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NCI CANCERLIT® Search: Intraocular Melanoma - October 2002
National Cancer Institute®
Last Modified: October 1, 2002
- Things that go bump in the light. The differential diagnosis of posterior uveal melanomas.
- Palliative vitrectomy for intraocular metastasis from cutaneous melanoma.
- Uveal melanoma, hormonal and reproductive factors in women.
- An evaluation of the influence of reproductive factors on the risk of metastases from uveal melanoma.
- Melanomas, metastases, and survival.
- Prognostic factors following enucleation of 111 uveal melanomas.
- Local resection of choroidal melanoma.
- Predictive factors of visual outcome after local resection of choroidal melanoma.
- Reduced expression of TAP-1 and TAP-2 in posterior uveal melanoma is associated with progression to metastatic disease.
- Metastasis of malignant melanoma in the small intestine. A case report.
- Immunophenotypic differences between uveal and cutaneous melanomas.
- Mode of presentation and time to treatment of uveal melanoma in Finland.
- Uveal melanoma: Finland v India.
- Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study
- Imaging to detect metastases from malignant uveal melanoma.
- Isolated ovarian metastasis from a spindle cell malignant melanoma of the choroid 14 years after enucleation: prognostic implication of the
- [Eyes of different colors--a sign of danger]
- [Lethal effect of boron neutron capture reaction on human uveal melanoma cells in culture incubated with borophenylalanine]
- [Morphological characterization of cell lines of human uveal melanoma]
- Occupational risk factors, ultraviolet radiation, and ocular melanoma: a case-control study in France.
- [Correlation between ICG angiography verified networks in uveal melanomas and rate of tumor regression after brachytherapy]
- [Nevus mimicking a basal cell carcinoma of the eyelid]
Table of Contents
1
UI - 12101438
AU - Rennie IG
TI -
Things that go bump in the light. The differential diagnosis of
posterior uveal melanomas.
SO - Eye 2002 Jul;16(4):325-46
AD - University of Sheffield Sheffield, UK. ig.rennie@shef.ac.uk
2
UI - 12194093
AU - Shankar J; Damato BE; Hiscott P
TI -
Palliative vitrectomy for intraocular metastasis from cutaneous
melanoma.
SO - Eye 2002 Sep;16(5):660-2
3
UI - 1997174
AU - Holly EA; Aston DA; Ahn DK; Kristiansen JJ; Char DH
TI -
Uveal melanoma, hormonal and reproductive factors in women.
SO - Cancer Res 1991 Mar 1;51(5):1370-2
AD - Program in Epidemiology, Northern California Cancer Center, Belmont
94002.
In a case-control study, we explored a potential association between
uveal melanoma and reproductive factors in women. Responses from
telephone interviews of 186 women diagnosed with uveal melanoma were
compared with responses of 423 women without this disease. All women
resided in 11 U.S. western states. We observed a decreased risk of uveal
melanoma for women who had ever been pregnant [relative risk (RR) =
0.60, 95% confidence interval (CI) = 0.37 -0.95], with an increase in
this protective effect with more live births after adjustment for age,
menopausal status, eye color, and skin sensitivity to the sun (1-2
births, RR = 0.47,95% CI 0.29-0.78; 3-4 births, RR = 0.38, 95% CI =
0.22-0.64; 5 or more births, RR = 0.33, 95% CI = 0.15-0.71). The largest
effect was observed between nulliparous and parous women. No other
reproductive factors, including use of oral contraceptives or
postmenopausal estrogens, were shown to be related to risk for uveal
melanoma. We conclude that most reproductive factors in this population
play little or no role in the etiology of uveal melanoma. The
association with number of live births must be confirmed in other
studies to assure that it is unrelated to confounding factors not
measured in this study.
4
UI - 8341495
AU - Egan KM; Walsh SM; Seddon JM; Gragoudas ES
TI -
An evaluation of the influence of reproductive factors on the risk of
metastases from uveal melanoma.
