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Abramson Cancer CenterNCI CANCERLIT® Search: Paranasal Sinus and Nasal Cavity Cancer - September 2002
National Cancer Institute®
Last Modified: September 1, 2002
- [Aetiology of Angiofibromas: Reflection on their Specific Vascular Component]
- Repositioning accuracy: comparison of a noninvasive head holder with thermoplastic mask for fractionated radiotherapy and a case report.
- [Sinus-nasal polyposis: one-year outcome after endoscopic sinus surgery followed by topical corticosteroid therapy in 72 patients]
- Sinonasal cancer and occupational exposures: a pooled analysis of 12 case-control studies.
- A giant pyogenic granuloma in the nasal cavity caused by nasal packing.
- Isolated sphenoid sinus adenocarcinoma: a case report.
- [Adenocarcinoma of the ethmoid sinuses: results of a retrospective study in Rouen]
- Vision-threatening complications of nasal T/NK lymphoma.
- [Clinical experience with power-regulated contact laser surgery for the paranasal sinuses and the anterior skull base]
- Computer graphic to design the approach for resection of esthesioneuroblastoma.
- Unilateral cleft lip complicated by a hemangioma.
- L-asparaginase induced durable remission of relapsed nasal NK/T-cell lymphoma after autologous peripheral blood stem cell transplantation.
- Sinonasal haemangiopericytoma-like tumour: a sinonasal glomus tumour or a haemangiopericytoma?
- A clinicopathological study of 20 patients with T/natural killer (NK)-cell lymphoma-associated hemophagocytic syndrome with special
- Invasive tricholemmal carcinoma of the nose.
- Co-expression of trkA and p75 neurotrophin receptor in extracranial olfactory neuroblastoma cells.
- Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality.
- Inverted papilloma of the sphenoid sinus presenting with auditory symptoms: a report of two cases.
- Orbital preservation in surgical management of sinonasal malignancy.
- Sinonasal papillomas: clinicopathologic review of 40 patients with inverted and oncocytic schneiderian papillomas.
- Endoscopic sinus surgery for inflammatory maxillary sinus disease.
- Sinonasal undifferentiated carcinoma: the search for a better outcome.
- Malignant melanoma of nasal cavity: case report and review of the literature.
- Radiotherapy management for squamous cell carcinoma of the nasal skin: the Princess Margaret Hospital experience.
- [Sinugenic metastasis of bilateral renal cell carcinoma (hypernephroma)]
- Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma.
- Endoscopic removal of esthesioneuroblastoma.
Table of Contents
1
UI - 11973680
AU - Schick B; Plinkert PK; Prescher A
TI -
[Aetiology of Angiofibromas: Reflection on their Specific Vascular
Component]
SO - Laryngorhinootologie 2002 Apr;81(4):280-4
AD - Klinik fur HNO-Krankheiten, Kopf- und Halschirurgie,
Universitatskliniken des Saarlandes, Homburg/Saar.
hnobsch@uniklinik-saarland.de
BACKGROUND: Even though numerous theories have speculated either on the
vascular or fibrous tumour component as tissue of origin, aetiology of
angiofibroma still remain unclear. Histological investigations recently
led Beham and coworkers to the assumption that angiofibromas have to be
considered as vascular malformations. METHODS: After giving a literature
review of the various theories on tumour origin the proposal to consider
angiofibromas as vascular malformations is discussed on an embryological
base. Taking typical clinical features of the tumour and knowledge of
vasculogenesis into account a new explanation for origin of the vascular
tumour component is presented. RESULTS: The vascular component of
angiofibromas can be explained embryologically due to incomplete
regression of the first branchial arch artery (vascular atavism). This
vessel arises regularly between embryological day 22 and 24 and recedes
during regular development completely until delivery via temporary
formation of a vascular plexus. In the late stages of embryological
development remnants of the plexus are found at the area of the
sphenopalatine foramen, the typical site of angiofibroma origin.
Incomplete regression of the vascular plexus of the former first
branchial arch artery may form the vascular component of an angiofibroma
arising due to growth stimulation at the time of adolescents.
CONCLUSIONS: Incomplete regression of the first branchial arch artery
presenting an atavism is suited to explain the vascular tumour component
of angiofibromas considering main tumour characteristics (origin in the
posterior nasal cavity close to the sphenopalatine foramen, main blood
supply from the maxillary artery with possible feeders arising from the
internal carotid artery). Our embryological contributions support to
define angiofibromas as vascular malformations.
2
UI - 9607367
AU - Sweeney R; Bale R; Vogele M; Nevinny-Stickel M; Bluhm A; Auer T;
TI -
Hessenberger G; Lukas P
Repositioning accuracy: comparison of a noninvasive head holder with
thermoplastic mask for fractionated radiotherapy and a case report.
SO - Int J Radiat Oncol Biol Phys 1998 May 1;41(2):475-83
AD - Department of Radiotherapy-Radiooncology, University Hospital Innsbruck,
Austria.
PURPOSE: To compare accuracy, clinical feasibility, and subjective
patient impression between a noninvasive head holder (Vogele Bale Hohner
[VBH]; Wellhoefer Dosimetry, Schwarzenbruck, Germany) developed at the
University of Innsbruck and the thermoplastic mask fixation system for
use in fractionated external radiotherapy. We present a case report of
an actual patient fixated in the VBH head holder during radiation
therapy. MATERIALS AND METHODS: The VBH head holder consists of an
individualized vacuum dental cast connected to a head plate via two
hydraulic arms allowing noninvasive, reproducible head fixation of even
uncooperative patients. Accuracy was tested and compared with that of
the thermoplastic mask using the Phillips EasyGuide navigation system on
five volunteers. Specific external registration points served as
landmarks and their positions were compared after each repositioning.
