Albert DeNittis, MD
OncoLink Assistant Editor
Last Modified: November 1, 1999
Presenter: Charles Ma
Affiliation: Stanford University School of Medicine
Breast cancer has traditionaly been treated with photon beams. The purpose of this study was to investigate the feasibility of using energy and intensity modulated electron beams for breast cancer treatment. The use of Electron Intensity Modulated Radiation Therapy (EIMRT) has the potential advantages of significantly improving dose uniformity in the target volume and decreasing the adverse effects to normal tissues including reducing the dose to the contralateral breast.
An inverse planning system based on Monte Carlo dose calculations was developed with the intention of optimizing electron beam energy and incident angles to achieve conformal doses near the skin surface. A specially manufactured multileaf collimator (MLC) was designed for electrons which would shape the incident beam, decrease scatter and replace cutouts. Electron beams from 4-20 MeV were analyzed. Ionization and field measurements were taken for comparison.
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Mar 1, 2011 - In patients with anal canal squamous cell carcinoma, intensity-modulated radiation therapy is associated with less toxicity, fewer and shorter treatment breaks, and good overall survival and locoregional control compared with conventional radiotherapy, according to a study published online Feb. 1 in Cancer.
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