Effect of the addition of rituximab to front line therapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) on the remission rate and time to treatment failure (TTF) compared to CHOP alone in mantle cell lymphoma (MCL): results of a pr
Reviewer: Maria Luisa Veronese, MD
Abramson Cancer Center of the University of Pennsylvania
Last Modified: June 5, 2004
This study discusses an off-label use of rituximab for the treatment of MCL.Presenter: W. Hiddemann
Presenter's Affiliation: Ludwig-Maximilians-University, Munchen, Germany
Type of Session: Scientific
Materials and Methods
- R-CHOP produced better CR and overall remissions
- R-CHOP produced a longer TTF
- There was no differences in PFS between the two regimens
- There were no differences in the two post-induction regimens between the the CHOP and R-CHOP groups
- R-CHOP did not induce major toxicities
MCL carries a poor prognosis and there are no standardized regimens. Promising results have been shown with the inclusion of rituximab to the FCM regimen and rituximab has significant clinical activity in MCL as single agent. Unfortunately, the progression free survival and the overall survival remain poor. This study compared CHOP and R-CHOP regimens as first line therapy in patients with MCL. R-CHOP induced better CRs and longer TTF. PFS was not improved by the addition of rituximab. The different regimens applied after CHOP/R-CHOP induction may partly account for the lack of differences in PFS. These data are encouraging and further studies with a larger number of patients with stratification by prognostic risk factors and longer follow-up time to evaluate overall survival are needed.
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