National Cancer Institute®
Last Modified: September 1, 2002
UI - 12076327
AU - Castrilli G; Fabiano A; La Torre G; Marigo L; Piantelli C; Perfetti G;
TI - Ranelletti FO; Piantelli M Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in salivary gland tumors.
SO - J Oral Pathol Med 2002 Apr;31(4):234-8
AD - Department of Oncology, University of Chieti, Chieti, Italy.
BACKGROUND: The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation and maintaining genomic stability. The MMR system in human cells is composed of at least six genes (hMSH2, hMLH1, hMSH3, hPMS1, hPMS2 and GTBP/hMSH6). In particular, hMSH2 and hMLH1 are expressed in cells undergoing rapid renewal; their reduced expression has been reported in several tumors. METHODS: We examined the expression of hMSH2 and hMLH1 by immunohistochemistry in tumor specimens from 43 patients with primary tumors. RESULTS: All carcinomas (n = 20) expressed these proteins. In addition, when compared to pleomorphic adenomas, malignant tumors contained significantly (P < 0.01) higher proportions of hMSH2 (56.1 +/- 31.5 vs. 31.1 +/- 22.6) and hMLH1 (27.9 +/- 26.0 vs. 14.0 +/- 12.6) positive cells. Warthin's tumors showed no specific nuclear staining of tumor cells for both hMSH2 and hMLH1. CONCLUSIONS: These data suggest a minor, if any, role for a defect in the hMMR system in the pathogenesis of malignant salivary gland tumors.
UI - 12076329
AU - Maruyama S; Cheng J; Inoue T; Takagi R; Saku T
TI - Sebaceous lymphadenoma of the lip: report of a case of minor salivary gland origin.
SO - J Oral Pathol Med 2002 Apr;31(4):242-3
AD - Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
A case of sebaceous lymphadenoma occurring in the lip of a 73-year-old female is described. The patient had noticed a painless mass in the region of her upper lip for a year. The surgically removed tumor, measuring about 10 mm in diameter, was located just beneath the lip mucosa, expanding into the submucosal and muscle layer. Histologically, the tumor was well encapsulated and consisted of scattered round-shaped islands of small squamous epithelial cells with focal but apparent sebaceous differentiation in a background of lymphoid stroma. This is the first case report of sebaceous lymphadenoma of minor salivary gland origin.
UI - 12148853
AU - Park YW; Hlivko TJ
TI - Parotid gland metastasis from renal cell carcinoma.
SO - Laryngoscope 2002 Mar;112(3):453-6
AD - Department of Otolaryngology, Northeastern Ohio Universities College of Medicine, Summa Health System, Akron, USA. firstname.lastname@example.org
OBJECTIVE: To discuss the diagnosis and management of metastatic renal cell carcinoma presenting as a parotid mass by studying such cases. STUDY DESIGN: Retrospective review. METHODS: Identification of 24 previously reported cases of renal cell carcinoma metastatic to the parotid gland in the English language literature and an analysis of a total of 25 patients including our case. RESULTS: Parotid metastasis was the initial presenting sign of the malignancy in the kidney in 14 of 25 (56%) cases; 11 of 25 (44%) cases presented with metachronous metastasis to the parotid. The most common presenting complaint was parotid mass. No case presented with facial paralysis. In three of six (50%) patients, fine-needle aspiration biopsy was diagnostic. CONCLUSIONS: In the majority of cases, parotid metastases are the first clinical sign of the renal cell carcinoma. Fine-needle aspiration biopsy can provide crucial information without parotidectomy as in our case. Parotidectomy with facial nerve preservation should be considered as a therapeutic option for solitary parotid metastasis.
UI - 11876541
AU - Becelli R; Perugini M; Mastellone P; Frati R
TI - Surgical treatment of recurrences of pleomorphic adenoma of the parotid gland.
SO - J Exp Clin Cancer Res 2001 Dec;20(4):487-9
AD - Dept. of Maxillo Facial Surgery, University of Rome La Sapienza, Rome, Italy.