SO - Ophthalmology 1993 Aug;100(8):1160-5; discussion 1166
AD - Retina Service, Massachusetts Eye and Ear Infirmary, Boston 02114.
BACKGROUND: There is a paucity of data concerning the possible role
played by hormonal factors in the risk of metastases from intraocular
melanomas. METHODS: The authors studied the influence of post-diagnosis
pregnancy and oral contraceptive use in a group of women of reproductive
age (45 or younger) who were treated for uveal melanoma by proton beam
irradiation. A baseline reproductive history had been collected before
irradiation for all women, and interim reproductive data were collected
by mailed questionnaire. RESULTS: In this age group, the overall rate of
metastasis among women was similar to that of men treated during the
same interval (adjusted rate ratio: 1.28; 95% confidence interval:
0.62-2.67). A total of 24 full-term pregnancies were reported among the
139 women still menstruating at diagnosis. Twenty-three women reported
regular oral contraceptive use. Metastases developed in 15 of the 139
women. Compared with other women in the series, rates of metastases were
not higher among the women who reported pregnancies (P = 0.932) or oral
contraceptive use (P = 0.424) after diagnosis. CONCLUSION: Although
based on limited numbers, results suggest that the hormonal environment
has no appreciable influence on risk of metastases in younger women with
uveal melanoma.
5
UI - 8280678
AU - Rennie I
TI -
Melanomas, metastases, and survival.
SO - Br J Ophthalmol 1993 Nov;77(11):685-6
6
UI - 8280680
AU - Coleman K; Baak JP; Van Diest P; Mullaney J; Farrell M; Fenton M
TI -
Prognostic factors following enucleation of 111 uveal melanomas.
SO - Br J Ophthalmol 1993 Nov;77(11):688-92
AD - Department of Pathology, Royal Victoria Eye and Ear Hospital, Dublin,
Ireland.
Follow up information was retrieved on 111 patients who underwent
enucleation for uveal melanoma between 1964 and 1987, allowing a minimum
postoperative period of 5 years. Univariate survival analysis was
carried out using Kaplan-Meier curves and the differences between the
curves were analysed with the Mantel-Cox test. Multivariate analysis
used the Cox proportional hazards model. Univariate analysis isolated
each of the following as significant prognosticators: largest tumour
diameter (LTD) (p < 0.002), presence of epithelioid cells (p < 0.03),
and glaucoma (p < 0.001). A combination of cell type, glaucoma, and LTD
(p < 0.0001) had strong and independent prognostic significance in
multivariate analysis. The results of this series are compared with
previous studies and the value of cell type information and new
quantitative parameters is discussed.
7
UI - 8218027
AU - Rennie I
TI -
Local resection of choroidal melanoma.
SO - Br J Ophthalmol 1993 Oct;77(10):613
8
UI - 8218028
AU - Damato BE; Paul J; Foulds WS
TI -
Predictive factors of visual outcome after local resection of choroidal
melanoma.
SO - Br J Ophthalmol 1993 Oct;77(10):616-23
AD - Tennent Institute of Ophthalmology, University of Glasgow.