System and operator inaccuracy were also taken into account. The times
taken for production and repositioning of the respective fixation
devices were compared, and subjective impressions were noted. RESULTS:
Mean VBH head holder repositioning accuracy was 1.02 mm while that of
the thermoplastic mask was 3.05 mm. 69% of mask repositionings showed a
deviation > 2 mm and 41% > 3 mm (as opposed to 8% and 1% respectively
for the VBH head holder) Those points located farthest away from the
respective plane of fixation showed the largest deviations. Both
production and repositioning times were similar between the systems;
depending upon the patient, the VBH head holder was generally better
tolerated than the mask system. CONCLUSION: Due to its significantly
better repositioning accuracy compared to that of the thermoplastic
mask, the VBH head holder is especially suited for external radiation
requiring precise repositioning due to critical tissues in immediate
surrounding of the area to be irradiated.
3
UI - 11845037
AU - Rombaux P; De Toeuf C; Hamoir M; Eloy P; Bertrand B
TI -
[Sinus-nasal polyposis: one-year outcome after endoscopic sinus surgery
followed by topical corticosteroid therapy in 72 patients]
SO - Ann Otolaryngol Chir Cervicofac 2001 Oct;118(5):291-8
AD - Service, Cliniques Universitaires Saint-Luc, avenue Hippocrate 10, 1200
Bruxelles, Belgique, France.
Nasal polyposis (NP) is considered as an inflammatory disease for which
first line therapy is topical and/or oral corticosteroid. In this paper
we attempted to determine the efficacy of endoscopic endonasal surgery
followed by topical corticoid in 72 adults suffering from bilateral NP
refractory to corticosteroid therapy and to delineate the clinical
characteristics of this cohort of patients. NP was confirmed
endoscopically and with computed tomography. Visual analog scale for the
subjective evaluation and endoscopic examination of the paranasal
cavities for the objective evaluation were obtained 3 and 12 months
postoperatively. Endoscopic endonasal surgery was based on a radical
removal of the NP with wide opening of all the sinuses in the vast
majority of the cases. Topical corticoid therapy was started 2 months
after surgery.Clinical characteristics of the 72 patients revealed:
29.2% of coexisting allergy; 34.7% of coexisting asthma; 19.4% with food
and/or aspirin intolerance. Anterior and posterior ethmoid sinus and
maxillary sinus were the most affected sinuses. 53.5% of our patients
presented a stage II. One year after surgery we observed that 59.1% of
our patients revealed a marked decrease of their symptoms with no polyp
on nasal endoscopic evaluation, that 28.8% revealed a marked decrease of
their symptoms with recurrence of the NP on nasal endoscopic evaluation
and that 12.1% presented moderate to severe symptoms with recurrence of
NP on nasal endoscopic evaluation. Based on this experience, we think
that endoscopic endonasal surgery will continue to play an important
role in the management of NP when the patient becomes refractory to
corticoid.
4
UI - 11936821
AU - Luc D; Leclerc A; Begin D; Demers PA; Gerin M; Orlowski E; Kogevinas M;
TI -
Belli S; Bugel I; Bolm-Audorff U; Brinton LA; Comba P; Hardell L; Hayes
RB; Magnani C; Merler E; Preston-Martin S; Vaughan TL; Zheng W; Boffetta
P
Sinonasal cancer and occupational exposures: a pooled analysis of 12
case-control studies.
SO - Cancer Causes Control 2002 Mar;13(2):147-57
AD - Inserm Unite 88, Hopital, National de Saint-Maurice, Saint-Maurice,
France. d.luce@st-maurice.inserm.fr
OBJECTIVE: In order to examine the associations between sinonasal cancer
and occupational exposures other than wood dust and leather dust, the
data from 12 case-control studies conducted in seven countries were
pooled and reanalyzed. METHODS: The pooled data set included 195
adenocarcinoma cases (169 men and 26 women), 432 squamous cell
carcinomas (330 men and 102 women), and 3136 controls (2349 men and 787
women). Occupational exposures to formaldehyde, silica dust, textile
dust, coal dust, flour dust, asbestos, and man-made vitreous fibers were
assessed with a job-exposure matrix. Odds ratios (ORs) were adjusted for
age, study, wood dust, and leather dust, or other occupational exposures
when relevant. 95% confidence intervals (CIs) were estimated by
unconditional logistic regression. RESULTS: A significantly increased
risk of adenocarcinoma was associated with exposure to formaldehyde. The
ORs for the highest level of exposure were 3.0 (Cl = 1.5-5.7) among men
and 6.2 (CI=2.0-19.7) among women. An elevated risk of squamous cell
carcinoma was observed among men (OR=2.5, CI=0.6-10.1) and women (OR =
3.5, CI = 1.2-10.5) with a high probability of exposure to formaldehyde.
Exposure to textile dust was associated with non-significantly elevated
risk of adenocarcinoma, among women only: the OR for the high level of
cumulative exposure was 2.5 (CI = 0.7-9.0). High level of asbestos
exposure was associated with a significantly increased risk of squamous
cell carcinoma among men (OR = 1.6, CI = 1.1-2.3). CONCLUSIONS: The
results of this pooled analysis support the hypothesis that occupational
exposure to formaldehyde increases the risk of sinonasal cancer,
particularly of adenocarcinoma. They also indicate an elevated risk of
adenocarcinoma among women exposed to textile dust, and suggest that
exposure to asbestos may increase the risk of squamous cell carcinoma.
5
UI - 12107523
AU - Lee HM; Lee SH; Hwang SJ
TI -
A giant pyogenic granuloma in the nasal cavity caused by nasal packing.
