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Types of Cancer > Breast Cancer > News
November 2009
Docetaxel, trastuzumab both improve survival in early breast cancer
Folate levels affect breast cancer risk with MTHFR variant
Benefits seen with capecitabine for breast cancer, but tolerability an issue
Immediate postmastectomy reconstruction tied to better breast cancer survival
HER2 status predicts recurrence of small breast cancers
Radiation for early breast cancer: 3 weeks may be as good as 5 to 7
October 2009
Letrozole and bevacizumab promising against breast cancer
Nulliparity, late age at first childbirth linked to aggressive breast cancer
Mutations in breast cancer gene linked to heart dysfunction
Trastuzumab-anastrozole combo improves metastatic breast cancer outcomes
CYP2D6 genetic variants influence tamoxifen treatment outcome
High fiber intake linked to reduced risk of breast cancer
September 2009
Circulating tumor cells tied to breast cancer progression during therapy
Nipple can be spared in selected mastectomy patients
Tamoxifen cuts risk of contralateral breast cancer in premenopausal women
HER2 testing being neglected in patients with breast cancer
Chemo "can't level the playing field" for triple negative breast cancer
High-dose fulvestrant helpful against breast cancer
August 2009
Excess mortality persists decades after breast cancer "cure"
Doxorubicin-docetaxel combination slows breast cancer
Peritoneal metastasis in breast cancer signals poor prognosis
Follow-up after grade 1 breast cancer may not be needed
Digital tomosynthesis could reduce mammography recalls
Digital mammography boosts breast cancer detection
Family history of breast cancer may raise colorectal cancer risk
Limiting radiation field cuts risk of breast cancer in Hodgkin's survivors
July 2009
Routine MRI may impair surgical outcomes of breast cancer
Risk of breast cancer after radiotherapy in childhood quantified
Glycemic load, glycemic index linked to breast cancer risk
Autotaxin and lysophosphatidic acid receptors induce breast cancer in mice
June 2009
Wet ear wax, osmidrosis may be linked with breast cancer risk
Partial irradiation is cost effective in breast cancer
Bisphosphonates may prolong survival in metastatic breast cancer patients
Nab-paclitaxel improves progression-free survival in metastatic breast cancer
Elevated inflammation markers point to reduced breast cancer survival
PARP inhibitor promising in triple-negative metastatic breast cancer
May 2009
ASCO issues updated guidance on breast cancer risk reduction
Women treated for DCIS are not obtaining regular surveillance mammograms
African American women often refuse treatment for advanced breast cancer
Caveolin-1 is the strongest prognostic marker for breast cancer to date
Adherence to hormone therapy low among disadvantaged breast cancer patients
Endocrine effects of letrozole and tamoxifen differ
Earlier breast cancer screening for black women may be warranted
Gene alterations associated with response to anthracycline therapy for breast cancer
April 2009
No rise in mastectomy rates with greater use of breast MRI
Rates of prophylactic mastectomy for DCIS rising in US
Eribulin prolongs survival in women with metastatic breast cancer
Biomarkers may predict response to breast cancer chemotherapy
Diabetes impacts breast cancer chemotherapy outcomes
Gemcitabine-cisplatin could be clinically useful in metastatic breast cancer
March 2009
Gemcitabine/docetaxel after anthracycline advised for advanced breast cancer
Early detection of second breast cancers improves survival
Hypertension partially explains racial disparity in breast cancer survival
Breast cancer risk assessment warranted in older women
Tumor gene profiles predict breast cancer response to letrozole
Prophylactic mastectomy on the rise in the US
PET/CT useful for initial staging of inflammatory breast cancer
February 2009
Tamoxifen sensitivity can be restored in breast cancer cells
Benefits of goserelin for early breast cancer persists long-term
Annual screening for ovarian cancer in BRCA1/2 carriers deemed ineffective
Docetaxel better than doxorubicin in early breast cancer
Radiotherapy helpful when breast cancer is advanced at diagnosis
Automated microscopy detects breast cancer cells in surgical specimens
Pregnancy may delay diagnosis and treatment of breast cancer
Combination surgery and radiotherapy benefits all women with DCIS
Breast cancer risk rapidly drops after stopping hormone therapy
January 2009
Breast tumor characteristics predict likelihood of contralateral breast cancer
Low estrogen receptor expression in melanoma reflects poor prognosis
ARF1 regulates breast cancer cell growth and invasion
Neoadjuvant ixabepilone promising against breast cancer
Imatinib suppresses breast cancer bone metastases by inhibiting osteoclasts
Salpingo-oophorectomy lowers cancer risk in BRCA1/2 carriers
Primary breast cancer in men has unique imaging features
Antiestrogens can enhance cellular invasion by certain breast cancer cells
December 2008
High hCG levels in pregnancy linked to reduced breast cancer risk
Simplified graphics help patients understand breast cancer treatment options
Moisturizers may provide unwanted estrogen exposure in breast cancer patients
Changes in breast density an early indicator of tamoxifen efficacy
Digoxin linked to increased risk of breast cancer
Ethnic variation in breast cancer incidence may reflect different disease types
European ancestry may raise breast cancer risk in US Latinas
BRCA1 haplotype influences lung cancer chemotherapy
Outcome good with brachytherapy for women with breast implants and breast cancer
November 2008
Hormonal treatments do not impair cognitive function in women with breast cancer
Some breast cancers may spontaneously disappear
Early vitamin D intake reduces breast cancer risk
Chemoradiotherapy feasible in breast cancer with brain metastases
Breast cancer risk high in women with family history but no BRCA mutations
Migraine linked to lower risk of breast cancer
Calcium and vitamin D use does not prevent invasive breast cancer
Estrogen-related receptor tied to tamoxifen resistance in lobular breast cancer
Family history boosts contralateral breast cancer risk after radiotherapy
October 2008
Tamoxifen may lower osteoporotic fracture risk
Bisphenol A confers chemoresistance in breast cancer cells in culture
Multiple wire localization reduces need for mastectomy
Current HRT use is associated with low-grade breast cancer tumors
Lumpectomy for breast cancer recurrence may reduce survival
Soy's protective effect against breast cancer varies by receptor status
High blood flow to breast cancer tumors linked to high recurrence risk
Breast cancer mortality falls soon after start of screening programs
Endoscopic surgery for early breast cancer may improve aesthetic results
Midlife bone fracture a risk factor for male breast cancer
Tamoxifen tied to earlier detection of ER-negative breast cancer
September 2008
Hormone therapy appears safe for BRCA1 mutation carriers
Index predicts outcome after neoadjuvant endocrine therapy for breast cancer
Accelerated radiation schedule effective, convenient for early breast cancer
Clodronate lowers long-term risk of osteoporosis in early breast cancer patients
Adding zoledronic acid to breast cancer therapy improves outcomes
Her-2/neu DNA vaccine controls refractory Her-2-positive breast cancer in mice
Higher BMI may reduce chemotherapy response with breast cancer
Insulin-like growth factor effects predict breast cancer prognosis
Routine MRI at breast cancer diagnosis linked to treatment delays
Black women less likely to receive radiation after lumpectomy
Anastrozole does not impair cognition as breast cancer preventative
August 2008
Estrogen receptor-beta status influences breast cancer prognosis
Levonorgestrel IUD may increase breast cancer relapse risk in some patients
Reproductive factors differ in effects on breast cancer type
Zoledronate prevents bone loss during endocrine treatment for breast cancer
Doxorubicin-zoledronic acid sequence effective against experimental breast cancer
Craniocaudal view on mammography important for breast cancer risk assessment
Tibolone prevents fractures and breast cancer, but raises risk of stroke
Relapse risk "substantial" after 5 years of adjuvant therapy for early breast cancer
Early screening for all breast cancer relatives may not be warranted
July 2008
Different screening approaches comparable in detecting breast cancer
High BMD is a risk factor for postmenopausal breast cancer
Breast cancer survival drops with increasing body mass index
Electrothermal vessel sealing effective during mastectomy
Breast self-examination does not cut breast cancer mortality
Lapatinib appears safe in patients with breast cancer
Lapatinib promising for advanced ErbB2-amplified breast cancer
Treatment delays common in men with breast cancer
HER-2 improves survival in patients with breast cancer brain metastasis
June 2008
Metastatic potential may be inherent in DCIS cells
Breast cancer cells traced to transplanted stem cells
African American women face higher death risk from metastatic breast cancer
Bone loss prevented by risedronate in breast cancer survivors
HER-2 has less prognostic value in inflammatory breast cancer
Ovarian stimulation with letrozole does not raise breast cancer recurrence risk
Glaxo gets formal EU okay for breast cancer drug
Accuracy of mammography readings varies by facility
Standard chemo better than capecitabine in older women with early breast cancer
Bevacizumab improves outcome in newly diagnosed advanced breast cancer
May 2008
Standard therapy plus paclitaxel improves early breast cancer survival
US panel mulls minimum breast cancer hospital stay
Acrylamide exposure linked to risk of breast cancer
Letrozole superior to tamoxifen for controlling breast cancer in elderly women
Anti-breast cancer effect of physical activity strongest in certain groups
Family history of breast cancer confers lifetime elevated risk
Taxanes confer limited benefit in metastatic breast cancer
CYP2D6 variants affect breast cancer response to tamoxifen
April 2008
