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Abramson Cancer CenterNCI CANCERLIT® Search: Salivary Gland Cancer - September 2002
National Cancer Institute®
Last Modified: September 1, 2002
- Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in salivary gland tumors.
- Sebaceous lymphadenoma of the lip: report of a case of minor salivary gland origin.
- Parotid gland metastasis from renal cell carcinoma.
- Lipomatous pleomorphic adenoma of parotid gland.
- Surgical treatment of recurrences of pleomorphic adenoma of the parotid gland.
- [Diffuse pseudotumorous oncocytosis of the parotid gland. A case report]
- [Giant pleomorphic adenoma of the parotid gland: a case report and review of the literature]
- Parotid and thyroid gland cancers in patients with ataxia-telangiectasia.
- Paediatric mucoepidermoid carcinoma of the palate.
- Immunohistochemical distinction of high-grade mucoepidermoid carcinoma and epidermoid carcinoma of the parotid region.
- Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature.
- Hybrid carcinomas of salivary glands.
- Immunohistochemical study of epidermal growth factor receptor in adenoid cystic carcinoma of salivary gland origin.
- Value of neck dissection in patients with cancer of the parotid gland and a clinical NO neck.
- Predictors of nodal metastasis in salivary gland cancer.
- 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells.
- Osteoblastic differentiation from atypical myoepithelial cells.
- Polymorphous low-grade adenocarcinoma of the salivary glands: clinicopathological and immunohistochemical study of a case.
- [The analysis of treatment methods in patients with parotid gland cancer]
- Electrical impedance scanning used in addition to ultrasound for the verification of submandibular and parotid lesions: initial results.
- Foreign body reaction to calcium alginate fibre mimicking recurrent tumour of the submandibular salivary gland.
- Carcinosarcoma (malignant mixed tumor) of the submandibular gland: A case report and review of the literature.
- The location of parotid gland tumors in relation to the facial nerve on magnetic resonance images and computed tomography scans.
- Fine-needle aspiration cytology of a primary ectopic meningioma.
- The role of imaging in the evaluation of parotid disease.
Table of Contents
1
UI - 12076327
AU - Castrilli G; Fabiano A; La Torre G; Marigo L; Piantelli C; Perfetti G;
TI -
Ranelletti FO; Piantelli M
Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair
system in salivary gland tumors.
SO - J Oral Pathol Med 2002 Apr;31(4):234-8
AD - Department of Oncology, University of Chieti, Chieti, Italy.
BACKGROUND: The human DNA mismatch repair (hMMR) system plays an
important role in reducing mutation and maintaining genomic stability.
The MMR system in human cells is composed of at least six genes (hMSH2,
hMLH1, hMSH3, hPMS1, hPMS2 and GTBP/hMSH6). In particular, hMSH2 and
hMLH1 are expressed in cells undergoing rapid renewal; their reduced
expression has been reported in several tumors. METHODS: We examined the
expression of hMSH2 and hMLH1 by immunohistochemistry in tumor specimens
from 43 patients with primary tumors. RESULTS: All carcinomas (n = 20)
expressed these proteins. In addition, when compared to pleomorphic
adenomas, malignant tumors contained significantly (P < 0.01) higher
proportions of hMSH2 (56.1 +/- 31.5 vs. 31.1 +/- 22.6) and hMLH1 (27.9
+/- 26.0 vs. 14.0 +/- 12.6) positive cells. Warthin's tumors showed no
specific nuclear staining of tumor cells for both hMSH2 and hMLH1.
CONCLUSIONS: These data suggest a minor, if any, role for a defect in
the hMMR system in the pathogenesis of malignant salivary gland tumors.
2
UI - 12076329
AU - Maruyama S; Cheng J; Inoue T; Takagi R; Saku T
TI -
Sebaceous lymphadenoma of the lip: report of a case of minor salivary
gland origin.
