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NCI CANCERLIT® Search: Thyroid Cancer - October 2002
National Cancer Institute®
Last Modified: October 1, 2002
- Monitoring isotretinoin therapy in thyroid cancer using 18F-FDG PET.
- Preoperative localization of parathyroid adenomas: the protagonist's view.
- Preoperative localization of parathyroid adenomas: the antagonist's view.
- Preoperative localization of parathyroid adenomas: cost-effective or just costly?
- Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.
- 123 I as a diagnostic tracer in the management of thyroid cancer.
- Effects of irradiation on 99m Tc sestamibi and 201Tl uptake in a human papillary thyroid carcinoma cell line.
- Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
- Quantitative analysis of thymosin beta-10 messenger RNA in thyroid carcinomas.
- Incidence of thyroid cancer in women in relation to reproductive and hormonal factors.
- New attempt of preoperative differential diagnosis of thyroid neoplasms by telomerase activity measurement.
- [Benign thyroid disease and cancer in our environment]
- [Carcinoma of the thyroid gland. Correlation between diagnostic tests and pathogenic anatomy]
- [Epidemiology of thyroid cancer in Poland]
- [Occurrence of papillary and follicular thyroid cancer among Silesian women]
- [The role of fine needle biopsy in diagnosis of thyroid cancer]
- [Evaluation of thyroid cancer morbidity in Warsaw in 1987-1997]
- [Thyroid cancer morbidity in the Olsztyn region in 1993-1999]
- [Incidence of thyroid cancer in children and adolescents in Bialorus after the Chernobyl catastrophe in 1986]
- [Ionizing radiation as a risk factor for thyroid cancer in Krakow and Nowy Sacz regions]
- [Biological risk factors for differentiated thyroid cancer]
- [Iodine deficiency and thyroid neoplasms in the Krakow region]
- [Geographic differences in iodine supply in the Silesia terrain in relation to thyroid cancer risk]
- [Evaluation of surgical treatment results in patients with differentiated thyroid cancer from materials in the Oncologic Institute
- [Radical surgical treatment of differentiated thyroid cancer--necessity or over-enthusiasm?]
- [Cervical lymph node surgery in differentiated thyroid cancer: selective or elective lymphadenectomy?]
- [Should cervical lymph nodes be electively removed in differentiated thyroid carcinoma?]
- [Current views on diagnostic standards and treatments with L-thyroxine of single non-toxic thyroid nodules or multinodular non-toxic goiter]
- [Early evaluation of results after total thyroidectomy in patients with thyroid cancer]
- [Evaluation of results after repeated radical surgery for differentiated thyroid cancer]
- [Clinical picture of differentiated thyroid carcinoma in the T1 stage]
- [Problems associated with general anesthesia in patients with thyroid cancer]
- [Significance of intraoperative isotope detection in primary and secondary radical surgical treatment of thyroid cancer]
- [Possibilities and limitations of intraoperative isotope detection for thyroid carcinoma]
- [Indications for adjuvant therapy of thyroid cancer with radioiodine therapy]
- [Radiobiologic basis for using 131I to treat patients with thyroid cancer]
- [Early evaluation of treatment effectiveness using 131I iodine radiotherapy in patients with differentiated thyroid cancer]
- [Use of recombinant human TSH for stimulation of iodine radioisotope uptake in metastases of thyroid cancer during therapy with 131I]
- [Non-iodine-absorbing metastasis of differentiated thyroid cancer--therapeutic probe with 13-cis retinoic acid]
- [Use of 13-cis retinoic acid for treatment of advanced differentiated thyroid cancer]
- [Problems with radiation protection for adjuvant radiotherapy of thyroid cancer]
- [Power Doppler as a method that is better than color Doppler for evaluation of thyroid nodular lesions]
- [Environmental radiation exposure of a thyroid cancer patient resulting from adjuvant iodine radiotherapy]
- [Clinical-pathomorphologic preparation of patients after surgical treatment of differentiated thyroid cancer to adjuvant treatment with
- [The role of teleradiotherapy in treatment of thyroid cancer]
- [Prospective analysis of criteria for interpreting measurements of thyroglobulin serum concentration during conditions of endogenous TSH
- [Comparison of efficacy of various methods of thyroglobulin measurements in differentiated thyroid cancer]
- [Thyroglobulin RT-PCR method for detection of lymph node metastases during the course of differentiated thyroid cancers]
- [99mTc Tetrofosmin in diagnosis of distant metastases from differentiated thyroid cancer]
- [Accuracy of ultrasound-guided fine-needle aspiration biopsy in diagnosis of changes in thyroid nodular lesions]
- [Evaluation of the relationship between chosen factors and results of whole body scintigraphy with 131I in patients with differentiated
- [Treatment with L-thyroxine for differentiated thyroid carcinoma]
- [Evaluation of effects of L-thyroxine therapy in differentiated thyroid carcinoma on the cardiovascular system --prospective study]
- [Evaluation of bone density in women after thyroid cancer surgery and treatment with suppressive doses of L-thyroxine]
- [Hormonal replacement therapy in women after surgery for thyroid cancer treated with suppressive doses of L-thyroxine]
- [Pregnancy in women with thyroid cancer treated with suppressive doses of L-thyroxine]
- [Parathyroid hypofunction after total thyroidectomy for differentiated thyroid carcinoma--perspectives after long term observation and
- [Consequences of clinical genetic analysis of RET proto-oncogene]
- [Proto-oncogene RET somatic mutations in medullary thyroid carcinoma]
- [Differential criteria between papillary and follicular thyroid carcinoma--initial conclusions from a multicenter trial]
- [Results of treating medullary thyroid carcinoma: the differences between sporadic and inherited forms]
- [Medullary thyroid carcinoma--personal observations]
- [Diagnosis and treatment of malignant thyroid neoplasms. Recommendations of the Scientific Committee of the 2nd Scientific Conference "Thyroid
- [Criteria for histopathologic diagnosis of thyroid cancer in a quick test of accuracy]
- [Prognostic significance of selected oncogene and suppressor gene expression in follicular thyroid carcinoma]
- [Poorly differentiated carcinoma of the thyroid--immunohistochemical evaluation of p53 and p27 protein expression]
- [Expression of protein p53: the marker of low neoplastic cell differentiation in thyroid carcinoma]
- Thyroid surgery--the Tan Tock Seng Hospital otolaryngology experience.