Exemestane may improve survival after tamoxifen therapy
Variants on chromosome 5 linked to estrogen receptor-positive breast cancer risk
Pre-op MRI influences type and timing of breast cancer treatment
CORRECTION: Alternating electric fields shrink breast cancer tumors
Breast cancer vaccine promising in HER2/neu "low-expressers"
Epithelial cells in nipple aspirate fluid predict breast cancer risk
False-positive MRI result has little impact on prophylactic mastectomy choice
Depressed mood predictable in spouses of women with breast cancer
Anemia predicts higher risk of relapse with chemotherapy-treated breast cancer
March 2008
REFILE: Nonclinical factors affect odds of breast cancer patients having sentinel node biopsy
Nonclinical factors affect odds of breast cancer patients having sentinal node biopsy
Hormone therapy raises risk of breast cancer recurrence
Optimal duration of neoadjuvant letrozole for breast cancer unclear
Single gene alters expression of many genes to promote breast cancer growth
Cardiac risk low with dose-dense chemo plus trastuzumab for breast cancer
Late treatment with letrozole reduces breast cancer recurrence
Breast cancer risk may be reduced after gestational diabetes
Anastrozole adherence by breast cancer patients often suboptimal
February 2008
Gene expression tests may improve breast cancer management
Combined breast screening provides best survival for BRCA1 mutation carriers
Hormone therapy hinders breast cancer detection
Epoetin beta does not affect survival in metastatic breast cancer
Macrophage activation may suppress breast cancer metastasis
Hair sample may provide non-invasive means of breast cancer diagnosis
Interval between menarche and first birth linked to breast cancer risk
Digital mammography best for screening in some younger women
Many DCIS patients overestimate recurrence risk
Dietary fiber intake inversely associated with breast cancer risk
January 2008
Surgeon factors affect receipt of radiotherapy for breast cancer
Statins don't appear to be linked with breast cancer risk
High-dose chemo doesn't improve survival in metastatic breast cancer
African American women less likely to undergo BRCA1/2 genetic testing
Hormone use for just 3 years ups lobular breast cancer risk
Oophorectomy ups survival of operable breast cancer in premenopausal women
Breast cancer metastasis suppressor microRNAs identified
Breast cancer risk varies widely among BRCA mutation carriers
Nonbreast cancer survival better among participants in breast screening program
Benefit of anthracyclines in early breast cancer limited to HER-positive tumors
December 2007
All-digital mammography for breast cancer screening not cost effective
Anticlusterin increases chemotherapy sensitivity in breast cancer cells
Placement of tumor localization clips improves outcomes in breast cancer
Adding bevacizumab to paclitaxel ups progression-free survival in breast cancer
Chemotherapy and tamoxifen cut long-term risk of contralateral breast cancer
Dietary fat not seen linked to overall breast cancer risk
Depression might influence breast cancer risk
Circulating tumor cells an early indicator of response to breast cancer treatment
Outcome of HER-2-positive breast cancer tied to hormone receptor status
High-dose chemo with HSCT outdated for breast cancer
Breast cancer survival longer with docetaxel than doxorubicin
Extended adjuvant aromatase inhibitor therapy beneficial in breast cancer
BRCA1 mutations promote breast cancer through effect on PTEN
Genotype tied to success of breast cancer therapy with tamoxifen
US panel rejects Avastin for treating breast cancer
New model predicts breast cancer risk in African American women
November 2007
3-D mammography cuts false-positive rates by half
Breast cancer risk elevated in male BRCA 1 and 2 mutation carriers
Breast cancer pain not controlled as well in non-whites
Simplified model predicts estrogen receptor-positive breast cancer risk
Breast cancer radiotherapy associated with some cardiac changes
Menopausal symptoms vary with tamoxifen or exemestane for breast cancer
Dieting reduces arm lymphedema after breast cancer treatment
Black women have higher breast cancer recurrence rates than white women
October 2007
Sunlight exposure may cut breast cancer risk in light-skinned women
Adult weight gain ups breast cancer risk in non-hormone users
Taxane chemotherapy supported for early breast cancer
Decision aid helps women make informed choice on mammography
Calcium deficiency may promote breast cancer metastasis to bone
High-dose NSAIDs linked to lower breast cancer risk
Fetal microchimerism may help ward off breast cancer
HER2 positivity in breast cancer predicts paclitaxel benefit
Low-dose tamoxifen attenuates risk biomarkers in HRT users
September 2007
Intraoperative radiotherapy may control breast cancer recurrence
Leukemia risk increases after breast cancer therapy in older women
Capecitabine-trastuzumab safe, effective in pretreated metastatic breast cancer
Gefitinib does not improve neoadjuvant treatment for early breast cancer
Bone health of breast cancer patients compromised by long-term chemotherapy
FDA approves Evista for prevention of breast cancer
'Lumpectomy' may be possible in some cases of prostate cancer
Fatigue persists after chemotherapy in breast cancer patients
BRCA status confers survival difference in surveillance-detected familial breast cancer
Estrogen receptor-negative breast cancer more common in African Americans
August 2007
Folate receptor expression tied to breast cancer outcome
Endometrial cancer in woman on tamoxifen requires no unusual treatment
Treated hypertension not a risk factor for breast cancer
Racial variations found in breast cancer type and size
Even low-dose medical radiation may raise breast cancer risk
Extra radiation dose helps local control of breast cancer
Fertility drugs do not increase breast cancer risk
Left-sided breast cancer radiation boosts coronary risk
Breast cancer incidence linked to hormone therapy and mammography use
Surveillance mammography reduces mortality in older breast cancer survivors
July 2007
New drugs tied to improving survival for metastatic breast cancer
Lilly drug cuts some breast cancer risk: FDA staff
High testosterone linked to worse breast cancer prognosis
Diet high in fruits and veggies of no particular benefit for breast cancer patients
Breast cancer risk increased in women with multiple foci of atypia
Breast cancer prognosis may be inherited
BRCA1 and BRCA2 mutations have little effect on breast cancer survival
Apparent rise in metastatic breast cancer tied to increased SLN biopsies
June 2007
Leuprorelin depot effective adjuvant therapy for premenopausal breast cancer
Adjuvant therapies for breast cancer appear cost-effective
Morning sickness may indicate lower breast cancer risk
Mammography lowers rates of advanced breast cancer
Contrast-enhanced MR spots contralateral breast cancer
Breast cancer chemotherapy does not worsen cognitive function
BRCA2 mutation linked to aggressive prostate cancer
Low number of uninvolved lymph nodes predicts breast cancer recurrence
MRI spots high-grade DCIS more often than mammography: study
Weight loss benefits women with breast cancer-related lymphedema
May 2007
In breast cancer, removing three sentinel lymph nodes isn't enough
Novel breast cancer susceptibility genes identified
Oophorectomy cuts breast, ovarian cancer risk for those with BRCA1/2 mutations
Breast-conserving therapy safe for younger breast cancer patients
Exercise program improves well-being in survivors of breast cancer
Genomic alterations in tumor stroma may help explain diversity of breast cancer
Adiponectin inversely associated with risk of postmenopausal breast cancer
TENS, TSE and placebo comparable for pain from breast cancer treatment
Combination hormone replacement therapy linked to lower-risk breast cancers
Herceptin gets Europe approval for combination breast cancer treatment
April 2007
Truncated HER2 receptor in breast cancer affects treatment responses
Abortion not linked to breast cancer in young women
US breast cancer mortality declining faster for ER-positive tumors
Biological factors may underlie racial differences in breast cancer
Tonsillectomy may raise breast cancer risk for some women
Possible new biomarker for breast cancer identified
Triple-negative breast cancers more likely to affect young, poor minority women
Age at endometriosis diagnosis is linked to breast cancer risk
Estrogen receptor gene amplification common, clinically important in breast cancer
Male breast cancer outcomes worse for blacks than whites
Tailored approach best for breast cancer screening of women in their 40s
March 2007
Roche's Avastin approved in Europe for breast cancer
Web-based system may improve mammography screening rates
Early discontinuation of tamoxifen more common than reported
Moderate drinking ups breast cancer risk
FDA clears Tykerb for breast cancer
Trastuzumab cost-effective for early HER2-positive breast cancer
MR imaging detects breast cancer in those at high risk
Radiotherapy for breast cancer raises heart disease risk
February 2007
SPECT/CT aids sentinel node mapping in breast cancer patients
Advantages seen when women with breast cancer join in selecting surgeon
Common gene mutation associated with lower breast cancer risk
Continuous letrozole better than continuous tamoxifen in early breast cancer
Prognostic markers in triple-negative breast cancer identified
Switch to aromatase inhibitor improves survival in early breast cancer
Risedronate prevents bone loss in breast cancer survivors
January 2007
ErbB2 inhibitor delays breast cancer growth, protects against metastasis
GHRH antagonists enhance docetaxel effects on breast cancer
Breast cancer patients often fail to complete tamoxifen regimen
Lower socioeconomic status linked to reduced drug doses for breast cancer
Mammographic density an independent risk factor for breast cancer
Mammogram comparison important in breast cancer screening
December 2006
Monoclonal antibody promising against breast cancer
Adding lapatinib to capecitabine cuts progression of advanced breast cancer
Insulin-like growth factor may be tied to breast cancer
