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Abramson Cancer CenterNCI CANCERLIT® Search: Paranasal Sinus and Nasal Cavity Cancer - August 2002
National Cancer Institute®
Last Modified: August 1, 2002
- Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella.
- Epstein-Barr virus nuclear antigen (EBNA)-1 carboxy-terminal and EBNA-4 sequence polymorphisms in nasal natural killer/T-cell lymphoma in the
- Esthesioneuroblastoma: case report.
- [Gamma knife radiosurgery for malignant melanoma in the paranasal sinuses: case report]
- High-dose chemotherapy with hematopoietic stem cell transplantation is effective for nasal and nasal-type CD56+ natural killer cell lymphomas.
- Inverted papilloma invading the orbit.
- Combination of surgery and gamma knife radiosurgery--a therapeutic option for patients with tumors of nasal cavity or paranasal sinuses
- Nasal squamous cell carcinoma in a child.
- Sensitivity of a new grading system for studying nasal polyps with the potential to detect early changes in polyp size after treatment with a
- Cell proliferation and p27Kip1 expression in endophytic schneiderian papillomas.
- [Frontal sinus osteomas: neuro-ophthalmological complications]
- [Statistical analysis of maxillary sinus squamous cell carcinoma]
- Inducible cyclooxygenase and interleukin 6 gene expressions in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal
- Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon
- Ectopic pituitary adenoma with malignant transformation.
- The use of a periosteal/forehead flap with sandwiched conchal cartilage graft: a novel approach for nasal reconstruction in the absence of a
Table of Contents
1
UI - 11922715
AU - Hori E; Akai T; Kurimoto M; Hirashima Y; Endo S
TI -
Growth hormone-secreting pituitary adenoma confined to the sphenoid
sinus associated with a normal-sized empty sella.
SO - J Clin Neurosci 2002 Mar;9(2):196-9
AD - Department of Neurosurgery, Toyama Medical and Pharmaceutical
University, Japan.
We present a case of growth hormone (GH)-secreting ectopic pituitary
adenoma confined to the sphenoid sinus associated with a normal-sized
empty sella. It has been well known that acromegaly is sometimes
associated with an empty sella. However, such a case usually has a
macroadenoma and an empty sella that is large. The authors considered
the possible mechanisms of the association between a normal-sized empty
sella and an ectopic pituitary adenoma in the sphenoid sinus as the
following. Primary empty sella existed originally, and the pituitary
adenoma developed later. The adenoma extended into the sphenoid sinus
because of the pulsatile intracranial cerebrospinal fluid pressure.
Copyright 2002, Elsevier Science Ltd. All rights reserved.
2
UI - 12118098
AU - Gaal K; Weiss LM; Chen WG; Chen YY; Arber DA
TI -
Epstein-Barr virus nuclear antigen (EBNA)-1 carboxy-terminal and EBNA-4
sequence polymorphisms in nasal natural killer/T-cell lymphoma in the
United States.
SO - Lab Invest 2002 Jul;82(7):957-62
AD - Division of Pathology, City of Hope National Medical Center, Duarte,
California 91010, USA. kgaal@coh.org
Epstein-Barr virus (EBV) polymorphisms were examined in 12 cases of
nasal natural killer (NK)/T-cell lymphoma diagnosed in the United States
(U.S.-NL) with respect to the EBV-associated nuclear antigen (EBNA)-1
carboxy (C)-terminal region and the EBNA-4 region. A single dominant EBV
strain was found in all cases. EBNA-1 sequences were remarkably
homogeneous, showing either a P-ala (2/12) or P-ala variant (9/12)
sequence. Other EBNA-1 subtypes known to be common in U.S.-reactive
samples, such as P-thr or V-leu, were not identified. The final case had
a base deletion with frame shift and premature stop codon. EBNA-1
C-terminal amino acid substitutions were common at codons 499 (10/12
cases), 502 (7/12), 524 (9/12), and 528 (6/12), all previously reported
"hot spots." However, unlike previous reports of other EBV-associated
neoplastic and reactive tissues, mutations were absent at residues 487
and 492. Mutations within HLA-A11-restricted immunogenic EBNA-4 epitopes
399-408 and 416-424 occurred in 3 of 12 cases but were not associated
with HLA-A11 status. In summary, the exclusive finding of P-ala variant
or P-ala EBNA-1 sequences in U.S.-NL cases differs from that reported in
U.S.-reactive and non-U.S.-NL cases. Although the significance of this
difference is not known for certain, it may be related to geographic
and/or site-specific variations, rather than oncogenicity per se.