SO - J Oral Pathol Med 2002 Apr;31(4):242-3
AD - Division of Oral Pathology, Department of Tissue Regeneration and
Reconstruction, Niigata University Graduate School of Medical and Dental
Sciences, Niigata, Japan.
A case of sebaceous lymphadenoma occurring in the lip of a 73-year-old
female is described. The patient had noticed a painless mass in the
region of her upper lip for a year. The surgically removed tumor,
measuring about 10 mm in diameter, was located just beneath the lip
mucosa, expanding into the submucosal and muscle layer. Histologically,
the tumor was well encapsulated and consisted of scattered round-shaped
islands of small squamous epithelial cells with focal but apparent
sebaceous differentiation in a background of lymphoid stroma. This is
the first case report of sebaceous lymphadenoma of minor salivary gland
origin.
3
UI - 12148853
AU - Park YW; Hlivko TJ
TI -
Parotid gland metastasis from renal cell carcinoma.
SO - Laryngoscope 2002 Mar;112(3):453-6
AD - Department of Otolaryngology, Northeastern Ohio Universities College of
Medicine, Summa Health System, Akron, USA. pywpark@neoucom.edu
OBJECTIVE: To discuss the diagnosis and management of metastatic renal
cell carcinoma presenting as a parotid mass by studying such cases.
STUDY DESIGN: Retrospective review. METHODS: Identification of 24
previously reported cases of renal cell carcinoma metastatic to the
parotid gland in the English language literature and an analysis of a
total of 25 patients including our case. RESULTS: Parotid metastasis was
the initial presenting sign of the malignancy in the kidney in 14 of 25
(56%) cases; 11 of 25 (44%) cases presented with metachronous metastasis
to the parotid. The most common presenting complaint was parotid mass.
No case presented with facial paralysis. In three of six (50%) patients,
fine-needle aspiration biopsy was diagnostic. CONCLUSIONS: In the
majority of cases, parotid metastases are the first clinical sign of the
renal cell carcinoma. Fine-needle aspiration biopsy can provide crucial
information without parotidectomy as in our case. Parotidectomy with
facial nerve preservation should be considered as a therapeutic option
for solitary parotid metastasis.
4
UI - 12010373
AU - Korkmaz H; Adsay NV; Jacobs JR; Lucas DR
TI -
Lipomatous pleomorphic adenoma of parotid gland.
SO - Histopathology 2002 May;40(5):487-8
5
UI - 11876541
AU - Becelli R; Perugini M; Mastellone P; Frati R
TI -
Surgical treatment of recurrences of pleomorphic adenoma of the parotid
gland.
SO - J Exp Clin Cancer Res 2001 Dec;20(4):487-9
AD - Dept. of Maxillo Facial Surgery, University of Rome La Sapienza, Rome,
Italy.
From 1989 to 1999 a retrospective study was conducted on 7 patients with
recurrent pleomorphic adenomas of the parotid gland who were referred to
the MaxilloFacial Department of the University of Rome "La Sapienza"
after having undergone surgery elsewhere. The mean time interval between
the first operation and recurrences ranged from 15 months to 13 years,
and the average time interval was 7.7 years. Implantability of the
lesion and inadequate surgery that produced rupture of tumour capsule
and tumour cells bleeding into surrounding glandular parenchyma, were
the reasons for tumour recurrence. The instrumental examinations used
for planning the surgical treatment to be applied and for studying the
relations of recurrence with glandular parenchyma were CT (with contrast
medium) or MR of head and neck. These patients underwent total
parotidectomy with facial nerve preservation and no recurrence occurred
in any patient. The results of this study underscore the importance of
adequate surgical excision of initial recurrences as well as primary
tumours to prevent tumour recidivism. Finally, tumour control rates and
facial nerve preservation are enhanced with formal parotidectomy for
recurrent tumour when feasible.