SO - Eur Arch Otorhinolaryngol 2002 May;259(5):231-3
AD - Department of Otorhinolaryngology-Head and Neck Surgery, Communication
Disorder Institute of Medical Research Center, Korea University College
of Medicine, Guro Hospital, Seoul, Korea, hmlee91@hotmail.com
Pyogenic granuloma is a benign, rapidly growing hemorrhagic lesion of
unknown origin. This disorder, however, is obscure to many rhinologists,
because the nose is a relatively rare location for the lesion. In the
practice of otorhinolaryngology, nasal packing is a very common
procedure for nasal bleeding and postoperative hemostasis. However, few
pyogenic granulomas occurring from nasal packing have been reported in
the literature. A 56-year-old man underwent nasal packing with vaseline
gauze because of nasal bleeding. Two months later, a dark brown nasal
tumor was found in his nasal cavity. He underwent endoscopic endonasal
removal of the tumor. The pathology result showed a pyogenic granuloma.
This is the third case recorded in the literature of a confirmed
pyogenic granuloma occuring as a complication of nasal packing. This
uncommon lesion should be considered in the differential diagnosis of a
rapidly growing hemorrhagic lesion within the nasal fossa.
6
UI - 12107531
AU - Cakmak O; Ergin NT; Aydin MV
TI -
Isolated sphenoid sinus adenocarcinoma: a case report.
SO - Eur Arch Otorhinolaryngol 2002 May;259(5):266-8
AD - Baskent University Hospital, Department of Otorhinolaryngology,
Bahcelievler, 06490 Ankara, Turkey. Ozcakmak@hotmail.com
While solitary sphenoid sinus disease is uncommon, primary isolated
sphenoid sinus carcinoma is extremely rare. We describe a case of
isolated sphenoid sinus adenocarcinoma in a 68-year-old man. The patient
presented with a persistent headache and with diplopia secondary to
complete ophthalmoplegia. Paranasal sinus tomography showed a
soft-tissue mass obliterating the sphenoid sinus and infiltrating the
cavernous sinuses. The histological diagnosis on endoscopic intranasal
biopsy was adenocarcinoma. The patient underwent radiotherapy, and his
symptoms resolved. However, multiple bone metastases developed 6 months
after he was diagnosed. This report is significant in that it presents a
rare condition and highlights the features of primary sphenoid sinus
lesions.
7
UI - 11431589
AU - Choussy O; Lerosey Y; Marie JP; Dhermain F; Seng SH; Francois A;
TI -
Andrieu-Guitrancourt J; Dehesdin D
[Adenocarcinoma of the ethmoid sinuses: results of a retrospective study
in Rouen]
SO - Ann Otolaryngol Chir Cervicofac 2001 Jun;118(3):156-64
AD - Service ORL et chirurgie cervico-faciale, CHRU de Rouen, 76031 Rouen
Cedex, France.
Ethmoid adenocarcinoma is a rare tumour of the ethmoidal sinuses. The
authors report on the clinical features, treatment and follow-up results
in 19 cases. Risk factors were those regularly encountered. Delay to
diagnosis was long due to the nonspecific clinical features and course.
Nasal endoscopy was essential for follow-up. Computed tomography and
magnetic resonance imaging were also required to assess tumour spread.
Our results suggest that radiotherapy following surgery should be
preferred. Survival rate is generally low for this type of tumor.We had
77% survival at 5 years.
8
UI - 12208253
AU - Hon C; Kwok AK; Shek TW; Chim JC; Au WY
TI -
Vision-threatening complications of nasal T/NK lymphoma.
SO - Am J Ophthalmol 2002 Sep;134(3):406-10
AD - Department of Ophthalmology, Queen Mary Hospital, Hong Kong, China.
PURPOSE: Nasal T/NK lineage lymphoma, previously known as lethal midline
granuloma, is common among Oriental, Native-American, and Hispanic
patients and is invariably associated with Epstein-Barr virus. Nasal
localization, local necrosis, angioinvasion, and aggressive behavior are
hallmarks of the disease. Ophthalmologic symptoms and signs may precede
lymphoma diagnosis or complicate its disease course. We aim to define
the incidence and disease pattern of ophthalmic involvement. DESIGN:
Retrospective single-institution consecutive interventional case series.
METHODS: Records of all lymphoma patients from 1996 to 2000 were
retrieved from a computer database, and the primary sites and lineage
were reviewed. Nasal T/NK lymphoma was defined by a combination of
morphology, positive CD3 varepsilon and CD56 expression, in situ
hybridization staining for Epstein-Barr virus expressed RNA (EBER), and
negative staining for B cell markers (CD20 and CD79a). RESULTS:
Thirty-five consecutive patients with T/NK lymphoma were identified.
Primary nasal or nasopharyngeal disease was found in 24 patients. Six
(25%) of the 24 patients suffered from vision-threatening complications
of two distinct categories, namely uveitis/vitritis and orbital
infiltration. The former preceded the diagnosis of lymphoma in two
patients and also led to novel ocular complications like rhegmatogenous
retinal detachment and macular hole that were successfully managed by
ocular surgery. In four patients, orbital extension of lymphomatous
disease accompanied biopsy-proven in-field disease relapse. Generally,
the prognosis is grave, but remission can still be achieved with
aggressive combined chemotherapy and radiotherapy. CONCLUSION: Both
oncologists and ophthalmologists should be aware of ocular complications
when dealing with known or suspected cases of T/NK lymphoma at diagnosis
and relapse. Regular ophthalmic assessment of these patients is
warranted.