From 1989 to 1999 a retrospective study was conducted on 7 patients with recurrent pleomorphic adenomas of the parotid gland who were referred to the MaxilloFacial Department of the University of Rome "La Sapienza" after having undergone surgery elsewhere. The mean time interval between the first operation and recurrences ranged from 15 months to 13 years, and the average time interval was 7.7 years. Implantability of the lesion and inadequate surgery that produced rupture of tumour capsule and tumour cells bleeding into surrounding glandular parenchyma, were the reasons for tumour recurrence. The instrumental examinations used for planning the surgical treatment to be applied and for studying the relations of recurrence with glandular parenchyma were CT (with contrast medium) or MR of head and neck. These patients underwent total parotidectomy with facial nerve preservation and no recurrence occurred in any patient. The results of this study underscore the importance of adequate surgical excision of initial recurrences as well as primary tumours to prevent tumour recidivism. Finally, tumour control rates and facial nerve preservation are enhanced with formal parotidectomy for recurrent tumour when feasible.
UI - 12015493
AU - Yacoubi MT; Abdelkefi M; Mokni M; Njim L; Harzallah L; Korbi S
TI - [Diffuse pseudotumorous oncocytosis of the parotid gland. A case report]
SO - Ann Otolaryngol Chir Cervicofac 2002 Apr;119(2):89-92
AD - Departement de pathologie, Service d'Oto-rhino-Laryngologie, Service de radiologie, Hopital universitaire F. Hached, 4000 Sousse, Tunisie, France.
Pseudotumorous oncocytosis of the parotid gland is very uncommon and frequently misdiagnosed since it generally presents as a true tumor. The clinical presentation and imaging features of a 6-cm diameter left parotid mass led to the diagnosis of a tumor in a 73-year-old man. At pathology examination of the partial parotidectomy specimen the "tumor" was found to be a metaplastic oncocytic lesion. We discuss the diagnostic criteria, differential diagnosis, and etiopathogeny of this lesion.
UI - 11845042
AU - Kici S; Peytral C
TI - [Giant pleomorphic adenoma of the parotid gland: a case report and review of the literature]
SO - Ann Otolaryngol Chir Cervicofac 2001 Oct;118(5):330-2
AD - Service ORL et de chirurgie cervico-faciale, Centre Hospitalier Intercommunal Le Raincy-Montfermeil, 10 rue du General Leclerc, 93370 Montfermeil, France.
We report the case history of a 72-year-old patient who had a giant parotid adenoma that developed over 12 years. Worrisome clinical signs started to develop when the tumor had reached the size of 50 cm and a weight of 2.6 kg. Histology reported a benign tumor of the parotid gland. We discuss this case in relation to the to similar cases in the literature, highlighting clinical and histological difficulties encountered in patients with giant tumors of the parotid.
UI - 11764097
AU - Sandoval C; Schantz S; Posey D; Swift M
TI - Parotid and thyroid gland cancers in patients with ataxia-telangiectasia.
SO - Pediatr Hematol Oncol 2001 Dec;18(8):485-90
AD - Department of Pediatrics and Medicine and the Institute for the Genetic Analysis of Common Diseases, New York Medical College, Valhalla 10595, USA. email@example.com
This study describes the clinicopathologic features of parotid and thyroid gland cancers in patients with ataxia-telangiectasia (AT). The medical records of 412 AT patients were reviewed to identify those patients who developed parotid or thyroid gland cancers. Presenting features, diagnoses, types of therapy, risk factors, and other primary cancers were analyzed. Five patients with parotid or thyroid gland cancers were identified. Three had parotid (2 mucoepidermoid and 1 acinic cell) and 2 had thyroid gland (1 papillary and 1 follicular) cancers. Four patients presented with head and neck masses and 1 had an occult papillary thyroid carcinoma. Four patients had more than one primary cancer. The only mode of therapy was surgery. The 2 patients with mucoepidermoid carcinoma had complete parotidectomies. One is alive without any evidence of disease 12 months after diagnosis and 1 died of refractory lymphoma without any evidence of mucoepidermoid carcinoma at autopsy. The patient with acinic cell carcinoma had a parotid biopsy only. The 2 patients with thyroid cancer were diagnosed at autopsy. The results indicate that patients with AT are at risk for developing multiple primary cancers including those of the parotid and thyroid gland, and should be evaluated for such primaries.
UI - 12102409
AU - Caccamese JF Jr; Ord RA
TI - Paediatric mucoepidermoid carcinoma of the palate.
