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| BRCA1/BRCA2 Germline Mutations in Locally Recurrent Breast Cancer Patients After Lumpectomy and Radiation Therapy: Implications for Breast-Conserving Management in Patients With BRCA1/BRCA2 Mutation Reviewers: Li Liu, MD Source: Journal of Clinical Oncology, Volume 17, No 10:3017-3024, October 1999.BackgroundFor women with early stage breast cancer, lumpectomy followed by radiation therapy (LRT) has been an acceptable standard of care. Much effort has been made to identify a subgroup of patients who are at higher risk for ipsilateral breast |
| Genetic Counseling & Testing for BRCA1 and BRCA2 Gene Mutations What are BRCA1 and BRCA2 Mutations? BRCA1 and BRCA2 is short for breast cancer susceptibility gene 1 and breast cancer susceptibility gene 2. The BRCA1 and BRCA2 genes are present in all individuals. Everyone has two copies of each of these genes - one from each parent. Mutations of genes are like spelling errors in the genetic code of a gene. |
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