3
UI - 12068366
AU - Gondim J; Ramos F Jr; Azevedo J; Carrero FP Jr; Tella OI Jr
TI -
Esthesioneuroblastoma: case report.
SO - Arq Neuropsiquiatr 2002 Jun;60(2-A):303-7
AD - Hospital Geral de Fortaleza, Fortaleza, CE, Brazil.
jagondim@secrel.com.br
Esthesioneuroblatoma (ENB) is a rare tumor arising from the olfactory
epithelium of the nasal vault which frequently invades the cranial base,
cranial vault and orbit. ENB has a bimodal age distribution between 11
and 20 years and between 51 and 60 years. ENB accounts for approximately
1 to 5% of intranasal cancers and no consensus has been reached
regarding treatment of this tumor. We report on a 66 year old female
patient with a Kadish stage C tumor with frontal lobe invasion submitted
a total craniofacial resection with a combined head neck and
neurosurgeon team. The purpose of this study is to analyze the natural
history, treatment and prognosis of this tumor, based on the literature
review.
4
UI - 12134673
AU - Horie N; Takahashi N; Furuichi S; Mori K; Shibata S
TI -
[Gamma knife radiosurgery for malignant melanoma in the paranasal
sinuses: case report]
SO - No Shinkei Geka 2002 Jul;30(7):753-7
AD - Department of Neurosurgery, Fukuoka Kinen Hospital, Japan.
A case of malignant melanoma in the paranasal sinuses, successfully
treated with gamma knife stereotactic radiosurgery, is reported. A
90-year-old man with left periorbital swelling was referred to our
hospital for gamma knife radiosurgery. He had a 4-month history of left
periorbital swelling and ophthalmalgia, but he was treated
conservatively due to his age. CT showed a large mass with bone
destruction located in the nasal cavity, paranasal sinuses, and orbita.
A 15 Gy peripheral dose was administered to the upper portion of the
tumor with the gamma knife technique, at the 50% isodose line using a 18
mm collimator (21 shots). Seven months after radiosurgery, his left
periorbital swelling was improved markedly, and CT showed a significant
reduction in the volume of the tumor. Gamma knife radiosurgery is a
feasible treatment for malignant melanoma in the paranasal sinuses. It
provides excellent quality of life, less injury to the patient, and
fewer side effects than other treatment strategies.
5
UI - 11911411
AU - Takenaka K; Shinagawa K; Maeda Y; Makita M; Kozuka T; Ashiba A; Yamamoto
TI -
K; Fujii N; Nawa Y; Hiramatsu Y; Sunami K; Ishimaru F; Yoshimo T; Kiura
K; Harada M
High-dose chemotherapy with hematopoietic stem cell transplantation is
effective for nasal and nasal-type CD56+ natural killer cell lymphomas.
SO - Leuk Lymphoma 2001 Nov-Dec;42(6):1297-303
AD - Second Department of Internal Medicine, Okayama University Medical
School, Japan. ktakenaka@clubaa.com
CD56+ natural killer (NK) cell lymphomas occur frequently in the nasal
and nasopharyngeal regions and carry a poor prognosis. We have studied
seven cases with NK-cell lymphomas. These lymphomas showed the following
immunophenotype: CD56+, CD2+, sCD3- and Epstein-Barr virus-encoded small
RNAs (EBERs)+. Six patients had localized (stage I or II) disease
involving the nasopharyngeal region, while one had stage III disease.