SO - Int J Oral Maxillofac Surg 2002 Apr;31(2):136-9
AD - Division of Oral and Maxillofacial Surgery, University of Maryland Medical Systems, Baltimore 21201, USA. firstname.lastname@example.org
The purpose of this paper is to review our experience with mucoepidermoid carcinoma (MEC), a rare tumour in minor salivary glands, in a small series of paediatric patients. A retrospective analysis of these, five (9%) occurred in children. There were 23 cases of MEC, four (17%) of which occurred in patients under the age of 18 who presented with T1 or T2N0M0 low- to intermediate-grade MEC of the palate and adjacent structures. These patients form the basis of this study. All patients were treated with wide local excision, obtaining tumour-free margins, and followed for a mean number of 58 months. None of these tumours invaded bone and resection of bone was not performed in any case as the periosteum was intact and the tumours were low to intermediate grade. To date, all patients remain free of disease. One patient who went elsewhere for treatment, was treated with local resection only, and has also experienced no recurrence. Wide local excision is the treatment of choice for low to intermediate grade MEC of the minor salivary glands in paediatric patients.
UI - 12110337
AU - Sobral AP; Loducca SV; Kowalski LP; Santos IR; Almeida OP; Araujo NS;
TI - Araujo VC Immunohistochemical distinction of high-grade mucoepidermoid carcinoma and epidermoid carcinoma of the parotid region.
SO - Oral Oncol 2002 Jul;38(5):437-40
AD - Oral Pathology Department, School of Dentistry, Sao Paulo University, Brazil.
The correct diagnosis of high-grade mucoepidermoid (MEC), which is composed of solid islands of intermediate and squamous cells, may be challenging, due to its similarity to other tumours, mainly with squamous cell carcinoma (SCC). The present report employed immunohistochemical technique against different cytokeratins (CKs), in order to differentiate these two entities. : Six high-grade MEC and six SCC of the parotid region, retrieved from the files of both Oral Pathology Department of the School of Dentistry of University of Sao Paulo and Pathology Department of A.C. Camargo Hospital, were submitted immunohistochemical technique against Cks 7,8, 10, 13, 14 and 19. : High-grade MEC was positive for Cks 7, 8, 13, 14 and 19. The cases of SCC showed strong positivity for CK14, and CK10 was present only in focal areas. Our results highlight the use of CKs (especially CK14) to differentiate high-grade MEC and SCC.
UI - 10420226
AU - Croitoru CM; Suarez PA; Luna MA
TI - Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature.
SO - Arch Pathol Lab Med 1999 Aug;123(8):698-702
AD - Department of Pathology, University of Texas Medical School, Houston 77030, USA.
OBJECTIVE: To report 4 cases of hybrid carcinoma and to review the literature on these rare neoplasms of the salivary gland. METHODS: Hematoxylin-eosin-stained, formalin-fixed, paraffin-embedded tissue sections from 3 parotid tumors and 1 palate tumor were examined. RESULTS: The cases were classified as adenoid cystic and mucoepidermoid carcinoma, adenoid cystic and epithelial-myoepithelial carcinoma, epithelial-myoepithelial and salivary duct carcinoma, and adenoid cystic and salivary duct carcinoma. All patients were men, 28 to 71 years old; 3 patients presented with parotid mass, and 1 patient presented with palatal mass. One patient presented with facial nerve paralysis and pain. The soft palatal tumor was a slowly growing mass with maxillary sinus involvement at the time of the diagnosis. All patients were treated with surgery and radiotherapy. CONCLUSIONS: Correct identification of 2 or more neoplastic entities will help assess the aggressiveness and metastatic potential of the tumor and influence the clinical course and treatment.
UI - 12112535
AU - Vered M; Braunstein E; Buchner A
TI - Immunohistochemical study of epidermal growth factor receptor in adenoid cystic carcinoma of salivary gland origin.
SO - Head Neck 2002 Jul;24(7):632-6
AD - Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
BACKGROUND: Epidermal growth factor (EGF) and its receptor (EGFR) are involved in the development of salivary gland tumors. Recently, treatment modalities for EGFR inhibition have shown an enhanced clinical response in carcinomas of different locations. Adenoid cystic carcinoma (ACC) of salivary gland origin is a malignant tumor with a poor long-term outcome. If salivary gland ACC does exhibit EGFR, then immunotherapy could have a major impact on improving its prognosis. METHODS: The study consisted of 34 samples of formalin-fixed, paraffin-embedded specimens of salivary gland ACC. Specimens were stained with a mouse antihuman monoclonal antibody for immunohistochemical detection of EGFR. Overlying oral mucosa and adjacent normal salivary ducts served as internal controls. Both membrane and cytoplasmic staining were evaluated. Staining score was calculated by multiplying the percentage of positively stained tumor cells by the intensity of the staining. The highest score for a given tumor was equal to 2. RESULTS: In the final analysis, 27 of the 34 specimens were included; 7 were excluded, because the internal control did not reveal any staining. Of these 27 specimens, 23 (85%) stained positively for EGFR with a staining score of 0.05 to 1.8. Three palatal tumors attained the highest scores (one tumor, 1.2, and the remaining two, 1.8). CONCLUSIONS: Most salivary gland ACC stained positively for EGFR, and in some the staining was quite intense. On the basis of the already proven antitumoral effect of agents acting as EGFR inhibitors, it is suggested that patients with ACC might benefit from these agents, especially when surgery has failed or in those with recurrent or metastatic disease. Copyright 2002 Wiley Periodicals
UI - 12006762
AU - Teymoortash A; Werner JA
TI - Value of neck dissection in patients with cancer of the parotid gland and a clinical NO neck.
