Christina S. Chu, MD
Last Modified: April 21, 2002
Dear OncoLink "Ask The Experts,"
What is Endometrial stromal sarcoma (low grade)?
Christina S. Chu, MD, Assistant Professor of the Division of Gynecologic Oncology at the University of Pennsylvania Health System, responds:
Endometrial stromal sarcomas are a rare type of uterine cancer. The normal endometrial lining of the uterus is the layer that sheds every month during a woman's menstural period, and is the lining where a developing embryo implants. This endometrial lining is made up of glandular cells and stromal cells. The typical endometrial cancer is made up of malignant glandular cells, while endometrial stromal sarcomas are composed of malignant stromal cells. The stage of the tumor when it is diagnosed is the most important prognostic factor. The low grade variety typically has a very slow growing, non-aggressive course. The recommended treatment is surgical removal of the uterus, fallopian tubes, and ovaries. Some physicians may recommend radiation to the pelvis after surgery depending on the extent of the tumor.
Jan 18, 2012 - ROR2 gene mutations are expressed in a subset of soft-tissue sarcomas, including leiomyosarcoma, gastrointestinal stromal tumors, and desmoid-type fibromatosis, and expression may be indicative of poor prognosis, according to a study published online Jan. 4 in The Journal of Pathology.
Jan 18, 2012