- Technetium-99m methoxyisobutylisonitrile imaging in the follow-up of differentiated thyroid carcinoma.
- Novel diagnostic and therapeutic approaches in medullary carcinoma of thyroid: emerging role of nuclear medicine in its management.
- [Hurthle cell thyroid carcinoma: report of 13 cases]
- Complementary role of 18F-fluorodeoxyglucose positron emission tomography and 131I scan in the follow-up of post-therapy differentiated
- [Dysfunction of calcium metabolism following resection of the thyroid gland. An analysis of important risk factors]
- [Is the timing of completion thyroidectomy for differentiated thyroid carcinoma prognostic significant?]
- [Patient selection criteria for single-sided or minimal invasive operative procedures in primary hyperparathyroidism (pHPT)]
- Testicular dose and fertility in men following I(131) therapy for thyroid cancer.
- [Our trend in conservative surgery in differentiated carcinoma of the thyroid]
- Gonadal damage from 131I therapy for thyroid cancer.
- The sestamibi scan as a preoperative screening tool.
- The helix-loop-helix transcription factor, Id-1, is overexpressed in medullary thyroid cancer.
- Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma.
- Outcome and toxicity associated with maximum safe dose radioiodine treatment of metastatic thyroid cancer.
- Benign solitary solid cold thyroid nodules: US-guided interstitial laser photocoagulation--initial experience.
- Ultrasonographic contrast agent: evaluation of time-intensity curves in the characterisation of solitary thyroid nodules.
- [Malignant thyroid lymphoma--diagnostic and treatment problems]
- Dose-response relationship for parathyroid adenoma after exposure to ionizing radiation in infancy.
- Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression.
- Intracranial metastatic parathyroid carcinoma: case report.
- Consistent decrease in telomere length in parathyroid tumors but alteration in telomerase activity limited to malignancies: preliminary
- [Drainage after thyroid surgery: 264 patients]
- [Video-assistive minimally invasive surgical procedures in the treatment of thyroid in children and adolescents]
- Comparison of primary thyroid lymphoma with anaplastic thyroid carcinoma on computed tomographic imaging.
- Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma.
- Why there is the tendency to "overdiagnose" the follicular variant of papillary thyroid carcinoma.
- Follicular-patterned lesions of the thyroid: the bane of the pathologist.
- Correlation between morphology of colonies formed by human thyroid tumor cells in collagen gel culture and invasive ability.
- Characteristics of follicular cell-derived thyroid carcinomas occurring after external radiation exposure: results of a case control study
- Thyroid cancer yield in patients with Graves' disease selected for surgery on the basis of cold scintiscan defects.
- Contralateral papillary thyroid cancer-high incidence in therapeutic completion thyroidectomy.
- Use of fractionated doses of iodine-131 for ablation of thyroid remnants.
- Evidence-based criteria for adequacy in thyroid fine-needle aspiration.
- Follicular thyroid carcinoma: prognostic factors and the role of radioiodine.
- Differentiated thyroid carcinoma in children and adolescents. Clinical characteristics, treatment and outcome of 15 patients.
- Molecular basis of epithelial thyroid tumorigenesis.
- Papillary and follicular neoplasms of the thyroid gland. Differential immunohistochemical staining with high-molecular-weight keratin and
- Insulin-like growth factor 1 expression in thyroid tumors.
- Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms.
- [Value of F-18 fluorodeoxyglucose positron emission tomography in thyroid carcinoma]
- [Surgical management of benign and malignant thyroid diseases. Selected aspects]
- Oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in the Japanese population.
- [Stimulation of adenyl cyclase and fixation of iodine in human cancerous thyroid cells in culture]
- [Functional characterization of thyroid neoplastic tissue using the ion microscope]
- [Influence of the distribution of the dose on carcinogenic effects of ionizing radiations of low lineal energy transfer on the thyroid tissue]
- [Description of cell line established from human thyroid papillary cancer and secreting human chorionic gonadotropin hormone]
- Mechanisms of mutagenesis in mammalian cells. Application to human thyroid tumours.
- Irradiation and second cancers. The thyroid as a case in point.
- Early change of thyroid hormone concentration after 131I treatment in patients with solitary toxic adenoma.
- Chromosomal aberrations by comparative genomic hybridization in hurthle cell thyroid carcinomas are associated with tumor recurrence.
- High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common
- Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth.
- Determination of galectin-3 messenger ribonucleic Acid overexpression in papillary thyroid cancer by quantitative reverse
- Galectin-3 messenger ribonucleic acid and protein are expressed in benign thyroid tumors.
- A histone deacetylase inhibitor enhances killing of undifferentiated thyroid carcinoma cells by p53 gene therapy.
- Multinucleated giant cells in fine needle aspirates. Can they help differentiate papillary thyroid cancer from benign nodular goiter?
Table of Contents
1
UI - 11926385
AU - Boerner AR; Petrich T; Weckesser E; Fricke H; Hofmann M; Otto D;
TI -
Weckesser M; Langen KJ; Knapp WH
Monitoring isotretinoin therapy in thyroid cancer using 18F-FDG PET.
SO - Eur J Nucl Med Mol Imaging 2002 Feb;29(2):231-6
AD - Department of Nuclear Medicine, Hannover Medical School, Germany.
boerner.anne-rose@mh-hannover.de
Treatment with isotretinoin (13-cis-retinoic acid, 13-cis-RA) is a
recent additional option in advanced, otherwise intractable
differentiated thyroid cancers. The aim of this study was to evaluate
fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG
PET) in the prediction and the monitoring of response to 13-cis-RA
therapy. Twenty-one patients with advanced differentiated thyroid
cancers were investigated using 18F-FDG PET and iodine-131 whole-body
scans before and 3, 6 and 9 months after initiation of 13-cis-RA
therapy. After 9 months, 13-cis-RA treatment was discontinued and
imaging procedures repeated 3 months later. Average 18F-FDG uptake (SUV)
decreased significantly during 13-cis-RA therapy but subsequently
increased in five of eight patients after withdrawal of 13-cis-RA.