- Estrogen-only HRT slightly raises breast cancer risk
PET scans track breast cancer response to chemotherapy
Tamoxifen resistance blocked in mice
Exemestane after tamoxifen improves breast cancer survival
Regulatory protein expression tied to breast cancer survival
Second opinions prompt changes in breast cancer management
Breast cancer family history raises prostate cancer risk in African Americans
New guidelines improve HER2 testing accuracy for breast cancer
Breast cancer regimen linked to cognitive decline
Low serum EGFR levels linked to poor prognosis in breast cancer
November 2006
Progesterone blocker prevents breast cancer in mice
Lobular regression reduces breast cancer risk
Different doses of docetaxel suitable for second-line treatment of breast cancer
FDA OKs Herceptin for early breast cancer
High dietary fat does not increase breast cancer risk
Letrozole alternative for fertility preservation in breast cancer
North American Scientific gets FDA nod for breast cancer device
Dendritic cell-based vaccine promising in early-stage breast cancer
Treatment order does not impact early breast cancer survival
Risk of early breast cancer slightly raised by oral contraceptive use
Adding epirubicin to CMF regimen increases survival in early breast cancer
October 2006
After tamoxifen, aromatase inhibitor may add little to breast cancer survival
Sentinel lymph node surgery may not be needed during prophylactic mastectomy
Low vitamin D levels linked to breast cancer progression
Abortion seen not related to breast cancer risk
Benign ovarian cysts linked to lower breast cancer risk
Dual functional role of VEGF receptor in breast cancer uncovered
Many suspected SNPs not connected to breast cancer
BRIP1 mutations tied to breast cancer
Breast cancer survivors at increased risk for suicide
Chemotherapy safely delayed for 12 weeks after surgery for early breast cancer
September 2006
- Raloxifene protects against breast cancer regardless of risk category
p53 gene therapy safe, possibly effective in breast cancer
CORRECTION: Glycosyltransferase points to breast cancer metastasis
Glycosyltransferase points to breast cancer metastasis
Family breast cancer history boosts ovarian cancer risk
Dual dose chemotherapy offers no boost in breast cancer
Plasticizer BPA metabolite may accumulate in breast cancer cells
Gene "profiling" may improve accuracy of breast cancer prognosis
BRCA1/BRCA2 mutations not common in U.S. women in general
Breast density may improve breast cancer prediction models
August 2006
Paclitaxel maintenance not recommended for stable metastatic breast cancer
PET may identify axillary breast cancer metastases
Breast cancer-involved sentinel nodes often contain micrometastases
Circulating tumor cells predict survival in metastatic breast cancer
Concordance seen among gene-expression predictors for breast cancer
Many women uncomfortable making breast cancer surgery decisions
Anastrozole safer than tamoxifen as adjuvant therapy for early breast cancer
July 2006
Farnesyltransferase inhibitor may enhance efficacy of breast cancer chemo
Estrogen plus testosterone use linked to breast cancer
G-CSF may worsen anemia with adjuvant chemotherapy for early breast cancer
Mouse breast stem cells resemble poor-prognosis human breast cancer cells
Estrogen receptor polymorphisms tied to liver cancer
Metabolic syndrome may predict breast cancer recurrence
Postmenopausal weight gain increases breast cancer risk
UK local health body appeals NICE's "yes" to Herceptin in early breast cancer
Boost radiotherapy may help prevent relapse of DCIS in young women
MDM2 variant interacts with p53 to influence breast cancer survival
June 2006
Cadmium linked to breast cancer
Possible locations for breast cancer susceptibility genes identified
Tamoxifen and raloxifene provide similar quality of life outcomes
Therapy sequence doesn't alter inflammatory breast cancer outcome
UK's NICE and SMC give green light to Herceptin in early breast cancer
Hormonal therapy benefits BRCA1/2 carriers with early breast cancer
MR spectroscopy aids breast cancer diagnosis
Switching from tamoxifen to exemestane has beneficial effects
May 2006
Aromatase inhibitors gain preliminary NICE approval for early breast cancer
Immune response tied to fatigue after breast cancer
Gene amplification improves breast cancer response to anthracyclines
75 years is an appropriate upper age limit for mammography
Increased protein expression may explain tamoxifen resistance
Breast cancer may be undertreated in octogenarians
Fenretinide cuts risk of second breast cancer in younger women
Long-term unopposed estrogen tied to increased breast cancer risk
Sentinel node biopsy supported for early-stage breast cancer
April 2006
CHMP recommends Herceptin for early stage-breast cancer
Pregnancy reduces breast cancer risk in BRCA1/2 carriers
Hormone use boosts breast cancer risk for black women
African American ethnicity a predictor for poor outcome in breast cancer
Tamoxifen extends survival in ER-positive breast cancer
Hormone use boosts breast cancer risk for black women
Two-gene expression ratio predicts recurrence and survival in breast cancer
Mammography rates tied to ethnic disparities in breast cancer outcomes
Ultrasound and mammography both useful in breast cancer during pregnancy
Breast cancer patients differ on treatment involvement
Prognosis similar in estrogen positive and negative breast cancer
Estrogen use after menopause does not increase breast cancer risk
Sex of first child not associated with breast cancer survival
COX-2 expression in atypia correlates with breast cancer risk
Vitamin D exposure early in life may lower breast cancer risk
March 2006
Wide excision alone inadequate for preventing local DCIS recurrence
Preschool diet linked to later breast cancer risk
Bevacizumab plus paclitaxel prolongs breast cancer survival
Automated assay detects metastatic breast cancer in sentinel lymph nodes
Breast cancer treatment guidelines rapidly adopted in practice
Breast cancer screening often detects clinically irrelevant disease
Family physicians offer safe follow-up for breast cancer patients
February 2006
Breast cancer risk linked to hormone therapy evident in different ethnic groups
BMI and estrogen metabolism linked to breast cancer risk
Adjuvant docetaxel more effective than vinorelbine for early breast cancer
Gn-RH analogues helpful in early breast cancer
Axillary lymph node dissection not needed for some breast cancer patients
COX-2 inhibitors may lower breast cancer risk
Ocular side effects common with adjuvant chemo for early breast cancer
Intensive therapy may benefit women with breast cancer of a poor prognosis
Intraductal therapy effective in breast cancer model
Lobular carcinoma in situ no bar to conservative breast cancer therapy
CDK4 activity tied to breast cancer progression
January 2006
Endogenous sex hormones may not predict breast cancer risk
Penetrance of BRCA2 mutations increases with time
Late diagnosis, treatment bias reduce survival in elderly breast cancer patients
Cytochrome P450 genotype influences clinical effects of tamoxifen
Palladium brachytherapy feasible as adjuvant treatment of early breast cancer
Fatigue persists in some long-term survivors of breast cancer
Optimal postmastectomy radiation therapy improves survival
Breast cancer chemotherapy increases cardiomyopathy risk
BRCA1, BRCA2 mutations underestimated in ovarian cancer
Coffee consumption may reduce breast cancer risk
December 2005
Letrozole better than tamoxifen as adjuvant therapy for early breast cancer
Adjuvant systemic therapy may improve male breast cancer outcomes
LIV-1 expression predicts outcome in breast cancer patients
Judge orders UK health body to pay for Herceptin in early breast cancer
Complications common with postmastectomy breast reconstruction
Fatigue fairly uncommon after adjuvant chemotherapy for breast cancer
MRI best for familial breast cancer detection
Low levels of inhibin A may predict risk of infertility after breast cancer treatment
No apparent benefit for dose-dense chemotherapy in early breast cancer
Risk of several malignancies increased in breast cancer survivors
HER-2/neu not linked to breast cancer indicators in black women
Estrogen may induce apoptosis in breast cancer resistant to antihormone therapy
Progesterone active against hormone-independent breast cancer
Passive and active smoking are both risk factors early breast cancer
High-dose chemo bests dose-dense conventional therapy for high-risk breast cancer
November 2005
Alzheimer's disease patients receive less aggressive breast cancer treatment
Distance from radiation therapy facility affects breast cancer treatment
Dietary fish oil curbs breast cancer progression in animal study
HER2/neu vaccine may curb breast cancer recurrence
Physical activity cuts breast cancer risk in black women too
Breast cancer-preventing benefits of tamoxifen confirmed
Gamma-linolenic acid suppresses breast cancer gene expression in vitro
Longer duration tamoxifen therapy cuts heart disease mortality
Alcohol consumption plus HRT increases breast cancer risk
Modern radiotherapy for breast cancer appears safe for heart
October 2005
Gene variant and relative with bilateral breast cancer confer high risk
Mammography and adjuvant therapies cut breast cancer deaths
Benefits of tamoxifen use not apparent for many years
Statins do not protect against breast cancer
Staged sentinel node biopsy helps in surgical planning of breast cancer
Marital status does not affect outcome in breast cancer treatment
Trastuzumab efficacy "stunning" in HER2-positive breast cancer
Genetic testing for breast cancer warranted in high-risk black women
Gene profile aids breast cancer adjuvant therapy choice
Combination approach effective for recurrent breast cancer
Estrogen receptor polymorphisms tied to breast cancer risk in older women
Comorbidity explains good deal of racial disparity in breast cancer survival
Computer-aided mammography improves breast cancer detection
Breast cancer risk can be high for Hodgkin lymphoma survivors
Low income linked to underuse of breast cancer screening in US cities
