Classification: Monoclonal Antibody
About Dinutuximab (Unituxin™)
Dinutuximab is a type of medication called a monoclonal antibody. A monoclonal antibody is designed to target a substance found on certain cells, in this case it targets glycolipid GD2. It binds specifically to GD2, which is expressed on the surface of neuroblastoma tumor cells, as well as some normal cells. Dinutuximab binds to the GD2 and causes the cell to breakdown and die.
How to Take Dinutuximab
Dinutuximab is given as an intravenous infusion (into the vein) over 10-20 hours for 4 consecutive days, for up to 5 cycles. It may be given with other chemotherapy. The actual dose is based on the patient’s weight. Intravenous (IV) fluids will be administered prior to the infusion of dinutuximab. Pre-medications, including an antihistamine and an antipyretic (medication that prevents fever), will be given to prevent a reaction to the medication. Analgesics (pain relievers) may also be administered to prevent pain during infusion.
Possible Side Effects of Dinutiximab
There are a number of things you can do to manage the side effects of dinutuximab. Talk to your doctor or nurse about these recommendations. They can help you decide what will work best for you. These are some of the most common side effects:
In some cases, patients can have an allergic reaction to this medication. Signs of a reaction can include: shortness of breath or difficulty breathing, chest pain, rash, flushing or itching, or a decrease in blood pressure. If you notice any changes in how you feel during the infusion, let your nurse know immediately. The infusion will be slowed or stopped if this occurs. Depending on the severity of your reaction, you may be able to receive the medication, with an increased dosage of premedications (antihistamine and antipyretic). The dosage of the medication may be decreased or infused at a slower rate if an allergic reaction persists.
Peripheral Neuropathy (Numbness or Tingling in the Hands and/or Feet)
Peripheral neuropathy is a toxicity that affects the nerves. It causes a numbness or tingling feeling in the hands and feet, often in the pattern of a stocking or glove. Dinutuximab can cause neuropathic pain during and after infusion. A patient will be given pain medications prior to the infusion, continuously throughout, and for two hours after the infusion is complete. This pain can get progressively worse with additional doses of the medication. In some people, the symptoms slowly resolve after the medication is stopped, but for some it never goes away completely. You should let your healthcare provider know if you experience numbness or tingling in the hands and feet, as they may need to adjust the doses of your medication.
Capillary Leak Syndrome
Capillary leak syndrome is a condition in which blood and components of blood leak out of vessels and into body cavities and muscles. The movement of this fluid out of the vessels can cause hypotension (low blood pressure) and organ failure. Signs and symptoms of capillary leak syndrome include: a sudden drop in blood pressure, weakness, fatigue, sudden swelling of the arms, legs or other parts of the body, nausea, and lightheadedness. If you are having any of these symptoms notify your infusion nurse or provider immediately.
Dinutuximab can cause neurological disorders of the eye. The infusion will be interrupted with any vision changes, including dilated pupils or a sluggish reflex to light. The infusion will be discontinued if vision is lost. Notify your infusion nurse or care provider immediately with any changes to your vision.
Atypical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome is a rare disease that affects kidney function and can cause kidney failure. Notify your care provider with any changes in your urine, including a change in the color of your urine, blood in the urine or a decrease in the amount of urine your are producing.
Dinutuximab can cause abnormal electrolyte levels in your blood. You will have blood work drawn frequently to monitor these electrolytes and measures will be taken to correct abnormal levels.
Low White Blood Cell Count (Leukopenia or Neutropenia)
White blood cells (WBC) are important for fighting infection. While receiving treatment, your WBC count can drop, putting you at a higher risk of getting an infection. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4), sore throat or cold, shortness of breath, cough, burning with urination, or a sore that doesn't heal.Tips to preventing infection:
- Washing hands, both yours and your visitors, is the best way to prevent the spread of infection.
- Avoid large crowds and people who are sick (i.e.: those who have a cold, fever or cough or live with someone with these symptoms).
- When working in your yard, wear protective clothing including long pants and gloves.
- Do not handle pet waste.
- Keep all cuts or scratches clean.
- Shower or bath daily and perform frequent mouth care.
- Do not cut cuticles or ingrown nails. You may wear nail polish, but not fake nails.
- Ask your doctor or nurse before scheduling dental appointments or procedures.
- Ask your doctor or nurse before you, or someone you live with, has any vaccinations.
Low Red Blood Cell Count (Anemia)
Your red blood cells are responsible for carrying oxygen to the tissues in your body. When the red cell count is low, you may feel tired or weak. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing or pain in your chest. If the count gets too low, you may receive a blood transfusion.
Low Platelet Count (Thrombocytopenia)Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. Let your doctor or nurse know if you have any excess bruising or bleeding, including nose bleeds, bleeding gums or blood in your urine or stool. If the platelet count becomes too low, you may receive a transfusion of platelets.
- Do not use a razor (an electric razor is fine).
- Avoid contact sports and activities that can result in injury or bleeding.
- Do not take aspirin (salicylic acid), non-steroidal, anti-inflammatory medications (NSAIDs) such as Motrin®, Aleve®, Advil®, etc. as these can all increase the risk of bleeding. Unless your healthcare team tells you otherwise, you may take acetaminophen (Tylenol).
- Do not floss or use toothpicks and use a soft-bristle toothbrush to brush your teeth.
Nausea and/or Vomiting
Talk to your doctor or nurse so they can prescribe medications to help you manage nausea and vomiting. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try antacids, (e.g. milk of magnesia, calcium tablets such as Tums), saltines, or ginger ale to lessen symptoms.
Call your doctor or nurse if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time.
Your oncology team can recommend medications to relieve diarrhea. Also, try eating low-fiber, bland foods, such as white rice and boiled or baked chicken. Avoid raw fruits, vegetables, whole grain breads, cereals and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea. Foods high in soluble fiber include: applesauce, bananas (ripe), canned fruit, orange sections, boiled potatoes, white rice, products made with white flour, oatmeal, cream of rice, cream of wheat, and farina. Drink 8-10 glasses on non-alcoholic, un-caffeinated fluid a day to prevent dehydration.
Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. For women, effective birth control is necessary during treatment and for at least 2 months after treatment. Men should use condoms while being treated. Even if your menstrual cycle stops or you believe you are not producing sperm, you could still be fertile and conceive.