18F-FDG uptake (SUV) 3 months after onset of 13-cis-RA therapy was
significantly lower in patients who developed increased 131I uptake in
their tumour sites than in patients with no subsequent increase in 131I
uptake. There was no relationship between serum thyroglobulin level on
the one hand and simultaneously measured 131I or 18F-FDG uptake on the
other hand. There was a tendency towards lower 18F-FDG uptake in tumour
manifestations with a better outcome. Therefore, 18F-FDG PET at 3 months
after the start of treatment promises to differentiate between those
patients who will eventually benefit from 13-cis-RA and those who will
not. In conclusion, these data indicate that 18F-FDG PET is a useful
tool for the evaluation and monitoring of adjuvant therapy with
13-cis-RA in thyroid cancer.
2
UI - 11951931
AU - Arkles LB
TI -
Preoperative localization of parathyroid adenomas: the protagonist's
view.
SO - Intern Med J 2002 Apr;32(4):179-82
AD - Department of Nuclear Medicine, and Peter MacCallum Cancer Institute,
Melbourne, Victoria, Australia. arkles@netspace.net.au
3
UI - 11951932
AU - Hartley L
TI -
Preoperative localization of parathyroid adenomas: the antagonist's
view.
SO - Intern Med J 2002 Apr;32(4):183-4
AD - The Princess Alexandra Hospital, Brisbane, Queensland, Australia.
hartley@orangemail.com.au
4
UI - 11951933
AU - Khafagi FA
TI -
Preoperative localization of parathyroid adenomas: cost-effective or
just costly?
SO - Intern Med J 2002 Apr;32(4):185-6
AD - Department of Nuclear Medicine & Cardiology, St Andrew's War Memorial
Hospital, Brisbane, Queensland, Australia. fkhafagi@bigpond.com
5
UI - 11953824
AU - de Nigris F; Cerutti J; Morelli C; Califano D; Chiariotti L; Viglietto
TI -
G; Santelli G; Fusco A
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid
carcinoma cell lines and tissues.
SO - Br J Cancer 2002 Mar 18;86(6):917-23
AD - Servizio di Oncologia Sperimentale "E", Istituto per lo Studio e la Cura
dei Tumori, Fondazione G. Pascale, 80131 Naples, Italy.
We used subtractive library screening to identify the changes that occur
in gene expression during thyroid cell neoplastic transformation.
Complementary DNA from normal thyroid cells (HTC 2) was subtracted from
a complementary DNA library constructed from a human thyroid papillary
carcinoma cell line. The library was screened for genes upregulated in
human thyroid papillary carcinoma cell line cells, and several cDNA
clones were isolated. One of these clones has a sirtuin core and high
homology with the human silent information regulator protein family.
This clone, designated "SIR-T8", was overexpressed in human thyroid
carcinoma cell lines and tissues, but not in adenomas. The human SIR-T8
protein has a molecular weight of 39 kDa and is primarily located in the
cytoplasm under the nuclear membrane. The SIR-T8 gene is located on
chromosome 17q25-1. Copyright 2002 Cancer Research UK
6
UI - 12029204
AU - Kalinyak JE
TI -
123 I as a diagnostic tracer in the management of thyroid cancer.
SO - Nucl Med Commun 2002 Jun;23(6):509-11
7
UI - 12029212
AU - Staudenherz A; Selzer E; Kochl H; Leitha T
TI -
Effects of irradiation on 99m Tc sestamibi and 201Tl uptake in a human
papillary thyroid carcinoma cell line.
SO - Nucl Med Commun 2002 Jun;23(6):565-8
AD - University Clinic of Nuclear Medicine, University of Vienna - AKH,
Austria. anton.staudenherz@akh-wien.ac.at
Both 99mTc sestamibi and 201Tl have been used in conjunction with 131I
scintigraphy for follow-up of patients with thyroid cancer. The aim of
the study was to determine if irradiation affects tracer uptake in
papillary thyroid cancer cells. The human papillary carcinoma cell line
(PAP/ES-1) used in this study was generated from a papillary thyroid
tumour obtained after surgery. For the in vitro uptake studies cells
were seeded at 2 x 105 cells/well into 12-well microtitre plates.
Irradiation was performed with a 60Co source (total dose, 2 Gy and 10
Gy). After incubation at 37 degrees C the supernatants were saved for
determination of the unincorporated activity. The reaction was stopped
by washing the cells four times in ice cold phosphate buffered saline.
Total cellular uptake was determined by measuring cell lysate
radioactivity in a Compugammasystem and was expressed as per cent uptake
per mg of total cellular protein. At continuous incubation 201Tl uptake
was significantly (P<0.01) higher after radiation whereas no effect of
irradiation was found on 99mTc sestamibi uptake. Pulsed experiments
revealed that irradiated cells displayed a faster 201Tl efflux. The net
tracer retention at 90 min was similar to 201Tl to that of 99mTc
sestamibi. We conclude that 99mTc sestamibi kinetics in thyroid cancer
are not affected by irradiation and may therefore be superior to 201Tl
in the follow-up of thyroid cancer shortly after radiotherapy.
8
UI - 12203783
AU - Sandrini F; Matyakhina L; Sarlis NJ; Kirschner LS; Farmakidis C; Gimm O;
TI -
Stratakis CA
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a
tumor-suppressor gene for sporadic thyroid cancer.
SO - Genes Chromosomes Cancer 2002 Oct;35(2):182-92
AD - Unit on Genetics and Endocrinology, Developmental Endocrinology Branch,
National Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, Maryland 20892-1862, USA.
