- Cancer Types
Information about risk, prevention, screening, symptoms, diagnosis, treatment, and support for all cancers Cancer A to Z - Cancer Treatment
Cancer Treatment
Information about cancer treatment, including surgery, chemotherapy, radiation therapy, clinical trials, proton therapy, complementary medicine, and cutting edge technologies.
- Risk and Prevention
- Cancer Drugs
- Support
Support
Ways for cancer patients and caregivers to cope with cancer, side effects, nutrition, general cancer support issues, grief/end of life issues, and shared survivor's experiences.
- Healthcare Professionals
- Clinical Trials
My Patient Treatment Binder
OncoLink Blogs
What's My Cancer Risk?
OncoPilot: Navigating Your Cancer Journey
Community Events Calendar
OncoLink eNews
Abramson Cancer CenterNCI CANCERLIT® Search: Paranasal Sinus and Nasal Cavity Cancer - October 2002
National Cancer Institute®
Last Modified: October 1, 2002
- Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis.
- Rare mesenchymal lesions: Hamartoma of the chest wall and juvenile active ossifying fibroma in siblings.
- Malignant tumors of the nasal cavity and paranasal sinuses.
- [Pleomorphic adenoma in unusual anatomic sites: case reports and review of literature]
- [Giant antro-choanal polyp]
- Comparison of two T-classification systems for sino-nasal carcinoma.
- [Ectopic prolactinoma of the sphenoidal sinus: case report]
- Nasofrontal dermoid sinus cyst: report of two cases.
- Cancer of the nasal cavity: survival and factors influencing prognosis.
- Expression of HLA class I, beta(2)-microglobulin, TAP1 and IL-10 in Epstein-Barr virus-associated nasal NK/T-cell lymphoma: Implications for
- The estimated incidence of symptomatic nasal polyps.
- Study of ethmoidal mucosa in a population at occupational high risk of sinonasal adenocarcinoma.
- Esthesioneuroblastoma and cervical lymph node metastases: clinical and therapeutic implications.
- [Four cases of inverted papilloma]
- Juvenile angiofibroma: case report and the role of endoscopic resection.
- Adenoid cystic carcinoma of the nasal septum.
- Mesenchymal chondrosarcoma of the maxilla.
- [Coexistence of choanal polyp and lymph node tuberculosis]
- Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa.
- [Value of secondary coronal reconstructions in computed tomography of the paranasal sinuses]
- Desmoplastic ameloblastoma with large cystic change in the maxillary sinus: report of a case.
- [Therapy of malignant tumors in the area of the paranasal sinuses]
- [Pleomorphic adenoma of the nasal cavity: a case arising from the wall of the maxillary sinus]
- [Treatment of inverted papilloma with endonasal endoscopic sinus surgery]
- [French multicenter prospective epidemiologic study (ORLI Group) of allergic and lung diseases associated with nasal polyposis]
- [Loss of visual acuity caused by ethmoidal mucocele cured after endonasal surgery: report of a case]
- [Olfactory esthesioneuroblastoma with an ophtalmological presentation: a case report]
- Esthesioneuroblastoma: irradiation alone and surgery alone are not enough.
Table of Contents
1
UI - 10807324
AU - Raynor EM; Butler A; Guill M; Bent JP 3rd
TI -
Nasally inhaled dornase alfa in the postoperative management of chronic
sinusitis due to cystic fibrosis.
SO - Arch Otolaryngol Head Neck Surg 2000 May;126(5):581-3
AD - Department of Otolaryngology, University of Florida--Health Science
Center, Jacksonville 32209, USA.
OBJECTIVE: To determine the benefit of nasally inhaled dornase alfa in
cystic fibrosis (CF) sinusitis. DESIGN: Retrospective chart review
comparing postsurgical course, radiographic studies, and pulmonary
function test results in patients who were treated with nasally inhaled
dornase alfa with those in patients who were not treated with dornase
alfa. PATIENTS: Twenty consecutive patients with CF who underwent
functional endoscopic sinus surgery from 1993 to 1997 were included in
the study. Treatment with nasally inhaled dornase alfa was initiated in
5 of the 20 patients after they underwent functional endoscopic sinus
surgery. SETTING: Tertiary care academic center. RESULTS: The dornase
alfa-treated patients had less mucosal edema and no polyps at serial
endoscopy over 3 years compared with the non-dornase alfa-treated
patients. The patients who received nasally inhaled dornase alfa also
underwent fewer revision functional endoscopic sinus surgical procedures
(1.6 vs 3.2), even though there was essentially no change in pulmonary
function test results in these patients. CONCLUSIONS: Sinusitis
continues to be a major cause of morbidity in patients with CF.
Symptomatic patients frequently require multiple drug regimens,
including long-term systemic antibiotic therapy, topical and systemic
steroid therapy, and antibiotic nasal irrigations. This preliminary
study indicates the potential impact of nasally inhaled dornase alfa in
controlling postoperative symptoms in CF sinusitis.
2
UI - 12194150
AU - Golla S; Wit J; Guschmann M; Lubbert E; Kerner T
TI -
Rare mesenchymal lesions: Hamartoma of the chest wall and juvenile
active ossifying fibroma in siblings.
SO - J Pediatr Surg 2002 Sep;37(9):E27
AD - Departments of Pediatric Surgery, Charite Medical Center, Virchow
Hospital, Humboldt University, Berlin, Germany.