One patient with stage I disease achieved a complete remission (CR)
after treatment with involved-field irradiation, but subsequently
relapsed and died. The remaining six patients received combination
chemotherapy as primary treatment: five patients with localized stage I
or II disease and one patient with advanced stage III disease. Responses
to initial chemotherapy were generally poor. These six patients received
a variety of salvage chemotherapy regimens, but never achieved a CR.
Subsequently, four of six patients showed a highly aggressive clinical
course and died of disseminated disease within 1 year from the
diagnosis. Three of six patients received high-dose chemotherapy
supported by syngeneic, autologous or allogeneic peripheral blood stem
cell transplantation. Two of the three transplant patients achieved a CR
and are now surviving in continuous CR. Our clinical experience suggests
that myeloablative high-dose chemotherapy and bone marrow rescue by
hematopoietic stem cell transplantation may be an effective salvage
treatment modality for refractory NK-cell lymphomas and could be
considered as a part of the initial therapy for these patients.
6
UI - 12029572
AU - Bajaj MS; Pushker N
TI -
Inverted papilloma invading the orbit.
SO - Orbit 2002 Jun;21(2):155-9
AD - Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute
of Medical Sciences, New Delhi, India.
Inverted papilloma is an unusual entity for many ophthalmologists. We
report a case of inverted papilloma of the nasal cavity and sinuses,
invading the orbit in a 33-year-old man. The patient presented with a
right medial canthal mass, proptosis, diminution of vision, epiphora and
nasal obstruction. In the past, he underwent multiple procedures for
surgical removal of the tumor with frequent recurrences. A computed
tomographic scan revealed a mass filling both the nasal cavities and
sinuses, destroying adjacent bones and invading the medial aspect of the
orbit, leading to proptosis. Excision of the tumor was performed by a
lateral rhinotomy approach. The tumor proved to be an inverted papilloma
with focal transformation to transitional cell carcinoma. Post-operative
CT scan revealed residual tumor, which responded to radiotherapy, with
no recurrence over six months. Histopathologically, these tumors are
benign, but locally invasive. The tumors that invade the orbit are
usually locally aggressive, highly malignant and recur frequently.
Radical excision of the tumor is technically difficult and often
incomplete, so radiotherapy should be considered as an adjunct to
surgery.
7
UI - 12068475
AU - Habermann W; Zanarotti U; Groell R; Wolf G; Stammberger H; Sutter B;
TI -
Pendl G
Combination of surgery and gamma knife radiosurgery--a therapeutic
option for patients with tumors of nasal cavity or paranasal sinuses
infiltrating the skull base.
SO - Acta Otorhinolaryngol Ital 2002 Apr;22(2):74-9
AD - Department of Otolaryngology-Head and Neck Surgery, University of Graz,
Medical School, Austria. w_habermann@yahoo.com
The purpose of this study was to investigate whether patients operated
for skull base-infiltrating malignant tumors of the nasal cavity and/or
the paranasal sinuses benefit from an additional Gamma knife
radiosurgery. Case series: eight consecutive patients, (male: female
ratio = 1:1, mean age = 52 years, range 34 to 79 years) presented with 2
cyclindric cell carcinomas, 2 adenocarcinomas, 2 malignant
neuroblastomas, 1 squamous cell carcinoma, 1 amelanotic melanoma. Tumor
stages (UICC) were: 1 T1, 3 T2, 3 T3, 1 T4, all N0, all M0. All patients
were primarily treated surgically and 4 weeks later received additional
stereotactic radiosurgery. Follow-up was based on computerized
tomography (CT), magnetic resonance imaging (MRI), endoscopy, and
biopsy. The course of disease was compared to tumor courses with surgery
but without radiosurgery reported in literature. Four times endoscopic
endonasal surgery (EES), once EES in combination with fluorescein
technique, once EES plus external approach of frontal sinus, once
lateral rhinotomy was performed. All 8 cases underwent radiosurgery
(Leksell gamma knife) 4 weeks after surgery. Thirty six months after
radiosurgery 6 patients were alive (4 patients without evidence of
disease, 1 patient with pulmonary metastasis but without local
recurrence, 1 patient with regional metastasis but no local recurrence),
1 patient died 11 months after treatment due to disease, 1 patient died
due to a second malignancy. No negative or adverse effects due to
radiosurgery were observed. The combination of microsurgery with Leksell
Gamma knife radiosurgery appears to be an encouraging therapeutic
option. To date no adverse effects have been observed in the presented
cases.