9
UI - 12001024
AU - Ilgner J; Emmerling O; Biesterfeld S; Westhofen M
TI -
[Clinical experience with power-regulated contact laser surgery for the
paranasal sinuses and the anterior skull base]
SO - Laryngorhinootologie 2002 May;81(5):346-50
AD - Klinik fur Hals-Nasen-Ohrenheilkunde und Plastische Kopf- und
Halschirurgie des Universitatsklinikums Aachen, Germany.
jilgner@ukaachen.de
BACKGROUND: While laser surgical methods in Otorhinolaryngology have
become widely established, their use in revision surgery for
chronic-polypous sinusitis has been regarded as hazardous due to the
vicinity of the anterior skull base and the orbit. However, new
experience with laser-tissue interaction in contact irradiation together
with effective power feedback control mechanisms require a re-evaluation
of laser revision surgery in this field. PATIENTS AND METHODS: After 742
primary, endonasal-microscopic sinus surgery procedures, 86 patients had
128 Nd:YAG-laser sessions performed within an interval of 1 - 24 months
after primary surgery for recurrent polyposis, which had been
irresponsive to medication. The maximum power delivered was 10 to 20 W.
RESULTS: Recurrent polyposis appeared mostly in the maxillo-ethmoid
angle, followed by the maxillary sinus roof and the maxillary sinus
bottom. In 63 of 86 patients, no further polyposis was seen after laser
surgery. If more than one laser session had to be performed, recurrent
polyposis appeared in a different region in most cases. Those areas
lasered first showed a reduced tendency to recurrence. There was
moderate bleeding during laser surgery in 6 cases with reduced
visibility, but no other serious complications were recorded.
CONCLUSIONS: Laser surgery for chronic-polypous sinusitis is an
alternative to conventional revision surgery, if medical treatment fails
and recurrent polyposis is confined to certain regions.
Feedback-controlled contact laser power delivery adds further
therapeutic safety when applied next to the anterior skull base and the
orbit.
10
UI - 12210038
AU - Burekhovich S; Ghosh BC
TI -
Computer graphic to design the approach for resection of
esthesioneuroblastoma.
SO - J Surg Oncol 2002 Aug;80(4):222-3
AD - State University of New York Health Science Center at Brooklyn, New York
Harbor Healthcare System, Brooklyn Campus, Brooklyn, New York 11209,
USA.
11
UI - 12198422
AU - Yavuzer R; Latifoglu O; Ozmen S; Ataoglu O; Cenetoglu S; Atabay K;
TI -
Celebi MC
Unilateral cleft lip complicated by a hemangioma.
SO - Plast Reconstr Surg 2002 Sep 15;110(4):1084-7
AD - Department of Plastic and Reconstructive Surgery, Gazi University,
Ankara, Turkey. ravuzery@hotmail.com
12
UI - 11794702
AU - Nagafuji K; Fujisaki T; Arima F; Ohshima K
TI -
L-asparaginase induced durable remission of relapsed nasal NK/T-cell
lymphoma after autologous peripheral blood stem cell transplantation.
SO - Int J Hematol 2001 Dec;74(4):447-50
AD - Department of Internal Medicine, Takagi Hospital, Fukuoka, Japan.
nagafuji@intmed1.med.kyushu-u.ac.jp
A 60-year-old Japanese woman who presented with right nasal congestion
diagnosed with nasal NK/T-cell lymphoma clinical stage IVB. Because her
NK/T-cell lymphoma was highly aggressive and chemo-resistant, she
underwent autologous peripheral blood stem cell transplantation (PBSCT).
The patient received a pretransplantation conditioning regimen of
ranimustine, etoposide, carboplatin, and cyclophosphamide. On July 29,
1999, 1.0 x 10(6)/kg CD34+ cells were infused. The patient achieved
in the skin and fever developed. CHOP (cyclophosphamide, vincristine,
doxorubicin, and prednisolone) was administered, resulting in partial
regression of the skin lesions, but fever persisted. L-asparaginase
(L-Asp) at a dose of 6,000 U/m2 per day was administered for 7 days,
resulting in the complete disappearance of the skin lesions and
resolution of the fever. The patient has been in second complete
remission for more than 18 months since the completion of L-Asp
dramatic. Several cases have been reported describing the effectiveness
of L-Asp in patients with nasal lymphoma and cutaneous T-cell lymphoma.
A front-line chemotherapy regimen containing L-Asp for NK/T-cell
lymphoma may warrant further evaluation.
13
UI - 12047761
AU - Tse LL; Chan JK
TI -
Sinonasal haemangiopericytoma-like tumour: a sinonasal glomus tumour or
a haemangiopericytoma?
SO - Histopathology 2002 Jun;40(6):510-7
AD - Department of Pathology, Queen Elizabeth Hospital, Hong Kong.
llytse@hotmail.com
AIMS: Sinonasal haemangiopericytoma-like tumour is controversial with
regard to its nosologic nature. This study aims to investigate its
relationship with glomus tumour and haemangiopericytoma. METHODS AND
RESULTS: Six cases of sinonasal haemangiopericytoma-like tumours
identified in our files were reviewed for clinicopathological features,
and compared with five cases each of soft tissue glomus tumour and
meningeal haemangiopericytoma. Immunohistochemical studies for
muscle-specific actin, smooth muscle actin, desmin and CD34 were
performed. Sinonasal haemangiopericytoma-like tumour demonstrated a
uniform histological appearance with bland-looking short, spindly cells
forming sheets and short fascicles. The tumour cells were interspersed
with slit-like, round and ectatic blood vessels. Actin immunoreactivity
was demonstrated in all six cases, although occasionally patchy. The
histological appearance and immunohistochemical phenotype of sinonasal
haemangiopericytoma-like tumour were very similar to and focally
indistinguishable from glomus tumour. Meningeal haemangiopericytoma, in
contrast, was characterized by high tumour cellularity, random nuclear
orientation, presence of staghorn vasculature and lack of
immunohistochemical evidence of myogenic differentiation. CONCLUSIONS:
We conclude that sinonasal haemangiopericytoma-like tumour is
biologically close to or identical to glomus tumour, but is not related
to haemangiopericytoma.