6
UI - 12015493
AU - Yacoubi MT; Abdelkefi M; Mokni M; Njim L; Harzallah L; Korbi S
TI -
[Diffuse pseudotumorous oncocytosis of the parotid gland. A case report]
SO - Ann Otolaryngol Chir Cervicofac 2002 Apr;119(2):89-92
AD - Departement de pathologie, Service d'Oto-rhino-Laryngologie, Service de
radiologie, Hopital universitaire F. Hached, 4000 Sousse, Tunisie,
France.
Pseudotumorous oncocytosis of the parotid gland is very uncommon and
frequently misdiagnosed since it generally presents as a true tumor. The
clinical presentation and imaging features of a 6-cm diameter left
parotid mass led to the diagnosis of a tumor in a 73-year-old man. At
pathology examination of the partial parotidectomy specimen the "tumor"
was found to be a metaplastic oncocytic lesion. We discuss the
diagnostic criteria, differential diagnosis, and etiopathogeny of this
lesion.
7
UI - 11845042
AU - Kici S; Peytral C
TI -
[Giant pleomorphic adenoma of the parotid gland: a case report and
review of the literature]
SO - Ann Otolaryngol Chir Cervicofac 2001 Oct;118(5):330-2
AD - Service ORL et de chirurgie cervico-faciale, Centre Hospitalier
Intercommunal Le Raincy-Montfermeil, 10 rue du General Leclerc, 93370
Montfermeil, France.
We report the case history of a 72-year-old patient who had a giant
parotid adenoma that developed over 12 years. Worrisome clinical signs
started to develop when the tumor had reached the size of 50 cm and a
weight of 2.6 kg. Histology reported a benign tumor of the parotid
gland. We discuss this case in relation to the to similar cases in the
literature, highlighting clinical and histological difficulties
encountered in patients with giant tumors of the parotid.
8
UI - 11764097
AU - Sandoval C; Schantz S; Posey D; Swift M
TI -
Parotid and thyroid gland cancers in patients with
ataxia-telangiectasia.
SO - Pediatr Hematol Oncol 2001 Dec;18(8):485-90
AD - Department of Pediatrics and Medicine and the Institute for the Genetic
Analysis of Common Diseases, New York Medical College, Valhalla 10595,
USA. claudio_sandoval@nymc.edu
This study describes the clinicopathologic features of parotid and
thyroid gland cancers in patients with ataxia-telangiectasia (AT). The
medical records of 412 AT patients were reviewed to identify those
patients who developed parotid or thyroid gland cancers. Presenting
features, diagnoses, types of therapy, risk factors, and other primary
cancers were analyzed. Five patients with parotid or thyroid gland
cancers were identified. Three had parotid (2 mucoepidermoid and 1
acinic cell) and 2 had thyroid gland (1 papillary and 1 follicular)
cancers. Four patients presented with head and neck masses and 1 had an
occult papillary thyroid carcinoma. Four patients had more than one
primary cancer. The only mode of therapy was surgery. The 2 patients
with mucoepidermoid carcinoma had complete parotidectomies. One is alive
without any evidence of disease 12 months after diagnosis and 1 died of
refractory lymphoma without any evidence of mucoepidermoid carcinoma at
autopsy. The patient with acinic cell carcinoma had a parotid biopsy
only. The 2 patients with thyroid cancer were diagnosed at autopsy. The
results indicate that patients with AT are at risk for developing
multiple primary cancers including those of the parotid and thyroid
gland, and should be evaluated for such primaries.
9
UI - 12102409
AU - Caccamese JF Jr; Ord RA
TI -
Paediatric mucoepidermoid carcinoma of the palate.