Pfizer gets FDA OK for breast cancer drug Aromasin
HRT increase breast density on mammography
September 2005
Breast cancer risk elevated in female soldiers
Flaxseed inhibits breast cancer in animal model
Two new genes linked to poor breast cancer prognosis
Non-BRCA hereditary breast cancer not linked to ovarian cancer
Docetaxel better than paclitaxel in metastatic breast cancer
Digital mammography has advantages in breast cancer screening
Referral to medical oncologist may improve older breast cancer patients' care
Growth factor receptor expression increased in ER+/PR- breast cancers
Letrozole after tamoxifen beneficial in breast cancer
Computer-aided detection system helps diagnose breast cancer
EGFR expression tied to poorer breast cancer survival
August 2005
Weight loss reduces breast cancer risk in women with BRCA mutations
Breast cancer outcome worse with micrometastasis in bone marrow
Reduced drug dose in obese women with breast cancer may jeopardize outcome
Microarrays help identify distinct breast cancer classes
Lymph node involvement tied to recurrence of breast cancer
Hormone receptor status independent in primary and contralateral breast cancer
Breast cancer detected by mammography linked to better prognosis
Revised staging system predicts survival after breast cancer therapy
Adjuvant therapy extends survival in high-risk breast cancer
Switch from tamoxifen to anastrozole benefits women with early breast cancer
Cyclin D1 nullifies BRCA1's tumor suppressive function
July 2005
Genes that mediate breast cancer spread to lungs identified
Computer system boosts breast cancer detection
Contralateral mastectomy protects against subsequent breast cancer
CORRECTION: Study shows no mortality benefit in breast cancer screening
Study shows no mortality benefit in breast cancer screening
Adding trastuzumab to docetaxel improves survival in metastatic breast cancer
High-dose epirubicin, cyclophosphamide for breast cancer tied to secondary AML
Environmental estrogen increases breast cancer risk in mice
Breast cancer outcome similar in women and men
June 2005
Europe okays wider use anastrozole for breast cancer
Hormone receptor status independently predicts breast cancer survival
Dense breast tissue at greatest risk for DCIS
Obese breast cancer patients may receive suboptimal chemotherapy
Regulatory T cell blocker curbs breast cancer growth in mice
Progesterone receptor may have a protective role in breast cancer
Percentage of positive lymph nodes prognostic in T1-T2 breast cancer
Docetaxel better than fluorouracil in combo breast cancer therapy
May 2005
Link between NSAID use and breast cancer unclear
Androgen levels directly linked to breast cancer risk in young women
Hair dye does not raise risk of bladder or breast cancer
Topical 4-hydroxytamoxifen gel reduces breast tumor cell proliferation
Breast cancer regimen increases risk of life-threatening complications
MRI plus mammography best screening strategy in high-risk women
Letrozole bests tamoxifen for preventing breast cancer recurrence
Chemohormonal therapy reduces long-term breast cancer mortality
Postmenopausal breast cancer survivors face higher osteoporosis risk
Low-grade DCIS can progress to invasive breast cancer after many years
Trastuzumab induces apoptosis in primary breast cancers
Hair diffraction testing could diagnose early breast cancer
In utero exposure to cigarette smoke inversely linked with breast cancer
Nipple fluid analysis may help breast cancer evaluation
April 2005
Adipocyte-derived collagen tied to breast cancer
Herceptin effective adjuvant therapy for breast cancer
Radiation exposure linked to male breast cancer
Avastin effective against breast cancer
Tamoxifen can reduce breast pain in prostate cancer patients
Blocking DNA repair slows breast cancer growth in mice
Few women opt for tamoxifen to cut breast cancer risk
Progestogen in HRT may be linked with increased breast cancer risk
High glycemic index diets may raise risk of breast cancer among older women
Eating beans may stave off breast cancer
Weight gain after breast cancer diagnosis worsens survival
Computer-aided breast cancer detection pinpoints even the smallest tumors
March 2005
Findings shed light on why BRCA2 mutations predispose to breast cancer
Usual risk factors account for most ethnic differences in breast cancer incidence
Prophylactic mastectomy prevents breast cancer in women at risk
Pegfilgrastim prevents febrile neutropenia during breast cancer chemotherapy
Multidrug resistance protein may be useful breast cancer therapy marker
Radiotherapy for breast cancer now less cardiotoxic
African-American breast cancer patterns resemble those of sub-Saharan Africa
Adnexal mass in breast cancer patients often benign
Micrometastases often persist in breast cancer patients
Age alone not a contraindication for adjuvant chemotherapy in breast cancer
February 2005
Gene expression profile predicts breast cancer metastases
Breast cancer radiation therapy linked with esophageal cancer risk
Hypothyroidism tied to reduced breast cancer risk
Tamoxifen use for breast cancer tied to reduced risk of MI
Findings shed light on DNA repair mechanism of normal BRCA2
Urokinase deficiency cuts breast cancer spread in mice
Possible breast cancer trigger identified
Neoadjuvant and adjuvant therapy generally comparable for breast cancer
In node-positive breast cancer, c-Met overexpression signals poor outcome
January 2005
Concurrent tamoxifen and radiation doesn't threaten breast cancer outcome
Breast cancers detected by mammography require less toxic therapy
Deficient DNA repair capacity linked to breast cancer risk
Estrogen may have role in breast cancer DNA damage
Locoregional radiation improves long-term breast cancer survival
Genetic signature tracks breast cancer metastasis
Westernization linked to breast cancer rise in Singapore
Impaired retinol storage may promote breast cancer progression
SSRIs may lower serum levels of tamoxifen metabolite
December 2004
Hormones tied to certain breast cancer risks in postmenopausal women
Model helps predict breast cancer mortality
Adjuvant chemotherapy effective in elderly women with node-positive breast cancer
Many women at high risk of breast cancer decline tamoxifen
Biennial mammography appears suitable for older women
Multigene assay predicts recurrence of tamoxifen-treated breast cancer
More evidence for anastrozole's efficacy as first-line breast cancer treatment
Tamoxifen's effects similar in black and white women
Population study clarifies tie between BRCA1/2 and non-breast cancers
Alcohol-related breast cancer metastasis linked to MMP-2
November 2004
Continued raloxifene use further reduces breast cancer risk
CXCR4 tied to breast cancer metastasis
Genetic counseling program can identify breast cancer early
Breast-conserving therapy may be appropriate for hereditary breast cancer
Multiple factors may stratify risk before prophylactic mastectomy
Taxanes don't increase breast cancer radiation pneumonitis risk
Aromatase inhibition recommended for receptor-positive breast cancer
76-gene signature identifies breast cancer patients at risk for metastasis
Novartis breast cancer drug Femara OK'd for wider U.S. use
October 2004
Laser ablation of liver metastases extends breast cancer survival
Breast cancer chemotherapy may increase stroke risk
Ductal lavage not sensitive screening tool for breast cancer
Aromatase inhibitor boosts fertility chances after breast cancer
Mastectomy may trigger cancer recurrence in young women
Early growth patterns influence breast cancer risk
Tamoxifen may raise stroke risk
MRI bests mammography for seeing multiple lesions in dense breasts
Lymphocyte transplant can induce regression of metastatic breast cancer
Obesity impairs survival in early breast cancer
Ovarian radioablation aids breast cancer therapy
September 2004
Mammaglobulin-A vaccine slows breast cancer in mice
Breast cancer associated with melanoma risk, and vice versa
Immediate reconstruction after mastectomy does not delay chemotherapy
MRI most sensitive in detecting cancer in BRCA1/2 carriers
Testosterone added to HRT may protect against breast cancer
French team improves assay for breast cancer micrometastases
Autocrine growth hormone output makes breast cancer cells more invasive
Tailored T cells prevent breast cancer metastases in mice
Geographical variation seen for breast cancer-linked virus
Radiotherapy may not be needed for elderly women with early breast cancer
August 2004
Mammographic detection of breast cancer independently tied to better prognosis
Elevated IGF-I linked to raised risk of breast cancer in premenopausal women
CORRECTION: HRT and low body mass reduce sensitivity of mammography
Race a factor in breast reconstruction after mastectomy
Suppressor gene linked with breast cancer treatment response
Cardiac risks 'acceptable' after breast cancer chemotherapy
Circulating tumor cells predict breast cancer survival
Low HDL-C ups risk of breast cancer in older overweight women
July 2004
Breast-feeding curbs risk of breast cancer in BRCA1 carriers
MRI more sensitive than mammography at detecting cancer in high-risk patients
"Decision aid" helps breast cancer patients with treatment decisions
High-dose chemo no better than conventional chemo after breast cancer surgery
Murine-style virus tied to breast cancer
Tamoxifen improves endothelial function in postmenopausal women
Dietary fiber curbs estradiol levels in breast cancer patients
Glucose intolerance predicts tamoxifen-induced hepatotoxicity
High-dose chemotherapy may help some breast cancer patients
June 2004
Digital mammography can outdo film in cancer detection
Tumor genes may reflect breast cancer chemotherapy outcome
Few women comply with screening mammography guidelines
Cognitive impairment in breast cancer not necessarily due to chemotherapy
Mechanism of tamoxifen resistance and its possible reversal is revealed
Balloon brachytherapy suitable alternative to standard breast cancer radiation
Parity and lactation influence on breast cancer risk similar in blacks and whites
IOM calls for increase in mammography services, access
Gemzar prolongs survival in breast cancer trial