14
UI - 11721967
AU - Takahashi N; Miura I; Chubachi A; Miura AB; Nakamura S
TI -
A clinicopathological study of 20 patients with T/natural killer
(NK)-cell lymphoma-associated hemophagocytic syndrome with special
reference to nasal and nasal-type NK/T-cell lymphoma.
SO - Int J Hematol 2001 Oct;74(3):303-8
AD - Third Department of Internal Medicine, Akita University School of
Medicine, Japan. naoto@doc.med.akita-u.ac.jp
We describe the clinicopathological features of 20 patients with
T/natural killer (NK)-cell lymphoma-associated hemophagocytic syndrome
(T/NK-LAHS). These patients were categorized into 2 groups according to
the onset of hemophagocytic syndrome (HPS). Group 1 developed HPS during
the clinical course, typically at the terminal phase of the disease.
This group consisted of 7 patients with extranodal lymphoma arising in
the nasal cavity, paranasal cavity, tonsils, or skin at presentation. In
5 of these patients, the preferred diagnosis was nasal and nasal-type
NK/T-cell lymphoma, whereas the disease diagnoses in the remaining 2
patients were peripheral T-cell lymphoma of unspecified type and
angioimmunoblastic T-cell lymphoma, respectively. Group 2 consisted of
13 patients whose disease corresponded to so-called malignant
histiocytosis-like lymphoma, which is characterized by HPS at the
initial presentation and the infiltration of the liver, spleen, and/or
bone marrow without tumor formation. Nine of these 13 cases were found
to have common histopathological features: CD56+, Epstein-Barr virus
positivity, cytotoxic molecules, and nasal-type NK/T-cell lymphoma. The
very poor prognosis of T/NK-LAHS may be partly explained by the finding
that nasal and nasal-type NK/T-cell lymphoma, which is resistant to
standard chemotherapy, made up the highest percentage (70%) of the
cases.
15
UI - 12077536
AU - Van Zele D; Arrese JE; Heymans O; Fissette J; Pierard GE
TI -
Invasive tricholemmal carcinoma of the nose.
SO - Dermatology 2002;204(4):315-7
AD - Department of Plastic, Reconstructive and Aesthetic Surgery, University
Medical Center of Liege, Belgium.
Tricholemmal carcinoma is a rare entity. It must be distinguished from
the benign proliferating variant of the tricholemmal cyst. We report a
case of tricholemmal carcinoma massively invading the nose. The neoplasm
was excised surgically with a satisfactory outcome. Copyright 2002 S.
Karger AG, Basel
16
UI - 12175342
AU - Zhao SP; Zhou XF
TI -
Co-expression of trkA and p75 neurotrophin receptor in extracranial
olfactory neuroblastoma cells.
SO - Neuropathol Appl Neurobiol 2002 Aug;28(4):301-7
AD - Department of ENT, Xiang-Ya Hospital, Central South University,
Changsha, PR China.
Olfactory neuroblastoma (ON, esthesioneuroblastoma) is a high-grade
malignant tumour of neuronal origin. Little is known about the
neurobiological behaviour of this tumour. Ten cases of ON and five cases
of nasopharyngeal carcinoma were examined for expression of trkA and p75
neurotrophin receptor (p75NTR) using immunohistochemistry and double
labelling fluorescence. We found that all ON tissues from 10 cases
expressed both trkA and p75NTR at different levels. Double staining
revealed that almost all trkA-immunoreactive ON cells also contained
p75NTR immunoreactivity. By contrast, no trkA or p75NTR immunoreactivity
was detected in nasopharyngeal carcinoma cells from five patients. These
results suggest that nerve growth factor may play a role in the
generation of ON and staining of trkA and p75NTR may assist in the
diagnosis of ON.
17
UI - 12182990
AU - Cheung MM; Chan JK; Lau WH; Ngan RK; Foo WW
TI -
Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic
factors, and the effect of treatment modality.
SO - Int J Radiat Oncol Biol Phys 2002 Sep 1;54(1):182-90
AD - Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne
Road, Kowloon, Hong Kong. mcc729@hkstar.com
PURPOSE: To determine the clinical outcome, prognostic factors, and
effect of adding combination chemotherapy to radiation therapy on
disease control and survival in early stage nasal natural killer
(NK)/T-cell lymphoma. METHODS AND MATERIALS: A retrospective "intent to
treat" analysis was carried out on 79 patients treated consecutively
stage (Ann Arbor Stage I(E): 63, II(E):16) nasal NK/T-cell lymphoma.
Sixty-one were planned for combined modality treatment (CMT);
radiotherapy alone (RT) was intended for 18. Three to 6 cycles of
anthracycline-containing regimens were aimed at for patients intended
for CMT. Patients selected for RT were generally older or treated during
the earlier part of the study period. RESULTS: The overall complete
response (CR) rate was 68.4% (54/79), of whom 44.4% (24/54) relapsed
after 54.9 months median follow-up of the survivors. The 5-year
disease-free survival (DFS) and overall survival (OS) rates were 35.5%
and 37.9%, respectively. On multivariate analysis, good performance
status (Eastern Cooperative Oncology Group [ECOG] <2) was shown to be a
significant favorable factor for DFS (p = 0.011), whereas good
performance status (ECOG <2) and Ann Arbor Stage I(E) disease were shown
to be significant favorable factors for OS (p = 0.001 and p = 0.013,
respectively). The type of intended treatment was not a significant
factor for DFS (5-year DFS CMT vs. RT = 35.8% vs. 30.5%, p = 0.795) or
OS (5-year OS CMT vs. RT = 40.3% vs. 29.8%, p = 0.693) though only 2 of
the 16 Stage II(E) patients were intended for RT alone. Resistance to
treatment, especially to chemotherapy, was common. Of 61 patients
intended to be given CMT, 31 showed disease progression while receiving
chemotherapy, of whom 17 progressed locoregionally. Nine of the latter
group were rendered CR by salvage radiotherapy. CONCLUSIONS: The overall
outcome in early stage nasal NK/T-cell lymphoma is poor. Performance
status and Ann Arbor stage are significant factors influencing DFS and
OS. The addition of anthracycline-containing chemotherapy to
radiotherapy does not appear to confer any survival benefit in Stage
I(E) patients. Therefore, radiation therapy remains the mainstay of
treatment for this lymphoma type.