Mesenchymal hamartomas of the thorax are known as rare dysontogenetic
tumorous non-neoplastic lesions. The juvenile active ossifying fibroma
(JAOF) also is considered as a benign tumor like lesion of the
mesenchymal connective tissue. The authors report the cases of 2
siblings-a 2-year-old girl with a hamartoma of the chest wall and her
4-year-old brother with a JAOF. The girl had bilocular mesenchymal
hamartoma in the area of the 8(th) rib diagnosed in the first year of
life, which was surgically removed completely. Her brother had been
treated for JAOF of the right nasal sinus area diagnosed at the age of
15 months. Both lesions are extremely rare mutations of the local
tissue, which occur typically in early childhood and continue benignly
after surgical resection, but such a familial occurrence in siblings has
not yet been reported. Furthermore, according to the histologic
findings, the JAOF also could be seen as a hamartomatous lesion.
Copyright 2002, Elsevier Science (USA). All rights reserved.
3
UI - 12211046
AU - Katz TS; Mendenhall WM; Morris CG; Amdur RJ; Hinerman RW; Villaret DB
TI -
Malignant tumors of the nasal cavity and paranasal sinuses.
SO - Head Neck 2002 Sep;24(9):821-9
AD - Department of Radiation Oncology, University of Florida Health Science
Center, P. O. Box 100385, Gainesville, Florida 32610-0385, USA.
PURPOSE: To evaluate the role of radiation therapy in patients with
nasal cavity and paranasal sinus tumors. MATERIALS AND METHODS: Between
nasal cavity (48 patients), ethmoid sinus (24 patients), sphenoid sinus
(5 patients), or frontal sinus (1 patient) were treated with curative
intent by radiation therapy alone or in the adjuvant setting. There were
25 squamous cell carcinomas, 14 undifferentiated carcinomas, 31 minor
salivary gland tumors (adenocarcinoma, adenoid cystic carcinoma, and
mucoepidermoid carcinoma), 8 esthesioneuroblastomas, and 1 transitional
cell carcinoma. Forty-seven patients were treated with irradiation
alone, 25 with surgery and postoperative irradiation, 2 with
preoperative irradiation and surgery, and 4 with chemotherapy in
combination with irradiation with or without surgery. RESULTS: The
5-year actuarial local control rate for stage I (limited to the site of
origin; 22 patients) was 86%; for stage II (extension to adjacent sites
(eg, adjacent sinuses, orbit, pterygomaxillary fossa, nasopharynx; 21
patients) was 65%; and for stage III (destruction of skull base or
pterygoid plates, or intracranial extension; 35 patients) was 34%. The
5-year actuarial local control rate for patients receiving postoperative
irradiation was 79% and for patients receiving irradiation alone was 49%
(p =.05). The 5-, 10-, 15-, and 20-year ultimate local control rates for
all 78 patients were 60%, 56%, 48%, and 48%, respectively. The 5-, 10-,
15-, and 20-year cause-specific survival rates for all 78 patients were
56%, 45%, 39%, and 39%, respectively. The 5-, 10-, 15-, and 20-year
absolute survival rates for all 78 patients were 50%, 31%, 21%, and 16%,
respectively. Of the 67 (86%) patients who were initially seen with
node-negative disease, 39 (58%) received no elective neck treatment, and
28 (42%) received elective neck irradiation. Of the 39 patients who
received no elective neck treatment, 33 (85%) did not experience
recurrence in the neck compared with 25 (89%) of 28 patients who
received elective neck irradiation. Most patients who received elective
neck irradiation (57%) had stage III disease. Twenty-one (27%) of 78
patients had unilateral blindness develop secondary to radiation
retinopathy or optic neuropathy; the complication was anticipated in
most of these patients, because the ipsilateral eye was irradiated to a
high dose. Four patients (5%) unexpectedly had bilateral blindness
develop because of optic neuropathy. All four of these patients received
irradiation alone. CONCLUSION: Surgery and postoperative radiation
therapy may result in improved local control, absolute survival, and
complications when compared with radiation therapy alone. Elective neck
irradiation is probably unnecessary for patients with early-stage
disease. Copyright 2002 Wiley Periodicals, Inc. Head Neck 24: 821-829,
2002
4
UI - 12173287
AU - Nardone M; Ferrara G; Nappi O; Di Maria D; Villari G
TI -
[Pleomorphic adenoma in unusual anatomic sites: case reports and review
of literature]
SO - Acta Otorhinolaryngol Ital 2002 Jun;22(3):158-63
AD - Istituto di Patologia e Clinica ORL, Universita di Napoli Federico II,
Napoli. m.nardone@katamail.com
Pleomorphic adenoma is the most common neoplasm of the major salivary
glands, in particular of the parotid gland. Only occasionally can it be
found in the cervicofacial area outside the major and minor salivary
glands of the oral cavity. The present article describes three cases of
pleomorphic adenoma, respectively of the external auditory canal, the
nose, and the larynx. The three tumors showed no clinical or
radiological signs of malignancy and were surgically excised with a
suitable margin of healthy tissue. Histologically, the typical features
of pleomorphic adenoma were observed in the larynx case alone. The
pleomorphic adenoma of the external auditory canal evidenced an
extensive apocrine glandular component; the neoplasm of the nose was
itself characterized by ample proliferation of fused cells.