The tumor-suppressor gene encoding the cyclic AMP-dependent protein
kinase A type I-alpha regulatory subunit PRKAR1A has been mapped to
chromosome 17 (17q22-24) and is mutated in Carney complex, a familial
neoplasia syndrome that is associated with thyroid tumors. Other genes
implicated in cyclic nucleotide-dependent signaling have been
investigated in thyroid tumorigenesis. We studied protein kinase A (PKA)
activity in noninherited follicular thyroid adenomas and follicular,
papillary, and undifferentiated (anaplastic) thyroid carcinomas. We then
examined these and additional thyroid tumors for losses of the 17q22-24
PRKAR1A region, mutations of the PRKAR1A gene, and expression of its
peptide product. Total PKA activity was markedly increased in carcinomas
over that in adenomas, whereas the ratio of free vs. total PKA activity
was decreased in cancer. Consistent with these findings, the 17q22-24
region was frequently lost in cancer but not in benign adenomas. A novel
inactivating mutation of the PRKAR1A gene (leading to premature
termination of the predicted protein) was found in an aggressive thyroid
cancer. The tumor with PRKAR1A gene mutation, as well as the tumors with
17q allelic losses, showed decreased PRKAR1A expression by
immunostaining. We conclude that PRKAR1A, the most abundant regulatory
subunit of protein kinase A and a principal cyclic AMP-signaling
modulator, acts as a tumor-suppressor gene in sporadic thyroid cancer.
Published 2002 Wiley-Liss, Inc.
9
UI - 12324571
AU - Takano T; Hasegawa Y; Miyauchi A; Matsuzuka F; Yoshida H; Kuma K; Amino
TI -
N
Quantitative analysis of thymosin beta-10 messenger RNA in thyroid
carcinomas.
SO - Jpn J Clin Oncol 2002 Jul;32(7):229-32
AD - Department of Laboratory Medicine, Osaka University Medical School,
Suita, Osaka, Japan. ttakano@labo.med.osaka-u.ac.jp
BACKGROUND: Genes that are differentially expressed in benign and
malignant tissues are important for the establishment of molecular-based
diagnosis of carcinomas. Our recent study on the gene expression profile
of thyroid carcinomas revealed an increased expression of thymosin
beta-10 mRNA. METHODS: To confirm this, we measured the expression
levels of thymosin beta-10 mRNA in 84 thyroid benign and malignant
thyroid tissues, including five anaplastic carcinomas, by means of
real-time quantitative reverse transcription-polymerase chain reaction.
RESULTS: We found an increased expression of thymosin beta-10 mRNA in
thyroid carcinomas, especially in anaplastic carcinomas. Expression
levels of thymosin beta-10 mRNA relative to thyroglobulin mRNA in
anaplastic carcinomas were greatly increased compared with those in
differentiated carcinomas. CONCLUSION: These results suggest the
usefulness of the quantitative measurement of thymosin beta-10 mRNA in
molecular-based diagnosis of thyroid anaplastic carcinomas, but not of
differentiated carcinomas.
10
UI - 6475918
AU - McTiernan AM; Weiss NS; Daling JR
TI -
Incidence of thyroid cancer in women in relation to reproductive and
hormonal factors.
SO - Am J Epidemiol 1984 Sep;120(3):423-35
Female residents of western Washington state aged 18-80 years in whom
interviewed concerning their reproductive histories and their prior use
of exogenous estrogens. Their responses were compared with those of a
sample of women from the same population, individually matched to cases
on telephone prefix. Use of each of several estrogen-containing
preparations was associated with a small increased risk of thyroid
cancer; parous women who had ever used a lactation suppressant had 1.7
times the risk of parous nonusers (95% confidence interval, 1.1-2.8);
ever users of oral contraceptives had 1.6 times the risk of never users
(95% confidence interval, 0.98-2.5); and ever users of postmenopausal
estrogens had 1.4 times the risk of never users (95% confidence
interval, 0.89-2.3). Among the low risk group of women, i.e., those who
had never undergone radiation therapy and who had never had a goiter, a
history of one or more pregnancies was also associated with a small
increase in the risk of thyroid cancer (relative risk = 1.8, 95%
confidence interval, 1.1-3.1). However, no increase in risk with
increasing duration of use of oral contraceptives or menopausal
estrogens or with increasing number of pregnancies was noted. While
pregnancy and use of exogenous estrogens have an impact on the
production of thyroid-stimulating hormone, their effect on the incidence
of thyroid carcinoma, if present at all, appears to be small.
11
UI - 11956624
AU - Suzuki S; Fukushima T; Ami H; Onogi H; Nakamura I; Takenoshita S
TI -
New attempt of preoperative differential diagnosis of thyroid neoplasms
by telomerase activity measurement.
SO - Oncol Rep 2002 May-Jun;9(3):539-44
AD - Department of Surgery II, Fukushima Medical University, School of
Medicine, Fukushima 960-1295, Japan. shsuzuki@fmu.ac.jp
Telomerase activity (TA) has been shown highly expressed in various
solid malignant neoplasms, but only rarely in benign tumor or normal
tissues. Most reports examined TA by the qualitative method, telomeric
repeat amplification protocol (TRAP) assay. We examined TA in tissues of
thyroid neoplasm by quantitative method to establish whether TA was a
useful marker for preoperative differential diagnosis of thyroid tumors.
TA was measured by the quantitative method, TRAP assay, fluorescence
based TRAP method in 32 frozen tissues of thyroid tumors (17 malignant,
15 benign). Cut-off values in TA were 0 unit and 9 units from mean +/-
2SD of TA in benign thyroid tumors. Mean (SD) TA levels in benign
thyroid tumors and thyroid carcinomas were 2.06 (3.58) units and 30.5
(38.2), respectively. Mean TA of carcinomas was significantly higher
than that of benign disease in thyroid tumors (p=0.0092). The
sensitivity of the malignancy was 64.7% (cut-off <0) (p=0.162), 52.9%
(cut-off <9) (p=0.0048). TA in thyroid carcinoma was significantly
correlated with UICC stage (p=0.029), and slightly correlated with tumor
size, pN and M. Positive rate of TA in microfollicular adenoma was
slightly higher than that in macrofollicular adenoma. Conclusively,
quantitative TA might be a useful marker for differential diagnosis
between benign and malignant thyroid tumors.
