National Cancer Institute®
Last Modified: October 1, 2002
UI - 12148390
AU - Haque MR; Abdullah M; Alauddin M; al-Haroon A; Majed MA; Ali MS
TI - Carcinoma larynx--topographical distribution.
SO - Mymensingh Med J 2002 Jan;11(1):15-21
AD - Faculty of Postgraduate Medicine, University of Dhaka.
One hundred and sixty subjects were included in our study, collected from four hospitals in Dhaka City. The mean age (+/- SD) of study subjects were 54.67 +/- 11.27 years. Out of 160 subjects 155 was males and 5 were females, and male to female ratio was 31:1. The highest number of study subjects was related to cultivation (40.62%). The majority of study subjects were from the low socio-economic status (68.72%). Carcinoma larynx is a multifactorial disease. Smoking and chewing habit are the most important factors associated with carcinoma larynx. Most of the male (93.12%) subjects were smoker. One hundred and fifteen (71.87%) subjects were found chewing habit of betel leaves with other ingredients. Hoarseness of voice was the commonest symptom 65.62%. Regional distribution of tumour showed supraglottic carcinoma topping the list (69.38%) followed by glottic carcinoma (30.62%) and there was no subglottic carcinoma. Site involvement in supraglottic carcinoma was found in combined location topping the list (89.20%). In glottic carcinoma majority was found glottic with supraglottic extension (65.31%). In majority cases growth were exophytic 52.50%. Palpable lymph mode was found in 48.75% of cases. All the carcinoma of larynx was found histologically of squamous cell type.
UI - 12211050
AU - Piyathilake CJ; Bell WC; Oelschlager DK; Heimburger DC; Grizzle WE
TI - The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavity.
SO - Head Neck 2002 Sep;24(9):859-67
AD - Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA. email@example.com
BACKGROUND: Despite the importance of reactive oxygen species (ROS) in the development of smoking-related cancers, little is known about the pattern of expression of ROS scavengers in these cancers. METHODS: In this present study, we examined the expression of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu-Zn-SOD), which are essential enzymes that eliminate ROS, in squamous cell cancers (SCCs) of the lung (n = 12), larynx (n = 13), and oral cavity (n = 20). RESULTS: SCCs of larynx and oral cavity showed significantly enhanced immuhistochemical expression of Mn-SOD compared with the matched uninvolved epithelium. The higher expression of Mn-SOD was shown to be late and early events in the process of SCC development in the larynx and the oral cavity, respectively. The expression of Mn-SOD in SCCs of the lung was significantly lower compared with luminal cells of the uninvolved epithelium but not compared with basal cells or an average expression of SOD in basal and luminal cells. The expression of both Mn-SOD and cytoplasmic or nuclear Cu-Zn-SOD in bronchial epithelium adjacent to invasive cancer was significantly lower compared with its expression in the uninvolved bronchial epithelium away from cancer. This resulted in a significant difference in SOD expression between cancer and uninvolved bronchial epithelium away from cancer but not between cancer and uninvolved epithelium adjacent to cancer. CONCLUSIONS: There are significant differences in the expression of Mn-SOD and Cu-Zn-SOD among SCCs of the lung, larynx, and oral cavity. The results also suggest that variations in distance between cancer and uninvolved tissues evaluated could contribute to conflicting results of SOD expression. Copyright 2002 Wiley Periodicals, Inc. Head Neck 24: 859-867, 2002
UI - 11991582
AU - Laccourreye O; Veivers D; Bassot V; Menard M; Brasnu D; Laccourreye H
TI - Analysis of local recurrence in patients with selected T1-3N0M0 squamous cell carcinoma of the true vocal cord managed with a platinum-based chemotherapy-alone regimen for cure.
SO - Ann Otol Rhinol Laryngol 2002 Apr;111(4):315-21; discussion 321-2
AD - Department of Otorhinolaryngology-Head and Neck Surgery, LaEnnec Hospital, Assistance Publique Hjpitaux de Paris, University of Paris V, France.
Based on an inception cohort of 35 patients with T1-3N0M0 squamous cell carcinoma of the true vocal cord who had a complete clinical response after a platinum-based induction chemotherapy regimen and a minimum of 3 years of follow-up, the current retrospective study documented the long-term results and consequences of local recurrence following the use of a platinum-based chemotherapy-alone regimen for cure. During the years 1985 to 1996, 231 patients with invasive squamous cell carcinoma of the true vocal cord classified as T1-3N0M0 were managed at our department with a platinum-based induction chemotherapy regimen. A complete clinical response was achieved in 77 patients. Thirty-five of the 77 patients with complete clinical response were managed at our institution with a platinum-based chemotherapy-alone regimen. The statistical analysis of data on survival, local control, nodal control, distant metastasis, and metachronous second primary tumor incidence was based on the Kaplan-Meier product limit method. Univariate analysis was performed for potential statistical relation between local recurrence and various variables. The 3- and 5-year actuarial survival estimates were 91.4% and 88.6%, respectively. Overall, the causes of death were intercurrent disease in 6 patients and metachronous second primary tumor in 4 patients. The 3- and 5-year actuarial local control estimate was 64.8%. No significant statistical relation could be demonstrated between the incidence for local recurrence and the variables under analysis. Salvage treatment in patients with local recurrence yielded a 100% local control rate and laryngeal preservation rate. The 3- and 5-year actuarial lymph node control estimate was 97.1%. The 3- and 5-year actuarial estimate for patients with distant metastasis was 0%. The 5- and 10-year actuarial estimates for patients with metachronous second primary tumor were 9.7% and 28.1%, respectively. Although local recurrence was noted in almost a third of patients with complete clinical response who were managed with a platinum-based chemotherapy-alone regimen, it did not appear to be detrimental, as none of the patients who had local recurrence ultimately died from their disease or lost their larynx.