18
UI - 12169898
AU - Eisen MD; Buchmann L; Litman RS; Kennedy DW
TI -
Inverted papilloma of the sphenoid sinus presenting with auditory
symptoms: a report of two cases.
SO - Laryngoscope 2002 Jul;112(7 Pt 1):1197-200
AD - Department of Otorhinolaryngology-Head and Neck Surgery, University of
Pennsylvania Medical Center, Philadelphia 19104, U.S.A.
eisenm@mail.med.upenn.edu
OBJECTIVES: The report aims to inform the reader of cases of inverted
papilloma involving the sphenoid sinus presenting with auditory
symptoms. STUDY DESIGN: Case series. METHODS: A retrospective medical
record analysis was carried out to identify patients with inverted
papilloma involving the sphenoid sinus that presented with a primary
complaint of hearing loss or tinnitus, or both. Clinical records,
including initial history and physical examination, audiologic and
radiologic studies, and operative and histopathologic reports, were
carefully examined. A complete literature review for relevant studies
was performed to explore possible pathophysiologic factors and similar
cases. RESULTS: Two patients with inverted papilloma presenting with
primary auditory complaints were identified. One patient had roaring
tinnitus and sensorineural hearing loss demonstrated with audiologic
assessment, whereas the other had pulsatile tinnitus. Both patients had
biopsy-proven inverted papilloma involving the sphenoid sinus, and both
patients underwent endoscopic resection of the disease. No other cause
or origin of their auditory symptoms was confirmed. The auditory
symptoms of both patients improved markedly after excision of their
inverted papillomas. CONCLUSIONS: Tinnitus with or without hearing loss
is an unusual presentation of inverted papilloma of the sphenoid sinus.
Sphenoid tumors should be considered in the workup of these symptoms.
19
UI - 12172245
AU - Imola MJ; Schramm VL Jr
TI -
Orbital preservation in surgical management of sinonasal malignancy.
SO - Laryngoscope 2002 Aug;112(8 Pt 1):1357-65
AD - Craniofacial-Skull Base Center, Denver, Colorado 80218, USA.
MJImola@qwest.net
OBJECTIVE: To determine the oncological and functional outcome when
applying defined criteria for orbital preservation during surgical
treatment of sinonasal malignancy encroaching on the orbital structures.
STUDY DESIGN: Retrospective consecutive review of patients in tertiary
care center setting. METHODS: Analysis of 66 patients undergoing
surgical treatment for sinonasal malignancy encroaching on the orbit.
Orbital preservation was performed in all patients with tumor extension
up to and including resectable periorbital involvement. Minimum
follow-up was 2 years. Detailed analysis of oncological and functional
outcomes is included. RESULTS: Of 66 tumors abutting or invading into
the orbit, 54 were amenable for surgical treatment with orbital
preservation and the remaining 12 underwent orbital exenteration.
Histopathological findings were divided into five subgroups: squamous
cell carcinoma, adenomatous carcinomas, sinonasal undifferentiated
carcinoma, sarcoma, and other. Squamous cell carcinoma represented the
largest subgroup (24 patients), and 5-year overall actuarial survival
was not statistically different (P = 1.4; relative risk, 0.713) between
patients treated with orbital preservation (53%) versus those undergoing
exenteration (46%). Similarly, no difference in survival was found in
the adenomatous carcinoma subgroup. Within the orbital preservation
group as a whole, local recurrence occurred in 30% patients (16 of 54)
compared with 33% patients (4 of 12) treated with orbital exenteration.
Of note, eye-sparing surgery was associated with local recurrence at the
original site of orbital involvement in only 7.8% of cases (4 of 54).
Overall eye function was graded as functional without impairment in 54%
of patients (29 of 54), functional with impairment in 37% (20 of 54),
and nonfunctional in 9% (5 of 54). The most common abnormality was globe
malposition (enophthalmos or hypophthalmos) that was seen in 34 patients
(63%) and was associated with the lack of adequate rigid reconstruction
of subtotal or total orbital floor or multisegment orbital defects.
However, enophthalmos was asymptomatic in the majority of cases, and
persistent diplopia occurred in only five patients (9%). Various ocular
sequelae were present in 20 of the 49 patients (41%) with functional
eyes. Radiation therapy increased the risk of ocular complications, in
particular, optic atrophy, cataract formation, excessive dryness, and
ectropion. CONCLUSIONS: Selective orbital preservation is oncologically
safe and is a worthwhile undertaking in attempting to maintain a
functionally useful eye with surgical management of sinonasal malignancy
encroaching on the orbit. Consideration should be given to rigid orbital
reconstruction in larger defects resulting from subtotal or total
orbital floor resection or resections involving two or more orbital
walls.
20
UI - 12172247
AU - Kaufman MR; Brandwein MS; Lawson W
TI -
Sinonasal papillomas: clinicopathologic review of 40 patients with
inverted and oncocytic schneiderian papillomas.