Immunohistochemical findings revealed focal or widespread positivity to
cytokeratin, S100 protein and muscle-specific actin in both the
epithelial and mesenchymal components of the neoplasm. Cases of
pleomorphic adenoma in sites other than the major salivary glands show
clinical and radiological signs of benignity. Their histopathological
identification is, however, not always straightforward;
immunohistochemistry can contribute significantly to the formulation of
a definitive diagnosis and to the realization of an appropriate
follow-up.
5
UI - 12173516
AU - Martinez Monedero R; Morais Perez D; Ramirez Cano B; Sancho Alvarez A;
TI -
Martinez Guisado P
[Giant antro-choanal polyp]
SO - An Otorrinolaringol Ibero Am 2002;29(3):281-7
AD - Servicio ORL, Hospital Clinico Universitario de Valladolid.
Antrochoanal polyps are, basically, pathologies of children and young
adults. The case here reported is really exceptional because its size
and its appearance at so unusual age. Etio-pathogenesis, clinical course
and differential diagnosis, face to other pathologies, are perused and
also with several varieties of choanal polyps and the treatments
proposed as well.
6
UI - 12169126
AU - Harbo G; Bundgaard T; Overgaard J; Grau C
TI -
Comparison of two T-classification systems for sino-nasal carcinoma.
SO - Clin Otolaryngol 2002 Aug;27(4):254-9
AD - Department of Head and Neck Surgery, Aarhus University Hospital,
Denmark.
It is often difficult to determine the actual site of origin of tumours
originating in the sino-nasal region, and a uniform classification
system that covers all tumours in this area is warranted. A
retrospective series of 165 consecutive patients with sino-nasal
carcinoma, treated and followed at the Aarhus University Hospital
between 1963 and 1991, was evaluated and T-staged according to the
Lederman classification. The 80 maxillary antrum carcinomas were also
staged according to the UICC 1997 system. In univariate analysis, the
UICC T-classification was prognostic for locoregional tumour control and
disease-specific survival. However, when adjusted for covariates (gender
and nodal involvement) in a multivariate analysis, the UICC
classification was not a significant independent prognostic parameter.
In contrast, the Lederman T-classification was prognostic both in
univariate and multivariate analysis. The Lederman T-classification was
more prognostic for locoregional control and disease-specific survival
than the UICC TNM classification. In addition, the Lederman
classification is easy to use and has a broader applicability as it
covers all sites in the sino-nasal area.
7
UI - 12193879
AU - Rebai R; Rekik N; Boudawara MZ; Khannous M; Bahloul K; Chaari S; Abid M;
TI -
Ben Mansour H
[Ectopic prolactinoma of the sphenoidal sinus: case report]
SO - Ann Endocrinol (Paris) 2002 Jun;63(3):226-30
AD - Service de Neurochirurgie, Tunisie, France.
A 34-year-old woman was hospitalized for exploration of amenorrhea and
galactorrhea. She had experienced primary sterility, diagnosed 11 years
earlier. Endocrine tests demonstrated hyperprolactinemia (serum
prolactin 594 ng/ml). Magnetic resonance imaging (MRI) showed a soft
tissue mass located within the posterior part of the sphenoidal sinus.
The pituitary gland appeared normal. Medical treatment with
bromocriptine was unsuccessful. Transsphenoidal tumor resection was
performed. Histology reported adenoma, which was consistent with
prolactin-producing tumor demonstrated by immunohistochemical staining
for prolactin. Because of the persistence of hyperprolactinemia related
to an intra-sphenoidal tumor remnant, bromocriptine (15 mg/d) was
initiated. Menses ensued and prolactin level declined (49 ng/ml). One
year later, the tumor remnant had disappeared on the MRI and the patient
became pregnant. Ectopic adenomas of the sphenoidal sinus are of
particular interest due to the diagnostic difficulties encountered.
Nevertheless, the nature of the lesion can be determined from the
endocrine manifestations. Some of these tumors respond to medical
treatment, similar to intra sellar tumors. Surgery remains however the
only means of obtaining definitive diagnosis and cure.
8
UI - 12188963
AU - Zerris VA; Annino D; Heilman CB
TI -
Nasofrontal dermoid sinus cyst: report of two cases.
SO - Neurosurgery 2002 Sep;51(3):811-4; discussion 814
AD - Department of Neurosurgery, Tufts New England Medical Center, Boston,
Massachusetts 02111, USA. zerris@attbi.com
OBJECTIVE AND IMPORTANCE: Nasofrontal dermoid sinus cysts are rare. The
embryological origin, presentation, treatment, and genetic associations
of two cases of these cysts are discussed. Emphasis is placed on
physical findings and the importance of addressing both the intracranial
and extracranial components. CLINICAL PRESENTATION: The first patient, a
33-year-old woman, sought care for chemical meningitis. As a child, she
was differentiated from her identical twin sister by a dimple on the tip
of her nose. The second patient, a 34-year-old man, sought care for
new-onset seizures. Since birth, he had a dimple on the tip of his nose.
