Dear OncoLink "Ask The Experts,"
My Labrador has been diagnosed with lymphosarcoma in the lower colon area and is undergoing chemotherapy treatments. However, she is experiencing chronic diarrhea. We hope the cause is the chemotherapy, however Imodium has not worked. I have read that Lomotil has been successful with dogs in this situation. Our Internist does not feel that other options besides Imodium will do any good. What is your opinion about prescription diarrhea medications?
Lili Duda, VMD, Section Editor of the OncoLink Veterinary Oncology Menu, responds:
The first step in treating diarrhea in a dog is determining the underlying cause.
In this particular case, the two most likely causes are chemotherapy and abnormal colon function as a result of lymphoma infiltration into the tissues.
In veterinary medicine, chemotherapy dosages are usually modest, and side effects such as nausea, vomiting, and diarrhea are usually mild to moderate and self-limiting. We typically treat diarrhea in our chemotherapy patients symptomatically using standard anti-diarrheal medications that are designed to treat diarrhea of any cause (Imodium, Lomotil), paying close attention to the contraindications for each specific drug. Dietary modifications might also help. Unfortunately, if the diarrhea is due to lymphoma and not chemotherapy, anti-diarrheal drugs will have limited effectiveness.
While Sandostatin ( octreotide) has not been reported for the use of chemotherapy-induced diarrhea in dogs, it has been used in dogs for other indications, and is also used in people to treat diarrhea.
Apr 23, 2014 - A new compound that delivers cancer-killing nitric oxide molecules via vitamin B12 receptors on cancer cells dramatically reduced the size of tumors in three dogs and could point the way for research in treating human cancers too, according to a case study presented at the American Chemical Society's 237th National Meeting, held March 22 to 26 in Salt Lake City.