SO - Onkologie 2002 Apr;25(2):122-6
AD - Klinik fur Hals-, Nasen- und Ohrenheilkunde der Philipps-Universitat Marburg, Germany.
Cervical lymph node metastases in patients with parotid gland carcinoma are not rare. Regional metastases have a significant influence on the prognosis of these patients. In spite of the clinical relevance of lymphogenous metastases, the indications for elective treatment of the neck are not well defined. In the present review the controversies and therapeutical strategies of ipsilateral neck lymph nodes and their extension in patients with potential occult lymph node metastases are discussed. On the basis of the published data, in consideration of the direction of lymphogenous metastatic spread of parotid gland carcinomas, an elective neck dissection is recommended in carcinomas with high percentage of lymphatic spread also in the N0 neck. Consideration of additional parameters (> T2, lymphangiosis carcinomatosa) is appropriate to perform also a neck dissection in carcinomas with low risk for lymphogenous metastases. An elective neck dissection should include levels I, II, III and upper V. Copyright 2002 S. Karger GmbH, Freiburg
UI - 12210032
AU - Korkmaz H; Yoo GH; Du W; Hocwald E; Otero-Garcia JE; Volkan Adsay N;
TI - Shibuya T; Jacobs JR Predictors of nodal metastasis in salivary gland cancer.
SO - J Surg Oncol 2002 Aug;80(4):186-9
AD - Department of Otolaryngology-Head and Neck Surgery, Karmanos Cancer Institute Wayne State University, Detroit, Michigan 48201, USA.
OBJECTIVES: This study was conducted to determine clinical and histologic factors that would predict nodal metastasis in patients with major salivary gland cancer. METHODS: A retrospective study of 40 patients who underwent surgery, including neck dissection, for major salivary gland cancer between 1975 and 1997 was performed. Patient charts were reviewed, and clinical and pathologic data were extracted along with outcome. Predictive factors were identified and survival curves were obtained. RESULTS: Neck dissections were performed in 40 patients, which revealed histologic evidence of tumor in lymph nodes in 15 cases. Histologically proven metastasis was found in 16% of specimens from elective and 73% of specimens from therapeutic neck dissection. Five-year overall and locoregional disease-free survival rates for histologically positive and negative groups were 40% versus 63% (P < 0.05) and 67% versus 69% (P = 0.59), respectively. Univariate analysis of the factors revealed that clinical evidence of nodal metastasis (P < 0.001) and high-grade cancer (P < 0.033) predicted histologic nodal involvement. Multivariate analysis revealed that only a positive neck examination was a significant predictive factor (OR = 31, 95%CI = 2.99-312). CONCLUSIONS: Our results suggest that clinical neck examination is a reliable predictor of regional metastasis in patients with major salivary gland cancer. In view of the low frequency of occult metastases, routine elective treatment of the neck is not recommended. Copyright 2002 Wiley-Liss, Inc.
UI - 10891390
AU - Aota K; Azuma M; Yamashita T; Tamatani T; Motegi K; Ishimaru N; Hayashi
TI - Y; Sato M 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells.
SO - Biochem Biophys Res Commun 2000 Jul 14;273(3):1168-74
AD - Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima, 770-8504, Japan.