8
UI - 11881772
AU - Amador-Zarco JJ; Mora-Tiscareno A; Sangri-Pinto AG; Braun-Roth G;
TI -
Dressler LG; Kulwichit W; Van DT; Calderon-Garciduenas L
Nasal squamous cell carcinoma in a child.
SO - J Otolaryngol 2002 Feb;31(1):45-9
AD - Instituto Nacional de Pediatria, Mexico City, Mexico.
9
UI - 11876598
AU - Johansson L; Holmberg K; Melen I; Stierna P; Bende M
TI -
Sensitivity of a new grading system for studying nasal polyps with the
potential to detect early changes in polyp size after treatment with a
topical corticosteroid (budesonide).
SO - Acta Otolaryngol 2002 Jan;122(1):49-53
AD - Department of Otorhinolaryngology, Central Hospital, Skovde, Sweden.
We have previously compared different scoring systems for endoscopic
staging of nasal polyps. Of the five methods evaluated, we found that
two were better than the others with regard to reproducibility and
agreement between physicians. One method was lateral imaging, developed
by the authors, and the other was a scoring system developed by
Lildholdt et al. The main objective of the present study was to compare
the sensitivity of these two methods. Another aim was to study the
effect on nasal polyposis of topical nasal corticosteroids over a 2-week
period. Patients with bilateral nasal polyposis (n = 100) were
randomized to a 2-week treatment with a topical corticosteroid
(budesonide aqueous nasal spray: 128 microg b.i.d.) or placebo in a
double-blind manner. Nasal symptoms were scored before treatment and
after 3, 7 and 14 days of treatment, and the patients underwent nasal
endoscopy at clinical visits. Patients treated with active substance had
an improvement in their symptoms, an effect already detectable after 3
days of treatment, compared with those who received placebo. In
addition, a statistically significant decrease in polyp size could be
registered after 14 days using lateral imaging but not with the other
scoring system. In conclusion, lateral imaging was more sensitive and
could detect effects earlier than the other scoring system and can be
recommended for the endoscopic staging of nasal polyps in clinical
studies.
10
UI - 12150617
AU - Schwerer MJ; Sailer A; Kraft K; Maier H
TI -
Cell proliferation and p27Kip1 expression in endophytic schneiderian
papillomas.
SO - Laryngoscope 2002 May;112(5):852-7
AD - Department of Pathology, Military Hospital Ulm, Ulm/Donau, Germany.
Michael.Schwerer@t-online.de
OBJECTIVE: To clarify epithelial cell proliferation and p27Kip1
expression along the stepwise histological changes from endophytic
schneiderian papillomas to associated carcinomas. STUDY DESIGN:
Retrospective investigation involved surgical specimens from 58
patients. METHODS: Immunohistochemical assessment involved the nuclear
Ki67 antigen expressed in proliferating cells. Further, the
cyclin-dependent kinase (cdk) inhibitor p27Kip1 was assessed. Binding of
p27Kip1 to the cyclin E-cdk2 complex inhibits this kinase, which results
in cell cycle arrest. The expression rates of both proteins were
compared between nonpapillomatous nasal mucosa, endophytic schneiderian
papillomas, carcinoma in situ, and invasive squamous cell carcinomas.
