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| Tamoxifen for weakly positive Estrogen and Progesterone breast cancers Dear OncoLink "Ask The Experts," I am a 31-year old ER negative and "weakly" PR positive breast cancer patient. I have had a mastectomy with no lymph node involvement and chemotherapy and now deciding whether to go on Tamoxifen. Does your practice recommend Tamoxifen for "weakly" PR positive patients?Julia Draznin Maltzman, MD, |
| Estrogen plus progestin (E+P) and breast cancer incidence and mortality Presenter: Rowan T. Chlebowski Presenter's Affiliation: Women's Health Initiative, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA Background The Women's Health Initiative (WHI) was a major research program launched in 1991 to address the most common causes of death, disability and poor quality of |
| Chemohormonal therapy in premenopausal node-positive, receptor positive breast cancer: An Eastern Cooperative Oncology Group phase III intergroup trial (E5188, INT 0101) Presenter: N. E. DavidsonPresenter's Affiliation: Eastern Cooperative Oncology GroupType of Session: ScientificBackground The benefits of combined chemotherapy and endocrine therapy in premenopausal pts with node-positive, hormone receptor-positive breast cancer are a topic of much research. The benefit of chemotherapy in node-positive breast |
| BIG 1-98: Randomized double-blind phase III study to evaluate letrozole (L) vs. tamoxifen (T) as adjuvant endocrine therapy for post-menopausal women with receptor-positive breast cancer. Presenter: B.J. ThurlimannPresenter's Affiliation: BIG 1-98 Collaborative, Bern, SwitzerlandType of Session: ScientificBackground Letrozole is a drug in a class of medications known as aromatase inhibitors, which almost completely inhibit the synthesis of estrogen. Tamoxifen is an estrogen receptor blocker. |
| A Phase II multicenter, randomized trial to compare anastrazole plus gefitinib with anastrazole plus placebo in postmenopausal women with hormone receptor-positive (HR+) metastatic breast cancer (MBC) Presenter: M. CristofanilliPresenter's Affiliation: MD Anderson Cancer CenterType of Session: ScientificBackground It is well known that hormonal receptor status is an important prognostic factor in metastatic breast cancer patients and has clinical implications for hormonal therapies. 55% of metastatic breast cancer patients are |
| Estrogen receptor negative breast cancers Dear OncoLink "Ask The Experts," Does breast cancer run along some continuum from estrogen-receptor positive to estrogen-receptor negative tumors? Are ER+ tumors a different disease than ER- tumors? I have been diagnosed with an ER- breast cancer and I am confused as to whether I am at increased risk of recurrence and general guidelines for |
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