Local resection of choroidal melanomas is not widely performed so that
the indications for this operation have not previously been defined
statistically. Univariate and multivariate Cox regression analyses were
used to identify the factors influencing visual acuity after 163
completed local resections for choroidal melanoma in patients with a
preoperative visual acuity of counting fingers or better. The variables
included in the analyses were patient age and sex; eye laterality and
preoperative visual acuity; location of anterior and posterior tumour
margins; tumour location (coronal and sagittal); tumour diameter,
thickness, and cell type; ocular decompression by vitrectomy; and
adequacy of surgical clearance. The surgical resections were performed
using a lamellar scleral flap for eye closure, hypotensive anaesthesia
for haemostasis, and, in the later years, ocular decompression by pars
plana vitrectomy to improve access. The patients (94 men, 69 women) had
a mean age of 50 years. The tumours had a mean diameter of 13.3 mm and a
mean thickness of 7.4 mm, with 38 tumours extending to within 1 disc
diameter (DD) of the optic disc, fovea or both (that is, 'posterior
tumour extension'). Cox multivariate analysis showed that the most
significant preoperative factors for predicting retention of good vision
(6/12 or better) were nasal tumour location (p = 0.002) and distance of
more than 1 DD between the tumour and the optic disc or fovea (p =
0.010). The most significant predictive risk factor for severe visual
loss (hand movements or worse) was posterior tumour extension to within
1 DD of the optic disc and/or fovea (p = 0.009).(ABSTRACT TRUNCATED AT
250 WORDS)
9
UI - 11468516
AU - Cresswell AC; Sisley K; Laws D; Parsons MA; Rennie IG; Murray AK
TI -
Reduced expression of TAP-1 and TAP-2 in posterior uveal melanoma is
associated with progression to metastatic disease.
SO - Melanoma Res 2001 Jun;11(3):275-81
AD - Institute of Cancer Studies, G Floor, Medical School, Beech Hill Road,
Sheffield, UK.
In order to determine the effects of the loss or reduced expression of
molecules associated with antigen presentation (transporter associated
with antigen presentation [TAP]-1, TAP-2, low molecular weight protein
[LMP]-2 and LMP-7), we examined the expression of these molecules in
primary uveal melanoma lesions. Paraffin-embedded sections from 29
primary uveal melanoma lesions were analysed for expression of TAP-1,
TAP-2, LMP-2 and LMP-7 using specific primary antibodies followed by a
three-stage immunoperoxidase technique. Microscopic examination was
undertaken to determine differences in expression of these molecules on
the tumour and the surrounding stroma. Overall, 72% (21 out of 29) of
the tumours showed some loss or reduced expression of TAP-1, TAP-2,
LMP-2 and/or LMP-7. Statistical analysis of these results showed that
progression to metastatic disease was strongly associated with reduced
expression of TAP-1 (P < 0.05) and TAP-2 (P < 0.01), taking patient age,
tumour site and histology into account. We conclude that the reduced
expression of molecules important in eliciting an immune response, such
as TAP-1 and TAP-2, may facilitate the metastatic spread of uveal
melanoma lesions and may have important implications for prospective
immunotherapy.
10
UI - 12096315
AU - Marin M; Vlad L; Grigorescu M; Sparchez Z; Dumitra D; Muti L
TI -
Metastasis of malignant melanoma in the small intestine. A case report.
SO - Rom J Gastroenterol 2002 Mar;11(1):53-6
AD - 3rd Medical Clinic, University of Medicine and Pharmacy, Cluj-Napoca,
Romania.
Malignant melanoma is the most common metastatic tumor of the
gastrointestinal tract and can present with fairly non-specific
symptoms. A 63-year old man with previous enucleation of the left eye
for a malignant coroidian melanoma presented signs of intestinal
subocclusion. Weight loss and a palpable mass deep on the paraumbilical
left region were the significant physical signs. Because the state of
the patient had worsened, the diagnosis was made by ultrasonography
examination. Segmental intestinal resection with regional lymph node
dissection was performed. Surgical resection can be performed safely as
patients for whom all sites of disease are completely resected
experience significant improvements in survival times, compared with
patients who undergo an incomplete resection. For selected patients,
surgical treatment of metastatic melanoma involving the gastrointestinal
tract is appropriate therapy.
11
UI - 11934320
AU - Iwamoto S; Burrows RC; Kalina RE; George D; Boehm M; Bothwell MA;
TI -
Schmidt R
Immunophenotypic differences between uveal and cutaneous melanomas.