Statistics involved the Wilcoxon and Mann-Whitney u tests. Significance
was set at P <.05. RESULTS: Comparable cell proliferation rates were
observed between non-papillomatous nasal mucosa and cylindrical cell
papillomas. Significant increases in cell proliferation were found along
the stepwise series of histological changes involving non-papillomatous
nasal mucosa, columnar epithelium in inverted papillomas, transitional
and squamous metaplasia in inverted papillomas, and dysplastic inverted
papillomas (P <.05, respectively). A tendency toward increased cell
proliferation in carcinoma in situ compared with dysplastic inverted
papillomas was present; however, this was not statistically significant.
The expression rates of p27Kip1 were comparable between
non-papillomatous nasal mucosa and all histological subtypes within
nondysplastic endophytic schneiderian papillomas. Significantly reduced
p27Kip1 expression was found in surface cells in dysplastic compared
with non-dysplastic inverted papillomas, as well as in the total number
of cells in carcinoma in situ compared with dysplastic inverted
papillomas (P <.05, respectively). CONCLUSIONS: Inverted papillomas but
not cylindrical cell papillomas show increased cell proliferation
compared with nonpapillomatous nasal mucosa. Stepwise increases in cell
proliferation accompany the consecutive histological changes within
inverted papillomas. Among them, increased cell proliferation along with
the development of dysplasia and carcinoma in situ is associated with
reduced p27Kip1 expression.
11
UI - 12053166
AU - Bourgeois P; Fichten A; Louis E; Vincent C; Pertuzon B; Assaker R
TI -
[Frontal sinus osteomas: neuro-ophthalmological complications]
SO - Neurochirurgie 2002 May;48(2-3 Pt 1):104-8
AD - Clinique Neurochirurgicale, Hopital Nord, Chemin des Bourrely, 13915
Marseille Cedex 20, France.
Osteomas are the most frequent benign tumors of the paranasal sinuses.
They often grow in the frontal sinus near the nasofrontal duct. They
remain frequently asymptomatic and they tend to be an incidental finding
on radiographic studies. Rarely, they extend out of the sinus limits.
Two cases with neuro-ophthalmological complications are reported and
discussed. A 19-year-old female presented with a progressive left visual
impairment and orbital bone deformity. A CT-scan revealed a large
calcified mass in both frontal sinuses, with left intraorbital and
frontobasal extension. A 21-year-old man suffered from acute
frontoethmoidal sinusitis. Radiological exams revealed a right frontal
sinus osteoma with bilateral nasofrontal ducts obstruction. The frontal
sinus cavities were filled with a large mucocele with intracranial
extension. Both patients were successfully treated using frontobasal
craniotomy with complete osteoma and mucocele removal and cranio facial
bone reconstruction. Neuro-ophthalmological or intrasinusal
complications of osteomas lead to radical treatment. CT-scan and MRI
analysis for surgical purpose and strategy are emphased.
12
UI - 12138701
AU - Yamashita T; Fujii M; Ishiguro R; Tashiro M; Ohno Y; Tokumaru Y; Kanke
TI -
M; Imanishi Y; Tomita T; Kanzaki J; Inuyama Y
[Statistical analysis of maxillary sinus squamous cell carcinoma]
SO - Nippon Jibiinkoka Gakkai Kaiho 2002 Jun;105(6):732-40
AD - Department of Otorhinolaryngology, Keio University School of Medicine,
Tokyo.