SO - Int J Oral Maxillofac Surg 2002 Apr;31(2):136-9
AD - Division of Oral and Maxillofacial Surgery, University of Maryland
Medical Systems, Baltimore 21201, USA. caccamese@mindspring.com
The purpose of this paper is to review our experience with
mucoepidermoid carcinoma (MEC), a rare tumour in minor salivary glands,
in a small series of paediatric patients. A retrospective analysis of
these, five (9%) occurred in children. There were 23 cases of MEC, four
(17%) of which occurred in patients under the age of 18 who presented
with T1 or T2N0M0 low- to intermediate-grade MEC of the palate and
adjacent structures. These patients form the basis of this study. All
patients were treated with wide local excision, obtaining tumour-free
margins, and followed for a mean number of 58 months. None of these
tumours invaded bone and resection of bone was not performed in any case
as the periosteum was intact and the tumours were low to intermediate
grade. To date, all patients remain free of disease. One patient who
went elsewhere for treatment, was treated with local resection only, and
has also experienced no recurrence. Wide local excision is the treatment
of choice for low to intermediate grade MEC of the minor salivary glands
in paediatric patients.
10
UI - 12110337
AU - Sobral AP; Loducca SV; Kowalski LP; Santos IR; Almeida OP; Araujo NS;
TI -
Araujo VC
Immunohistochemical distinction of high-grade mucoepidermoid carcinoma
and epidermoid carcinoma of the parotid region.
SO - Oral Oncol 2002 Jul;38(5):437-40
AD - Oral Pathology Department, School of Dentistry, Sao Paulo University,
Brazil.
The correct diagnosis of high-grade mucoepidermoid (MEC), which is
composed of solid islands of intermediate and squamous cells, may be
challenging, due to its similarity to other tumours, mainly with
squamous cell carcinoma (SCC). The present report employed
immunohistochemical technique against different cytokeratins (CKs), in
order to differentiate these two entities. : Six high-grade MEC and six
SCC of the parotid region, retrieved from the files of both Oral
Pathology Department of the School of Dentistry of University of Sao
Paulo and Pathology Department of A.C. Camargo Hospital, were submitted
immunohistochemical technique against Cks 7,8, 10, 13, 14 and 19. :
High-grade MEC was positive for Cks 7, 8, 13, 14 and 19. The cases of
SCC showed strong positivity for CK14, and CK10 was present only in
focal areas. Our results highlight the use of CKs (especially CK14) to
differentiate high-grade MEC and SCC.
11
UI - 10420226
AU - Croitoru CM; Suarez PA; Luna MA
TI -
Hybrid carcinomas of salivary glands. Report of 4 cases and review of
the literature.
SO - Arch Pathol Lab Med 1999 Aug;123(8):698-702
AD - Department of Pathology, University of Texas Medical School, Houston
77030, USA.
OBJECTIVE: To report 4 cases of hybrid carcinoma and to review the
literature on these rare neoplasms of the salivary gland. METHODS:
Hematoxylin-eosin-stained, formalin-fixed, paraffin-embedded tissue
sections from 3 parotid tumors and 1 palate tumor were examined.
RESULTS: The cases were classified as adenoid cystic and mucoepidermoid
carcinoma, adenoid cystic and epithelial-myoepithelial carcinoma,
epithelial-myoepithelial and salivary duct carcinoma, and adenoid cystic
and salivary duct carcinoma. All patients were men, 28 to 71 years old;
3 patients presented with parotid mass, and 1 patient presented with
palatal mass. One patient presented with facial nerve paralysis and
pain. The soft palatal tumor was a slowly growing mass with maxillary
sinus involvement at the time of the diagnosis. All patients were
treated with surgery and radiotherapy. CONCLUSIONS: Correct
identification of 2 or more neoplastic entities will help assess the
aggressiveness and metastatic potential of the tumor and influence the
clinical course and treatment.
12
UI - 10747300
AU - Chetty R; Medley P; Essa A
TI -
Hybrid carcinomas of salivary glands.
SO - Arch Pathol Lab Med 2000 Apr;124(4):494-6
13
UI - 12112535
AU - Vered M; Braunstein E; Buchner A
TI -
Immunohistochemical study of epidermal growth factor receptor in adenoid
cystic carcinoma of salivary gland origin.
SO - Head Neck 2002 Jul;24(7):632-6
AD - Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela
Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv,
Israel.