As a child, he had undergone resection of a nasal cyst. Imaging studies
in both patients indicated a midline anterior cranial base mass within
the falx and a defect in the crista galli. INTERVENTION: Both patients
underwent biorbitofrontal nasal craniotomy. A bifrontal craniotomy was
performed first, then removal of the orbitonasal ridge. The dermoid and
involved falx were resected. The sinus tract was followed through the
crista galli and resected up to the osteocartilaginous junction in the
nose. The remainder of the tract was resected via a small incision
through the nares. The dura was closed primarily by mobilizing the dura
along the sides of the crista galli. After surgery, both patients still
possessed their sense of smell. CONCLUSION: Nasofrontal dermoid sinus
cysts have a unique embryological origin. A midline basal frontal
dermoid associated with a dimple on the nasal surface with or without
protruding hair and sebaceous discharge is the pathognomonic
presentation. It is important to address both the intracranial and
extracranial component surgically. Although concomitant anomalies and
familial clustering have been described, most cases are spontaneous
occurrences.
9
UI - 12220216
AU - Bhattacharyya N
TI -
Cancer of the nasal cavity: survival and factors influencing prognosis.
SO - Arch Otolaryngol Head Neck Surg 2002 Sep;128(9):1079-83
AD - Division of Otolaryngology, Brigham and Women's Hospital, Department of
Otology and Laryngology, Harvard Medical School, Boston, Mass, USA.
OBJECTIVE: To determine overall survival and prognostic factors for
cancer of the nasal cavity. DESIGN: Cross-sectional analysis of a
national cancer database. METHODS: All cases of nasal cavity cancer were
extracted from the Surveillance, Epidemiology and End Results database
for 1988 through 1998. Cases with distant metastatic disease were
excluded. Tumor histologic types, TNM staging, and pathological features
were computed. Kaplan-Meier and Cox proportional hazards analyses were
conducted to determine factors influencing overall survival. RESULTS: A
total of 981 cases were identified, with 3.5% presenting with distant
metastatic disease. After exclusion of missing variables, 783 cases were
analyzed, with a mean patient age of 63.8 years. Squamous cell carcinoma
was the most common tumor histologic type (49.3%), followed by
esthesioneuroblastoma (13.2%). More than half of the cases presented
with early (T1) primary site disease, and only 5% had positive nodal
disease at presentation. Overall mean (median) survival was 76 (81)
months, with an overall 5-year survival rate of 56.7%. On multivariate
analysis, male sex, increasing age, T stage, N stage, and poorer tumor
grade independently adversely affected survival (P<.05). Radiotherapy
was administered in 50.5% of patients and also independently predicted
poorer survival (P =.03). The mean (median) survival for squamous cell
carcinoma was 79 (84) months; only melanoma showed a statistically
significantly poorer mean survival of 40 (30) months when compared with
other tumors (P<.001). CONCLUSIONS: Age, sex, and staging variables have
a significant prognostic impact in nasal cavity cancer. Melanomas of the
nasal cavity manifest very poor survival.
10
UI - 11340574
AU - Shen L; Chiang AK; Liu WP; Li GD; Liang RH; Srivastava G
TI -
Expression of HLA class I, beta(2)-microglobulin, TAP1 and IL-10 in
Epstein-Barr virus-associated nasal NK/T-cell lymphoma: Implications for
tumor immune escape mechanism.
SO - Int J Cancer 2001 Jun 1;92(5):692-6
AD - Department of Pathology, The University of Hong Kong, Queen Mary
Hospital Compound, 102 Pokfulam Road, Hong Kong, ROC.
Several mechanisms of immune escape might be in operation in
Epstein-Barr virus (EBV)-associated nasal NK/T-cell lymphoma. We have
previously shown the downregulation of the immunogenic EBV nuclear
antigens by alternative promoter usage and the preferential selection of
the deletion genotype of latent membrane protein 1 in nasal lymphoma. To
understand further the strategies used for immune escape by this tumor,
we examined by immunohistochemistry HLA class I expression in 15 cases
using frozen sections, along with beta(2)-microglobulin and transporter
associated with antigen processing 1 (TAP1) expression in 39 cases using
paraffin sections. All nasal NK/T-cell lymphomas showed positive
staining for HLA class I, beta(2)-microglobulin and TAP1 on most tumor
cells, except for two cases (5%) in which most of the tumor cells lacked
beta(2)-microglobulin staining. We next immunostained for interleukin-10
on frozen sections in 13 cases, all of which showed strong expression by
most tumor cells. Transcription of human interleukin-10 but not EBV
BCRF1 (viral interleukin-10) was identified by reverse
transcriptase-polymerase chain reaction in these nasal NK/T-cell
lymphomas. Overall, our data suggest that global downregulation of HLA
class I or TAP1 rarely accounts for the ability of nasal NK/T-cell
lymphoma to evade immunosurveillance and that other immune escape
mechanisms may be operating in nasal NK/T-cell lymphoma, such as
production of interleukin-10 to suppress the local immune response.
Copyright 2001 Wiley-Liss, Inc.
11
UI - 11936910
AU - Larsen K; Tos M
TI -
The estimated incidence of symptomatic nasal polyps.
SO - Acta Otolaryngol 2002 Mar;122(2):179-82
AD - ENT Clinic, Esbjerg, Denmark.
The objective of the present study was to establish the estimated
incidence of symptomatic nasal polyps within a defined geographic area.
Over a 6-year period all polyp patients diagnosed for the first time (n
= 252; 174 males, 78 females) were prospectively registered at the study
clinic. An estimated background population from which the patients were
recruited was defined. Polyps were diagnosed by endoscopic examination.