Cases of squamous cell carcinoma of the maxillary sinus initially
1998 studied retrospectively involved 60 untreated cases--46 men and 14
women aged 36 to 86 years (mean: 59.8 years). Of these, 7 had T2, 41 T3
and 12 T4 tumors based on 1997 AJCC TNM classification. Seven (11.7%)
had nodal involvement but none had distant metastasis at diagnosis. Of
the 60, 53 (88.3%) were stage III or IV. Prognostic factors and survival
were statistically analyzed for 59 cases, excluding the 60th who died of
another cause. Follow-up was 4 to 227 months, with a median of 59 months
and a mean of 38 months. Of the 59, 48 (81.4%) underwent neoadjuvant
chemotherapy (NAC). Survival was estimated using the Kaplan-Meier method
as univariate analysis. Cause-specific 5-year survival was 56.8% for all
stages, 68.2% for T2, 60.0% for T3, and 41.7% for T4. T stage
classification was thus a significant independent prognostic factor in
multivariate analysis using Cox's proportional hazards model (p =
0.0240). It also identified T stage classification (p = 0.0486) and NAC
(p = 0.0419) as significant independent factors affecting survival with
organ preservation. We also statistically analyzed 48 cases treated with
NAC, which showed complete response (CR) for 11, partial response (PR)
for 25, no change (NC) for 11, and progressive disease (PD) for 1.
Responders (CR + PR) showed significantly better survival and organ
preservation than nonresponders (NC + PD). The NAC response enables us
to predict prognosis. T4 cases without NAC response should be treated
intensively.
13
UI - 12162776
AU - Liu CM; Hong CY; Shun CT; Hsiao TY; Wang CC; Wang JS; Hsiao M; Lin SK
TI -
Inducible cyclooxygenase and interleukin 6 gene expressions in nasal
polyp fibroblasts: possible implication in the pathogenesis of nasal
polyposis.
SO - Arch Otolaryngol Head Neck Surg 2002 Aug;128(8):945-51
AD - Department of Otolaryngology, National Taiwan University Hospital,
Taipei, Taiwan.
BACKGROUND: Inflammation is believed to be related to the pathogenesis
of nasal polyp (NP). Inducible cyclooxygenase (COX-2) and interleukin
(IL) 6 are important mediators of inflammation. However, no information
is available regarding the expression of these mediators in nasal polyp
fibroblasts (NPFs). The inductive effects of proinflammatory cytokines
(IL-1alpha or tumor necrosis factor alpha) alone or in combination with
prostaglandin E(2) on IL-6 and COX-2 messenger RNA (mRNA) synthesis in
NPFs were investigated. DESIGN: The expressions of IL-6 and COX-2 mRNAs
in NPFs and in 34 surgical specimens of NP were detected by Northern
blot and in situ hybridization. RESULTS: Significant amounts of
constitutive IL-6 and COX-2 mRNAs were produced in NPFs. Cytokines
induced IL-6 and COX-2 mRNA synthesis in NPFs. Meloxicam (a specific
COX-2 inhibitor) suppressed the induction of cytokines on IL-6 mRNA
levels, and these effects could be reversed by exogenous prostaglandin
E(2). In situ hybridization revealed that IL-6 and COX-2 mRNAs were
detected primarily in fibroblasts, macrophages, and plasma cells.
Aggregation of plasma cells as well as collagen deposition in vicinity
to IL-6 mRNA-producing fibroblasts was found. Rich vascularity around
COX-2 mRNA(+) fibroblasts was also identified. CONCLUSIONS: The
pathogenesis of nasal polyposis involves NPFs through synthesizing IL-6
to modulate the activation of immune responses (plasma cell formation)
and synthesis of stroma. Inducible cyclooxygenase also contributes to NP
development by promoting vasodilatation and modulating the
cytokine-induced IL-6 gene expression in NPFs.
14
UI - 12173330
AU - Fitzek MM; Thornton AF; Varvares M; Ancukiewicz M; Mcintyre J; Adams J;
TI -
Rosenthal S; Joseph M; Amrein P
Neuroendocrine tumors of the sinonasal tract. Results of a prospective
study incorporating chemotherapy, surgery, and combined proton-photon
radiotherapy.
