high, about 50% of the samplings being over 1mg/m(3) (actual TWA in France). Although the studies present limits, particularly for the quantitative assessment of individual exposure levels, it seems that nonmalignant effects are susceptible to arise at the level of 1mg/m(3); a limit value of 0.5mg/m(3) would credibly allow to protect exposed workers from most of the risks of nonmalignant pulmonary effects. However, it is impossible to assure that this value will avoid the induction of sinonasal cancer, even if this level is certainly lower than the levels to which the cases of sinonasal cancers published in the literature were exposed.
UI - 12053656
AU - Manasterski J; Leszczynska M
TI - [A case of inverted papilloma of the nose and sinuses]
SO - Otolaryngol Pol 2002;56(1):107-9
AD - Katedra i Klinika Otolaryngologii AM im. Karola Marcinkowskiego w Poznaniu.
Two cases of inverted papilloma with unilateral nasal obstruction since 2 years, bleeding from the nose and headache are described. Surgical treatment was applied. Histological examination revealed inverted papilloma.
UI - 11548290
AU - Fekh AR; Robustova TG
TI - [Experimental study of endosurgical approaches to maxillary sinuses]
SO - Stomatologiia (Mosk) 2001;80(3):4-6
Studies on 30 cadavers were carried out in order to develop endoscopic approaches to diagnosis and treatment of inflammatory and tumorous diseases of the maxillary sinuses. Morphometric data helped objectively validate surgical accesses and experimentally confirmed the efficiency of three accesses: from the maxillary tuber, through the anterior wall, and through the inferior nasal passage. Endosurgical approaches allow radical operations with minimum injury and ensure functional and esthetic effects.
UI - 11561531
AU - Emel'ianov SI; Fekh AR; Robustova TG; Sdvizhkov AM
TI - [Modern endosurgical technologies in the diagnosis and treatment of maxillary inflammations and tumors (part 2)]
SO - Stomatologiia (Mosk) 2001;80(4):33-5
A total of 102 patients with inflammatory diseases and tumors of the maxillary sinuses were examined and treated using endosurgical technologies. X-Ray computer-aided tomography and magnetic imaging helped determine the access to the maxillary sinus, and the endosurgical instrument was inserted through the anterior wall of the sinus, medial wall, and maxillary tuberosity. Endosurgery was the most effective in polypous sinusitis, mucocele, inverted papilloma, and for biopsy. Endosurgical technologies allow a full-scale surgical intervention with the least invasion.
UI - 12073520
AU - Gadban H; Talmon Y; Samet A; Cohen I
TI - [Malignant teratocarcinosarcoma of the nose and paranasal sinuses]
SO - Harefuah 2002 May;141(5):430-2, 499
AD - Department of Otolaryngology Head and Neck Surgery, Western Galilee Hospital, Nahariya, Israel.
Malignant teratocarcinosarcoma of the nasal cavity and the paranasal sinuses is a rare and invasive tumor. It is characterized by a mixture of mesenchymal and epithelial components, with cellular elements of a fetal nature. We describe in detail the first and only case in Israel of a patient with such a tumor. Only 40-50 such cases have been described in the medical literature. We have also reviewed the existing literature dealing with malignant teratocarcinosarcoma.
UI - 12094652
AU - Popko E; Popko M; Famulski W
TI - [Esthesioneuroblastoma of nasal cavity and ethmoid sinus]
SO - Otolaryngol Pol 2002;56(2):235-7
AD - Katedra i Klinika Otolaryngologii AM w Bialymstoku.
This paper presents a rarely occurring tumor of nasal cavity and ethmoid sinus (esthesioneuroblastoma--2nd grade of the pathological grading system proposed by Hyams). It was observed in a woman aged 68. Moreover, there were described surgical therapy and repair of cerebral spinal fluid leaks using composite bone/mucosal graft of the lower turbinate as a donor material. The treatment was successful.
UI - 11910234
AU - Terashi H; Kurata S; Hashimoto H; Asada Y; Shibuya H; Fujiwara S;
TI - Takayasu S Adequate depth of excision for basal cell carcinoma of the nose.
SO - Ann Plast Surg 2002 Feb;48(2):214-6
UI - 12062609
AU - Yoshimura R; Shibuya H; Ogura I; Miura M; Amagasa T; Enomoto S;
TI - Kishimoto S Trimodal combination therapy for maxillary sinus carcinoma.