SO - Arch Ophthalmol 2002 Apr;120(4):466-70
AD - Department of Medicine, Division of Dermatology, University of
Washington Medical Center, Box 356524, Seattle, WA 98195-6524, USA.
siwamoto@u.washington.edu
OBJECTIVE: To determine the immunophenotypic differences between uveal
and cutaneous melanomas, employing standard melanoma markers as well as
p75 neurotrophin receptor (p75NTR) and microphthalmia transcription
factor (MITF). DESIGN: Fifteen uveal melanomas (5 spindle, 5
epithelioid, and 5 mixed uveal subtypes) were immunolabeled with a panel
of antibodies that included S100, tyrosinase, melan-A, HMB-45 and HMB-50
combination, MITF, and p75NTR. The results were tabulated on the basis
of intensity and pervasiveness of the labeling and compared with a prior
study on cutaneous spindle and epithelioid melanomas. RESULTS: In
contrast to its strong labeling of cutaneous melanomas, S100
immunolabeling of uveal melanomas was weak and variable. p75NTR, known
to differentiate spindle from epithelioid melanomas of the skin, did not
immunolabel uveal melanomas. HMB-45, HMB-50, tyrosinase, melan-A, and
MITF immunolabeled all uveal melanomas strongly, irrespective of the
histologic subtype, but not cutaneous melanomas. Microphthalmia
transcription factor was especially clear in its labeling of uveal
melanomas. CONCLUSIONS: Although cutaneous and uveal melanomas share
many molecular markers in common, there are differences between the 2
types of melanoma. First, the level of expression of S100 differs
between cutaneous and uveal melanomas. Second, while cutaneous melanomas
can be further subdivided into spindle and epithelioid types based on
their immunophenotype, the uveal melanomas cannot.
12
UI - 11864894
AU - Eskelin S; Kivela T
TI -
Mode of presentation and time to treatment of uveal melanoma in Finland.
SO - Br J Ophthalmol 2002 Mar;86(3):333-8
AD - Department of Ophthalmology, Helsinki University Central Hospital,
Helsinki, Finland. sebastian.eskelin@hus.fi
AIMS: To investigate the current referral pattern and delays in
treatment of patients with primary uveal melanoma. METHODS: 184
consecutive Finnish patients with uveal melanoma diagnosed between July
86%). Their mean age was 60 years (range 14-87). The dates of visits to
dispensing optician, physician, ophthalmologist and ocular oncologist,
the presence of symptoms, and reason for consultation were determined by
structured telephone interview. Time intervals to treatment planning and
treatment were calculated. RESULTS: 139 patients (87%) had symptoms at
presentation and 44 patients (28%) had been seen by an ophthalmologist
less than 2 years previously. The median height of the tumour was 6 mm
(range, 1.0-17.0) and its largest basal diameter 11 mm (range 2.5-22.0)
at diagnosis. Melanoma developed from a previously detected presumed
naevus in 13 patients (8%). When the first contact was a dispensing
optician (15%) the median time to treatment planning was 22 days (range
1-1156). When a physician other than an ophthalmologist (19%) was
contacted the delay was 68 days (range 0-1283) and when an
ophthalmologist (65%) was seen it was 34 days (range 1-1426). These
differences were not significant (p=0.32). The chance of being referred
at first visit was 89%. Median time to treatment was not associated with
symptoms (p=0.16) and tumour volume (p=0.29), but it was significantly
different between patients who were and were not referred at first visit
(140 days v 34 days; p<0.001) and between those treated by ruthenium and
iodine brachytherapy (59 days v 33 days; p=0.009). CONCLUSIONS: Analysis
of delays in management indicates that earlier treatment could be
achieved if dilated fundus examinations were performed without
exceptions, all suspicious naevi were referred for a second opinion, and
if the patients with melanoma were referred to the ocular oncology
service concurrently with staging examinations done at the regional
hospital.
13
UI - 12234912
AU - Biswas J; Agarwal M; Krishnakumar S; Shanmugam MP
TI -
Uveal melanoma: Finland v India.
SO - Br J Ophthalmol 2002 Oct;86(10):1193
14
UI - 11346394
AU - The Collaborative Ocular Melanoma Study Group.