Activation of the transcription factor NF-kappaB results in protection against apoptosis, and the chemotherapeutic agent 5-Fluorouracil (5-FU) exerts its cytotoxic effect through the induction of apoptosis. Thus, we examined whether 5-FU could induce apoptosis through the suppression of NF-kappaB activity. We found that upon treatment of a human salivary gland cancer cell line (cl-1) with 5-FU, the NF-kappaB activity was suppressed in a time-dependent manner. This inhibition was mediated by a prevention of the degradation of the inhibitory IkappaB-alpha protein. In addition, the expression of TRAF-2 and cIAP-1, which are transcriptionally regulated by NF-kappaB and function as anti-apoptotic molecules through the interruption of caspase pathway, was also inhibited by 5-FU. Finally, the activity of caspase-8 and caspase-3 showed a significant increase in response to 5-FU. By flow cytometric analysis, 5-FU did not affect the expression level of Fas on the cell surface. Thus, our results suggest that one of the molecular mechanisms involved in 5-FU-induced apoptosis in cl-1 cells may be due to the suppression of NF-kappaB activity, resulting in the activation of the pro-apoptotic pathway. Copyright 2000 Academic Press.
UI - 12168949
AU - Tralongo V; Becchina G; Genovese F; Nagar C; Ottoveggio G; Pinto G
TI - Polymorphous low-grade adenocarcinoma of the salivary glands: clinicopathological and immunohistochemical study of a case.
SO - Anticancer Res 2002 Mar-Apr;22(2B):1347-52
AD - Servizio di Anatomia ed Istologia Patologica e Citopatologia, Presidio Ospedaliero G.F. Ingrassia-Azienda, Palermo, Italy. email@example.com
Polymorphous low-grade adenocarcinoma (PLGA) is a distinctive salivary gland neoplasm with a predilection for intraoral sites. Histological and immunohistochemical analyses were used to study a case involving the minor salivary glands of the buccal mucosa in a 68-year-old woman. Histologically, the tumor was characterized by unenca-psulated, progressing and focally-infiltrative borders and showed variable growth patterns including solid, tubular, microcystic and cribriform; papillary and papillary-cystic areas of more than focal extent were present. Cytologically the neoplasm was composed of uniform, round to cuboidal cells with bland, round to oval nuclei. Immunohistochemical analysis showed that the tumor cells were positive for cytokeratin, S-100 protein, vimentin, focally-positive for EMA and actin and negative for CEA. The significance of the papillary component and the possible relationship to other salivary gland tumors is discussed.
UI - 12108041
AU - Debniak E; Jozefowicz-Korczynska M; Lukomski M
TI - [The analysis of treatment methods in patients with parotid gland cancer]
SO - Przegl Lek 2002;59(1):17-20
AD - Katedra i Klinika Otolaryngologii Akademii Medycznej w Lodzi.
The analysis of 105 patients treated due to parotid gland cancer was performed. The choice of the treatment method depends on the tumor's histological type and the advancement of the clinical stage. Clinical observation and statistic evaluation proved that the best treatment method was surgical procedure, in some cases supplemented with radio- and chemiotherapy.
UI - 12138357
AU - Facius M; Malich A; Schneider G; Boehm T; Anderson R; Kaiser WA
TI - Electrical impedance scanning used in addition to ultrasound for the verification of submandibular and parotid lesions: initial results.
SO - Invest Radiol 2002 Aug;37(8):421-7
AD - Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Jena, Germany. firstname.lastname@example.org
OBJECTIVES: Different dielectric properties of cancerous tissues are correlated with increased conductance potentially measurable using Electrical Impedance Scanning (EIS). Sonographically based differentiation of lesions in the salivary glands remains difficult. The clinical value of EIS used additionally to Ultrasound was investigated. METHODS: Sonographically suspicious lesions of parotid (n = 25) and submandibular (n = 16) glands were examined using TransScan TS2000 (TransScan Medical, Israel; distributed by Siemens, Sweden). Bright focal spots representing areas of high conductance were read as positive; absence of a focal spot (ie, homogeneous gray) was read as negative. All lesions were histopathologically proved. RESULTS: 14/15 malignant (93.3%) and 13/26 benign lesions (50.0%) were correctly detected using EIS, NPV 93%, PPV 52%. All cases of squamous cell carcinoma were correctly identified. Lymph node relapse of T-cell lymphoma, lymph node relapse of malignant melanoma, malignant hemangioendothelioma and 2/3 adenocystic carcinoma (primary metastases) were correctly detected. CONCLUSIONS: Our initial results suggest EIS to be of interest when used adjunctively to ultrasound for the identification of malignant lesions of the salivary glands. However, low specificity induced in part by current technical restrictions (bone interference, skin alterations, contact artifacts, prominence of the lesions) limit this clinical application.
UI - 12180215
AU - Bhalla RK; Murphy J; Jones TM; Roland NJ
TI - Foreign body reaction to calcium alginate fibre mimicking recurrent tumour of the submandibular salivary gland.