12
UI - 12173512
AU - Pons Rocher F; Carrasco Llatas M; Brotons Durban S; Estelles Ferriol E;
TI -
Lopez Martinez R
[Benign thyroid disease and cancer in our environment]
SO - An Otorrinolaringol Ibero Am 2002;29(3):247-54
AD - Servicio de Otorrinolaringologia, Hospital Dr. Peset, Valencia.
We compile our experience about the association between benign thyroid
disease and thyroid carcinoma, and perform a review on the literature
about this theme. We conclude on the importance of knowing this
association, even not statistically significative, when it is detected
modifies totally our therapeutic attitude and the vigilance of these
patients.
13
UI - 12173513
AU - Pons Rocher F; Brotons Durban S; Carrasco Llatas M; Estelles Ferriol E;
TI -
Lopez Martinez R
[Carcinoma of the thyroid gland. Correlation between diagnostic tests
and pathogenic anatomy]
SO - An Otorrinolaringol Ibero Am 2002;29(3):255-67
AD - Servicio de Otorrinolaringologia, Hospital Dr. Peset, Valencia.
We present the results of a retrospective study about 101 cases of
thyroid carcinoma treated in our ENT-department during the period
1979-1998. We consider the epidemiologic, diagnostic and therapeutic
aspects. Epidemiologically 82% of patients were female and 18% male,
with a mean age of 51 year. About 12 percent of patients had familiar
antecedents of thyroid pathology. The thyroid pathology affected
preferently the right thyroid lobe in 40 percent of cases, the left lobe
in 28.9 percent, the isthmus in the 6.7 percent and in 24.4 percent it
was bilateral. Hormonal 93.8 percent were in euthyroid state and the 6.2
percent of the whole were tested and show hyperparathyroidism.
Complementary examinations showed, in gammagraphy, a cold solitary
nodule in 48 percent of patients. The echography more frequently
discovered a solitary nodule in 36.7 percent or multiple solid nodules
in 34.7 percent. Fine needle biopsy sensitivity was in 85.7 percent.
Histologic types encountered were: papillary carcinoma (74.26),
follicular carcinoma (14.85), Hurthle cells carcinoma (3.96), medullary
carcinoma (3.96) and anaplastic carcinoma (2.97 percent). Choice
treatment of thyroid carcinoma, in our Department, was total
thyroidectomy.
14
UI - 12182013
AU - Szybinski Z; Huszno B; Rachtan J; Przybylik-Mazurek E; Buziak-Bereza M;
TI -
Trofimiuk M
[Epidemiology of thyroid cancer in Poland]
SO - Wiad Lek 2001;54 Suppl 1():106-16
AD - Katedry i Kliniki Endokrynologii, Collegium Medicum Uniwersytetu
Jagiellonskiego w Krakowie.
The aim of the paper is to analyse the epidemiological situation of
thyroid cancer in Cracow region from 1986 to 1999 and to review regional
thyroid cancer registers in Poland (including 43.7% of the Polish
population) in 1999. The standardized register was based upon
assumptions: 100% of histopathological verification according to ICD-10,
the register ascertainment in at least 80%, the demographic area not
smaller than 100,000 inhabitants, the incidence rate (IR) calculated as
the newly diagnosed cases number per 100,000 inhabitants in a calendar
year. Since 1990 a statistically significant rise of the thyroid cancer
incidence affecting mainly women > 40 years of age have been observed.
From 1998-1999 the cancer morbidity was reduced. Within the last 5 years
in the Cracow area the follicular carcinoma incidence has decreased
significantly, which has been associated with effective iodine
prophylaxis. The highest incidence values have been observed in Cracow
and Olsztyn, showing a territorial relationship with the highest thyroid
irradiation doses after Chernobyl accident. The mean IR value has been
3.86 (1.48 men, 6.08 women), which corresponds to about 1500 newly
diagnosed cases in Poland in 1999. The follicular to papillary carcinoma
ratio has been 5.32. The major etiological factors have been iodine
deficiency and ionising radiation. The present data have indicated that
iodine prophylaxis should be continued and that the population should be
protected against ionising radiation.
15
UI - 12182014
AU - Zemla B
TI -
[Occurrence of papillary and follicular thyroid cancer among Silesian
women]
SO - Wiad Lek 2001;54 Suppl 1():117-22
AD - Zakladu Epidemiologii Nowotworow, Centrum Onkologii-Instytut im. M.
Sklodowskiej-Curie, Oddzial w Gliwicach.
In the years 1990-2000 within Silesia District 1067 thyroid cancer cases
were diagnosed. From the total, papillary carcinoma established 59.9%
(639 cases), and follicular carcinoma--26.0% (276 cases). An existence
of some distinct endemic areas--for both papillary and follicular
thyroid cancers simultaneously was confirmed. The etiologic background
is unclear, but the significant impact of environmental iodine supply
seems unprobable.
16
UI - 12182015
AU - Sporny S
TI -
[The role of fine needle biopsy in diagnosis of thyroid cancer]
SO - Wiad Lek 2001;54 Suppl 1():12-20
AD - Katedry i Zakladu Patomorfologii Akademii Medycznej w lodzi.
The majority of changes in the structure and consistency of the thyroid
gland is a clear indication for fine needle aspiration biopsy (FNAB).
This does not mean, however, that cytological evaluation provides an
unequivocal diagnostic confirmation for every pathological change found
by palpation or by imaging technology. The main purpose of FNAB is to
differentiate the type of examined pathological lesion (i.e. neoplastic
or non-neoplastic) and to help in the selection of appropriate therapy.