UI - 12174612
AU - Miyahara H; Yane K; Tsuruta Y; Uemura H
TI - [A clinical study of 213 patients with laryngeal cancer]
SO - Nippon Jibiinkoka Gakkai Kaiho 2002 Jul;105(7):790-8
AD - Department of Otolaryngology Head and Neck Surgery, Nara Medical University, Nara.
We retrospectively analyzed 213 patients--197 men and 14 women aged 40 to 87 years--with laryngeal cancer treated at our department from 12:1. Cases included 120 glottic (56.3%), 90 supraglottic (42.3%), and 3 subglottic (1.4%). Radiotherapy for early cases and surgery, mainly total laryngectomy for T3 and T4 were conducted first. The 5-year cause-specific survival by site was 97.6% glottic and 77.5% supraglottic. The five-year survival was 88.6% overall. Local control was 83.8% in glottic T1a and 84.6% in glottic T1b. The 3-year preservation of the larynx was 89.1% in glottic T1a and 92.3% in glottic T1b. Distant metastases were observed in 14 cases, mostly to the lung, bones, and liver. At high risk for distant metastasis were those with supraglottic T3-T4, N1, N2b, or pN2c.
UI - 12296331
AU - Shiga K; Tateda M; Saijo S
TI - Complication-free laryngeal surgery after irradiation failure with prostaglandin E1 administration.
SO - Ann Otol Rhinol Laryngol 2002 Sep;111(9):783-8
AD - Department of Head and Neck Surgery, Miyagi Cancer Center Hospital, Natori, Japan.
To examine the usefulness and efficacy of administration of prostaglandin E1 (PGE1) after laryngeal surgery in patients who were previously treated with radiotherapy, we retrospectively examined the clinical data of 12 patients who had undergone partial laryngectomy and 21 patients who had undergone total laryngectomy. Complications were observed in 5 of the 7 cases treated with partial laryngectomy without PGE1 administration, while no complications were observed in the 5 cases treated with PGE1 after operation. Also, complications, including major leakage, were observed in 6 of the 15 patients who underwent total laryngectomy without PGE1, and no complications were observed in the 6 patients who received PGE1. The hospital stay was shorter for the patients treated with PGE1 than for those not receiving such treatment. Although this study was a small, nonrandomized pilot trial, the results indicated that PGE1 administration may be useful and effective for patients who undergo laryngeal surgery after irradiation failure, in decreasing the risk of postoperative complications and increasing the quality of life of the patients.
UI - 10564583
AU - Feenstra M; Bakema J; Verdaasdonk M; Rozemuller E; van den Tweel J;
TI - Slootweg P; de Weger R; Tilanus M Detection of a putative HLA-A*31012 processed (intronless) pseudogene in a laryngeal squamous cell carcinoma.
SO - Genes Chromosomes Cancer 2000 Jan;27(1):26-34
AD - Department of Pathology, University Hospital, Utrecht, The Netherlands.
HLA class I and beta-2-microglobulin (beta2m) expression in a moderately differentiated laryngeal squamous cell carcinoma appeared to be downregulated when analyzed by immunohistochemical procedures using the monomorphic anti-HLA class I monoclonal antibody (mAb; W6/32), locus-specific (HCA2 and HC10) and allele-specific (LT129.11 and KRE501) mAbs and anti-beta2m mAbs. To reveal the molecular basis of downregulated HLA class I expression, HLA-A typing was performed on DNA derived from peripheral blood lymphocytes (PBL) and the tumor. Sequencing-based typing (SBT) revealed HLA-A*02011, 31012. In addition to HLA-A*02011, 31012 alleles, the tumor contained an HLA-A*31012 allele, which lacked all introns when sequenced from the initiation codon through exon eight. The 3' UTR region was intact up to at least 200 bp downstream. The mutant HLA-A*31012 is restricted to laryngeal tumor tissue since it was not amplified in flanking tumor-free laryngeal tissue. The mutant HLA-A*31012 shares structural characteristics with processed pseudogenes, i.e., absence of introns and an intact 3' UTR. This indicates that the mutant HLA-A*31012 allele resulted from a retroposition (reverse transcription and integration) from the processed transcript of the wild-type HLA-A*31012 allele within a clonal tumor cell. Genes Chromosomes Cancer 27:26-34, 2000. Copyright 2000 Wiley-Liss, Inc.
UI - 11580231
AU - Vambutas A; DeVoti J; Pinn W; Steinberg BM; Bonagura VR
TI - Interaction of human papillomavirus type 11 E7 protein with TAP-1 results in the reduction of ATP-dependent peptide transport.
SO - Clin Immunol 2001 Oct;101(1):94-9
AD - Department of Otolaryngology, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
Human papillomaviruses (HPVs) cause benign and malignant epithelial tumors of the respiratory and genital mucosa. We previously reported that recurrent respiratory papillomas caused by HPV 6/11 express low levels of antibody-detectable TAP-1, the protein that transports peptides into the endoplasmic reticulum for assembly and presentation by MHC Class I, and that the extent of TAP-1 immunostaining is inversely related to the frequency of disease recurrence. We have now determined a mechanism for the reduction in TAP-1 detection. Anti-TAP-1 antibody immunoprecipitated very low amounts of protein from papilloma cells. However, immunoprecipitation of calreticulin, another member of the MHC I assembly complex, coprecipitated TAP-1 at levels comparable to those of uninfected cells. Immunoprecipitation of an HPV-positive cell line with either anti-TAP-1 or anti-calreticulin coprecipitated HPV E7 protein. Finally, purified HPV 11 E7 protein inhibited ATP-dependent peptide transport in vitro. We propose that the interaction of E7 with TAP-1 prevents TAP-1 antibody detection and efficient peptide transport, resulting in poor presentation of viral antigen on HPV-infected cells and thus failure to mount an effective immune-mediated prevention of disease recurrence. Copyright 2001 Academic Press.
