HPV: The Basics
An introduction to this virus and related cancers, as well as the transmission and prevention of HPV.

Expert answers to common questions about anal cancer.

Treatment Options for Peri-anal Paget's Disease
In 1986 and l987 I was operated on twice to excise Peri-anal Paget's disease and obtain clean margins. Pathology revealed underlying adenocarcinoma and the sphincter was excised, but not destroyed. After the second operation there were still some underlying cancer cells, but I was told I would just be watched--and I was for every three

Resuming sexual relations after completion of chemotherapy and radiation therapy for anal cancer
Dear OncoLink "Ask The Experts," I have just completed chemo and radiotherapy treatment for anal cancer I am worried about having sex again. Presently I have a yellow mucus discharge from my vagina and anus. It does seem to be getting better. Can I hope it will disappear and is it normal?James M. Metz, MD, Editor-in-Chief of OncoLink and Assistant

Proton Therapy for Anal Cancer
Dear OncoLink "Ask The Experts," Is the new proton beam radiation a viable option for anal cancers? James M. Metz, MD, Editor-in-Chief of OncoLink and Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania, responds:Proton beam therapy is being explored as a possible form of treatment for a number of cancers.

News stories related to anal cancer.

Comprehensive Analysis Supports SERMs for Cutting Breast Cancer
May 1, 2013 - Treatment with selective estrogen receptor modulators is associated with a significant reduction in the incidence of breast cancer, especially for the first five years after treatment, according to research described as the first comprehensive analysis, published online April 30 in The Lancet.

Study Tracks Patterns of U.S. Cases of Anal Canal Carcinoma
Apr 3, 2013 - Available screening and identification of human papillomavirus likely contributed to the increased incidences of squamous cell carcinoma of the anal canal (SCCA) and anal carcinoma in situ (CIS) after 1997, according to research published online March 18 in Journal of Clinical Oncology.

Despite cART, Anal Cancer Risk Still High for HIV-Infected
Dec 14, 2012 - For HIV-infected patients, despite combined antiretroviral treatment, the risk of anal cancer is still much higher than in the general population, according to a study published in the Dec. 10 issue of the Journal of Clinical Oncology.

Reviews of presentations from professional meetings related to anal cancer.

Intergroup RTOG 98-11: A phase III randomized study of 5-fluorouracil (5-FU), mitomycin, and radiotherapy versus 5-fluorouracil, cisplatin and radiotherapy in carcinoma of the anal canal
Presenter: J.A. AjaniPresenter's Affiliation: M.D. Anderson Cancer Center, Houston, TXType of Session: ScientificBackground The current standard treatment of squamous cell carcinoma of the anus is concurrent chemoradiation (CRT) with 5-FU and mitomycin-C The 5-yr disease free survival (DFS) is ~65% Mitomycin-C has an undesirable

Intergroup RTOG 9811: Phase III Comparison of Chemoradiation With 5-FU and Mitomycin Vs. 5-FU and Cisplatin for Anal Canal Carcinoma: Impact on Disease-Free, Overall and Colostomy-Free Survival
Presenter: L.L. GundersonPresenter's Affiliation: Mayo Clinic Cancer Center ? Arizona, Scottsdale, AZType of Session: ScientificBackground Anal cancer is frequently a loco-regional disease The RTOG 8704/ECOG 1289 study showed the superiority of RT/5-FU/Mitomycin C over RT/5FU The current standard treatment of squamous cell

Long-term Quality of Life after Chemoradiation for Anal Cancer
Presenter: Prajnan DasPresenter's Affiliation: UT MD Anderson Cancer Center, Houston, TXType of Session: ScientificBackground There are an estimated 4700 cases/year of anal cancer in the US. Definitive radiation therapy with concurrent chemotherapy represents the standard of care for squamous cell carcinoma of the anus. RTOG 9811

NCI CANCERLIT^® Search: Anal Cancer - October 2001
Reconstruction of perianal skin defect using a V-Y advancement of bilateral gluteus maximus musculocutaneous flaps: reconstruction Primary anorectal malignant melanoma: clinical features and results of surgical therapy in Singapore--a case...

NCI CANCERLIT^® Search: Anal Cancer - September 2001
Table of ContentsHigh-dose radiation therapy and neoadjuvant plus concomitant chemotherapy with 5-fluorouracil and cisplatin in patients with locally advanced squamous-cell anal canal cancer: final results of a phase II study.What is the...

NCI CANCERLIT^® Search: Anal Cancer - April 2002
Adenocarcinoma arising within a Crohn's-related anorectal fistula: a form of anal gland carcinoma? Current management of perianal intraepithelial neoplasia. [Complaints in the anal area. Risk a glance at the taboo zone!] Table of Contents ...