Breast cancers can acquire HER-2 gene amplification during tumor progression
Transcription factor activation linked to favorable breast cancer prognosis
Two-gene molecular signature predicts breast cancer recurrence after tamoxifen
May 2004
13C inhibits expression of MUC1 marker in breast cancer cells
Anti-breast cancer effects of aspirin may vary with hormone receptor status
False positive mammography findings more common in obese women
Breast cancer course similar in elderly and younger women
Micro MRI tracks breast cancer metastasis, in mice
Moderate exercise cuts breast cancer biomarkers in postmenopausal women
April 2004
Expression of FOXO factor tied to better outcome in breast cancer
Lower-category benign breast disease raises risk of invasive breast cancer
Statins do not increase breast cancer risk: study
Multiple factors predict breast cancer prognosis
Annual breast cancer screening may not suffice for BRCA-positive women
Transient severe caloric restriction may raise breast cancer risk
BRCA1/2 genetic test aids decision-making in breast cancer patients
March 2004
Radiofrequency ablation potential treatment for small breast cancers
Moderate exercise may improve odds of surviving breast cancer
Abortions do not raise breast cancer risk--meta-analysis
Breast disease type main predictor of tamoxifen use
Interval since childbirth points to breast cancer mortality in young women
Targeted delivery of vitamin D analog inhibits Her-2-positive breast cancer cells
Caloric intake has "important" etiologic role in breast cancer
Breast cancer diagnosis and treatment delayed in African American women
Mammography recall and detection rates directly related
February 2004
Increased mortality persists for women diagnosed with breast cancer before age 50
Double mastectomy markedly reduces cancer risk in BRCA1/2 carriers
Tamoxifen analog added to doxorubicin ups survival in metastatic breast cancer
Breast cancer can recur in interpectoral lymph nodes
Antibiotic use linked with breast cancer risk
Cancer charity waives patent rights to breast cancer gene
Mutation of p53 in breast cancer prognostic when neu/erbB-2 overexpressed
Computer analysis does not improve mammographic detection of breast cancer
Swedish HRT trial stopped early due to elevated breast cancer risk
January 2004
Androgen receptor blockade a potential therapy for ER-negative breast cancer
Many patients elect against adjuvant breast cancer therapy with tamoxifen
Breast cancer vaccine tests encouraging
Zoledronic acid better than pamidronate for bone metastases from breast cancer
Breast cancer drug Herceptin fails in lung cancer trial
Nomogram predicts breast cancer spread beyond sentinel lymph node
Active smoking may play a prominent role in breast cancer etiology
December 2003
Delayed diagnosis explains worse breast cancer survival in Europe than U.S.
Stressful life events are not related to breast cancer risk
Distinctive genomic alterations seen in sporadic early onset breast cancer
Lymph node features may indicate breast cancer metastasis risk
Adjuvant chemo plus goserelin may be effective for some early breast cancers
Early breast cancers often treated with suboptimal dose of chemotherapy
Pregnancy not tied to poor outcomes in breast cancer survivors
Cyclooxygenase-2-derived prostaglandin E2 induces angiogenic switch in breast cancer
Disruption of estrogen receptor zinc finger function suppresses breast cancer
EGFR expression in breast cancer linked to aggressive disease
Recurrence rates unexpectedly high in DCIS not treated with radiation
Tamoxifen's anticancer effects blunted by paroxetine
November 2003
Trastuzumab + paclitaxel every three weeks an option for metastatic breast cancer
Anastrozole bests tamoxifen as adjuvant treatment for early-stage breast cancer
Ibandronic acid does not impair renal function in breast cancer patients
Intraoperative electron beam therapy reduces risk of breast cancer recurrence
K-ras mutations common in tamoxifen-related endometrial polyps
Nuclear grade and palpability predict invasive cancer recurrence with DCIS
Mammography deemed cost-effective for healthy older women
Utilization of radiotherapy for breast cancer suboptimal
Advanced breast cancer more responsive to letrozole than anastrozole
Britain offers breast cancer screening to Hodgkin's disease survivors
Estrogen may repress growth of tamoxifen-resistant breast cancer
October 2003
BRCA1 mutations only predict poor cancer prognosis when chemo not given
New test indicates oestrogen receptor activity on breast cancer cells
Inherited factors do not increase risk for tamoxifen-related venous thrombosis
Mortality rates lower for breast cancers linked to HRT use
Breast cancer vaccine generates immune response in cancer patients
American recall rates following mammography higher than in England
Smoking cessation confers survival advantage in early breast cancer
Neutropenia may help explain racial disparity in breast cancer outcomes
Inherited BRCA2 mutations linked to pediatric brain tumors
Contrast mammography shows promise in cancer detection
Laser treatment seems to ameliorate post-mastectomy lymphedema
Letrozole reduces cancer recurrence after tamoxifen therapy ends
Exercise linked to reduced risk of early breast cancer
September 2003
Global breast cancer prevention trial launched
Exemestane promising in metastatic breast cancer therapy
Testing breast cancer tumors for BRCA1 may guide therapy
Childhood tumors associated with maternal breast cancer
MMP-9 points to prognosis in breast cancer patients
New AJCC staging criteria for breast cancer could affect outcome reporting
Modest physical exercise protects against breast cancer
Tumor size unrelated to node status in BRCA1 carriers
VEGF polymorphism associated with lower breast cancer risk
Green tea appears to protect against breast cancer
Age alone a factor in use of adjuvant chemotherapy for breast cancer
August 2003
Breast cancer risk not increased among antihistamine users
Radioactive glucose kills breast cancer cells
Aromatase inhibitors should not always replace tamoxifen
Fulvestrant no bar to breast cancer cell proliferation
Irradiation of mammary lymph nodes may improve high-risk breast cancer survival
Childbearing after breast cancer diagnosis does not raise mortality risk
HER-2 overexpression in highly proliferative breast cancer predicts poor outcome
Current combined HRT use doubles risk of breast cancer
Health food stores offer wide range of advice to breast cancer patients
T cell elevation linked with fatigue in breast cancer survivors
Hepatitis B virus reactivation common during breast cancer chemotherapy
Spontaneous but not induced abortion may increase risk of breast cancer
July 2003
Mammography detects early-stage breast cancer among women over 40
Long-term survival similar with mastectomy or breast-conserving therapy
Risk of breast cancer after treatment for Hodgkin disease quantified
Flawed research methods may mask a link between dietary fat and breast cancer
Fat intake linked to breast cancer in premenopausal women
High plasma cysteine associated with decreased risk of breast cancer
Radiotherapy reduces risk of invasive cancer after surgery for DCIS
Candidemia infrequent but serious in breast cancer patients after BMT
Benefits of high-dose chemo/stem cell therapy for high-risk breast cancer still unclear
Chemotherapy reduces breast cancer risk in radiation-treated Hodgkin's patients
June 2003
Radiation for Hodgkin lymphoma before age 30 ups breast cancer risk: study
Electromagnetic field exposure not linked to breast cancer
"Compelling evidence" implicates combined HRT in early, aggressive breast cancer
Good breast cancer outcomes attainable in pregnant women
Breast cancer survivors may be protected against myocardial infarction
Adjuvant chemo affects bone density in postmenopausal breast cancer patients
No clear link between antidepressants and breast cancer risk
"Thelarche pathway" linked to obesity, possibly breast cancer
CNS metastases common among breast cancer patients given trastuzumab
Breast-conserving procedures preferred in older patients with breast cancer
Metastatic dissemination occurs early in breast cancer tumorigenesis
Hereditary breast cancer related to timing of puberty
Low dose tamoxifen retains antiestrogenic activity in normal breast tissue
Low-dose tamoxifen retains antiproliferative activity against breast cancer
Phytoestrogens ineffective for menopausal symptoms in breast cancer patients
May 2003
Letrozole shown superior to tamoxifen for breast cancer
Gothenburg Breast Screening Trial finds benefit to screening mammography
Young black women with breast cancer fare worse than white women
Accelerated chemotherapy regimen may improve breast cancer outcome
Gene expression profiling could improve risk assessment of breast cancer
High breast cancer risk may warrant MR screening rather than mammography
BRCA-associated breast cancer has identifiable premalignant phase
April 2003
Molecular link between estrogen receptor and breast cancer growth identified
Life-saving benefit of mammography screening confirmed
Resveratrol effects in breast cancer cells elucidated
New gene detected in early-stage breast cancers
Paclitaxel after standard chemotherapy improves outcomes in early breast cancer
Newly identified gene associated with breast cancer
Decision tool helps women with early breast cancer make informed choices
Pain involved in mammography less stressful than waiting for results
Docetaxel with doxorubicin boosts metastatic breast cancer response
Mammaglobin in blood a potential marker of breast cancer recurrence
New breast cancer gene identified
Primary hypothyroidism linked to reduced incidence of breast cancer
More than 2 million US women would benefit from tamoxifen chemoprevention
March 2003
Dysregulation of tumor suppressors aid in breast cancer progression
Increased risk of male breast cancer seen in prostate cancer patients
Meat and fish intake later in life does not increase breast cancer risk
Non-BRCA mutations may play role in breast cancer risk
Lobular breast cancer rates in US increased steadily in last decade