The mean estimated incidences for all age groups were 0.86 and 0.39
patients per thousand per year for males and females, respectively. The
incidence increased with age, reaching peaks of 1.68 and 0.82 patients
per thousand per year for males and females, respectively in the age
group 50-59 years. The overall estimated incidence of symptomatic nasal
polyps was 0.627 patients per thousand per year. Five percent of the
patients had antrochoanal polyps and these patients had a lower mean age
at diagnosis than the other patients, of whom 41% also had unilateral
presentation at the time of diagnosis. This study seems to give a fairly
reliable estimated incidence of symptomatic nasal polyps for different
age groups and provides results that do not contradict prevalence
studies in the literature, making it useful in a clinical context.
12
UI - 11936913
AU - Bussi M; Gervasio CF; Riontino E; Valente G; Ferrari L; Pira E;
TI -
Cortesina G
Study of ethmoidal mucosa in a population at occupational high risk of
sinonasal adenocarcinoma.
SO - Acta Otolaryngol 2002 Mar;122(2):197-201
AD - Dipartimento di Fisiopatologia Clinica Sezione ORL II, Universita di
Torino, Turin, Italy.
The occurrence of nasal adenocarcinomas was first described in 1965.
Since 1988 these tumors have been accepted as an occupational disease
for woodworkers in Italy. There are several underlying reasons why there
is interest in studying the ways in which sinonasal adenocarcinomas
occur. Often diagnosed at advanced stages of development because their
symptoms are non-specific, these tumors are associated with a high
mortality rate. A multidisciplinary study protocol was developed in this
investigation. The aim was to identify the factors and conditions that
promote sinonasal tumor growth in a population at risk due to
occupational exposure to wood dust. Sixty-eight carpenters with a
minimum of 10 years exposure to wood dust were studied. The control
group comprised 81 volunteers. The patients underwent the following
protocol: completion of a case report form, physical examination,
evaluation of nasal cavity patency, clinical laboratory tests and
histological study of the nasal mucosa. Our study provides significant
evidence of the elevated incidence of pavimentous metaplasia in workers
occupationally exposed to wood dust. In addition, it underscores a
significant deficit of immunoglobulin A in such workers compared to the
controls. However, we did not find, as reported elsewhere in the
literature, a statistically significant difference between cases and
controls as regards nasal symptoms and hyperemia of the nasal mucosa.
Our study showed that, even in the absence of evident sinonasal lesions,
it is still possible to determine an increased incidence of
morphofunctional changes in subjects occupationally exposed to wood
dust. Our findings may lead to the identification of occupational groups
prone to elevated risk of the disease.
13
UI - 11936917
AU - Rinaldo A; Ferlito A; Shaha AR; Wei WI; Lund VJ
TI -
Esthesioneuroblastoma and cervical lymph node metastases: clinical and
therapeutic implications.
SO - Acta Otolaryngol 2002 Mar;122(2):215-21
AD - Department of Otolaryngology-Head and Neck Surgery, University of Udine,
Policlinico Universitario, Italy.
14
UI - 12122629
AU - Onal K; Uguz MZ; Gokce H; Deniz A; Tunakan M
TI -
[Four cases of inverted papilloma]
SO - Kulak Burun Bogaz Ihtis Derg 2002 Jan-Feb;9(1):66-9
AD - Department of Otolaryngology, Izmir Ataturk Training Hospital, Izmir,
Turkey.
Inverted papilloma is a benign lesion fo the nasal cavity and paranasal
sinuses. Its aggressiveness and association with malignancy have been
emphasized in the literature. In this paper, four patients (3 females, 1
male) with inverted papilloma are presented. Their ages ranged between
45 and 68 years. Surgery was performed using the degloving method which
enables a wide exposure and radical resection with minimal scar on the
face. No recurrences were detected in the postoperative period in
patients with regular controls. The importance of postoperative
histopathologic examination is addressed with a review of the
literature.
15
UI - 12188068
AU - Lim IR; Pang YT; Soh K
TI -
Juvenile angiofibroma: case report and the role of endoscopic resection.
SO - Singapore Med J 2002 Apr;43(4):208-10
AD - Department of Otolaryngology, National University Hospital, Singapore.
Ruen_lim@yahoo.com
Juvenile angiofibroma is benign yet aggressive. Due to its inaccessible
location in the nasopharynx, open surgery usually requires osteotomies
which cause stunting of facial growth in adolescent males. Advances in
imaging and treatment techniques have now facilitated more accurate
staging of this disease. For small, extracranial tumours limited to the
nasal cavity and paranasal sinus, endoscopic resection is a viable
alternative. This case report will illustrate how endoscopic resection
allows good control with minimal morbidity compared to open surgery or
radiotherapy.
16
UI - 12297822
AU - Schneiderman TA; Chaudhury SI
TI -
Adenoid cystic carcinoma of the nasal septum.
SO - Otolaryngol Head Neck Surg 2002 Sep;127(3):251-2
AD - Sumerset ENT Associates, Summerville, New Jersey, USA.
toddschneiderman@yahoo.com
17
UI - 12239076
AU - Ly JQ
TI -
Mesenchymal chondrosarcoma of the maxilla.
SO - AJR Am J Roentgenol 2002 Oct;179(4):1077-8
AD - Wilford Hall Medical Center, Lackland AFB, TX 78236-5300, USA.