The diagnoses obtained by FNAB may be divided into five categories. FNAB
plays the key role in the diagnostics of papillary and anaplastic
thyroid carcinoma.
17
UI - 12182016
AU - Wronkowski Z; Zwierko M; Chmielarczyk W
TI -
[Evaluation of thyroid cancer morbidity in Warsaw in 1987-1997]
SO - Wiad Lek 2001;54 Suppl 1():123-35
AD - Zakladu Organizacji Badan Masowych, Centrum Onkologii-Instytut im. M.
Sklodowskiej-Curie w Warszawie.
The crude and standardized thyroid cancer incidence rates calculated for
the period 1987-1997 in Poland increased from 0.5 to 0.9 and 0.5 to 0.8
per 100,000 men, and from 1.8 to 3.6 and 1.4 to 2.8 per 100,000 women.
The incidence of the cancer in women in Warsaw doubled during the same
period. The upward trend only slightly showed up in the male population
of Warsaw. Mortality rates caused by the thyroid cancer in both sexes in
Warsaw population declined over the years 1963-1997. The 5-year relative
survival rates, calculated for the period 1985-1989, were lower in men
than in women (respectively 66 and 49%). This fact can be partly
explained by more frequent occurrence of anaplastic tumours in men than
in women (respectively 14.2 and 7.8%).
18
UI - 12182017
AU - Bandurska-Stankiewicz E; Stankiewicz A; Shaffie D; Wadolowska L
TI -
[Thyroid cancer morbidity in the Olsztyn region in 1993-1999]
SO - Wiad Lek 2001;54 Suppl 1():136-42
AD - Olsztynskiego Osrodka Diabetologii i Zaburzen Metabolizmu, Wojewodzkiego
Szpitala Specjalistycznego w Olsztynie.
Olsztyn region (in the north of Poland) was classified as an iodine
deficiency area with moderate endemic goiter prevalence. Following
Chernobyl accident, the population had one of the highest radiation
doses affecting thyroid. Aims of the study were to estimate the
incidence of thyroid cancer and to determine its histopathological type.
The register was carried out in Olsztyn region population including each
newly diagnosed case of thyroid cancer in the calendar year. The
personal data of patients were collected and processed on in computer.
The incidence rate was calculated as the number of newly diagnosed cases
in the calendar year per 100,000 inhabitants dependent on sex and age.
The results were statistically evaluated. 242 newly diagnosed cases of
thyroid cancer were registered including 8 young patients (up to 18
years of age) and 234 adults. The increase in the number of cancer cases
was observed year by year. The predominant type of thyroid cancer was
papillary carcinoma--66.8%. Follicular carcinoma constituted 17% of
cases. A statistically significant increase of incidence rate was
observed in women--from 2.8/100,000 to 11.1/100,000.
19
UI - 12182018
AU - Gembicki M
TI -
[Incidence of thyroid cancer in children and adolescents in Bialorus
after the Chernobyl catastrophe in 1986]
SO - Wiad Lek 2001;54 Suppl 1():143-8
Fifteen years after Chernobyl nuclear plant catastrophe thyroid cancer
was diagnosed in 882 persons among the group of 2,618,482 persons aged
6-18 years. The radioactive contamination, mainly with isotopes of
radioactive iodine, seems to be a major cause of such a high incidence
of thyroid cancer in children and adolescents. However, it is necessary
to consider other factors which also might influence the process of
transformation of the thyroid cells to the thyroid cancer. The iodine
deficiency in environment was recognized as an important factor.
Therefore, the countrywide programme of the investigations of iodine
deficiency and goiter prevalence was established in the Republic of
Belarus with the assistance of WHO Office for Europe. Within this
program the examination of 11,562 children and adolescents aged 6-18
years from 30 schools in urban and rural areas was performed. The
results obtained are typical for significant iodine deficiency and
moderate goiter endemy. The analysis of these two factors and their
influence on the incidence and distribution of thyroid cancer in
different regions of Belarus is a subject of this paper. It is worth
adding that 15 years after the catastrophe a visible rise in the number
of thyroid cancers is noted in the group of adolescents and adults.
20
UI - 12182019
AU - Szybinski Z; Olko P; Przybylik-Mazurek E; Burzynski M
TI -
[Ionizing radiation as a risk factor for thyroid cancer in Krakow and
Nowy Sacz regions]
SO - Wiad Lek 2001;54 Suppl 1():151-6
AD - Katedry i Kliniki Endokrynologii Collegium Medicum Uniwersytetu
Jagiellonskiego w Krakowie.
In a group of 224 patients with thyroid cancer registered from 1990 to
1999 and in 243 controls matched for sex and age doses for the thyroid
due to accumulation of 131I after Chernobyl accident and radiological
diagnostic procedures involving the neck and dentition was calculated
according to Johnson's model and based upon questionnaires. There was a
significantly higher dose for the thyroid due to accumulation of 131I in
the Krakow area in comparison with the Nowy Sacz area. There was also a
significantly higher frequency of radiological procedures involving the
thyroid gland preceding the development of thyroid cancer in comparison
with the control group. The present findings are concordant with about
40% increase of thyroid cancer in the Krakow area in comparison with the
Nowy Sacz region. The present study has indicated that ionising
radiation may be a factor involved in the pathogenesis of thyroid cancer
and its significant rise within the last 10 years. However, it has not
been the main factor, but only one of the risk factors. The study has
also indicated that iodine prophylaxis should be continued and that
radiological procedures involving the neck and head in patients with
nodular goitre should be carried out with caution.
21
UI - 12182020
AU - Przybylik-Mazurek E; Szybinski Z
TI -
[Biological risk factors for differentiated thyroid cancer]
SO - Wiad Lek 2001;54 Suppl 1():157-62
AD - Katedry i Kliniki Endokrynologii, Collegium Medicum Uniwersytetu
Jagiellonskiego w Krakowie.