Stressful life events may contribute to breast cancer risk
Doxorubicin and paclitaxel comparable in treatment of metastatic breast cancer
Plasma folate levels inversely linked with risk of alcohol-related breast cancer
Estrogen-only HRT does not increase risk of breast cancer
Nonadherence to tamoxifen common among early breast cancer patients
Breast cancer diagnosed late in Europe
February 2003
Egg intake during adolescence may reduce breast cancer risk
Less benign breast disease, fewer biopsies seen in women on tamoxifen
BRCA2 mutations linked to familial pancreatic cancer
BRCA2 N372H polymorphism linked to small increased risk of ovarian cancer
January 2003
Birth size directly related to premenopausal breast cancer risk
Novel breast cancer gene identified, may aid early detection
Hormone receptor-positive breast cancer on the rise
Axillary node dissection may not be needed in sentinel node-positive breast cancer
Chemotherapy often neglected in postmenopausal women with breast cancer
Myriad gets European patent for BRCA2 breast cancer gene
HER-2/neu overexpression linked to lower estrogen receptor levels in breast tumors
Low fat intake during puberty may cut breast cancer risk
Breast cancer progression faster in women with deleterious BRCA1 and BRCA2 mutations
Combination therapy outperforms monotherapy for node-positive breast cancer
Meat consumption not linked to breast cancer risk
Mammaglobin-A may provide target for breast cancer immunotherapy
December 2002
US Asian/Pacific women with breast cancer more likely to undergo mastectomy
Hormonal therapy improves relapse-free survival in premenopausal breast cancer
Breast cancer cases rising fast in UK
Antipsychotic drug linked to increased risk of breast cancer
Undertreatment with tamoxifen seen in oldest breast cancer patients
Long-term consequences of breast cancer treatment now need to be considered
Pneumatic compression helpful in lymphedema related to breast cancer treatment
"Dose-dense" adjuvant chemotherapy helps prevent breast cancer recurrence
Increased breast cancer risk declines with discontinuation of HRT
Combination HRT linked with increased lobular breast cancer risk
November 2002
Sentinel lymph node biopsy under local anesthesia advantageous for early stage breast cancer
Etiologic risk factors do not predict mortality in second primary breast cancer
Excision plus brachytherapy may obviate mastectomy for recurrent breast cancer
Mammography in women over 75 identifies smaller, earlier stage tumors
Alcohol and HRT increase breast cancer risk in postmenopausal women
Hyaluronidase curbs human breast cancer in murine model
Alcohol consumption increases risk of breast cancer
Mammographic patterns point to breast cancer risk
Prophylactic oophorectomy has "striking" effect on BRCA1 breast cancer relapse
October 2002
BRCA2 mutation may increase prostate cancer risk
Socioeconomic status, not race, key in predicting outcome in breast cancer
California urges study of alarming breast cancer rates
BRCA1-linked breast cancer highly responsive to chemotherapy
Adjuvant radiotherapy after lumpectomy reduces recurrence of very small tumors
Estrogen replacement does not affect disease-free survival after breast cancer
New protocol improves embryo cryopreservation rates for breast cancer patients
Long-term data support breast-conserving surgery for most breast cancer patients
Ductal carcinoma in situ accounts for 20% of mammogram-detected breast cancers
Low recurrence rate of breast cancer seen with brachytherapy
Breast conservation most chosen option by women with early stage breast cancer
Anti-EGF-R antibody effective in experimental breast cancer
Radiation reduces risk of recurrence in node-positive mastectomy patients
Global attack on breast cancer urged by consensus panel
Smoking in early adolescence significantly increases breast cancer risk
Breast self-exam training does not reduce breast cancer mortality
September 2002
MR spectroscopy may reduce need for lymph node biopsy in breast cancer
Cyclosporin A enhances activity of fenretinide against breast cancer cells
Clodronate prevents bone metastases in primary breast cancer
Many UK women lack knowledge about breast cancer screening
Hair dye use not tied to breast cancer
Long-term HRT may raise breast cancer risk disproportionately in Hispanic women
High intake of dairy products reduces breast cancer risk in premenopausal women
Genentech's Avastin breast cancer trial fails to meet primary endpoint
MRI useful in women with early-stage breast cancer
Value of mammography in reducing breast cancer mortality remains unclear
August 2002
Trilostane mechanistically dissimilar to tamoxifen in controlling breast cancer
Ovarian cancer risk in young breast cancer patients increased with family history
Normal BRCA1 enhances DNA repair independent of p53
Breast cancer screening reduces mastectomy rates in Italy
Case proband studies overstate breast cancer risk related to BRCA mutations
Breast cancer survivors have increased risk of lung cancer
BRCA2 mutation accounts for excess cancer risk in families of breast cancer patients
Stress may increase breast cancer risk in daughters of breast cancer patients
Progesterone receptor in breast tumor more prognostic than estrogen receptor
Clodronate may reduce risk of bone metastases with breast cancer
Cytoplasmic protein causes breast cancer cells to become hormone independent
Estrogen receptor signaling modulates human prostate cancer telomerase activity
Mammography screening reduces breast cancer mortality
July 2002
German study to focus on link between HRT and breast cancer
Lymph node stromal cells promote breast cancer cell growth
Adjuvant chemo before tamoxifen beneficial in ER-negative breast cancer
Mammographic breast cancer detection ups survival in women from age 65 to 85
Bodyweight modulates benefit of physical activity in reducing breast cancer risk
Lymph node cells may promote breast cancer metastasis
Lack of screening does not explain breast cancer stage variations in minorities
Risk of breast cancer chemoprevention outweighs benefit for most women
June 2002
Mammography detects early recurrent cancer in reconstructed breast
Oral contraceptive use does not increase breast cancer risk
Failure to perform biopsy delays breast cancer diagnosis
Anastrozole effective, well tolerated adjuvant therapy for breast cancer
Breast cancer mortality high in x-ray techs who worked before 1950
Capecitabine plus docetaxel improves survival in metastatic breast cancer
Possible tumor-suppressor gene for breast cancer identified
Breast cancer increasing among Asian-American women
Effect of family history on breast cancer survival varies
Diffusing capacity of CO2 predictive of pneumonitis in breast cancer patients
'Western' risk factors for breast cancer do not seem to hold in India
'Real-world' testing for HER2-positive breast cancer found inaccurate
May 2002
Weight gain, waist-hip ratio identified as risk factors for breast cancer
Breast cancer referral programme "not working" in UK
"Stiff upper lip" may predict risk of breast cancer recurrence
Adjuvant chemo-hormonal breast cancer therapies best given sequentially
Age, receptor status, tumor grade predict BRCA1 mutation risk
Lifelong vegetarians may have lower risk of breast cancer
FDA approves breast cancer treatment device
Study findings suggest genetic basis for many breast cancers
Radiation therapy for Hodgkin's disease increases breast cancer risk
April 2002
Menstrual cycle phase seen to affect outcome of mastectomy plus oophorectomy
FDA approves AstraZeneca's Faslodex for metastatic breast cancer
Mutation in checkpoint kinase gene associated with increased breast cancer risk
New method detects BRCA1 and BRCA2 gene mutations
High endogenous sex hormone levels raise breast cancer risk in older women
Male breast cancer more common, outcome better among Ashkenazi Jews
Delay in diagnosing asymptomatic breast cancer linked to disease progression
Soy drink does not relieve hot flashes in breast cancer survivors
Anthracycline/taxane neoadjuvant chemotherapy advised for breast cancer
Socioeconomic status effects US breast cancer care more than race
Postmastectomy breast reconstruction rates rise in UK and Ireland
March 2002
Margin status predictive of breast cancer recurrence following lumpectomy
Local cellular factors explain tamoxifen's tissue-specific effects
Correct positioning during mammography improves breast cancer detection
After breast cancer, excess risk for second cancer persists for decades
Intraoperative radiotherapy for breast cancer may obviate external radiotherapy
Antiestrogen for tamoxifen-resistant breast tumors has good preclinical results
Optical biopsy method shows promise in detecting breast cancer
Breast cancer screening does reduce death rates, UN researchers say
Physician-patient communication improves breast cancer care
Britain gives go-ahead to breast cancer drug
Fluoxetine improves hot flashes in women with breast cancer risk
Saliva test to detect breast cancer under development
Elevated Cox-2 expression linked to poor breast cancer prognosis
Mammography reader volume directly linked to diagnostic accuracy
February 2002
Xeloda/Taxotere seen as cost-effective in metastatic breast cancer
US officials recommend earlier breast cancer screening
Raloxifene following tamoxifen provides no further reduction in breast cancer risk
More evidence for link between HRT use and breast cancer
Four biopsy needle passes optimal in assessing breast cancer grade
January 2002
Mammography screening effective when data are analyzed correctly
Novel gene analysis predicts breast cancer outcome
Skewed X-chromosome inactivation seen in young breast cancer patients
Value of routine mammography questioned by NCI-sponsored panel
Herceptin and Iressa have synergistic inhibitory effect in some breast cancers
Clodronate's bone-sparing effects are long-lasting in breast cancer patients
Tamoxifen cost-effective for women at highest risk of breast cancer
Existence of putative BRCA3 breast cancer susceptibility gene disputed
Initial hormone therapy seen as option for some patients with locally advanced breast cancer