BACKGROUND: Epidermal growth factor (EGF) and its receptor (EGFR) are
involved in the development of salivary gland tumors. Recently,
treatment modalities for EGFR inhibition have shown an enhanced clinical
response in carcinomas of different locations. Adenoid cystic carcinoma
(ACC) of salivary gland origin is a malignant tumor with a poor
long-term outcome. If salivary gland ACC does exhibit EGFR, then
immunotherapy could have a major impact on improving its prognosis.
METHODS: The study consisted of 34 samples of formalin-fixed,
paraffin-embedded specimens of salivary gland ACC. Specimens were
stained with a mouse antihuman monoclonal antibody for
immunohistochemical detection of EGFR. Overlying oral mucosa and
adjacent normal salivary ducts served as internal controls. Both
membrane and cytoplasmic staining were evaluated. Staining score was
calculated by multiplying the percentage of positively stained tumor
cells by the intensity of the staining. The highest score for a given
tumor was equal to 2. RESULTS: In the final analysis, 27 of the 34
specimens were included; 7 were excluded, because the internal control
did not reveal any staining. Of these 27 specimens, 23 (85%) stained
positively for EGFR with a staining score of 0.05 to 1.8. Three palatal
tumors attained the highest scores (one tumor, 1.2, and the remaining
two, 1.8). CONCLUSIONS: Most salivary gland ACC stained positively for
EGFR, and in some the staining was quite intense. On the basis of the
already proven antitumoral effect of agents acting as EGFR inhibitors,
it is suggested that patients with ACC might benefit from these agents,
especially when surgery has failed or in those with recurrent or
metastatic disease. Copyright 2002 Wiley Periodicals
14
UI - 12006762
AU - Teymoortash A; Werner JA
TI -
Value of neck dissection in patients with cancer of the parotid gland
and a clinical NO neck.
SO - Onkologie 2002 Apr;25(2):122-6
AD - Klinik fur Hals-, Nasen- und Ohrenheilkunde der Philipps-Universitat
Marburg, Germany.
Cervical lymph node metastases in patients with parotid gland carcinoma
are not rare. Regional metastases have a significant influence on the
prognosis of these patients. In spite of the clinical relevance of
lymphogenous metastases, the indications for elective treatment of the
neck are not well defined. In the present review the controversies and
therapeutical strategies of ipsilateral neck lymph nodes and their
extension in patients with potential occult lymph node metastases are
discussed. On the basis of the published data, in consideration of the
direction of lymphogenous metastatic spread of parotid gland carcinomas,
an elective neck dissection is recommended in carcinomas with high
percentage of lymphatic spread also in the N0 neck. Consideration of
additional parameters (> T2, lymphangiosis carcinomatosa) is appropriate
to perform also a neck dissection in carcinomas with low risk for
lymphogenous metastases. An elective neck dissection should include
levels I, II, III and upper V. Copyright 2002 S. Karger GmbH, Freiburg
15
UI - 12210032
AU - Korkmaz H; Yoo GH; Du W; Hocwald E; Otero-Garcia JE; Volkan Adsay N;
TI -
Shibuya T; Jacobs JR
Predictors of nodal metastasis in salivary gland cancer.
SO - J Surg Oncol 2002 Aug;80(4):186-9
AD - Department of Otolaryngology-Head and Neck Surgery, Karmanos Cancer
Institute Wayne State University, Detroit, Michigan 48201, USA.
OBJECTIVES: This study was conducted to determine clinical and
histologic factors that would predict nodal metastasis in patients with
major salivary gland cancer. METHODS: A retrospective study of 40
patients who underwent surgery, including neck dissection, for major
salivary gland cancer between 1975 and 1997 was performed. Patient
charts were reviewed, and clinical and pathologic data were extracted
along with outcome. Predictive factors were identified and survival
curves were obtained. RESULTS: Neck dissections were performed in 40
patients, which revealed histologic evidence of tumor in lymph nodes in
15 cases. Histologically proven metastasis was found in 16% of specimens
from elective and 73% of specimens from therapeutic neck dissection.