Apart from the two relatively well documented risk factors for thyroid
cancer i.e. iodine deficiency and ionising radiation, the mechanism of
carcinogenesis involves a number of biological and environmental
factors. The aim of the study was to analyse the selected biological and
environmental risk factors in patients with differentiated thyroid
cancer in comparison with a reference group in a case-control study.
METHODS: Both the group of 188 women and 30 men with thyroid cancer
including 92 with follicular carcinoma and 126 with papillary carcinoma
and the control group of 287 women and 58 men were subjected to the
examination. All the study participants were given a standard
questionnaire and underwent physical examination including thyroid USG,
blood hormone levels and urine iodine concentration. The following risk
factors were included in the analysis: family history, sex, age, thyroid
morbidity, employment, body weight, hormone replacement therapy in
women, cigarette smoking. In both groups with thyroid cancer women
predominant with the female to male ratio 6.7 in follicular carcinoma
and 6.0 in the papillary variant. In both groups of diagnoses the mean
age was high--above 50, higher in men than in women. Over 70% of the
patients with thyroid cancer had nodular goitre before the detection of
cancer. In the control group the proportion of diagnosed goitre was
slightly above 10%. A significantly more frequent hormone replacement
therapy and contraception and more frequent miscarriages in women with
thyroid cancer were noteworthy. One may assume that initiation,
promotion and progression of the neoplastic process in the thyroid is
triggered by a number of factors, both biological and environmental, and
only multifactorial analysis may provide an insight into the mechanisms
of carcinogenesis followed by initiation of preventives measures in
appropriate cases.
22
UI - 12182021
AU - Huszno B; Szybinski Z; Trofimiuk M; Przybylik-Mazurek E; Buziak-Bereza
TI -
M; Golkowski F; Pantoflinski J
[Iodine deficiency and thyroid neoplasms in the Krakow region]
SO - Wiad Lek 2001;54 Suppl 1():163-8
AD - Katedry i Kliniki Endokrynologii, Collegium Medicum Uniwersytetu
Jagiellonskiego w Krakowie. huszno@endo.cm-uj.krakow.pl
The aim of the study was to evaluate the correlation between incidence
rate (IR) of thyroid cancer and severity of iodine deficiency. The
influence of iodine prophylaxis on IR was also investigated. The
suspension of iodine prophylaxis in 1980 resulted in goitre prevalence
increase in schoolchildren (up to 60%) and elevated TSH levels in
neonates observed in early 1990-ties. In 1990 rise in thyroid cancer IR
was observed. IR of papillary and follicular carcinoma in 1995 were 1.6
and 1.5 respectively. Papillary to follicular ratio was about 1.0. Such
a high prevalence of follicular cancer was specific for iodine deficient
regions. In 1997, after introduction of mandatory model of iodine
prophylaxis in Poland, increase in papillary thyroid cancer IR was
observed, reaching in 1998 6.23 per 100,000 inhabitants. Papillary to
follicular cancer ratio rose to 2.48. In 1999 no further increase in
thyroid cancer IR was observed. Increase in papillary cancer incidence
between 1990 and 1999 may be related to overlapping of iodine deficiency
and other cancer risk factors i.e. radiation after Chernobyl accident.
23
UI - 12182022
AU - Szpak S; Zeman M; Handkiewicz-Junak D; Kochanska-Dziurowicz A; Kurzeja
TI -
E; Stanjek A; Bijak A; Bogacz A; Zemla B
[Geographic differences in iodine supply in the Silesia terrain in
relation to thyroid cancer risk]
SO - Wiad Lek 2001;54 Suppl 1():169-75
AD - Zakladu Medycyny Nuklearnej i Endokrynologii Onkologicznej, Centrum
Onkologii-Instytut im. M. Sklodowskiej-Curie, Oddzial w Gliwicach.
Risk factors associated with differentiated thyroid carcinoma depend on
its histotype. Follicular carcinoma is described as a predominant type
in the areas with iodine deficiency, in opposite to papillary thyroid
cancer. The incidence of thyroid cancer and its histotypes varies
considerably throughout Silesia (data obtained from the Institute of
Oncology Cancer Register, Gliwice). The factors responsible for these
differences are unknown. The aim of our study was to evaluate the
present iodine supply in Silesia region and to relate it to the
incidence of the various histotypes of thyroid carcinoma. Urinary iodine
excretion observed in 7-11 year-old-children was used as a parameter of
iodine supply and measured in the group of 1037 school children in
sixteen localities, equally dispersed throughout Silesia. Urine samples
were obtained to measure iodine concentration by the modified
Sandell-Kolthoff's catalytic method. Mean incidence rates of papillary
and follicular thyroid carcinoma were calculated for regions of Silesia
by averaging the rates of the communities in each region. Despite the
intensive iodine prophylaxis the persistent symptoms of iodine
deficiency were observed. There were significant differences in
children's ioduria among investigated regions. The percentage of low
ioduria (lower then 100 micrograms/l) varied from 35.7% to 87.7%. We
observed no correlation between age-adjusted rates for histotypes of
thyroid carcinoma and the percentage of urine iodine below 100
micrograms/l, which served as an estimation of iodine deficiency. Our
study indicates that Silesia is still an area of moderate iodine
deficiency. We were unable to explain the factors responsible for the
observed differences in the incidence rates of papillary and follicular
thyroid carcinoma.
24
UI - 12182023
AU - Wloch J; Czarniecka A; Turska M; Wilgus J
TI -
[Evaluation of surgical treatment results in patients with
differentiated thyroid cancer from materials in the Oncologic Institute
in Gliwice]
SO - Wiad Lek 2001;54 Suppl 1():178-88
AD - Kliniki Chirurgii Onkologicznej, Centrum Onkologii-Instytut im. M.
Sklodowskiej-Curie, Oddzial w Gliwicach.