SO - Br J Oral Maxillofac Surg 2002 Apr;40(2):172-4
AD - Department of Otolaryngology and Head & Neck Surgery, University Hospital Aintree, Liverpool, UK.
A 50-year-old woman was referred after the discovery of adenoid cystic carcinoma in an excised left submandibular gland. Treatment involved clearance of the left submandibular fossa, and bilateral levels II and III selective neck dissections. A left-sided submandibular haematoma developed during the immediate postoperative period. After removal of the clot, there was a persistent, low volume capillary ooze from the left submandibular fossa and a calcium alginate fibre pack (Kaltostat) was left in place to control the bleeding. After an extended period of time the pack excited a foreign body reaction which, on a computed tomogram, mimicked a recurrence of the tumour. We review the role of Kaltostat in this setting and its potential for foreign body reaction, which may mimic serious disease.
UI - 12215996
AU - Bhalla RK; Jones TM; Taylor W; Roland NJ
TI - Carcinosarcoma (malignant mixed tumor) of the submandibular gland: A case report and review of the literature.
SO - J Oral Maxillofac Surg 2002 Sep;60(9):1067-9
AD - Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, England. DrRKBhalla@doctors.org.uk
UI - 12215980
AU - de Ru JA; van Benthem PP; Hordijk GJ
TI - The location of parotid gland tumors in relation to the facial nerve on magnetic resonance images and computed tomography scans.
SO - J Oral Maxillofac Surg 2002 Sep;60(9):992-4; discussion 995
AD - Department of Otorhinolaryngology, University Medical Center Utrecht, The Netherlands. J.A.deRu@KMB.AZU.NL
PURPOSE: The facial nerve, which cannot be visualized radiographically in its intraparotid part, divides the parotid gland into 2 lobes. When planning surgery, it is important to know where to locate a parotid gland tumor in relation to the facial nerve, because the location can influence the duration and difficulty of the operation. In this study, an anatomic line that predicts the course of the facial nerve in the parotid gland, is applied clinically and compared with another line recently described to evaluate the usefulness of both tools in the use of computed tomography scans and magnetic resonance images. MATERIALS AND METHODS: We reviewed 28 scans (15 computed tomography and 13 magnetic resonance) and used both lines to predict tumor location in the parotid gland. The accuracy of each prediction was checked later by referring to the surgical report. RESULTS: This new anatomic line helped us to correctly predict tumor location in relation to the facial nerve in 24 cases (85.7%), whereas the other line was helpful in 20 cases (71.4%). CONCLUSION: Our new line may be a very useful tool to predict the location of parotid gland tumors. Copyright 2002 American Association of Oral and Maxillofacial Surgeons
UI - 11992371
AU - Hameed A; Gokden M; Hanna EY
TI - Fine-needle aspiration cytology of a primary ectopic meningioma.
SO - Diagn Cytopathol 2002 May;26(5):297-300
AD - Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 517, Little Rock, AR 72205-7199, USA. email@example.com
Meningiomas are benign tumors derived from arachnoid cells. Most commonly an intracranial lesion, meningiomas may be found extracranially in various anatomic sites. A 23-yr-old white female presented with left-sided palpable mass located submucosally in the floor of the mouth. CT scan revealed no evidence of mass elsewhere in the head and neck region. Fine-needle aspiration cytology (FNAC) showed loose and cohesive cellular fragments with lobular growth pattern and uniform round or ovoid cells. The diagnosis of low-grade salivary gland neoplasm, not further classified, was made. The tumor was locally excised. The differential diagnoses of an extracranial meningioma and pleomorphic adenoma were discussed at the frozen section. Based on light microscopic, immunohistochemical, and electron microscopic (EM) findings, the final diagnosis of an ectopic meningioma was rendered. Ectopic meningiomas may pose a diagnostic challenge to clinicians and cytopathologists. It is easily forgotten in the list of differential diagnosis at an ectopic site. Primary ectopic meningioma in a region containing salivary gland(s) may mimic benign and low-grade malignant salivary gland tumors in FNAC. Copyright 2002 Wiley-Liss, Inc.
UI - 12169280
AU - Howlett DC; Kesse KW; Hughes DV; Sallomi DF
TI - The role of imaging in the evaluation of parotid disease.
SO - Clin Radiol 2002 Aug;57(8):692-701
AD - Departments of Radiology, Eastbourne District General Hospital, Eastbourne, U.K.
In this review the imaging features of a range of parotid lesions are presented and the roles of ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) in the assessment of parotid disease are discussed.
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