Diet and sunlight linked to breast cancer risk
Loss of heterozygosity in BRCA1 gene predicts mutation status of ovarian tumors
Adjuvant therapy for breast cancer impacts sexual function over many years
December 2001
Breast cancer risk determines cost-effectiveness of HRT versus raloxifene
Her-2/neu blood test aids breast cancer prognosis
Group psychosocial support does not seem to improve breast cancer survival
Anastrozole seen as more effective than tamoxifen for breast cancer
Abnormal nipple aspiration cytology tied to increased risk of breast cancer
Paclitaxel use by breast cancer patients tied to pneumonitis after radiotherapy
November 2001
Following tamoxifen with aromatase inhibitor may improve survival in early breast cancer
British study details new breast cancer treatment
Ductal lavage can guide breast cancer prophylaxis choices
October 2001
Most women with family history of breast cancer do not get cancer
Trial tests safety of HRT for women with breast cancer
Docetaxel undergoes new breast cancer trial
Most women overestimate the efficacy of mammography
Chemotherapy may compromise bone in postmenopausal breast cancer patients
p53 may mediate pregnancy-induced resistance to breast cancer
Outpatient mastectomy on the rise in US
Cost cited in rejecting Herceptin for advanced breast cancer in Australia
September 2001
Australian breast cancer treatment guidelines a "world first"
Riboflavin carrier protein seen as a marker for breast cancer
Elderly breast cancer patients "denied treatment" in UK
Breast cancer mortality is not increased in HRT users
Negative association observed between milk consumption and breast cancer
Anastrozole improves survival in advanced breast cancer
Women reluctant to participate in UK trials of breast cancer chemoprevention
Gene expression patterns in breast cancer predictive of outcome
Xeloda/Taxotere combination approved for metastatic breast cancer
UK women get breast cancer after screening mixup
FDG PET scanning aids the management of breast cancer
Many women want immediate mammography report, but not if it costs more
Hormone replacement therapy tied to lower mortality from breast cancer
August 2001
Ribozyme, Elan breast cancer drug enters new phase I trial
ACR says proposed mammography rate cut too low
Online support network may help patients with breast cancer
Breast cancer risk may be lowered by long-term physical activity
BMI linked to mortality in younger women with breast cancer
Mutations other than BRCA1 and BRCA2 may be responsible for early-onset breast cancer
BRCA2 status may predict response to docetaxel in breast cancer patients
BRCA mutation status does not significantly influence breast cancer survival
European Breast Cancer coalition enumerates breast cancer priorities
Breast-conserving therapy is preferred treatment for most cases of DCIS
Letrozole effective in advanced breast cancer
Compromised placental function linked to lower risk of maternal breast cancer
July 2001
MRI superior to mammography in screening high-risk women for breast cancer
Upside of adjuvant chemotherapy for breast cancer outweighs downside
Fatty acid composition of erythrocyte membranes linked to breast cancer risk
Revision of British breast cancer screening targets urged
Green tea consumption linked with reduced breast cancer risk
Prophylactic mastectomy reduces incidence of breast cancer in high-risk women
Multiple factors trigger weight gain during breast cancer chemotherapy
Folate reduces postmenopausal breast cancer risk related to alcohol consumption
Canadian groups release guideline on breast cancer chemoprevention
MUC1 vaccination of breast cancer patients induces antitumor antibodies
Tamoxifen use linked with increased risk of estrogen-receptor negative tumors
Breast-feeding tied to reduced risk of breast cancer
June 2001
Weekly trastuzumab plus paclitaxel active in metastatic breast cancer
Letrozole superior to tamoxifen for treatment of advanced breast cancer
May 2001
Weight gain in breast cancer patients not tied to overeating
Breast cancer risk is not linked with PCB or DDT exposure
Animal model of hereditary breast cancer created
Brca1 binds to DNA without sequence specificity
Consumer group sues AstraZeneca, Barr over tamoxifen deal
Bill to research links between breast cancer and environment introduced
Comparison with previous mammography improves yield of diagnostic imaging
Systemic therapy improves local control of node-negative breast cancer
MRI may be best diagnostic option for women at high risk of breast cancer
No clinical benefit seen from extending tamoxifen beyond 5 years
Methylation-specific PCR detects breast cell abnormalities before mammography
April 2001
Positive BRCA1/2 results may promote more aggressive breast cancer treatment
Mammography may save twice as many lives as previously thought
Distance from home influences use of free mammography services
NHS deal allows free breast cancer genetic testing
Low bone mineral density associated with decreased risk of breast cancer
Many women have unrealistic expectations about genetic test for breast cancer
Long-term tamoxifen therapy unnecessary for women with operable breast cancer
March 2001
Mexican women develop breast cancer younger than women in the US
BRCA2 mutation carriers have an increased risk of prostate cancer
Single women facing major stressor at increased risk of breast cancer
Chemokines determine breast cancer metastatic destinations
February 2001
FDA limits scope of digital mammography pending quality plan, guide says
Safety committee approves continued study of anastrozole plus tamoxifen
Hereditary and sporadic breast cancers show different gene-expression profiles
Age and comorbidities affect prognosis and treatment options in breast cancer
Sentinel lymph node biopsy useful in male breast cancer
Few infectious complications after bone marrow transplantation for breast cancer
Breast cancer risk not reduced by high intake of fruits and vegetables
Tamoxifen may confer cardiovascular benefit in healthy women
Post-mastectomy breast reconstruction an underused option
Psychological support often wanted after testing for BRCA1/BRCA2 mutation
Long-term breastfeeding lowers mother's breast cancer risk
January 2001
BRCA2 regulates cell cycle progression
Epoxide hydrolase expression points to tamoxifen response in breast cancer patients
November 2000
Adjuvant therapy seen to be reducing breast cancer recurrence
Breast cancer-benign breast disease link stronger for proliferative forms of BBD
HRT use increases cumulative risk of breast cancer at age 70
Novartis' Femara appears more effective than tamoxifen in treating breast cancer
October 2000
Early breast cancer treated suboptimally is prone to recurrence
Estrogen metabolism affects breast cancer risk in premenopausal women
President signs breast cancer bill
Breast exam, Pap smear predict mammography uptake
Radiation boost reduces recurrence of localized breast cancer in young patients
Scoring system identifies patients with metastatic breast cancer at highest risk
Maspin gene protects high-risk breast cancer patients from relapse
Single cause of breast cancer still not identified
Breast cancer mortality unrelated to secondhand smoke
Less than definitive care of breast cancer increases risk of recurence, death
UK surgeons to offer more women immediate reconstruction after mastectomy
Ultrasonography effectively measures tamoxifen's effect on endometrium
BRCA1/2 mutations may soon be detectable on buccal smears
Early oophorectomy protects against breast cancer in BRCA1/2 mutation carriers
September 2000
Fewer US women receiving appropriate primary treatment for breast cancer
Cdc25A phosphatase associated with poor breast cancer survival
BRCA mutation carriers with breast cancer often opt for prophylactic oophorectomies
Breast cancer risk influenced by timing of estrogen exposure
Burn cream reduces skin toxicity during radiation therapy for breast cancer
Mammography offers no survival advantage over annual breast examination
Radiation booster associated with reduced recurrence of breast cancer
FDA issues guidance on final mammography regulations
Population-wide breast screening substantially reduces breast cancer mortality
Ovarian cancer prognosis better in women with history of breast cancer
Long-term tamoxifen increases risk of poor-prognosis endometrial cancer
Mammography screening uptake low among Hispanics and American Indians
FDA approves AstraZeneca's Arimidex as first-line therapy for advanced breast cancer
August 2000
Long-term OC use doubles risk of breast cancer in older women
Breast cancer patients need counseling on what to tell their children
Adjuvant treatment for breast cancer increases leukemia risk
Syk gene may be a tumor suppressor in breast cancers
DDE exposure linked to increase in breast cancer risk
Marker of breast cancer, prostate cancer found in tears
Additional breast cancer susceptibility gene identified
Radioiodide may have role in diagnosis, treatment of breast cancers
Fine-needle aspiration identifies candidates for chemoprevention of breast cancer
Very elderly women in US often not offered full range of breast cancer treatments
July 2000
Laser treatment allows killing of breast cancers in situ
More older American women undergoing mammography
Genta's gene drug enhances chemotherapy for breast cancer
BRCA1 part of a complex that regulates chromatin access
Patients with small breast cancers should have axilla investigated for metastasis
Satisfaction high after prophylactic bilateral mastectomy
Cognitive function declines in breast cancer patients undergoing chemotherapy
Undetectable genetic mutations appear to increase risk of ovarian/breast cancers
Brca1 required for T-cell development
Program improves menopausal symptoms in breast cancer survivors
Anti-CEA imaging useful complementary follow-up to mammography
June 2000
UK's NICE gives green light to taxanes for breast cancer
Radiation for breast cancer not associated with greater risk of second malignancy
Android fat distribution increases risk of breast cancer death
Beef additive may stimulate growth of breast cancer cells