Five-year overall and locoregional disease-free survival rates for
histologically positive and negative groups were 40% versus 63% (P <
0.05) and 67% versus 69% (P = 0.59), respectively. Univariate analysis
of the factors revealed that clinical evidence of nodal metastasis (P <
0.001) and high-grade cancer (P < 0.033) predicted histologic nodal
involvement. Multivariate analysis revealed that only a positive neck
examination was a significant predictive factor (OR = 31, 95%CI =
2.99-312). CONCLUSIONS: Our results suggest that clinical neck
examination is a reliable predictor of regional metastasis in patients
with major salivary gland cancer. In view of the low frequency of occult
metastases, routine elective treatment of the neck is not recommended.
Copyright 2002 Wiley-Liss, Inc.
16
UI - 10891390
AU - Aota K; Azuma M; Yamashita T; Tamatani T; Motegi K; Ishimaru N; Hayashi
TI -
Y; Sato M
5-Fluorouracil induces apoptosis through the suppression of NF-kappaB
activity in human salivary gland cancer cells.
SO - Biochem Biophys Res Commun 2000 Jul 14;273(3):1168-74
AD - Second Department of Oral and Maxillofacial Surgery, Tokushima
University School of Dentistry, Tokushima, 770-8504, Japan.
Activation of the transcription factor NF-kappaB results in protection
against apoptosis, and the chemotherapeutic agent 5-Fluorouracil (5-FU)
exerts its cytotoxic effect through the induction of apoptosis. Thus, we
examined whether 5-FU could induce apoptosis through the suppression of
NF-kappaB activity. We found that upon treatment of a human salivary
gland cancer cell line (cl-1) with 5-FU, the NF-kappaB activity was
suppressed in a time-dependent manner. This inhibition was mediated by a
prevention of the degradation of the inhibitory IkappaB-alpha protein.
In addition, the expression of TRAF-2 and cIAP-1, which are
transcriptionally regulated by NF-kappaB and function as anti-apoptotic
molecules through the interruption of caspase pathway, was also
inhibited by 5-FU. Finally, the activity of caspase-8 and caspase-3
showed a significant increase in response to 5-FU. By flow cytometric
analysis, 5-FU did not affect the expression level of Fas on the cell
surface. Thus, our results suggest that one of the molecular mechanisms
involved in 5-FU-induced apoptosis in cl-1 cells may be due to the
suppression of NF-kappaB activity, resulting in the activation of the
pro-apoptotic pathway. Copyright 2000 Academic Press.
17
UI - 12047773
AU - Tsukinoki K; Watanabe Y
TI -
Osteoblastic differentiation from atypical myoepithelial cells.
SO - Histopathology 2002 Jun;40(6):576-7
18
UI - 12168949
AU - Tralongo V; Becchina G; Genovese F; Nagar C; Ottoveggio G; Pinto G
TI -
Polymorphous low-grade adenocarcinoma of the salivary glands:
clinicopathological and immunohistochemical study of a case.
SO - Anticancer Res 2002 Mar-Apr;22(2B):1347-52
AD - Servizio di Anatomia ed Istologia Patologica e Citopatologia, Presidio
Ospedaliero G.F. Ingrassia-Azienda, Palermo, Italy.
vtralongo@hotmail.com
Polymorphous low-grade adenocarcinoma (PLGA) is a distinctive salivary
gland neoplasm with a predilection for intraoral sites. Histological and
immunohistochemical analyses were used to study a case involving the
minor salivary glands of the buccal mucosa in a 68-year-old woman.
Histologically, the tumor was characterized by unenca-psulated,
progressing and focally-infiltrative borders and showed variable growth
patterns including solid, tubular, microcystic and cribriform; papillary
and papillary-cystic areas of more than focal extent were present.