UI - 2828816
AU - Sivachenko TP; Mechev DS; Abyzov RA
TI - [Radionuclide and thermographic diagnosis of laryngeal tumors]
SO - Med Radiol (Mosk) 1988 Jan;33(1):27-31
The paper is concerned with an analysis of the results of positive scintigraphy and thermography obtained from an investigation of 84 laryngeal and laryngopharyngeal cancer patients. The diagnostic accuracy of positive scintigraphy (38 patients) was 89.5%, that of thermography--78.9%, of both methods--93.3%. The authors described methodological aspects of the use of both methods and worked out indications for their use in combined diagnosis of laryngeal cancer: topical and differential diagnosis of malignant and benign laryngeal lesions, definition of a degree of tumor spreading (visualization of metastases to the lymph nodes), determination of the presence of laryngeal cancer recurrences and their differential diagnosis with postradiation edemas.
UI - 11936918
AU - Ferlito A; Silver CE; Rinaldo A; Kim H; Shaha AR
TI - Parastomal recurrence: a therapeutic challenge.
SO - Acta Otolaryngol 2002 Mar;122(2):222-9
AD - Department of Otolaryngology-Head and Neck Surgery, University of Udine, Policlinico Universitario, Italy. firstname.lastname@example.org
UI - 11936920
AU - Ricci E; Cavalot AL; Sanvito F; Bussi M; Albera R; Staffieri A;
TI - Cortesina G; Marchisio PC Differential expression and topography of adhesion molecules in laryngeal and oropharyngeal carcinomas.
SO - Acta Otolaryngol 2002 Mar;122(2):234-40
AD - Ear, Nose and Throat Clinic II, University of Turin, Italy. email@example.com
This work describes the different patterns of expression of integrins and extracellular matrix proteins in normal and transformed mucosa in laryngeal and oropharyngeal carcinomas. Samples from each tumor group were sectioned and examined by immunohistochemistry using monoclonal antibodies raised against integrin chains (alpha2, alpha3, alpha6, beta1 and beta4) and their ligands (laminins 1 and 5, collagen type IV and two fibronectin isoforms: ED-A and ED-B). Controls were provided by samples of tumor-free laryngeal and oropharyngeal mucosa that had been removed during the surgical procedure. We found that the known distinct topographical pattern of integrins and the continuity of basement membrane components was altered in both groups but that the extent of changes was significantly more marked in oropharyngeal tumors, which are known to be more infiltrating and diffusive and to have a bad prognosis. These molecular patterns of expression can be used as an additional prognostic factor as they suggest a greater biological tumor aggressiveness of oropharyngeal tumors. We suggest that performing immunohistochemical analysis on biopsy samples may help in selecting the correct therapeutic strategy for these tumors and enable more accurate follow-up. The above-mentioned molecules may become part of the diagnostic toolbox of head and neck surgical pathologists.
UI - 12002877
AU - Kawaida M; Fukuda H; Kohno N
TI - New visualization technique with a three-dimensional video-assisted stereoendoscopic system: application of the BVHIS display method during endolaryngeal surgery.
SO - J Voice 2002 Mar;16(1):105-16
AD - Department of Otolaryngology, Tokyo Metropolitan Ohtsuka Hospital, Japan. firstname.lastname@example.org
A three-dimensional video-assisted stereoendoscopic system (3D video system) developed by the Shinko Optical Company, Ltd. (Tokyo, Japan), and referred to as the binocular vision by horizontal image shifting display method (BVHIS display method), has been developed to digitally process ordinary video signals obtained with a video camera connected to a direct videolaryngoscope. The three-dimensional video system provides the surgeon with stereoendoscopic video images and enhances the ability of the surgeon to perform delicate endoscopic procedures. The three-dimensional video-assisted stereoendoscopic laryngosurgical procedure and its underlying principles are described in this paper. A total of 12 patients with laryngeal lesions causing dysphonia underwent three-dimensional video-assisted stereoendoscopic laryngosurgery. Although the video image obtained with the BVHIS display method is only pseudo-three-dimensional, this method enables the surgeon to perceive both depth perception and realism. We describe a surgical procedure using this new visualizing technique and the underlying principles of the technique. Preoperative and postoperative evaluations of the patients' vocal functions are also described. This system is a useful tool for the treatment of laryngeal lesions causing dysphonia.
UI - 12122625
AU - Uguz MZ; Onal K; Karagoz S; Gokce AH; Firat U
TI - [Coexistence of laryngeal cancer and laryngocele: a radiologic and pathologic evaluation]
SO - Kulak Burun Bogaz Ihtis Derg 2002 Jan-Feb;9(1):46-52
AD - Department of Otolaryngology, Ataturk Training and Research Hospital, Izmir, Turkey. email@example.com
OBJECTIVES: We investigated the incidence of laryngocele in patients with laryngeal cancer and in healthy controls and evaluated the role of laryngocele in neck metastasis and thyroid cartilage invasion. PATIENTS AND METHODS: The incidence of laryngocele was investigated by computed tomography (CT) preoperatively in 52 patients (49 men, 3 women; mean age 56 years; range 36 to 79 years) with laryngeal cancer. The findings were compared with those of histopathologic studies; moreover, neck metastasis and thyroid cartilage invasion were sought. In addition, the incidence of laryngocele was examined in 50 normal controls. RESULTS: Histopathologic examination showed laryngocele in 17 patients (32.7%). The incidence of laryngocele by CT was 30.7% (n = 16). Computed tomography showed laryngocele in three cases (6%). Of patients with laryngocele, lymph node metastasis and thyroid cartilage invasion were detected histopathologically in 47% and 23.5%, respectively, whereas lymph node metastasis and thyroid cartilage invasion were found in 22.8% of patients without laryngocele (p > 0.05). CONCLUSION: The association between laryngeal cancer and laryngocele requires a detailed evaluation for laryngeal carcinoma in patients in whom an asymptomatic laryngocele had been detected by CT.