18
UI - 12162029
AU - Golusinski W; Kaczmarek J; Wrobel M; Bierla J
TI -
[Coexistence of choanal polyp and lymph node tuberculosis]
SO - Otolaryngol Pol 2002;56(3):365-8
AD - Katedra i Klinika Otolaryngologii AM w Poznaniu.
The authors present a case of coexistence of choanal polyp and lymph
node tuberculosis in patient referred to ENT Clinic of K. Marcinkowski
University of Medical Sciences in Poznan with suspicion of
nasopharyngeal malignant tumor and lymph node metastases. Performed
surgery and histopathological evaluation of obtained tissues revealed
lymph node tuberculosis and polyp.
19
UI - 11395556
AU - Prasad ML; Jungbluth AA; Iversen K; Huvos AG; Busam KJ
TI -
Expression of melanocytic differentiation markers in malignant melanomas
of the oral and sinonasal mucosa.
SO - Am J Surg Pathol 2001 Jun;25(6):782-7
AD - Department of Pathology, Memorial Sloan-Kettering Cancer Center, New
York, NY, USA.
Malignant melanomas of the oral and sinonasal mucosa are rare tumors.
Amelanotic variants can, on occasion, be difficult to recognize by
routine light microscopy. Immunohistochemical studies may be needed for
a final diagnosis. A number of new monoclonal antibodies to melanocytic
differentiation antigens have been studied recently on primary cutaneous
and metastatic melanoma. However, little is known about these antibodies
for the diagnosis of mucosal melanomas. In this study the authors
analyzed 79 oral and sinonasal mucosal melanomas of 65 patients. A total
of 35 tumors originated from the oral mucosa (21 primary tumors, eight
local recurrences, and six metastases) and 44 melanomas were from the
sinonasal tract (27 primary tumors, nine local recurrences, and eight
metastases). Immunohistochemical studies were performed on
paraffin-embedded tissues, using the following antibodies: anti-S-100
protein, T311 (anti-tyrosinase), A103 (anti-Mart-1/Melan-A), D5
(antimicrophthalmia-associated transcription factor), and HMB-45
(anti-gp100). Of 35 oral mucosal tumors, 34 (97%) were positive with
anti-S-100 protein, 33 (94%) with T311, 30 (85%) with A103, 26 (74%)
with D5, and 25 (71%) with HMB-45. All five desmoplastic melanomas of
the oral mucosa were positive for S-100 protein, four for tyrosinase,
and one each for HMB-45 and A103. No desmoplastic melanoma was positive
with D5. All 44 sinonasal melanomas were positive for tyrosinase and
Mart-1/Melan-A (100%). Forty-three (98%) were positive with HMB-45, 42
(95%) with anti-S-100 protein, and 40 (91%) with D5. These results
reveal that T311 is the most sensitive marker for sinonasal melanomas
and closely approaches the sensitivity of anti-S-100 protein for oral
mucosal melanomas. For desmoplastic mucosal tumors, anti-S-100 protein
remains the most sensitive marker.
20
UI - 12063628
AU - Lang S; Jager L; Grevers G
TI -
[Value of secondary coronal reconstructions in computed tomography of
the paranasal sinuses]
SO - Laryngorhinootologie 2002 Jun;81(6):418-21
AD - Klinik und Poliklinik fur Hals-, Nasen- und Ohrenkranke, Germany.
INTRODUCTION: Before sinus surgery, computed tomography (CT) of the
paranasal sinuses and anterior skull base is a standard procedure in the
diagnostic evaluation. However, coronal sections necessary for the
analysis of the complex anatomy of this region are often not applicable
in multiple injured or elderly patients due to the impossibility to
maintain the required position for the coronal scans. Secondary coronal
reconstruction of primary axially acquired scans could help to overcome
this problem. This technique was, however, hampered so far by an
insufficient resolution in case of conventional CT. We therefore
compared the quality of primary coronally acquired conventional CT
images with the resolution of multiplanar reformatted coronal images of
primary axially acquired scans by means of a new CT generation, the
Multidetector Computed Tomography (MDCT). MATERIAL AND METHODS: 10
patients were each examined with conventional CT or MDCT respectively.
The quality of primary coronally acquired conventional scans (CT) versus
secondary coronal reconstructions (MDCT) was compared by evaluating
typical anatomic landmarks. RESULTS: As compared to conventional CT, the
coronal reconstruction of primary axially acquired scans by means of
MDCT revealed an equal resolution and additionally no essential
impairment by amalgam artefacts. CONCLUSION: Our results demonstrate the
excellent quality of secondary coronal reconstructions by means of MDCT
in the CT evaluation of the paranasal sinuses and the anterior skull
base as compared to primary coronally acquired images via conventional
CT.
21
UI - 12378499
AU - Iida S; Kogo M; Kishino M; Matsuya T
TI -
Desmoplastic ameloblastoma with large cystic change in the maxillary
sinus: report of a case.