Cytologically the neoplasm was composed of uniform, round to cuboidal
cells with bland, round to oval nuclei. Immunohistochemical analysis
showed that the tumor cells were positive for cytokeratin, S-100
protein, vimentin, focally-positive for EMA and actin and negative for
CEA. The significance of the papillary component and the possible
relationship to other salivary gland tumors is discussed.
19
UI - 12108041
AU - Debniak E; Jozefowicz-Korczynska M; Lukomski M
TI -
[The analysis of treatment methods in patients with parotid gland
cancer]
SO - Przegl Lek 2002;59(1):17-20
AD - Katedra i Klinika Otolaryngologii Akademii Medycznej w Lodzi.
The analysis of 105 patients treated due to parotid gland cancer was
performed. The choice of the treatment method depends on the tumor's
histological type and the advancement of the clinical stage. Clinical
observation and statistic evaluation proved that the best treatment
method was surgical procedure, in some cases supplemented with radio-
and chemiotherapy.
20
UI - 12138357
AU - Facius M; Malich A; Schneider G; Boehm T; Anderson R; Kaiser WA
TI -
Electrical impedance scanning used in addition to ultrasound for the
verification of submandibular and parotid lesions: initial results.
SO - Invest Radiol 2002 Aug;37(8):421-7
AD - Institute of Diagnostic and Interventional Radiology, Friedrich Schiller
University Jena, Jena, Germany. mirijam.facius@med.uni-jena.de
OBJECTIVES: Different dielectric properties of cancerous tissues are
correlated with increased conductance potentially measurable using
Electrical Impedance Scanning (EIS). Sonographically based
differentiation of lesions in the salivary glands remains difficult. The
clinical value of EIS used additionally to Ultrasound was investigated.
METHODS: Sonographically suspicious lesions of parotid (n = 25) and
submandibular (n = 16) glands were examined using TransScan TS2000
(TransScan Medical, Israel; distributed by Siemens, Sweden). Bright
focal spots representing areas of high conductance were read as
positive; absence of a focal spot (ie, homogeneous gray) was read as
negative. All lesions were histopathologically proved. RESULTS: 14/15
malignant (93.3%) and 13/26 benign lesions (50.0%) were correctly
detected using EIS, NPV 93%, PPV 52%. All cases of squamous cell
carcinoma were correctly identified. Lymph node relapse of T-cell
lymphoma, lymph node relapse of malignant melanoma, malignant
hemangioendothelioma and 2/3 adenocystic carcinoma (primary metastases)
were correctly detected. CONCLUSIONS: Our initial results suggest EIS to
be of interest when used adjunctively to ultrasound for the
identification of malignant lesions of the salivary glands. However, low
specificity induced in part by current technical restrictions (bone
interference, skin alterations, contact artifacts, prominence of the
lesions) limit this clinical application.
21
UI - 12180215
AU - Bhalla RK; Murphy J; Jones TM; Roland NJ
TI -
Foreign body reaction to calcium alginate fibre mimicking recurrent
tumour of the submandibular salivary gland.
SO - Br J Oral Maxillofac Surg 2002 Apr;40(2):172-4
AD - Department of Otolaryngology and Head & Neck Surgery, University
Hospital Aintree, Liverpool, UK.
A 50-year-old woman was referred after the discovery of adenoid cystic
carcinoma in an excised left submandibular gland. Treatment involved
clearance of the left submandibular fossa, and bilateral levels II and
III selective neck dissections. A left-sided submandibular haematoma
developed during the immediate postoperative period. After removal of
the clot, there was a persistent, low volume capillary ooze from the
left submandibular fossa and a calcium alginate fibre pack (Kaltostat)
was left in place to control the bleeding. After an extended period of
time the pack excited a foreign body reaction which, on a computed
tomogram, mimicked a recurrence of the tumour. We review the role of
Kaltostat in this setting and its potential for foreign body reaction,
which may mimic serious disease.
22
UI - 12215996
AU - Bhalla RK; Jones TM; Taylor W; Roland NJ
TI -
Carcinosarcoma (malignant mixed tumor) of the submandibular gland: A
case report and review of the literature.
