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Cancer Types / Endocrine System Cancers / Adrenal Cancer / NCI Resources

NCI CANCERLIT^® Search: Adrenocortical Carcinoma - September 2002

National Cancer Institute^®
Last Modified: September 1, 2002

[Low-grade oncocytic adrenal carcinoma]
[Malignant adrenal gland tumors. A case report and an overview of the literature]
Expression of the gene for the alpha-subunit of inhibin in human adrenocortical tumours.
An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.
Adrenal cortical carcinoma presenting initially with radius metastasis.
[Bilateral non-secreting adrenal cortical adenoma ]

Table of Contents

1
UI - 11852522
AU - Lazaro Santander R; Andres Gozalbo C; Cortes Vizcaino V; Vera Roman JM
TI - [Low-grade oncocytic adrenal carcinoma]
SO - Arch Esp Urol 2001 Dec;54(10):1123-6
AD - Servicio de Anatomia Patologica, Hospital General de Castellon, Castellon, Espana.
OBJECTIVE: To report a case of left adrenocortical neoplasm. METHODS: A case of left adrenocortical neoplasm measuring 16 x 10 x 7 cm in a 47-year-old male is presented. After puncture biopsy, a left adrenalectomy through the abdominal approach was performed. RESULTS: Immunohistochemical studies showed reactivity to the anti-Melan-A A103 antibody, suggesting an adrenal origin of the tumor cells. Strong reactivity to the mES-13 mitochondrial antibody, which is characteristic of oncocytes, made ultrastructural studies unnecessary. CONCLUSIONS: In this type of tumor, an increased mitotic activity and necrosis are suggestive of malignancy. Despite the foregoing, most of this type of lesions are clinically benign and nonfunctioning.

2
UI - 11678072
AU - Adams T; Mattelaer P; Casselman J
TI - [Malignant adrenal gland tumors. A case report and an overview of the literature]
SO - Acta Urol Belg 2000 Nov;68(3):50-2
AD - Dienst Urologie, AZ Damiaan, Oostende.

3
UI - 12006719
AU - Rich N; Gaston V; Le Bouc Y; Gicquel C
TI - Expression of the gene for the alpha-subunit of inhibin in human adrenocortical tumours.
SO - Horm Res 2002;57(1-2):43-7
AD - Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hopital Armand Trousseau, Assistance Publique, Hopitaux de Paris, France.
BACKGROUND: To determine whether the pathogenesis of human adrenocortical tumours is associated with variations of inhibin expression, we assayed the mRNA of the alpha-subunit of inhibin in 5 normal adrenals and 48 adrenocortical tumours, including 10 paediatric tumours. RESULTS: mRNA of alpha-subunit of inhibin was detected in all adrenocortical tissues. It was similarly abundant in the three pathological groups of adult tumours (benign, suspect and malignant) and in normal adrenal tissues, irrespective of the hormonal pattern. However, in paediatric tumours, the levels of the mRNA for the alpha-subunit of inhibin were significantly higher than those in adult tumours (p < 0.01). CONCLUSION: Inhibin is more abundant in the foetal than in the adult adrenal cortex and therefore these data suggest that the paediatric tumours may have a foetal pattern. Copyright 2002 S. Karger AG, Basel

4
UI - 11481490
AU - Ribeiro RC; Sandrini F; Figueiredo B; Zambetti GP; Michalkiewicz E;
TI - Lafferty AR; DeLacerda L; Rabin M; Cadwell C; Sampaio G; Cat I; Stratakis CA; Sandrini R An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.
SO - Proc Natl Acad Sci U S A 2001 Jul 31;98(16):9330-5
AD - Department of Hematology-Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. raul.ribeiro@stjude.org
The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patients had an identical germ-line point mutation of p53 encoding an R337H amino acid substitution. Differences within intragenic polymorphic markers demonstrated that at least some mutant alleles arose independently, thus eliminating a founder effect. In tumor cells, the wild-type allele was deleted, and mutant p53 protein accumulated within the nuclei. Although these features are consistent with Li-Fraumeni syndrome-associated adrenal tumors, there was no history of increased cancer incidence among family members. Therefore, this inherited R337H p53 mutation represents a low-penetrance p53 allele that contributes in a tissue-specific manner to the development of pediatric ACC.

5
UI - 11898793
AU - Durusu M; Aksoy DY; Altundag MK; Abali H; Turker A; Cetin BE
TI - Adrenal cortical carcinoma presenting initially with radius metastasis.
SO - Clin Oncol (R Coll Radiol) 2002 Feb;14(1):83-4

6
UI - 12189755
AU - Benchekroun A; Ghadouane M; Amhajji R; Alami M; Zannoud M; Faik M
TI - [Bilateral non-secreting adrenal cortical adenoma ]
SO - Prog Urol 2002 Jun;12(3):459-61
AD - Clinique Urologique A, Hopital Avicenne, CHU Rabat, Maroc. benchek@mtds.com
Non-secreting malignant adrenal cortical adenoma is rare and the bilateral form is exceptional. Diagnosis is often delayed and it has a very poor prognosis. The authors report a case of bilateral adrenal cortical adenoma in a 53-year-old man.

The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.

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