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| BRCA1/BRCA2 Germline Mutations in Locally Recurrent Breast Cancer Patients After Lumpectomy and Radiation Therapy: Implications for Breast-Conserving Management in Patients With BRCA1/BRCA2 Mutation Reviewers: Li Liu, MD Source: Journal of Clinical Oncology, Volume 17, No 10:3017-3024, October 1999.BackgroundFor women with early stage breast cancer, lumpectomy followed by radiation therapy (LRT) has been an acceptable standard of care. Much effort has been made to identify a subgroup of patients who are at higher risk for ipsilateral breast |
| Prophylactic Surgery Decisions and Surveillance Practices One Year Following BRCA1/2 Testing Reviewers: Li Liu, MD Source: Preventive Medicine, Volume 31:75-80, (August) 2000Précis: BRCA testing has low impact on screening complianceIntroductionGermline BRCA1/2 mutations are associated with greatly increased risk of developing breast and ovarian cancers. Genetic testing has made it possible for some women to determine whether or |
| BRCA1 and BRCA2 testing for Ovarian Cancer Dear OncoLink "Ask The Experts," My mother had ovarian cancer at the age of 50, I am now 49 and of Jewish heritage. It seems that the genetic testing is no longer easily accessible. How would I go about getting genetic testing? Stephen C. Rubin, MD, Professor and Chief of the Division of Gynecologic Oncology, University of Pennsylvania Health |
| BRCA1 mRNA expression in patients with bladder cancer treated with neoadjuvant cisplatin-based chemotherapy BRCA1 mRNA expression in patients with bladder cancer treated with neoadjuvant cisplatin-based chemotherapy Improved overall survival has been demonstrated with the use of cisplatin-based chemotherapy given prior to radical cystectomy in patients with locally advanced bladder cancer, as compared to radical cystectomy alone (Lancet, 2003). |
| Genetic Counseling & Testing for BRCA1 and BRCA2 Gene Mutations What are BRCA1 and BRCA2 Mutations? BRCA1 and BRCA2 is short for breast cancer susceptibility gene 1 and breast cancer susceptibility gene 2. The BRCA1 and BRCA2 genes are present in all individuals. Everyone has two copies of each of these genes - one from each parent. Mutations of genes are like spelling errors in the genetic code of a gene. |
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