TI -
Assessment of metastatic disease status at death in 435 patients with
large choroidal melanoma in the Collaborative Ocular Melanoma Study
(COMS): COMS report no. 15.
SO - Arch Ophthalmol 2001 May;119(5):670-6
BACKGROUND: A systematic review and assessment of disease-related
mortality as part of standardized prospective patient follow-up and
evaluation within a multicenter clinical trial have been lacking in
previous studies of choroidal melanoma. OBJECTIVE: To describe disease
status at death in patients with large choroidal melanoma treated and
followed up in the Collaborative Ocular Melanoma Study (COMS). DESIGN:
Analysis of reviews of patient status at death performed by the COMS
Mortality Coding Committee using available clinical and histopathologic
information. SETTING AND PATIENTS: Reviews of deaths as of July 31,
1997, the cutoff date for reporting initial mortality findings.
INTERVENTIONS: Patients were treated by either enucleation preceded by
external beam radiotherapy or enucleation only. MAIN OUTCOME MEASURES:
Disease status at the time of death and certainty associated with the
coding of disease status, sites of metastasis, and availability of
autopsy. RESULTS: Of 1003 patients enrolled in the trial, 457 had died;
the estimated median survival from time of enrollment was 7.4 years.
Disease status at time of death had been reviewed for 435 deaths (95%).
The autopsy rate was 6%. A total of 269 patients (62%) had
histopathologically confirmed melanoma metastasis at the time of death,
and metastasis was suspected in 92 additional patients (21%) on the
basis of imaging and tests but without tissue confirmation. The common
sites were liver (93%), lung (24%), and bone (16%); multiple sites were
identified in 87% of patients with metastasis. The likelihood of 3 or
more sites increased more than 4-fold when autopsy results were
available. CONCLUSIONS: Detailed mortality coding following a standard
protocol provides the most accurate reporting to date of disease-related
mortality in patients with choroidal melanoma and also identifies
difficulties. Guidelines for the evaluation of future patients in
clinical studies of choroidal melanoma are suggested.
15
UI - 12003636
AU - Eskelin S; Kivela T
TI -
Imaging to detect metastases from malignant uveal melanoma.
SO - Arch Ophthalmol 2002 May;120(5):676
16
UI - 11127926
AU - Santeusanio G; Ventura L; Mauriello A; Carosi M; Spagnoli LG; Maturo P;
TI -
Terranova L; Romanini C
Isolated ovarian metastasis from a spindle cell malignant melanoma of
the choroid 14 years after enucleation: prognostic implication of the
keratin immunophenotype.
SO - Appl Immunohistochem Mol Morphol 2000 Dec;8(4):329-33
AD - Dipartimento di Biopatologia e Diagnostica per Immagini, Universita
degli Studi di Roma Tor Vergata, Rome, Italy.
santeusanio@med.uniroma2.it
A 47-year-old woman developed metastatic melanoma to the right ovary 14
years after the enucleation of the right eye for a choroidal spindle
cell melanoma. An immunohistochemical study was performed on paraffin
sections of both primary and metastatic melanoma specimens to identify
markers of both aggressive phenotype and metastatic potential with
particular attention to the anomalous expression of cytokeratin
intermediate filament proteins. Neoplastic cells of both primary and
metastatic tumors immunostained positively for S-100, HMB45, MART-1, and
vimentin antibodies, but they were negative for cytokeratins 1-19, 8,
18, and 8,18; <10% of neoplastic cells in both the primary and the
metastatic melanomas immunostained for Ki-67 proliferating antigen using
MIB-1 antibody. We speculate that the indolent behavior of this ovarian
metastasis is reflected by the absence of coexpression of cytokeratins 8
and 18 with vimentin. This case supports the practical value of using
this panel of antibodies to evaluate the aggressive potential of uveal
melanomas.