SO - J Oral Maxillofac Surg 2002 Oct;60(10):1195-8
AD - First Department of Oral and Maxillofacial Surgery, Osaka, Japan.
iida@dent.osaka-u.ac.jp
22
UI - 12168392
AU - Hosemann W; Dammer R; Bloss HG; Fietkau R
TI -
[Therapy of malignant tumors in the area of the paranasal sinuses]
SO - HNO 2002 Jun;50(6):578-92; quiz 593-5
AD - Klinik fur Hals-Nasen-Ohrenkrankheiten, Kopf- und Halschirurgie,
Universitat Greifswald, Walther-Rathenau-Strasse 43-45, 17487
Greifswald. hosemann@uni-greifswald.de
23
UI - 12360715
AU - Facon F; Paris J; Ayache S; Chrestian MA; Dessi P
TI -
[Pleomorphic adenoma of the nasal cavity: a case arising from the wall
of the maxillary sinus]
SO - Rev Laryngol Otol Rhinol (Bord) 2002;123(2):103-7
AD - CHU de la Timone, Federation d'ORL et de Chirurgie Cervico-Faciale,
Service d'Anatomo-Pathologie Pr Pelissier (CAM), Bd Jean Moulin, F-13385
Marseille, France. fredybeans@wandoo.fr
INTRODUCTION: Pleomorphic adenoma is a common and benign tumour,
originating from sero-mucous glands. Location in the nasal cavity and
particularly on the medial wall of the maxillary sinus is very rare.
PATIENTS AND METHODS: One patient with a pleomorphic adenoma of the
nasal cavity and a review of literature are reported in order to
describe the diagnostic and therapeutic management of this tumour.
RESULTS: A 63-year-old woman was referred to our institution for
evaluation of an unilateral nasal tumour. Clinical and radiological
studies revealed an intra-nasal tumour, slightly lytic in nature,
arising from the mucosa of the medial wall of the maxillary sinus. More
than 2 years after complete excision of the tumour using an endoscopic
procedure, the nasal cavity was free of tumour. DISCUSSION: Pleomorphic
adenoma of the nasal cavity is a rare and benign tumour, usually
presenting as a unilateral nasal tumour. Prognosis of this tumour is
mainly linked to recurrences in cases of incomplete resection and to
possible metastasis, such as an eventual malignant evolution. The gold
standard treatment is complete surgical resection. After a complete
imaging study for patient selection (CT scan and MRI), endonasal
endoscopic surgery seems to be a reliable therapeutic treatment.
CONCLUSION: Intra-nasal pleomorphic adenoma originates from nasal
seromucous glands. Radiological study reveals a slightly lytic tumour
developed from the septum of the medial wall of the maxillary sinus.
Resecton can be performed with endoscopic endonasal surgery as long as
the orbital bony framework and the ethmoidal roof are free of tumour.
Whatever technique is employed, long term follow-up has to be used to
detect any recurrence.
24
UI - 12362870
AU - Andersen PJ; Kjeldsen AD; Pedersen AT
TI -
[Treatment of inverted papilloma with endonasal endoscopic sinus
surgery]
SO - Ugeskr Laeger 2002 Sep 9;164(37):4283-7
AD - Otologisk afdeling, Vejle Sygehus, DK-7100 Vejle.
INTRODUCTION: Inverted papilloma is a benign sinonasal tumour and has a
marked tendency to recur after surgical excision. The tumour may be
associated with malignancy and during growth it may destroy surrounding
tissue. The treatment is either lateral rhinotomy or endoscopic sinus
surgery. The aim of the study was to describe the course of all patients
treated with endoscopic sinus surgery at the ENT Department at Vejle
MATERIAL AND METHODS: Twenty-eight journals of patients diagnosed with
inverted nasal papillomas were reviewed retrospectively. RESULTS: All
patients underwent endoscopic sinus surgery with at least antrostomy.
Caldwell-Luc's operation was additionally performed in 16 patients.
There was a male predominance of 6:1. Seven suffered recurrences after
the primary surgical procedure, none of the recurrences were associated
with carcinoma. We did not see any serious side effects to the
treatment. DISCUSSION: Endoscopic sinus surgery in combination with
Caldwell-Luc can be recommended as an alternative treatment to lateral
rhinotomy in patients with inverted papillomas. Preoperative staging
with CT or MR-scanning, experienced surgeons, and a close follow-up
period of five years must be recommended.
25
UI - 11938522
AU - Crampette L; Serrano E; Klossek JM; Rugina M; Rouvier P; Peynegre R;
TI -
Bebear JP; Stoll D
[French multicenter prospective epidemiologic study (ORLI Group) of
allergic and lung diseases associated with nasal polyposis]
SO - Rev Laryngol Otol Rhinol (Bord) 2001;122(4):231-6
AD - Hopital Gui de Chauliac, Service ORL et CCF, 2 avenue Bertin Sans,
F-34295 Montpellier, France. louis.crampette@wanadoo.fr
224 patients presenting with nasal polyposis (NP) were included in a
french prospective multicenter study. NP was evaluated by nasal
endoscopy and computed tomography. Allergic status was documented using
skin prick-tests and/or specific IgE. Pneumologic assessment included
spirometry with carbamyl-choline hyper-reactivity test or beta 2 mimetic
broncho-dilation test. Minimal follow up period was 1 year. 45% of the
whole population were considered as asthmatic. Asthma onset occurred
before and after the NP onset in respectively 45.7%, 22.3% and 32% of
cases; these two conditions started simultaneously in 32% of patients.