UI - 12122626
AU - Aygenc E; Celikkanat S; Ozbek C; Dere H; Ozdem C
TI - [Functional outcomes after supracricoid partial laryngectomy]
SO - Kulak Burun Bogaz Ihtis Derg 2002 Jan-Feb;9(1):54-8
AD - Department of Ear Nose and Throat Diseases, Ankara Numune Hospital, Ankara, Turkey. firstname.lastname@example.org
OBJECTIVES: We evaluated functional outcomes in patients undergoing supracricoid partial laryngectomy (SCPL). PATIENTS AND METHODS: The study included 20 male patients (mean age 61.5 years; range 43 to 76 years) who underwent SCPL for advanced laryngeal carcinoma. Correlations were sought between variables (age, medical history, reconstruction techniques such as cricohyoidopexy or cricohyoidoepiglottopexy, arytenoid resection) and decannulation time, duration for oral feeding, weight change, and complications. The mean follow-up was 20.9 months (range 7 to 39 months). RESULTS: All patients were decannulated in a mean of 19.9 days. Eighty-five percent of patients achieved normal deglutition without aspiration or weight loss within six months postoperatively. The nasogastric feeding tube was removed in a mean of 39.7 days. Voice quality of patients was sufficient for their social communications. CONCLUSION: Our functional results suggest that SCPL is an alternative technique to total laryngectomy in patients in whom other partial laryngectomy techniques are not considered.
UI - 12122633
AU - Ozudogru E; Cingi E; Cakli H; Kecik MC; Cingi C; Gurbuz MK
TI - [Patient selection for near-total laryngectomy and oncologic results]
SO - Kulak Burun Bogaz Ihtis Derg 2002 Mar-Apr;9(2):121-5
AD - Osmangazi Universitesi Tip Fakultesi, Kulak Burun Bogaz Hastaliklari Anabilim Dali, Eskisehir, Turkey. email@example.com
OBJECTIVES: We reviewed preoperative, perioperative, and postoperative findings and the survival data to determine which patients may be appropriate for near-total laryngectomy. PATIENTS AND METHODS: We reviewed hospital records of 20 patients (all males; mean age 56.6 years; range 35 to 73 years) who underwent near-total laryngectomy. Indications for patient selection for near-total laryngectomy and survival data were evaluated in comparison with literature reports. RESULTS: The site of the tumor was the sinus pyriformis in two, and the larynx in 18 patients. Thirteen patients had T3, seven patients had T2 tumors. The lesions were localized in the sinus pyriformis in two patients with T2 tumors. The locoregional control rate at the end of two years was 75%; two- and three-year survival rates were 81.2% and 64.2%, respectively. CONCLUSION: Following a detailed and meticulous investigation in the preoperative period, near-total laryngectomy seems to be appropriate in selected patients with advanced laryngeal and hypopharyngeal tumors in which partial laryngectomy procedures are not considered. It may both provide cure and preserve phonation. It may also be considered for functional purposes in patients whose pulmonary functions are insufficient for partial laryngectomy, in those in whom food aspiration is inevitable after partial laryngectomy, and in those suffering from lifelong food aspiration due to neurologic causes, and for oncologic reasons in patients who develop local recurrences after partial laryngectomy.
UI - 12189579
AU - Feldmann H
TI - [Diagnosis and therapy of diseases of the larynx in the history of medicine. Part III. After the invention of laryngoscopy]
SO - Laryngorhinootologie 2002 Aug;81(8):596-604
AD - HNO-Klinik, Universitat Munster, Germany.
BACKGROUND: Laryngology a discipline of its own: When in 1855 Garcia had invented the indirect laryngoscopy and Turck and Czermak had introduced the method in clinical medicine numerous laryngological centres were founded in Austria, Germany, England, and France. FIRST INTERVENTIONS AND SOLUTION OF TECHNICAL PROBLEMS: In 1859 Czermak had already examined 20 patients with laryngeal diseases and demonstrated that it was possible to apply local treatment such as cautery under laryngoscopic view. The surgeon von Bruns in Tubingen (Germany) reported in 1862 on the successful removal of a polyp in the larynx. One common problem was the epiglottis preventing the view on the anterior part of the glottis. Czermak had suggested to make the epiglottis rise by intoning "hee". Methods of holding the epiglottis with a suture or with a forceps were not successful. In 1879 Reichert in Rostock (Germany) presented his epiglottis retractor which is still in common use. The irritability of the laryngeal mucosa remained the major problem for the next 20 years. CONSERVATIVE ENDOLARYNGEAL TREATMENT: The dominant means were local applications with brushes, powder blowers or injections of caustic fluids. Starting at about 1860 there were also steam inhalations. SURGICAL ENDOLARYNGEAL INTERVENTIONS: In a very early stage numerous instruments were devised such as sickle knives, various forceps, polyp snares and instruments for applications of electric currents. These were used in a monopolar and a bipolar way to induce electrolysis, coagulation and stimulation. INTRODUCTION OF SURFACE ANAESTHESIA: In 1884 in Vienna the surface anaesthesia with cocaine was introduced by Koller in the ophthalmology and by Jelinek in the laryngology. THE SPECIAL CASE HISTORY: The case history of the German emperor Frederick III, who died of laryngeal cancer in 1888, is briefly reported, because here all knowledge and technical facilities available at that time were brought into play. The treatment was guided by the German surgeons von Bergmann and Bramann, the laryngologists Gerhardt, Tobold and Schrotter (Vienna), the pathologists Virchow and Waldeyer, and the English laryngologist Mackenzie. The dominant problem was to have a safe diagnosis preoperatively. There was a passionate discussion about who was to blame for the fatal outcome of the emperor's disease. CONCLUDING.: Another case history is reported when the surgeon von Bergmann believed he could demonstrate a successful operation on a patient with an apparently secure diagnosis of a laryngeal carcinoma the way it should have been done on the emperor. He was wrong: it turned out to be a tuberculosis and the patient died three hours after the operation.