SO - Int J Radiat Oncol Biol Phys 2002 Jul 1;53(3):656-63
AD - Department of Radiology, Tokyo Medical and Dental University, 5-45 Yushima I-chome, Bunkyo-ku, Tokyo 113-8519, Japan. firstname.lastname@example.org
PURPOSE: This study was conducted to evaluate the effectiveness of trimodal combination therapy (radiotherapy, intra-arterial chemotherapy, antrotomy) for the treatment of primary maxillary sinus carcinoma. METHODS AND MATERIALS: Between 1977 and 1996, 110 patients with maxillary squamous cell carcinoma were treated with trimodal combination therapy at Tokyo Medical and Dental University Hospital. All tumors were classified according to the 1997 UICC TNM staging system. Eighty percent of patients had T3 or T4 tumors. The T3 and T4 tumors were also classified into three groups according to their location, as visualized using computed tomography: the posterior-lateral (P) group, the medial (M) group, and the upper (U) group. Eight patients received additional radiotherapy, and 37 patients underwent a second surgical procedure, in addition to the trimodal combination therapy. RESULTS: The 5-year cause-specific survival and local control rates were 71% and 65%, respectively. The 5-year local control rate was 80% for the T1+2 tumors, 64% for the T3 tumors, and 52% for the T4 tumors (p = 0.06). Patients in the P+M group who received a 5-fluorouracil (5-FU) dosage of more than 3500 mg had a better 5-year local control rate than patients who received a 5-FU dosage of less than 3500 mg (p = 0.01). No improvement in the local control rate after a second surgical procedure or additional irradiation treatment was observed in any of the groups. CONCLUSION: Trimodal combination therapy provides good local control, with the final outcome depending on the T stage of the tumor and the dosage of 5-FU.
UI - 11771365
AU - Agut Fuster MA; Riera Sala C; Cortes Vizcaino V; Diaz-Albo Hermida C;
TI - Valladares Molina J [Sinonasal hemangiopericytoma]
SO - Acta Otorrinolaringol Esp 2001 Nov-Dec;52(8):699-702
AD - Servicio de ORL, Hospital General de Castello, Castello.
The hemangiopericytoma is an infrequent vascular tumour in the nose, that produces epistaxis and obstructive respiratory clinical like principal symptoms. It has, in the nose, special clinical characteristics that makes it different of the others localitations. We report a case of nasosinusal hemangiopericytoma with appearance of polyposis and treated with nasosinusal endoscopic surgery; after that, the patient had a complete remission and subsequent follow-up without recurrence. We review the literature and study the most important characteristics.
UI - 12056159
AU - Vakker AV
TI - [Malignant multifocal ENT tumors]
SO - Vestn Otorinolaringol 2002;(2):37-9
Of 6787 patients with ENT cancer, multifocal tumors were detected in 319 cases (4.7%). 306(95.9%) patients had two tumors, 13(4.1%)--three tumors. Synchronous and metachroneous tumors were diagnosed in 39.2 and 60.8% patients, respectively. Primary tumors located more frequently in the larynx (n = 146) and pharynx (n = 50). The second tumors were more often found in the lungs (25.5%), pharynx (22.1%), oral cavity (13.2%). In 84.9% patients with multifocal tumors the first and the second lesions arose in the same organ system--respiratory and gastrointestinal tracts. Metachroneous tumors developed more often 2-5 years (49.1%) after cure of the primary tumor.
UI - 12089982
AU - Cobzeanu MD; Dinu C; Costinescu V; Mihailovici MS; Grigoras M
TI - Therapeutical aspects of the plasmocytoma localized at the level of head and neck.
SO - Rev Med Chir Soc Med Nat Iasi 2000 Apr-Jun;104(2):151-4
AD - Faculty of Medicine, E.N.T. Department of the Sf. Spiridon Universitary Hospital, University of Medicine and Pharmacy Gr. T. Popa, Iasi.
The authors present a study on 7 cases of extramedullary plasmocytoma localized in E.N.T. area, hospitalized and solved in the E.N.T. Department of the the "Sf. Spiridon" Universitary Hospital, in the last 15 years, between 1983-1997. We insist on the last solved case, presenting a double isolated localization, a laryngeal and a rhinosinusal one. We consider that the most indicated treatment in the isolated extramedullary plasmocytoma, is the radiosurgical therapy with a good rate of survival.
UI - 12087330
AU - Gibbons MD; Sillers MJ
TI - Minimally invasive approaches to the sphenoid sinus.
SO - Otolaryngol Head Neck Surg 2002 Jun;126(6):635-41
AD - Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, 35249-6889, USA. email@example.com
OBJECTIVE: We sought to develop an algorithm for surgical approaches to the sphenoid sinus. STUDY DESIGN AND SETTING: Retrospective review was conducted of all patients who underwent a sphenoid sinusotomy by the population consisted of 141 patients, in whom 5 different surgical approaches were used: transseptal (47 [33.3%]), transnasal (19 [13.5%]), transethmoid (72 [51.1%]), transmaxillary (2 [1.42%]), and external (1 [0.7%]). Of the 47 transseptal approaches, 43 (91.5%) were for extirpation of a neoplasm. In contrast, 60 of 72 (83.3%) transethmoid procedures were for infectious/inflammatory disorders. An endoscopic approach was used for 7 of 8 (87.5%) skull base repairs. Four transsphenoid optic nerve decompressions were performed. The minor and major complication rates were 2.1% and 0.71%, respectively. CONCLUSIONS: The anatomic location of the pathologic process can guide the surgeon in selecting the most appropriate technique. SIGNIFICANCE: Surgical treatment of sphenoid pathology can be safely and successfully performed through a variety of approaches.
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