The optimal surgical treatment for patients with differentiated thyroid
carcinoma is still controversial and discussed. The aim of this study
was to analyze the effectiveness of treatment in differentiated thyroid
carcinoma, to establish the prognostic value of histopathological type,
clinical advancement, the extent of surgery and to estimate the
therapeutic benefit rate of the radical approach. The randomized group
of 768 patients with differentiated thyroid carcinoma, aged between 16
to 40 (median age 44), treated in Oncology Center Institute in Gliwice
between 1986 and 1997 were analyzed. They were operated in different
surgical clinics in Poland. The primary total thyroidectomy was
performed in 153 of patients (20%), the secondary radical operation in
474 (62%). 136 persons were operated by less radical approach. Cervical
lymph node metastases were observed in 26% of patients. Distant
metastases occurred in 8% of cases. 610 persons were treated with 131I.
All patients were administered hormonal therapy to suppress TSH.
Locoregional recurrence occurred in 7.5% of patients. Complete remission
was observed in 71.5% of persons (548 patients). The influence of
distant metastases lymph node metastases and tumor size on the long-term
prognosis was analyzed in univariate statistic analysis. There were no
differences in survival in patients with papillary and follicular
carcinoma. The 10-year survival was statistically significantly longer
in patients who underwent radical surgical treatment (92%) than after
non-total thyroidectomy (80%). Despite the relatively high risk of
surgical complications the benefits of the radical approach were
significant.
25
UI - 12182024
AU - Nowak W; Szybinski P
TI -
[Radical surgical treatment of differentiated thyroid cancer--necessity
or over-enthusiasm?]
SO - Wiad Lek 2001;54 Suppl 1():189-97
AD - I Katedry Chirurgii Ogolnej i Kliniki Chirurgii Gastroenterologicznej,
Collegium Medicum Uniwersytetu Jagiellonskiego w Krakowie.
The extent of surgical treatment of well differentiated thyroid cancer
has been controversial and widely discussed for years. Although the
recommendations defining the strategy of thyroid surgery were approved
in 1995, a lot of questions remained. The aim of this retrospective
study was to analyse long-term results of surgical treatment of thyroid
cancer according to the type of applied surgical procedure. The study
group consisted of 206 patients surgically treated for well
differentiated thyroid cancer with the minimal follow-up period of 5
years. The median age patients was 49.1 years. 159 patients (77.2%) have
still remained in the follow-up programme, 23 died because of thyroid
cancer (11.1%) and the remaining 24 have either refused to participate
in the programme or died of other causes. Median follow-up period was
10.7 years. Total thyroidectomy was performed in 90 patients (43.7%) and
less extensive procedures in 106 (51.4%). The remaining patients were
qualified for palliative reduction of the tumour mass and they were not
included in this study. The comparison of the patients with I and II
stage of the disease according to the type of surgical procedure did not
show differences in 10-year survival. In stage III the difference was
very close to statistical significance. The same results were observed
with regard to disease recurrence. Long-time survival in low risk
patients was not related to the extent of surgical procedure. The risk
of recurrence and death was higher in the patients with advanced disease
in stage III who underwent less radical procedures like total resection
of involved lobe with isthmus and subtotal resection of contralateral
lobe.
26
UI - 12182025
AU - Pomorski L
TI -
[Cervical lymph node surgery in differentiated thyroid cancer: selective
or elective lymphadenectomy?]
SO - Wiad Lek 2001;54 Suppl 1():198-204
AD - Kliniki Chirurgii Endokrynologicznej i Ogolnej, Akademii Medycznej w
Lodzi.
The value and prognostic significance of regional lymph node dissection
in patients with thyroid cancer remains a matter of controversy. The
classification of the cervical lymph nodes and the extent of their
resection in patients with different thyroid cancers is also discussed.
The aim of the paper was to present the space classification of regional
lymph nodes, the incidence of their involvement and the extent of their
resection in patients with differentiated thyroid cancer. The results of
multicenter studies have indicated that regional lymph node metastases
in patients with differentiated thyroid cancer, especially of a
papillary type, have been frequent. Ipsilateral central, ipsilateral
lateral, contralateral lateral, and mediastinal lymph nodes have been
affected in 42-86%, 32-68%, 12-24%, and 3-20% of patients respectively.
In 20% of patients only central lymph nodes have been affected, whereas
in others metastases have been determined at least in 2 or more lymph
node groups. Regional lymph nodes have been classified into Groups I-IV.
Moreover, lymph node recurrences have been more frequent in patients who
either have not got the regional lymph nodes removed or have only
enlarged ones determined as involved excised. Therefore, primary
regional lymph nodes dissection is indicated. Elective resection of the
lymph nodes of Group I (central lymph nodes) as a part of primary total
thyroidectomy in patients with thyroid cancer and more selective
excision of the lymph nodes of Groups II-IV are recommended. The author
has presented his own experience in lymph node dissection in patients
with differentiated thyroid cancer and compared it with other results.
27
UI - 12182026
AU - Herman K; Wysocki W; Fortuna J
TI -
[Should cervical lymph nodes be electively removed in differentiated
thyroid carcinoma?]
SO - Wiad Lek 2001;54 Suppl 1():205-9
AD - Kliniki Chirurgii Onkologicznej, Centrum Onkologii, Oddzial w Krakowie.
Differentiated thyroid carcinomas (DTC; papillary and follicular)
constitute merely 0.5-1% of all malignancies in the world. The proper
extent of their surgical resection has been discussed for many years.
Two different approaches predominate in the literature. One group
claims, that elective, modified radical neck dissection (MRND) should be
performed. That strategy is supported by high frequency (80%) of
observed "occult", clinically not evident, micrometastases in regional
lymph nodes on the neck. On the other hand, there have been no studies
so far which would unquestionably confirm the prognostic value of neck
lymph node involvement in DTC, or the favorable influence of elective
lymph node dissection on long-term survival. Therefore, other authors do
not recommend prophylactic lateral neck dissection. MRND, apart from its
doubtful influence on prognosis, is connected with a higher complication
rate and longer hospitalization. The authors of this review also share
this opinion.
28
UI - 12182027
AU - Lewinski A
TI -
[Current views on diagnostic standards and treatments with L-thyroxine
of single non-toxic thyroid nodules or multinodular non-toxic goiter]
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