UI - 12228204
AU - Piantelli M; Iacobelli S; Almadori G; Iezzi M; Tinari N; Natoli C;
TI - Cadoni G; Lauriola L; Ranelletti FO Lack of expression of galectin-3 is associated with a poor outcome in node-negative patients with laryngeal squamous-cell carcinoma.
SO - J Clin Oncol 2002 Sep 15;20(18):3850-6
AD - Department of Oncology and Neurosciences, G. D'Annunzio University, Chieti, Italy. firstname.lastname@example.org
PURPOSE: Galectin-3 is a pleiotropic carbohydrate-binding protein participating in a variety of normal and pathologic processes, including cancer progression. This study was aimed at evaluating the prognostic value of galectin-3 expression in node-negative laryngeal squamous-cell carcinoma (SCC). PATIENTS AND METHODS: Galectin-3 expression was analyzed by immunohistochemistry using M3/38 monoclonal antibody, in a single-institution series of 73 node-negative laryngeal SCC patients (median follow-up, 52 months; range, 2 to 90 months). RESULTS: Forty-two (57.5%) of 73 patients expressed galectin-3. Galectin-3 expression was positively associated with tumor keratinization and histologic grade. A significant correlation was found between galectin-3 tumor positivity and longer relapse-free and overall survival. In univariate analysis, high-grade (grade 3 or 4) tumors, nonkeratinizing tumors, and galectin-3-negative tumors showed a significantly increased risk of relapse and death. In multivariate analysis, only galectin-3 expression retained an independent prognostic significance for both relapse-free and overall survival. CONCLUSION: We conclude that the absence of galectin-3 expression is an independent negative prognostic marker in laryngeal SCC patients. Thus, histochemical detection of galectin-3 in these tumors could be useful for the selection of node-negative patients with potentially unfavorable outcomes, to establish adjuvant therapy protocols.
UI - 12269628
AU - Bertino G; Bellomo A; Ferrero FE; Ferlito A
TI - Acoustic analysis of voice quality with or without false vocal fold displacement after cordectomy.
SO - J Voice 2001 Mar;15(1):131-40
AD - Department of Otolaryngology-Head Neck Surgery University of Udine, Italy.
Conventional cordectomy by means of a laryngofissure is one of the therapeutic options for treatment of early glottic cancer. To improve the poor voice quality related to this kind of operation, many authors have developed different techniques to repair the mucosal defect. We analyzed voice quality acoustically and compared it after cordectomy alone and after cordectomy with the reconstruction of the vocal cord in a group of 14 patients affected by T1 glottic carcinoma. All the patients underwent postoperative speech therapy. Three patients who underwent cordectomy with reconstruction showed the presence of diplophonia, while two patients without reconstruction showed the presence of bitonality. The differences of the acoustic parameters (jitter, shimmer, harmonic-to-noise ratio) between the two groups of patients were not statistically significant. Reconstruction of the vocal cord does not seem to improve voice quality after cordectomy even in combination with postoperative speech therapy.
UI - 12045791
AU - Menezes AM; Horta BL; Oliveira AL; Kaufmann RA; Duquia R; Diniz A; Motta
TI - LH; Centeno MS; Estanislau G; Gomes L [Attributed risk to smoking for lung cancer, laryngeal cancer and esophageal cancer]
SO - Rev Saude Publica 2002 Apr;36(2):129-34
AD - Departamento de Clinica Medica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
OBJECTIVE: Lung, laryngeal and esophageal cancers have smoking as one of their main risk factors. The objective of this study was to evaluate the population attributed risk (PAR) of smoking for these forms of cancer. METHODS: The study was based in three case-control studies conducted in medium size cities in Brazil. Incident cases of lung cancer, laryngeal cancer and esophageal cancer seen at a hospital setting and diagnosed through biopsy were analyzed; controls were hospitalized patients with another diagnoses. Smoking was the exposure factor measured at three levels: non-smokers, former smokers and smokers, which were defined using a questionnaire applied by trained interviewers. For effect measure, odds ratio was used and the populational attributed risk for smoking was then calculated for a 95% CI. RESULTS: A total of 122 lung cancer cases and 244 controls, 50 cases of laryngeal cancer and 48 cases of esophageal cancer, and 96 controls for both of them were studied. The prevalence of smoking exposure was 34%, which is the overall prevalence of smoking in this city's adult population. Odds ratios (OR) for the PAR analysis were the adjusted OR for confounding variables from each study. Lung cancer PAR was 63% (95% IC, 0.58-0.68) for former smokers and 71% (95%IC, 0.65-0.77) for smokers. Larynx cancer PAR was 74% (95% IC, 0.70-0.78) and 86% (95%IC, 0.81-0.85) for former smokers and smokers, respectively. Esophageal cancer PAR was 54% (95%IC, 0.46-0.62) for smokers. CONCLUSION: Smoking is an avoidable risk factor and smoking cessation could be responsible for significant reductions in the incidence of these three forms of cancer.
