National Cancer Institute®
Last Modified: September 1, 2002
UI - 12190215
AU - Carver BS; Mata JA; Venable DD; Eastham JA
TI - Squamous cell carcinoma of the penis: a retrospective review of forty-five patients in northwest Louisiana.
SO - South Med J 2002 Aug;95(8):822-5
AD - Department of Urology, Louisiana State University Health Science Center, Shreveport 71130, USA.
BACKGROUND: Squamous cell carcinoma of the penis is a rare malignancy in the United States, accounting for only 0.4% of all cancers in men. treated for squamous cell carcinoma of the penis at our institution. Their medical records were reviewed retrospectively. RESULTS: The mean age at diagnosis was 63 years; 62% were white and 38% African American. Eighty-nine percent of our population was uncircumcised. Twenty patients had primary ilioinguinal lymph node dissections, with 11 positive for squamous cell carcinoma. Follow-up was documented for 42 patients, with a mean of 47 months. Four patients had local penile recurrence at a mean of 22 months after initial treatment. Nine patients had died of penile carcinoma at a mean of 18 months. CONCLUSION: Squamous cell carcinoma of the penis accounts for 0.3% of malignancies in men seen at our institution. Nodal metastasis was a poor prognostic indicator. Although local penile recurrence was rare (8.8%), patients should be counseled on the importance of self-examination.
UI - 12100215
AU - Nijsten TE; Stern RS
TI - Genital squamous cell carcinoma in men treated by photochemotherapy. A cancer registry-based study from 1978 to 1998.
SO - Br J Dermatol 2002 Jul;147(1):184-5; discussion 185-6
UI - 12108356
AU - Buffet M; Aynaud O; Piron D; Dupin N; Escande JP
TI - [Buschke-Lowenstein penile tumor]
SO - Prog Urol 2002 Apr;12(2):332-6
AD - Service de Dermatologie-venereologie, Groupe Hospitalier Tarnier-Cochin.
The Buschke-Lowenstein genital tumour is a poorly defined, uncommon tumour. The distinction between benign lesions, potentially malignant lesions and carcinomatous lesions is difficult. The authors report a case of Human Papillomavirus (HPV) 11-associated Buschke-Lowenstein tumour with an area of micro-invasive carcinoma on histological examination of the surgical resection specimen. A 34-year-old patient was operated for recurrent condylomatous lesions of the penis with scrotal extension. Histological examination of the complete operative specimen confirmed the presence of Buschke-Lowenstein tumour as well as an area of dermal micro-invasion on one section. Molecular hybridization revealed the presence of HPV 11 DNA and immunohistochemistry showed basal cells weakly expressing mutant p53. The classification of Buschke-Lowenstein tumours is controversial. Some authors consider these tumours to be benign tumours or giant condylomata (non-metastatic, associated with HPV 6-11), while others consider these tumours to be borderline malignant (local extension and risk of progression to invasive carcinoma). The role of HPV as cofactor involved in carcinomatous transformation also remains controversial. The authors emphasize the need for surgical resection of this type of tumour with histological examination of the entire operative specimen looking for areas of micro-invasion. In the presence of micro-invasion with healthy resection margins and staging by clinical examination and complementary investigations, treatment essentially consists of regular surveillance.
UI - 1321267
AU - Iftner T; Oft M; Bohm S; Wilczynski SP; Pfister H
TI - Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium.
SO - J Virol 1992 Aug;66(8):4639-46
AD - Institut fur Klinische und Molekulare Virologie, Friedrich Alexander Universitat Erlangen-Nurnberg, Germany.
The E6 and E7 genes of human genital papillomaviruses (HPVs) appear to transform cells by different mechanisms. They seem to act synergistically but are not equally important when tested under diverse experimental conditions. We were therefore tempted to investigate the E6- and E7-specific transcription pattern in HPV6-infected condylomas separately, by in situ hybridization. Recent studies have identified three promoters within the E6-E7 region of HPV6 and HPV11 by applying S1, exonuclease VII, and cDNA analyses. On the basis of these data, we cloned subgenomic fragments of HPV6 into plasmid pBS to obtain riboprobes that differentiated between transcripts starting upstream of the E6 and E7 open reading frames, respectively. These different species of mRNAs were analyzed in serial thin sections of eight HPV6-positive anogenital condylomas. The E6 probe (nucleotides 7862 to 241) led to weak signals within the basal layer. In three cases, rather strong signals were confined to a few basal cells. The E7 probe (nucleotides 242 to 534) gave rise to a more pronounced labeling of all cells within the two to three lowest epidermal layers. In situ hybridization with a riboprobe for human c-fos revealed an expression pattern similar to that observed with the E7 probe. In contrast to the preferential expression of the transforming E6 and E7 genes in the lower epithelium, the major transcriptional activity of the virus was detected in the middle and upper third by probes colinear with the 3' moiety of the early region.
UI - 12174420
AU - Gallo Rolania FJ; Beneitez Alvarez ME; Izquierdo Garcia FM
TI - [The role of inguinal lymphadenectomy in epidermoid carcinoma of the penis. Use of Ligasure and analysis of the results]
SO - Arch Esp Urol 2002 Jun;55(5):535-8
AD - Servicio de Urologia, Hospital de Leon, Leon, Espana.
OBJECTIVE: To compare the morbidity of conventional inguinal lymphadenectomy for epidermoid carcinoma of the penis using ligation versus ultrasonic sealing of the lymph nodes with Ligasure. METHODS: 29 cases of carcinoma of the penis are analyzed; 8 underwent superficial and deep inguinal lymphadenectomy using the conventional procedure for ligation of lymph nodes (4 cases) and ultrasonic ligation with Ligasure (4 cases). The early and late complications are analyzed. RESULTS: The operating time was found to be significantly shorter in patients treated with Ligasure, no lymphoceles were observed and lymphedema was reduced. CONCLUSIONS: The use of Ligasure for sealing the lymphatic vessels in inguinal lymphadenectomy for carcinoma of the penis appears to have the advantages of a shorter operating time and reduced complications in comparison with conventional ligation.
UI - 12145439
AU - Kaspari M; Gutzmer R; Kiehl P; Dumke P; Kapp A; Brodersen JP
TI - Imiquimod 5% cream in the treatment of human papillomavirus-16-positive erythroplasia of Queyrat.
SO - Dermatology 2002;205(1):67-9
AD - Department of Dermatology and Allergology, Hannover Medical University, Germany. email@example.com
Erythroplasia of Queyrat is a human-papillomavirus-associated carcinoma in situ of the penis. Imiquimod, a new topically applied immunomodulatory agent, has been successfully used in the treatment of anogenital warts. We report the complete clearance of HPV-16-positive erythroplasia of Queyrat with 5% imiquimod cream. Copyright 2002 S. Karger AG, Basel
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