SO - Laryngoscope 2002 Aug;112(8 Pt 1):1372-7
AD - Departments of Otolaryngology, Mount Sinai School of Medicine, New York,
New York 10029, USA. Kaufmanmatthew@hotmail.com
OBJECTIVE: To evaluate the pathological features and variations of
sinonasal inverted and oncocytic papillomas and correlate the
microscopic findings with the clinical behavior. STUDY DESIGN: A
retrospective review and pathological assessment. METHODS: A
retrospective review and pathological assessment were performed on 40
patients with a diagnosis of inverted papilloma treated by the senior
author (w.l.) between 1994 and 2001. RESULTS: Forty cases were
identified and reviewed. Seven patients developed recurrences (18%), and
four underwent malignant transformations (10%). Pathological assessment
revealed 34 (85%) inverted papillomas and 6 (15%) oncocytic schneiderian
papillomas. Dysplasia was present in 26 cases (65%), including 9 cases
(22%) of high-grade dysplasia (moderate to severe). Metaplasia of the
sinonasal mucosa adjacent to inverted papillomas and oncocytic
schneiderian papillomas was seen in 18 (45%) cases. Recurrence developed
in two patients with oncocytic schneiderian papillomas (33%) and five
patients with inverted papillomas (15%). Four cases (10%) of carcinoma
ex papilloma were seen; one arose from oncocytic schneiderian papilloma
(17%), and three arose from inverted papilloma (9%). Oncocytic
schneiderian papilloma was more often mixed with typical inverted
papilloma, rather than presenting in its pure form. CONCLUSIONS:
Although oncocytic schneiderian papilloma is uncommon relative to
inverted papilloma, the results suggest that they have higher rates of
both recurrence and malignant transformation. The common admixture of
oncocytic schneiderian papilloma with inverted papilloma speaks for a
common etiological factor of these two lesions. A larger number of cases
for analysis would be necessary to confirm the trend noted in our data.
Nonetheless, pathological findings consistent with oncocytic
schneiderian papilloma should be explicit in any classification system
and justify aggressive treatment and careful postoperative surveillance.
21
UI - 12172248
AU - Busaba NY; Kieff D
TI -
Endoscopic sinus surgery for inflammatory maxillary sinus disease.
SO - Laryngoscope 2002 Aug;112(8 Pt 1):1378-83
AD - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary,
Division of Otolaryngology, Veterans Affairs Boston Health Care System,
Harvard Medical School, Boston, Massachusetts 02114, USA.
nicolas_busaba@meei.harvard.edu
OBJECTIVE/HYPOTHESIS: The role of endoscopic sinus surgery for treating
chronic maxillary sinusitis is well established. The purpose of the
study is to determine the efficacy of endoscopic sinus surgery in the
treatment of maxillary sinus inflammatory disease that includes
mucoceles, retention cysts, and antrochoanal polyps. STUDY DESIGN: This
is a retrospective review of 32 consecutive patients who underwent
endoscopic sinus surgery for mucoceles (n = 21), retention cysts (n =
5), or antrochoanal polyps (n = 6). METHODS: The medical records were
reviewed for patient demographics, presenting symptoms, and type of
operation. Surgical outcome was determined by resolution of symptoms,
recurrence of disease, and need for revision or additional surgery.
RESULTS: Ethmoidectomy with middle meatal antrostomy was performed in
all patients; 28 patients had additional middle turbinectomy.
Postoperative follow-up ranged from 6 months to 4 years. The operation
resulted in resolution of symptoms and a patent antrostomy on long-term
follow-up in all cases of mucoceles. No case required revision surgery.
On the other hand, the disease recurred in three patients (60%) with
retention cysts and three patients (50%) with antrochoanal polyps
despite patent antrostomies. The recurrences occurred 3 to 6 months
after the surgery. The recurrent cases of antrochoanal polyps required
Caldwell Luc procedures. The three failures in cases of retention cysts
were successfully managed with repeated office endoscopic
marsupialization through a patent antrostomy. CONCLUSIONS: Endoscopic
sinus surgery is an effective treatment for mucoceles, with favorable
long-term outcome. Maxillary retention cysts commonly recur after
endoscopic sinus surgery. However, the recurrence can be managed in the
office through a patent antrostomy. Endoscopic sinus surgery may be
offered as initial surgical treatment for antrochoanal polyps, but a
Caldwell Luc operation may be needed for recurrent disease.
22
UI - 12172261
AU - Musy PY; Reibel JF; Levine PA
TI -
Sinonasal undifferentiated carcinoma: the search for a better outcome.
SO - Laryngoscope 2002 Aug;112(8 Pt 1):1450-5
AD - Department of Otolaryngology-Head and Neck Surgery, University of
Virginia, Charlottesville, Virginia 22908, USA.
OBJECTIVE: To evaluate the clinical outcomes of a standardized treatment
approach for sinonasal undifferentiated carcinoma (SNUC). STUDY DESIGN:
Single-center, retrospective case series. METHODS: Fifteen patients with
newly diagnosed SNUC were seen in the Department of Otolaryngology-Head
and Neck Surgery at the University of Virginia from 1991 to 2000.
Long-term follow-up on five additional patients diagnosed between 1986
and 1991 was also analyzed. RESULTS: Overall, 10 patients were treated
with curative intent with neoadjuvant chemoradiotherapy followed by
craniofacial resection (CFR). The majority of the remainder was treated
with palliative radiotherapy or chemoradiotherapy alone. Four patients
who underwent CFR are currently free of disease at 4, 36, 49, and 164
months postoperatively. The 2-year survival of all evaluable patients,
regardless of treatment, was 47%. Two-year survival was 64% in the group
treated by CFR and 25% in the group treated with chemo- and/or
radiotherapy (P =.076). CONCLUSION: For patients with good performance
status and limited intracranial or intraorbital disease, we continue to
advocate initial chemoradiotherapy followed by craniofacial resection.