SO - Cancer 2002 May 15;94(10):2623-34
AD - Department of Radiation Oncology, Massachusetts General Hospital,
Harvard Medical School, Boston, Massachusetts, USA.
markus.fitzek@uni-essen.de
BACKGROUND: The authors report the results of a prospective study of
patients with malignant neuroendocrine tumors of the sinonasal tract who
received multimodality treatment incorporating high-dose proton-photon
radiotherapy. METHODS: Nineteen patients with olfactory neuroblastoma
(ONB) or neuroendocrine carcinoma (NEC) were treated between 1992 and
1998 on a prospective study. Four patients had Kadish Stage B disease,
and 15 patients had Kadish Stage C disease. The median patient age was
44 years. Patients received chemotherapy with 2 courses of cisplatin and
etoposide followed by high-dose proton-photon radiotherapy to 69.2
cobalt-Gray equivalents (CGE) using 1.6-1.8 CGE per fraction twice daily
in a concomitant boost schedule. Two further courses of chemotherapy
were given to responders. RESULTS: Of 19 patients, 15 patients were
alive at the time of this report with a median follow-up of 45 months
(range, 20-92 months). Four patients died from disseminated disease 8-47
months after their original diagnosis. The 5-year survival rate was 74%.
There were two local recurrences, and both patients underwent salvage
surgery. The 5-year local control rate of initial treatment was 88%.
Acute toxicity of chemotherapy was tolerable, with no patient sustaining
more than Grade 3 hematologic toxicity. Thirteen patients showed a
partial or complete response to chemotherapy. One patient developed
unilateral visual loss after the first course of chemotherapy;
otherwise, visual preservation was achieved in all patients. Four
patients who were clinically intact developed radiation-induced damage
to the frontal or temporal lobe by magnetic resonance imaging criteria.
Two patients showed soft tissue and/or bone necrosis, and one of these
patients required surgical repair of a cerebrospinal fluid leak.
CONCLUSIONS: Neoadjuvant chemotherapy and high-dose proton-photon
radiotherapy is a successful treatment approach for patients with ONB
and NEC. Radical surgery is reserved for nonresponders. Due to the
precision of delivery of radiation with stereotactic setup and protons,
no radiation-induced visual loss was observed.
15
UI - 12170097
AU - Hosaka N; Kitajiri S; Hiraumi H; Nogaki H; Toki J; Yang G; Hisha H;
TI -
Ikehara S
Ectopic pituitary adenoma with malignant transformation.
SO - Am J Surg Pathol 2002 Aug;26(8):1078-82
AD - Department of Clinical Pathology, Toyooka Hospital, Toyooka City, Hyogo,
Japan.
We report here a case of ectopic pituitary adenoma with malignant
transformation after repeated relapses. First, an ectopic pituitary
adenoma producing follicle-stimulating hormone was found in the nasal
cavity extending to the frontal cranial fossa. Despite repeated surgical
resections of the tumor, it recurred three times in 2 years. The tumor
gradually showed cellular atypia, mitosis, and necrosis.
Immunohistochemical analyses revealed that the expressions of
proliferating cell nuclear antigen and MIB-1 increased progressively.
Moreover, the expression of p53 was detected at the second recurrence.
Finally, at the third recurrence the tumor showed dissemination to the
subarachnoid space and multiple metastases in the brain. The patient
died of the tumor 10 months after the last resection. These findings
indicate that the ectopic pituitary adenoma became malignant. To our
knowledge, this is the first report on malignant transformation of
ectopic pituitary adenoma. It is important to know that ectopic
pituitary adenomas show malignant transformation and that the above
parameters (proliferating cell nuclear antigen, MIB-1, and p53) may be
useful indicators of the malignant potential of both ectopic and sellar
pituitary tumors.
16
UI - 12172147
AU - Brackley PT; Jones NS
TI -
The use of a periosteal/forehead flap with sandwiched conchal cartilage
graft: a novel approach for nasal reconstruction in the absence of a
nasal septum.
SO - Plast Reconstr Surg 2002 Sep 1;110(3):831-5
AD - Department of Otorhinolaryngology, Queens Medical Centre, University
Hospital, Nottingham NG7 2UH, United Kingdom.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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