UI - 12162017
AU - Dutkiewicz W; Iciek W; Staniewicz W; Jablonska M
TI - [Comparison of the state of acceptance by patients after total and partial laryngectomy]
SO - Otolaryngol Pol 2002;56(3):303-6
AD - Oddzial Laryngologii Szpitala Wojewodzkiego w Zielonej Gorze.
In this study authors asked about 400 patients (or their families) after surgery procedures because of larynx carcinoma. The questions was connected with acceptance the postoperative state. We collected 170 answers on the question, 137 from patients after total laryngectomy and 33 after partial laryngectomy. On of the question exactly sounded: how patients accepted their postoperative state? They had 3 answers: not content, agreed with the injury or content with the treatment. The results was very astonished: from extreme discontent patients to very satisfied. The most acceptable from the patients point of view is the partial laryngectomy. Even if that sparing operation is enough for some time patient is more satisfied than after total laryngectomy. The acceptance for the total operation is lower, but grows together with a time alive's. The important conditions of acceptance the injuries after the total operations are the awareness of the threats because of the condition, the possibilities of the treatment and it's choice and the knowledge about a rehabilitations after surgery and possibilities to achieve it. The acceptance of the injuries depends on the acceptance this patients by society.
UI - 12162018
AU - Milecki P; Kruk-Zagajewska A; Stryczynska G
TI - [Timing and duration of postoperative radiotherapy in patients with laryngeal cancer]
SO - Otolaryngol Pol 2002;56(3):307-11
AD - Zaklad Radioterapii, Wielkopolskiego Centrum Onkologii w Poznaniu.
Aim of this was an evaluation of the impact of prolongation of combined treatment time on the local-regional control laryngeal cancer patients treated with surgery and postoperative radiotherapy. Study was based on retrospective analysis of 254 patients with T3/T4 and N0-N2 laryngeal surgery and postoperative radiotherapy (RT). Median age of investigated group was 56.3 years. Surgery consisted of total laryngectomy in all cases and with selective neck dissection. RT began 22 to 78 days postoperatively (median 45 days) and continued for a median of 47 days (range, 40-74 days). The primary tumor bed and all lymph neck nodes were treated in all patients. The total dose to the primary tumor bed was about 60 Gy, fraction dose was 2 Gy. All lymph nodes were irradiated with a dose of 50 Gy. The factors studied for prognostic importance for a local-regional failure included: overall combined treatment time, interval between surgery and the start of radiotherapy, radiotherapy treatment time, age, sex, T and N categories. The 5-year actuarial disease-free local-regional survival was 50%. On univariate analysis, using log rank test, only N status, sex were predicted for the locoregional control of postoperative radiotherapy. Overall treatment time longer than 90 days and especially 100 days was correlated with worse locoregional results of combined treatment respectively (p = 0.003 and p = 0.0007). Also prolongation of interval time between surgery and postoperative radiotherapy beyond 50 days was connected with higher rate of failures (p = 0.02). The same trend was observed when time of irradiation was longer than 47 days (p = 0.01). This analysis indicated that the prolongation of the overall treatment time of combined modality, the the time between surgery, and radiotherapy and time of postoperative radiotherapy were correlated with increased of local regional failures.
UI - 12162035
AU - Mikaszewski B
TI - [Prognostic factors in laryngeal carcinoma based on clinical and pathological analysis of 344 patients treated surgically]
SO - Otolaryngol Pol 2002;56(3):393-4
AD - Katedra i Klinika Chorob Uszu, Nosa, Gardla i Krtani AM w Gdansku.
UI - 12162036
AU - Zaorski P
TI - [Extracapsular spread of lymph nodes as a prognostic factor in laryngeal carcinoma]
SO - Otolaryngol Pol 2002;56(3):395-6
AD - Katedra i Klinika Chorob Uszu, Nosa, Gardla i Krtani AM w Gdansku.
UI - 11936307
AU - Stewart BW; Semmler PC
TI - Sharp v Port Kembla RSL Club: establishing causation of laryngeal cancer by environmental tobacco smoke.
SO - Med J Aust 2002 Feb 4;176(3):113-6
AD - South East Sydney Public Health Unit, Randwick, NSW. email@example.com
A New South Wales Supreme Court jury has decided that environmental tobacco smoke (ETS) can cause or materially contribute to the development of laryngeal cancer. Evidence presented that ETS may cause or materially contribute to laryngeal cancer included the molecular genetics of tobacco-smoke-induced carcinogenesis, and two relevant epidemiological studies. The plaintiff's exposure to ETS was established indirectly, on the basis of occupational history involving work as a bar attendant in licensed premises. The jury's decision seems likely to encourage other "passive smoking" cases, and may result in measures to reduce occupational exposure to ETS.
UI - 9839909
AU - Porter MJ; McIvor NP; Morton RP; Hindley AC
TI - Audit in the management of T3 fixed-cord laryngeal cancer.
SO - Am J Otolaryngol 1998 Nov-Dec;19(6):360-4
AD - Department of Otolaryngology/Head and Neck Surgery, Green Lane Hospital, Auckland, New Zealand.