Patients who are deemed inoperable as a result of advanced disease may
nevertheless experience significant palliation with chemoradiotherapy
only.
23
UI - 11915171
AU - Malaguarnera M; Vinci M; Pistone G
TI -
Malignant melanoma of nasal cavity: case report and review of the
literature.
SO - Cancer Biother Radiopharm 2002 Feb;17(1):29-34
AD - Institute of Internal Medicine and Geriatrics, University of Catania,
Italy. malaguar@mbox.unict.it
24
UI - 11958891
AU - Tsao MN; Tsang RW; Liu FF; Panzarella T; Rotstein L
TI -
Radiotherapy management for squamous cell carcinoma of the nasal skin:
the Princess Margaret Hospital experience.
SO - Int J Radiat Oncol Biol Phys 2002 Mar 15;52(4):973-9
AD - Department of Radiation Oncology, Princess Margaret Hospital, University
Health Network, University of Toronto, Toronto, Ontario, Canada.
PURPOSE: To evaluate the outcome of radiotherapy (RT) for squamous cell
carcinoma (SCC) of the nasal skin. MATERIALS AND METHODS: The charts of
100 patients referred and treated with RT during 1982 to 1993 for SCC of
nasal skin were reviewed. Most patients (81%) were treated with
orthovoltage X-rays. In general, lesions 5 cm or those associated with bone or cartilage invasion
were typically treated to 50 Gy in 20 fractions. Six patients were lost
to follow-up, leaving 94 patients assessable for local or regional
failure analysis. Using the UICC staging system, the T stage at first
presentation was as follows: T1, 60 patients; T2, 11 patients; T3, 0
patients, T4, 7 patients; TX, 16 patients. Only 1 patient had regional
lymph node disease at presentation. Thirty-one patients were treated
with surgery, followed by RT. Sixty-three patients were treated with
primary RT. RESULTS: The local relapse-free rate was 90% and 85% at 2
and 5 years, respectively. The actuarial 2 and 5-year overall survival
rate was 75% and 51%, respectively. The cause-specific survival was 96%
at both 2 and 5 years. No Radiation Therapy Oncology Group Grade 4
toxicities occurred. Univariate analysis could not identify any patient,
tumor, or treatment factors that were statistically significant
prognosticators. CONCLUSION: RT for SCC of nasal skin achieves excellent
outcome, is well tolerated, and should continue to be recommended in the
management of this disease.
25
UI - 12080628
AU - Reiter R; Allert M; Knuchel R; Strutz J
TI -
[Sinugenic metastasis of bilateral renal cell carcinoma (hypernephroma)]
SO - HNO 2002 Feb;50(2):165-8
AD - HNO-Klinik, Universitat Regensburg, Franz-Josef-Strauss-Allee 11, 93053
Regensburg.
The paranasal sinuses are a rare location of metastases. The most
frequent infraclavicular primary tumor is the renal cell carcinoma
(hypernephroma). We report a case of a 64-old-woman with a bilateral
renal cell carcinoma and metastases in the paranasal sinuses with
destruction of the skull base. If symptoms such as progressive indolent
periorbital swelling or intermittent epistaxis occur in adults, one
should consider a metastasis of a renal cell carcinoma to the paranasal
sinuses even 10 years after nephrectomy.
26
UI - 12139736
AU - Yoshino T; Nakamura S; Suzumiya J; Niitsu N; Ohshima K; Tsuchiyama J;
TI -
Shinagawa K; Tanimoto M; Sadahira Y; Harada M; Kikuchi M; Akagi T
Expression of cutaneous lymphocyte antigen is associated with a poor
outcome of nasal-type natural killer-cell lymphoma.
SO - Br J Haematol 2002 Aug;118(2):482-7
AD - Department of Pathology, Okayama University Graduate School of Medicine
and Dentistry, Okayama 700-8558, Japan. yoshino@md.okayama-u.ac.jp
Nasal and nasal-type natural killer (NK) lymphoma is a distinct
clinicopathological entity mostly associated with Epstein-Barr virus.
Cases that have widespread lesions are resistant to ordinary anti-cancer
therapy and take a highly aggressive course. To date, there are no
available data on the relationships between the localization, clinical
outcome and expression of adhesion molecules in such cases. We examined
the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of
NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the
CLA+ group (n=29) had a much worse prognosis than the CLA- group (n=23),
regardless of the primary site or clinical staging. Univariate analysis
identified some significant prognostic factors, and multivariate
analysis of these factors showed that the expression of CLA was an
independent prognostic indicator. In conclusion, the present findings
established that CLA is an independent and important prognostic factor
in patients with NK-cell lymphomas.
27
UI - 12090952
AU - Cakmak O; Ergin NT; Yilmazer C; Kayaselcuk F; Barutcu O
TI -
Endoscopic removal of esthesioneuroblastoma.
SO - Int J Pediatr Otorhinolaryngol 2002 Jul 9;64(3):233-8
AD - Department of Otorhinolaryngology, Baskent University Faculty of
Medicine, Adana Hospital, Adana, Turkey.
Esthesioneuroblastoma is a rare tumor of neural crest origin that arises
in the nasal cavity. There is still no consensus on the optimal
treatment for this neoplasm, and the literature contains very few
accounts of endoscopic excision in these cases. We described a case
report of 12-year-old girl with esthesioneuroblastoma that was confined
to the nasal cavity and paranasal sinuses, with no orbital or
intracranial extension. The tumor was removed via intranasal endoscopic
approach and radiotherapy was administered postoperatively. The patient
is currently being followed, and there has been no recurrence in 24
months after surgery.
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