17
UI - 12238198
AU - Toivonen P; Kivela T
TI -
[Eyes of different colors--a sign of danger]
SO - Duodecim 2002;118(8):831-3
AD - HYKS:n silmatautien klinikka, silmakasvainyksikko, silmapatologian
laboratorio PL 220, 00029 HUS. tero.kivela@hus.fi
18
UI - 1297526
AU - Belkhou R; Mykita S; Meyer L; Sahel J; Abbe JC; Dreyfus H; Massarelli R
TI -
[Lethal effect of boron neutron capture reaction on human uveal melanoma
cells in culture incubated with borophenylalanine]
SO - C R Acad Sci III 1992;315(12):485-91
AD - Centre de Recherches nucleaires, Strasbourg.
Cell cultures obtained from human uveal tumours have been used as
experimental model to study the lethal effect consecutive to the neutron
capture reaction on boron incorporated into cells as borophenylalanine.
An irradiation with a neutron fluence of 6 x 10(9) n cm-2 reduced the
number of viable cells by about 30%.
19
UI - 7987688
AU - Massarelli R; Belkhou R; Dunel-Erb S; Chevalier C; Abbe JC; Pignol JP;
TI -
Moutaouakkil M; Sahel J
[Morphological characterization of cell lines of human uveal melanoma]
SO - C R Acad Sci III 1994 Jan;317(1):25-33
AD - Centre de Recherches Nucleaires, Laboratoire de Chimie Nucleaire,
Strasbourg, France.
Several cell lines have been derived from an ocular melanoma obtained
from an enucleated patient. Three cell types are observed during the
time in culture of all the cell lines under study. Two of them have
epithelial and spindle shape respectively. A third cell type, having a
spheroidal shape, is formed from spindle cells and may be transformed
into epithelial cells upon re-seeding. Further experiments showed that
the same cell may change of shape following the cycle:
spheroidal-->epithelial-->fusiform-->spheroidal. Scanning microscopy
shows the coexistence of the three cell shapes in the same culture and
the presence of several filaments and processes protruding at the
surface of the cells. Transmission electron microscopy shows that the
cell lines, in general, contain melanosomes empty or fairly pigmented
and several filaments and microtubules. The presence of melanin may be
stimulated by seeding of melanoma cells over a "feeder layer" of
fibroblasts.
20
UI - 11545460
AU - Guenel P; Laforest L; Cyr D; Fevotte J; Sabroe S; Dufour C; Lutz JM;
TI -
Lynge E
Occupational risk factors, ultraviolet radiation, and ocular melanoma: a
case-control study in France.
SO - Cancer Causes Control 2001 Jun;12(5):451-9
AD - Inserm Unite 88, Hopital National de Saint-Maurice, Saint-Maurice,
France. p.guenel@st-maurice.inserm.fr
BACKGROUND: Ultraviolet radiation has been suspected as a possible cause
of ocular melanoma. Because this association is controversial, we
examine the role of occupational exposure to ultraviolet radiation on
the occurrence of this rare cancer. MATERIAL AND METHODS: A
population-based case-control study was conducted in 10 French
administrative areas (departements). Cases were 50 patients with uveal
melanoma diagnosed in 1995-1996. Controls were selected at random from
electoral rolls, after stratification for age, gender, and area. Among
630 selected persons, 479 (76%) were interviewed. Data on personal
characteristics, occupational history, and detailed information on each
job held were obtained from face-to-face interviews using a standardized
questionnaire. Estimates of occupational exposure to solar and
artificial ultraviolet light were made using a job exposure matrix.
RESULTS: Results show elevated risks of ocular melanoma for people with
light eye color, light skin color, and for subjects with several eye
burns. The analysis based on the job exposure matrix showed a
significantly increased risk of ocular melanoma in occupational groups
exposed to artificial ultraviolet radiation, but not in outdoor
occupational groups exposed to sunlight. An elevated risk of ocular
melanoma was seen among welders (odds ratio = 7.3; 95% confidence
interval = 2.6-20.1 for men), and a dose-response relationship with job
duration was observed. The study also showed increased risk of ocular
melanoma among male cooks, and among female metal workers and material
handling operators. CONCLUSION: Following the present study, the
existence of an excess risk of ocular melanoma in welders may now be
considered as established. Exposure to ultraviolet light is a likely
causal agent, but a possible role of other exposures in the welding
processes should not be overlooked.
