Janet L. Stanford, Ziding Feng, Ann S. Hamilton, et al
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Source: JAMA, 2000 Jan 19; 283(3): 354-60
Urinary incontinence and impotence are among the most common side effects after radical prostatectomy for early stage prostate cancer. The rates of incontinence range from 4% to 40% and impotence from 30% to 75% depending upon the selection of the patients and clinical practices. Dr. Janet L. Stanford of the Fred Hutchinson Cancer Research Center in Seattle and a multicenter team reported the incidences of these side effects in patients who underwent radical prostatectomy for prostate cancer.
A total of 1,291 black, white, and Hispanic men, age 39 to 79, with primary prostate cancer who underwent radical prostatectomy within 6 months of diagnosis were included. They were followed for up to 2 years.
In this study, radical prostatectomy was associated with significant erectile dysfunction and some compromise in urinary function. Erectile dysfunction may significantly affect quality of life, particularly in younger men. Medications and other measures are currently available to address this problem. Some studies have suggested that radical prostatectomy and radiation therapy are equally effective in local tumor control in selected patients with early stage prostate cancer. Patients should be aware of potential treatment sequelae of each and how these might be treated if they arise.
Oct 11, 2010 - Radical prostatectomy, external-beam radiotherapy, and brachytherapy result in several quality-of-life issues after prostate cancer treatment in patients not receiving adjuvant hormonal treatment, including either improvement in or worsening of urinary irritative-obstructive symptoms in addition to the more commonly discussed sexual and incontinence issues, according to research published online Oct. 4 in the Journal of Clinical Oncology.