SO - J Oral Maxillofac Surg 2002 Sep;60(9):1067-9
AD - Department of Otolaryngology and Head and Neck Surgery, University
Hospital Aintree, Liverpool, England. DrRKBhalla@doctors.org.uk
23
UI - 12215980
AU - de Ru JA; van Benthem PP; Hordijk GJ
TI -
The location of parotid gland tumors in relation to the facial nerve on
magnetic resonance images and computed tomography scans.
SO - J Oral Maxillofac Surg 2002 Sep;60(9):992-4; discussion 995
AD - Department of Otorhinolaryngology, University Medical Center Utrecht,
The Netherlands. J.A.deRu@KMB.AZU.NL
PURPOSE: The facial nerve, which cannot be visualized radiographically
in its intraparotid part, divides the parotid gland into 2 lobes. When
planning surgery, it is important to know where to locate a parotid
gland tumor in relation to the facial nerve, because the location can
influence the duration and difficulty of the operation. In this study,
an anatomic line that predicts the course of the facial nerve in the
parotid gland, is applied clinically and compared with another line
recently described to evaluate the usefulness of both tools in the use
of computed tomography scans and magnetic resonance images. MATERIALS
AND METHODS: We reviewed 28 scans (15 computed tomography and 13
magnetic resonance) and used both lines to predict tumor location in the
parotid gland. The accuracy of each prediction was checked later by
referring to the surgical report. RESULTS: This new anatomic line helped
us to correctly predict tumor location in relation to the facial nerve
in 24 cases (85.7%), whereas the other line was helpful in 20 cases
(71.4%). CONCLUSION: Our new line may be a very useful tool to predict
the location of parotid gland tumors. Copyright 2002 American
Association of Oral and Maxillofacial Surgeons
24
UI - 11992371
AU - Hameed A; Gokden M; Hanna EY
TI -
Fine-needle aspiration cytology of a primary ectopic meningioma.
SO - Diagn Cytopathol 2002 May;26(5):297-300
AD - Department of Pathology, University of Arkansas for Medical Sciences,
4301 West Markham, Slot 517, Little Rock, AR 72205-7199, USA.
hameedarif@uams.edu
Meningiomas are benign tumors derived from arachnoid cells. Most
commonly an intracranial lesion, meningiomas may be found extracranially
in various anatomic sites. A 23-yr-old white female presented with
left-sided palpable mass located submucosally in the floor of the mouth.
CT scan revealed no evidence of mass elsewhere in the head and neck
region. Fine-needle aspiration cytology (FNAC) showed loose and cohesive
cellular fragments with lobular growth pattern and uniform round or
ovoid cells. The diagnosis of low-grade salivary gland neoplasm, not
further classified, was made. The tumor was locally excised. The
differential diagnoses of an extracranial meningioma and pleomorphic
adenoma were discussed at the frozen section. Based on light
microscopic, immunohistochemical, and electron microscopic (EM)
findings, the final diagnosis of an ectopic meningioma was rendered.
Ectopic meningiomas may pose a diagnostic challenge to clinicians and
cytopathologists. It is easily forgotten in the list of differential
diagnosis at an ectopic site. Primary ectopic meningioma in a region
containing salivary gland(s) may mimic benign and low-grade malignant
salivary gland tumors in FNAC. Copyright 2002 Wiley-Liss, Inc.
25
UI - 12169280
AU - Howlett DC; Kesse KW; Hughes DV; Sallomi DF
TI -
The role of imaging in the evaluation of parotid disease.
SO - Clin Radiol 2002 Aug;57(8):692-701
AD - Departments of Radiology, Eastbourne District General Hospital,
Eastbourne, U.K.
In this review the imaging features of a range of parotid lesions are
presented and the roles of ultrasound (US), computed tomography (CT) and
magnetic resonance imaging (MRI) in the assessment of parotid disease
are discussed.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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