PURPOSE: To determine results of various treatments for T3 fixed-cord lesions and the subset T3 glottic cancer in Auckland from 1979 to 1995. PATIENTS AND METHODS: Data were collected retrospectively from a departmental database, and the notes were reviewed. Because of the difficulty in determining the subsite of some fixed-cord lesions, the entire group of T3 fixed-cord lesions was examined, and those tumors that were considered to be definitely arising from the glottis were then analyzed as a specific subset. RESULTS: Fixed-cord lesions were diagnosed in 75 patients (21 supraglottic, 54 glottic). Primary surgery (total laryngectomy) was performed on 46 patients, primary radical dose radiotherapy was undertaken on 25 patients, and four patients were treated palliatively. For T3 fixed-cord lesions, disease-specific survival for radiotherapy and surgery was 36% and 66%, respectively, and 32% and 67%, respectively, for T3 glottic lesions. For both T3 fixed-cord and T3 glottic lesions, surgery produced significantly better survival than did radiotherapy (<60 Gy; P = .0157). With radiotherapy greater than 60 Gy, cancer of the larynx has been controlled in seven of 13 patients, although only five patients are alive, with a median follow-up of 24 months (range, 12-49 months). CONCLUSION: Radiotherapy less than 60 Gy produced markedly inferior results to surgery for T3 fixed-cord lesions and T3 glottis in Auckland. Radiotherapy at more than 60 Gy shows promise, but an ongoing audit is essential to ensure that survival is similar to surgery and to that reported by those promoting organ-preservation protocols.
UI - 12073267
AU - Amiraliev NM
TI - [Therapeutic policy in stage I-II laryngeal cancer]
SO - Lik Sprava 2002;(2):72-6
Radio-, chemoradiation (with making use of cysplatin and 5-fluorouracil) therapies were employed together with a surgical method as treatment of 197 patients with T1-2N0M0 laryngeal cancer. Efficiency of the methods each was assessed by recurrence-free source of the disease, survivals, and by functional results as well. The best results in the treatment of T1N0M0 laryngeal cancer have been found out to be secured with the use of the surgical method, as evidenced by the analysis of the clinical material--94.3 percent of patients are free from recurrence and metastases for more than three years versus 81.6 percent with the radiotherapy method. In T2N0M0 laryngeal cancer, 70% of patients are free from recurrence and metastases after radiotherapy treatments. With chemoradiotherapy and surgical treatment these parameters comprised 88.8% and 11.2%; 91.5% and 8.5%. In T2N0M0 glottic cancer the surgical method is considered to be superior to other options.
UI - 12218866
AU - Duflo S; Chrestian M; Guelfucci B; Champsaur P; Moulin G; Zanaret M
TI - [Comparison of magnetic resonance imaging with histopathological correlation in laryngeal carcinomas]
SO - Ann Otolaryngol Chir Cervicofac 2002;119(3):131-7
AD - Service ORL Adulte, CHU la Timone bu. Jean Moulin 13005 Marseille, France.
Apart from a clinical examination including direct laryngoscopy and biopsy, pretherapeutic staging for local extension of laryngeal carcinoma requires computed tomography. The role of magnetic resonance imaging (MRI) remains controversial. The aim of this study was to determine its value for detecting invasion of the main laryngeal structures. Histological findings were compared with axial MRI slices to remain in the same plane. A double-blind study of 10 areas of the larynx was performed: vocal muscle, anterior and posterior paraglottic spaces, anterior and posterior laryngeal commissures, anterior and posterior subglottic area, arytenoid, thyroid, and cricoid cartilages. MRI appeared to be the method of choice to detect neoplastic cartilage, and subglottic and commissural invasion. MRI allows a treatment strategy adapted to the areas involved by the laryngeal carcinoma.
UI - 9353428
AU - Chatani M; Matayoshi Y; Masaki N; Teshima T; Inoue T
TI - Radiation therapy for early glottic carcinoma (T1N0M0). The adverse effect of treatment interruption.
SO - Strahlenther Onkol 1997 Oct;173(10):502-6
AD - Department of Radiation Therapy, Osaka Medical Center for Cancer and Cardiovascular Disease, Japan.
PURPOSE: Clarification of the adverse effects of treatment interruption on the local control of early glottic carcinoma. PATIENTS AND METHODS: carcinoma (T1N0M0) were treated at this department. Of 253 patients administered 60 Gy in 30 fractions 77 patients had no treatment interruption and treatment was completed within 6 weeks (group I), overall treatment time was prolonged for 176 patients: 141 patients 43 to 49 days (group II) and 35 patients 50 to 62 days (group III). Treatment was interrupted due to public holidays (156 cases), patients convenience (13 cases) and severe mucosal reactions (seven cases). The major reason was public holidays, 91% in group II and 80% in group III. RESULTS: The 3-year recurrence-free survival rates were for group I 95%, group II 89% and group II 80%. Survivals for groups I and II, groups II and III and groups I and III were essentially the same. At 40 Gy tumor clearance was more than 50% in the 3-groups. For complete clearance cases at 40 Gy, recurrence-free survival was essentially the same for the 3 groups although for incomplete clearance cases, statistically significant difference for groups I and III (log-rank test p = 0.0004; Wilcoxon test p = 0.0004) and marginally significant difference for groups II and III (p = 0.0157, p = 0.0045) but no difference for groups I and II (p = 0.0669, p = 0.0853) were noted by adjusting the p-value. CONCLUSION: Prolongation of overall treatment time and tumor clearance at 40 Gy appeared to be a factor of the local control.