UCSF begins studies of Chinese and Tibetan herbal remedies for breast cancer
Girls born prematurely have an increased risk of breast cancer
Breast cancer risk unaffected by use of household electrical appliances
Breast cancer metastasis-suppressor gene identified
Pharmachemie is granted FDA approval for tamoxifen
May 2000
Docetaxel/5-fluorouracil combination safe in metastatic breast cancer
No link found between "ever" use of antidepressants and breast cancer risk
Tamoxifen reduces rate of contralateral breast cancer in African American women
Molecular methods point to breast cancer cells in bone marrow
Quality of care study of breast cancer and colon cancer patients gets under way
Risks of radiation may outweigh benefits in some breast cancer patients
Neoadjuvant tamoxifen effective for advanced localized breast cancer
High vegetable diet moderately protective against breast cancer
Socioeconomic disparities persist in screening mammography in Canada
Simple steps help radiologists avoid liability exposure on breast cancer claims
Biomira receives FDA fast track designation for breast cancer vaccine
April 2000
Few patients tested for BRCA1 support testing of children
Mammography-screened patients have better breast cancer outcomes
Early age at first full-term pregnancy decreases breast cancer risk
IL-2-secreting tumor vaccine prolongs survival in breast cancer animal model
Earlier screening beneficial for women with family history of breast cancer
Breast cancer lesions on chest wall respond to low-dose photodynamic therapy
Tumor factor assay guides treatment of women with node-negative breast cancer
Bilateral mastectomy protects BRCA gene mutation carriers from breast cancer
Breast cancer detected sooner among HRT users
March 2000
Bill would authorize study of link between environment and breast cancer
Level of alpha-linolenic acid in breast tissue inversely linked to breast cancer risk
VEGF level linked to survival in patients with node-positive breast cancer
Depression, BMI linked to eating pathologies in breast cancer survivors
Retinol binding protein lost in some breast cancers
ASCO releases guidelines on use of bisphosphonates in breast cancer patients
Pamidronate prevents skeletal complications in breast cancer patients
Decision about breast cancer adjuvant therapy should be based on recurrence risk
February 2000
Adjuvant chemotherapy recommended in all young breast cancer patients
Aetna unit to drop bone marrow transplant coverage for breast cancer patients
Aggressive measures extend life of BRCA1/2-positive breast cancer patients
Researcher admits misrepresenting results of breast cancer trial
High-dose epirubicin effective against advanced breast cancer despite toxicity
Patient population with high probability of BRCA1 mutations identified
Adjunctive high-dose chemotherapy ineffective for certain breast cancer patients
January 2000
Estrogen-progestin HRT raises breast cancer risk more than estrogen alone
Colitis associated with use of docetaxel for metastatic breast cancer
Gene identified that confers antiestrogen resistance on breast cancer cells
Favorable outcome likely when breast cancer diagnosed between ages 60 and 69
E-cadherin predicts breast cancer prognosis in combination with other markers
African-American women at increased risk of death from breast cancer
December 1999
Waist circumference a risk factor for breast cancer
Parity, age at first childbirth linked to breast cancer stage at diagnosis
Exposure to magnetic fields does not increase risk of breast cancer in women
Postmenopausal breast cancer progression slowed with anastrozole
November 1999
Racial gap in breast cancer mortality widening
Mailed risk notification to high-risk women improves mammography use
Survival again linked to timing of surgery in breast cancer patients
Fertility drugs linked to transient rise in breast cancer incidence
BRCA2 tumors usually estrogen and progesterone receptor-positive
October 1999
Taxol receives approval for early-stage breast cancer indication
Daily exercise cuts breast cancer risk by up to 20% in middle-aged women
Degree of fatigue greater in breast cancer patients who experience other chemo side effects
Postmastectomy radiation does not increase cardiac mortality in high-risk patients
Tumor genetics can help to direct therapy in breast cancer patients
Breast cancer risk unrelated to stress; response to diagnosis may affect survival
Autotransplantation not effective in subsets of women with advanced breast cancer
Weight gain after breast cancer diagnosis common
Obesity and prior estrogen replacement augment risk of endometrial cancer in tamoxifen users
September 1999
Survival in early-stage breast cancer cases reduced if axillary node dissection not performed
Bulk of data refutes psychosocial link to breast cancer
Anastrozole superior to tamoxifen for advanced breast cancer in postmenopausal women
Conflicting tamoxifen trial results debated at European Cancer Conference
Immunohistochemistry improves detection of lymph node metastases in breast cancer patients
Breast cancer needle aspirates useful for Bcl-2 evaluation
Bilateral oophorectomy reduces breast cancer risk in BRCA1 carriers
August 1999
Liposome Company, Bristol-Myers Squibb to collaborate on breast cancer therapy
Dense breast tissue linked to risk of familial breast cancer
CYP17 polymorphism influences risk of breast cancer in young women
Chemotherapy increases risk of menopause after breast cancer diagnosis
Metastatic potential of breast cancer linked to specific loss of heterozygosity
MRI may be useful in the workup of early-stage breast cancer
More women with Stage II breast cancer should receive breast-conserving surgery
Trex Medical digital mammography system not equivalent to analog systems
BRCA2 gene mutations linked to increased risk of a variety of cancers
Neoadjuvant chemo can eradicate axillary lymph node metastases before surgery for breast cancer
July 1999
MRI detects breast tumors missed by mammography
Computer model predicts fewer breast cancer deaths with more frequent mammography
Genetic screening for breast cancer advised for subset of Ashkenazi Jewish women
Lilly barred from claiming that Evista lowers breast cancer risk
Addition of epirubicin to tamoxifen reduces recurrence of node-positive breast cancer
Age should be considered in choice of adjuvant breast cancer chemotherapy
Estrogen-deficient breast cancer patients at increased risk of depression
June 1999
Postmastectomy radiation beneficial for DCIS patients with positive margins
Addition of low-dose chemo to tamoxifen not beneficial in receptor-positive breast cancer
Breastfeeding reduces breast cancer risk
Low BRCA1 expression linked to progression of sporadic breast cancers
Tamoxifen does not improve treatment of advanced malignant melanoma
Vysis and Eos to identify new markers for breast cancer
Tamoxifen useful for breast cancer risk reduction; jury still out on raloxifene
Intraoperative sentinel node exam predicts axillary node status in breast cancer patients
Tamoxifen protocol involving lumpectomy and radiation prevents invasive breast cancer
HRT use does not increase risk of invasive breast cancers with poor prognosis
High adolescent growth rate may be linked to breast cancer risk
New use of alternative medicine after breast cancer surgery signals distress
Pregnancy after breast cancer does not adversely affect survival
May 1999
Enrollment under way for trial comparing tamoxifen and raloxifene in breast cancer prevention
Breast cancer protein BRCA1 regulates estrogen receptor function
No recommendation yet to use raloxifene to reduce breast cancer risk
Concurrent chemo and radiation for breast cancer does not worsen QOL deterioration
Small breast cancers may not require axillary node dissection
MRI accurate in detection, staging of invasive lobular breast cancer
FDA asked to issue stronger warnings on tamoxifen
April 1999
Estrogen replacement therapy may be possible in selected breast cancer patients
Conclusion that OC use does not increase breast cancer risk called premature
Role of high-dose chemo plus BMT in breast cancer treatment still inconclusive
Herceptin improves survival in metastatic breast cancer patients with HER-2/neu gene mutation
Length of gestation influences maternal breast cancer risk
Prolactin levels linked to postmenopausal breast cancer risk
Multidisciplinary protocol for breast cancer during pregnancy safe for fetus, mother
UK introduces fast-track breast cancer referral program
Buccal smears a possible means of testing for BRCA1 mutations
March 1999
Breast cancer diagnosis before age 50 increases risk of later ovarian cancer diagnosis
At-risk women may overexamine themselves for breast cancer
BRCA1 expression downregulated in some sporadic breast cancers
ERT poses no further breast cancer risk in women with benign breast disease
No link found between fat intake, breast cancer
Hair analysis could screen for breast cancer
Patient version of breast cancer practice guidelines released
Pamidronate reduces skeletal morbidity in breast cancer patients with bone lesions
February 1999
Women with breast cancer overestimate cancer gene risk
Tamoxifen linked to ovarian cyst formation in premenopausal breast cancer patients
Endogenous steroid hormone levels correlate with risk for breast cancer
PSA levels in women may predict effectiveness of breast cancer treatment
Long-term outcomes after dose-intensive chemo for high-risk breast cancer mixed
Predictors of local recurrence of DCIS after conservative surgery identified
Outcome predictors identified for locally advanced breast cancer
Coumarin ineffective against arm lymphedema after breast cancer treatment
BRCA1/2 gene mutations unrelated to survival in women with breast or ovarian cancers
Chemotherapy linked to impaired cognitive function in breast cancer patients
January 1999
Postmenopausal obesity linked to increased breast cancer risk
Breast cancer risk reduced after bilateral prophylactic mastectomy in high-risk patients
Vorozole comparable with megestrol acetate as second-line treatment for advanced breast cancer
Persistent symptoms common after node dissection in breast cancer patients