Skin prick-tests and/or specific IgE were positive in 32.5% of cases. In
most of the cases (80%), patients were polysensitized to house dust mite
and/or pollens and/or animal danders and/or fungi. 31% of the population
had idiosyncrasy, caused by drugs in general and especially aspirin in
44% of cases. The global population could be divided in two groups
according to the occurrence of previous polypectomy or not. The group
"polypectomy" and the group "no polypectomy" were similar regarding the
frequency, the age of onset, the course and the severity of associated
asthma. Familial history (parents, children, brothers and sisters) was
of great interest: 58.7% of the patients had one (or more) relative
suffering from NP, 43.6% of the patients had one (or more) relative
suffering from asthma and 12.2% of the patients had one (or more)
relative suffering from idiosyncrasy. These results support a genetic
etiology for NP.
26
UI - 11938524
AU - Bouscau-Faure F; Carrat X; Pescio P; Longueville E; Devars F; Traissac L
TI -
[Loss of visual acuity caused by ethmoidal mucocele cured after
endonasal surgery: report of a case]
SO - Rev Laryngol Otol Rhinol (Bord) 2001;122(4):241-4
AD - CHU Pellegrin, Clinique ORL, Place Amelie Raba Leon, F-33076 Bordeaux,
France.
A posterior and/or ethmoidal mucocele remains a rare occurrence. The
condition usually follows a past history of sinonasal surgery. Extension
of the lesion may have ophtalmological implications, with the
possibility of causing visual impairment. The predilection for a site of
origin in the posterior sinuses explains the frequent absence of nasal
symptoms, and the usual pattern of discovery by the ophtalmologist.
Modern imaging techniques, especially scanning, allows the diagnosis to
be made immediately after the first orbital symptoms. By the same token,
recent techniques of endoscopic endonasal surgery have radically changed
the treatment. Early complete surgical removal holds out hope for
remission of the symptoms that led originally to discovery of the
mucocele. We report here a case of posterior ethmoidal mucocele causing
a visual field defect which reversed completely after endoscopic
treatment.
27
UI - 12223953
AU - Kriet M; Laktaoui A; Zrara S; Harmouchi N; Souhail H; Chana H; Terhzaz A
TI -
[Olfactory esthesioneuroblastoma with an ophtalmological presentation: a
case report]
SO - J Fr Ophtalmol 2002 Jun;25(6):632-5
AD - Service d'Ophtalmologie, Rabat, France.
Esthesioneuroblastoma (ENB) is a rare malignant tumor, which develops
from the olfactory neuroepithelium and is one of the rarest tumors of
the nasal cavity. Revelation by ocular signs is unusual. We report the
original observation of a case of ENB of the olfactive placodes in a
28-year-old adult discovered during exophthalmia. The authors studied
the clinical, radiological, pathological, and therapeutic aspects. ENB
should not be forgotten in case of unilateral tumorous exophthalmia
associating rhinological signs.
28
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
UI - 12243826
AU - Gruber G; Laedrach K; Baumert B; Caversaccio M; Raveh J; Greiner R
TI -
Esthesioneuroblastoma: irradiation alone and surgery alone are not
enough.
SO - Int J Radiat Oncol Biol Phys 2002 Oct 1;54(2):486-91
AD - Department of Radiation-Oncology, University of Berne, Inselspital,
Bern, Switzerland. guenther.gruber@insel.ch
PURPOSE: To evaluate the long-term outcome of patients with
esthesioneuroblastoma treated with neoadjuvant or definitive
radiotherapy (RT). METHODS AND MATERIALS: Between 1980 and 2001, 28
patients with histologically confirmed esthesioneuroblastoma underwent
RT, with a median dose of 60 Gy (range 38-73). The median age was 58
years (range 16-85). According to the Kadish classification, 4 patients
had Stage A, 8 Stage B, and 16 Stage C tumors. Radical resection was
performed in 13 cases, in 9 before RT and in 4 after RT because of
stable or progressive disease. The outcome analyses included the median
age (58 years), Kadish stage, skull base penetration, intraorbital
extension, resection status, and total dose (
Cancer Types
Bone Cancer
Brain Tumors
Breast Cancer
Carcinoid Tumors
Endocrine System Cancers
Gastrointestinal Cancers
Gynecologic Cancers
Head and Neck Cancers
Leukemia
Lung Cancers
Lymphomas
Myelomas
Pediatric Cancers
Penile Cancer
Prostate Cancer
Sarcomas
Skin Cancers
Testicular Cancer
Thyroid Cancer
Urinary Tract Cancers
OncoLink Vet
Cancer Treatment
Biologic Therapy
Bone Marrow Transplants
Chemotherapy
Clinical Trials
Complementary Medicine
Gene Therapy
General Treatment Concerns
Hormone Therapy
PDT Center
Proton Therapy
Radiation Oncology
Surgical Oncology
Targeted Therapies
Vaccine Therapies
Cancer Support
Caregivers
Hospice Care and Bereavement
Nutrition and Cancer
Sexuality & Fertility
Side Effects
Support
Survivorship
Exercise and Cancer
Cancer Resources
Cancer News
OncoLink University
Nurses' Notes
Conferences
Newly Diagnosed Patients
Causes and Prevention
Legal and Financial Information for Patients
LGBT Resources
NCI Resources
Global Resources
Cancer Resource List
Resources for Young Adults
OncoLink Media Library
OncoLink TV
Book, Music and Video Reviews
Ask the Experts
Brown Bag Chat
Tracy's Corner
About OncoLink
About OncoLink
Giving to OncoLink
Contact Information
Usage Policy
Editorial Board
How to Partner with OncoLink
Link to OncoLink
Mission Statement