UI - 12368631
AU - Galli J; Cammarota G; Calo L; Agostino S; D'Ugo D; Cianci R; Almadori G
TI - The role of acid and alkaline reflux in laryngeal squamous cell carcinoma.
SO - Laryngoscope 2002 Oct;112(10):1861-5
AD - Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy. firstname.lastname@example.org
HYPOTHESIS: At present, main factors considered responsible for the onset of squamous cell carcinoma are tobacco smoking, alcohol abuse, and exposure to viral and toxic agents. In last years, great interest has been focused on gastroesophageal reflux as independent carcinogenic factor and co-carcinogen in association with smoking and alcohol assumption. STUDY DESIGN: Initially, the aim of this study was to objectively evaluate the presence of distal and proximal esophageal reflux with multielectrode pH measurement in patients with cancer of the larynx and/or hypopharynx (group A). However, in the course of the study, pharyngolaryngeal cancer was also observed in 4 patients with achlorhydria; therefore, the hypothesis that alkaline reflux might be involved in the onset of laryngeal cancer was tested (group B). METHODS: Twenty-one consecutive patients with laryngeal or hypopharyngolaryngeal squamous cell carcinoma (group A) entered the study. Twenty-one patients without laryngo-pharyngeal diseases were used as control subjects. A validated questionnaire of the clinical history was completed by all patients who underwent 24-hour pH monitoring. Group B included 40 consecutive gastrectomized patients (28 males and 12 females) in whom biliary or alkaline reflux was directly consequent to Billroth I or Billroth II operation. The control group was composed of 40 non-gastrectomized dyspeptic patients. The clinical history was controlled and obtained; EDGS and ENT examination with videolaryngoscopy was performed in all patients. RESULTS: In group A, pH measurement showed pathological reflux in 80.9% (17 of 21) of patients with no typical symptoms in 63.7% of them. The difference was significant with respect to the control group. In group B, 6 of 40 (15%) had preneoplastic lesions or a history of laryngeal tumor. The difference was significant with respect to the control group. A total of 7.5% of group B patients had previously undergone CO2 laser cordectomy for laryngeal squamous cell carcinoma and 7.5% had leukoplakia. We found a significantly higher incidence (<.05) of neoplastic and preneoplastic disease of the larynx in patients undergoing Billroth II and total gastrectomy than in those undergoing Billroth I and Roux-en-Y resection. We also found a significant increase (<.01) in ENT lesions in the group of patients who had undergone gastrectomy more than 20 years previously. CONCLUSIONS: In agreement with literature reports, results obtained in group A confirmed that gastroesophageal reflux is often present in patients with neoplastic lesions of the pharynx and larynx. Furthermore, gastric resection is indicated for the first time as an additional risk factor or cofactor of precancerosis and squamous cell carcinoma of the pharynx or larynx. Further studies are necessary to establish the cause and effect relationship between biliary reflux and pharyngo-laryngeal tumors.
UI - 11938525
AU - Raji A; Mahtar M; Atlassi B; Essaadi M; Detsouli M; Kadiri F; Chekkoury
TI - IA; Benchekroun Y [Unusual benign tumors of the larynx: report of 17 cases]
SO - Rev Laryngol Otol Rhinol (Bord) 2001;122(4):245-8
AD - Hopital 20 Aoput, CHU Ibn Rochd, Service ORL, Casablanca, Maroc, 20 rue 19 Douam, Casablanca 04, Maroc.
Rare benign tumours of the larynx (RBTL) form a heterogeneous group. The clinical picture is non-specific. Based on a series of 17 cases of RBTL treated in our department, we wish to draw attention to the diagnosis, treatment and clinical course of these tumours. The mean age of the patients was 37 years, with the male sex predominating. The presenting symptom was most commonly progressive dysphonia, while 5 patients were admitted in respiratory distress. Examination and special investigations revealed 8 cases of laryngocoele, 6 cases of angioma, 2 cases of schwannoma, and one of chondroma. Treatment was surgical, by an external approach in 10 cases and endoscopically in 7. The postoperative course was satisfactory. No long-term recurrences were encountered. Conservative surgery by an external or endoscopic approach has revolutionised the functional outcome in these benign tumours.
UI - 11938707
AU - Galli J; Frenguelli A; Calo L; Agostino S; Cianci R; Cammarota G
TI - [Role of gastroesophageal reflux in precancerous conditions and in squamous cell carcinoma of the larynx: our experience]
SO - Acta Otorhinolaryngol Ital 2001 Dec;21(6):350-5
AD - Istituto di Otorinolaringoiatria, Universita Cattolica Sacro Cuore, Roma. email@example.com
The major risk factors for the onset of precancerous lesions and squamous cell carcinoma of the larynx are, above all, tobacco smoke, alcohol abuse and exposure to viral and toxic agents. In recent years, however, gastro-esophageal reflux (GER) has also aroused significant interest not only as carcinogen but also as co-carcinogen in association with smoking and alcohol consumption. The purpose of the present work is to provide an objective evaluation of the presence of distal and proximal esophageal reflux using multi-electrode pH monitoring in patients with precancerous lesions of the larynx and laryngeal and pharyngolaryngeal neoplasms. A total of 24 patients consecutively hospitalized during 2000 were evaluated: 20 with squamous cell carcinoma of the larynx and/or pharynx-larynx and 4 with precancerous vocal cord lesions. All the patients provided a case history using a validated questionnaire and underwent electronic videolaryngoscopy and 24-hour pH monitoring. Data analysis showed that in 83.3% of the cases (20/24) pH monitoring was indicative of pathological GER and 63.7% of these patients had no complaints related to reflux. Moreover, 7/24 patients have had a previous gastrectomy (Billroth II) strictly related