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NCI CANCERLIT® Search: Hairy Cell Leukemia - September 2002
National Cancer Institute®
Last Modified: September 1, 2002
- Epithelioid microgranulomas after Pentostatin therapy in hairy cell leukaemia.
- Efficacy of anti-CD20 monoclonal antibodies (Mabthera) in patients with progressed hairy cell leukemia.
- Reactive polyclonal T-cell lymphocytosis mimicking Sezary syndrome in a patient with hairy cell leukemia.
Table of Contents
1
UI - 12010371
AU - Sironi M; Lodato A; Sciariada L; Spinelli M
TI -
Epithelioid microgranulomas after Pentostatin therapy in hairy cell
leukaemia.
SO - Histopathology 2002 May;40(5):483-5
2
UI - 11602410
AU - Lauria F; Lenoci M; Annino L; Raspadori D; Marotta G; Bocchia M; Forconi
TI -
F; Gentili S; La Manda M; Marconcini S; Tozzi M; Baldini L; Zinzani PL;
Foa R
Efficacy of anti-CD20 monoclonal antibodies (Mabthera) in patients with
progressed hairy cell leukemia.
SO - Haematologica 2001 Oct;86(10):1046-50
AD - Department of Hematology "A. Sclavo" Hospital, via Tufi 1, 53100 Siena,
Italy. lauria@unisi.it
BACKGROUND AND OBJECTIVES: Recently, a chimeric monoclonal antibody
(MoAb) directed against the CD20 antigen (rituximab) has been
successfully introduced in the treatment of several CD20-positive B-cell
neoplasias and particularly of follicular lymphomas. Based on these
premises we evaluated the efficacy and the toxicity of chimeric
anti-CD20 monoclonal antibody (MoAb) in relapsed/progressed hairy cell
leukemia (HCL). DESIGN AND METHODS: Ten patients with
relapsed/progressed HCL entered the study. Eight patients were males and
two females with a median age of 55 years (range 41-78) and all of them
had been previously treated with 2-chlorodeoxyadenosine and/or
deoxycoformycin and a-interferon. Two out of 10 patients were anemic (Hb
< 10 g/dL), 4 thrombocytopenic (Plt < 100 x 10(9)/L), 3 had fewer than
1.0 x 10(9)/L neutrophils and 3 had circulating hairy cells (HC). All
patients received 375 mg/m2 i.v. of anti-CD20 MoAb once a week for 4
doses. RESULTS: All patients were evaluable for response, one patient
showing a complete remission and 4 a partial response. Adverse
reactions, such as fever, chills, bone pain, hypotension and
thrombocytopenia, were transient and mild (grade 1-2) and occurred only
during the first course of treatment. One month after the last infusion,
patients who had had anemia, neutropenia or thrombocytopenia, recovered
normal peripheral blood values. Circulating HC also disappeared within
one month. Immunostained bone marrow biopsies were checked 1, 3 and 6
months after the end of therapy and in 5 out of 10 patients a >50%
reduction of bone marrow HC infiltration was recorded. INTERPRETATION
AND CONCLUSIONS: On the basis of these preliminary results observed in
10 patients with progressed HCL, it appears that treatment with
anti-CD20 MoAb is safe and effective in at least 50% of patients,
particularly in those with a less evident bone marrow infiltration (50%)
and in those previously splenectomized.
3
UI - 11602434
AU - Wulf GG; Schulz H; Hallermann C; Kunze E; Wormann B
TI -
Reactive polyclonal T-cell lymphocytosis mimicking Sezary syndrome in a
patient with hairy cell leukemia.
SO - Haematologica 2001 Oct;86(10):E27
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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