Neutropenia Tip Sheet

Last Modified: May 11, 2016

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White blood cells (WBC) are one part of our body's immune system, working to protect us against infection. A neutrophil is one type of WBC and they make up the majority of WBCs. They are the "first responders" and quickly appear at the site of infection, ingesting and destroying foreign particles. They can be found in the pus of a wound and play a role in acute inflammation (redness, warmth, swelling, and pain). A normal neutrophil count (also called absolute neutrophil count or ANC) is between 2500 and 6000. A low neutrophil count (less than 1000) is known as neutropenia. The lower the neutrophil count, the higher the risk of infection. Neutropenia is most often caused by cancer therapies, including chemotherapy and radiation therapy. Ask your healthcare team when your counts are likely to be at their lowest (also called nadir), as you will most likely be at home during the nadir. For chemotherapy, low counts usually occur 7-12 days after treatment.

Given that neutropenia is caused by cancer treatments, there is not much you can do to prevent it from occurring, but you can decrease the risk of getting an infection while your count is low.

Steps to help prevent infection:

  • Hand washing, hand washing, hand washing! This includes the patient and those around the patient.
  • Avoid large crowds where you may come into contact with germs, such as shopping malls, church, or public transportation. If need be, go at off peak hours to avoid the crowds.
  • Avoid anyone who is sick (including colds), including other people in your household that are sick.
  • Avoid children or adults who have recently received vaccines.
  • Do not handle animal waste (including cat litter, bird cage, fish tank water, chicken coops, etc.)
  • If you have a central catheter (PICC, Port, Hickman), use caution to keep it clean and dry. Check the area for redness or tenderness (soreness) daily.
  • Follow an oral care regimen.
  • Wear sunscreen (SPF 15 or higher) to prevent sunburn.
  • Use only electric razors to avoid cuts that can become infected.
  • Use caution to avoid any cuts or injuries. (avoid contact sports, wear gloves for household chores)
  • Do not use rectal suppositories.
  • Do not have dental work without first talking with your healthcare team.
  • Do not get any vaccines without first talking with your healthcare team.
  • Women should not use tampons while neutropenic as these can pose a risk of infection and toxic shock syndrome. Use sanitary napkins instead.
  • Neutropenic patients should not have intercourse, any type of vaginal or anal penetration (including toys/props) or oral sex as these can pose an infection risk. Talk with your healthcare providers if you have specific sexual practices that you are concerned about.

You may receive a growth factor to stimulate neutrophil production. This is a man-made version of a natural hormone that causes the body to produce more neutrophils. It is given by an injection just under the skin. There are a few growth factors available in the United States: filgrastim (Neupogen®), pegfilgrastim (Neulasta®) and sargramostim (Leukine®).

Even the best hand washers can end up with an infection. An infection in a neutropenic patient is an emergency! If you notice any signs or symptoms of infection, you should call your doctor right away - even if it is the middle of the night. You will likely need to have blood work drawn and other testing to look for any source of infection. It is important to receive antibiotics in a timely fashion since your body is immunocompromised and unable to fight some infections on its own. Make sure you know how to reach someone when the office is closed!

Signs and symptoms of infection to look for:

  • Check your temperature twice a day or if you feel feverish. If your temperature is 100.4 or higher, call your doctor right away.
  • Do not take acetaminophen (Tylenol) or aspirin to reduce the fever without talking to your doctor first.
  • Shaking chills.
  • Cough, sore throat, nasal congestion, or shortness of breath.
  • Burning with urination or new lower back pain.
  • Blood in urine.
  • Diarrhea (worsening) or change in the odor of your stool.
  • Rash, redness or swelling of the skin.
  • Redness, soreness around central line catheter, feeding tube or a wound.
  • Soreness or swelling in your mouth or throat, ulcers or white patches in your mouth, or a change in the color of your gums.

Practice Food Safety

While your immune system is not functioning properly, you could have a more difficult time fighting a food-borne illness. There are some steps you can take to make food safety a priority.

  • Wash all fresh fruits and vegetables well before consuming.
  • Avoid raw or rare-cooked meat and fish. Meat should be cooked to established safe internal temperatures.
  • Use only pasteurized eggs, milk, yogurt, cheese, other dairy products, fruit juices and honey.
  • Avoid soft mold-ripened and blue-veined cheese including: Brie, Camembert, Roquefort, Stilton, Gorgonzola, Bleu.
  • Hot dogs, lunch meats and deli meats should be reheated to steaming hot or 165 degrees.
  • Abide by sell by or use by dates.
  • Avoid buffets, salad bars and self-serve bulk containers.
  • Follow these 4 basic steps to food safety:
    • Clean - Wash your hands well before preparing any food and keep your work area clean.
    • Separate - Don’t cross-contaminate. Keep raw meat and poultry apart from cooked foods.
    • Cook - Use a food thermometer to be sure meat and poultry are safely cooked.
    • Chill - Refrigerate or freeze food promptly.

Every cancer center follows different rules regarding diet restrictions. Be sure to ask your healthcare team for any special instructions. Patients undergoing bone marrow or stem cell transplant typically have stricter dietary restrictions. Remember, this diet is only temporary while your blood counts are low. Learn more from the USDA booklet, Food Safety for People with Cancer.


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