21
UI - 12148301
AU - Schaller UC; Mueller AJ; Bartsch DU; Schaumberger M; Freeman WR; Kampik
TI -
A
[Correlation between ICG angiography verified networks in uveal
melanomas and rate of tumor regression after brachytherapy]
SO - Ophthalmologe 2002 Jul;99(7):545-8
AD - Augenklinik der Ludwig-Maximilians-Universitat, Mathildenstrasse 8,
80336 Munchen. Ulrich.Schaller@ak-i.med.uni-muenchen.de
INTRODUCTION: The post-irradiation regression rate of uveal melanomas is
a prognostically significant factor for the development of metastases.
Other predictive factors for metastases are histological networks which
are imagable with confocal ICG angiography. The purpose of this study
was to evaluate a possible connection of networks in the ICGA and tumor
regression rates. METHODS: We compared the post-irradiation regression
rates (as %) in 20 patients 1 year after brachytherapy with networks
identified in pre-treatment indocyanine green angiography (ICGA). The
ICG angiography was performed before irradiation, 10 patients were
irradiated with Ru-106 and 10 were irradiated with Id-125. RESULTS: The
mean preoperative maximum apical height was 5.2 mm [SD: 1.5 mm; Ru106
group: 5.7 mm (SD: 1.0 mm); Id-125 group: 5.0 mm (SD: 1.9 mm)]. In 11
patients (55%) (Ru-106: 5; Id-125: 6) we found networks in the
preoperative ICG. The mean regression rate in tumors with networks was
51.3% (SD: 14.7%) and 28.0% (SD: 16.4%) in the group without networks.
The difference between both groups was statistically significant (p =
0.003, Mann-Whitney test). No statistically significant difference in
the regression rates was found between the two groups of brachytherapy
Ru-106 and Id-125 (p = 0.165, Mann-Whitney test). DISCUSSION: Highly
proliferative tumors are known to be more sensitive to irradiation. This
may be one reason why tumors with a rapid post-irradiation regression
are the more aggressive ones with regard to later development of
metastases. Histopathological networks are also known to be a strong
indication of more aggressive, metastasizing tumors. These networks are
also imagable in ICG angiography. Our observation emphasizes a
connection between networks in ICG angiography and regression rates of
uveal melanomas after brachytherapy.
22
UI - 12223957
AU - Morel X; Meyer A; Le Rouic JF; Tahn Trong T; Behar-Cohen F; Halhal M; Vu
TI -
TA; Elmaleh C; Dighiero P; Renard G; D'hermies F
[Nevus mimicking a basal cell carcinoma of the eyelid]
SO - J Fr Ophtalmol 2002 Jun;25(6):657-60
AD - Service d'Ophtalmologie du Pr. Renard, Hotel Dieu, 1, place du parvis
Notre-Dame, 75181 Paris Cedex 04, France.
A clinicopathologic case of a 41-year-old female patient exhibited a
single cutaneous tumor at the inner part of the free margin of the
inferior left eyelid. It was a pink, fleshy, and nodular
well-circumscribed exophytic mass with thin vessels on its surface.
Experienced already for 20 years, this lesion had been observed 6 years
before and has not exhibited much change since then. However, its
clinical appearance argued for a possible small basal cell carcinoma,
which had grown over the inferior left lachrymal duct. After surgical
removal, histopathology showed that the tumor was an amelanotic dermal
nevus. No disturbance of lachrymal drainage was observed after surgery.
This case shows that nodular amelanotic tumors of the eyelid, even when
located on the inner segment of the eyelid, may be a nevus.
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