Conference Coverage

Reviews of presentations at professional meetings related to Ewing's sarcoma.
Proton Beam Radiation Therapy Treatment of Pediatric Patients: A 2011 Survey of the U.S. Proton Centers
Presenting Author: A. Chang, MD Presenting Author Affiliation: Hampton University Proton Therapy Institute, Hampton Background Proton beam radiation has unique physical characteristics that allow optimal dose distribution to tumors while ..
High Dose Proton Therapy for Soft Tissue Sarcoma of Trunk Type of Session: Scientific Session
Presenter: Hiroshi Fuji Presenter's Institution: Shizuoka Cancer Center, Japan Background Soft tissue sarcomas are a group of tumors that originate from muscle, fat, and tendons. Soft tissue sarcomas are a ..
Long-Term Follow-Up on Phase II Study of High-Dose Proton/Photon Radiotherapy for Spine Sarcomas
Presenting Author/Institution: Thomas DeLaney, MD/Massachusetts General Hospital Background The primary treatment of tumors of the spine and paraspinal tissues is challenging; surgical resection is the mainstay of treatment but negative ..
Patients Self-Administer Protein in Nose Drops to Treat Kaposi's Sarcoma
An anti-angiogenesis and immune-stimulating protein, delivered via nose drops, has resulted in a complete or major response in more than one-third of patients with late-stage Kaposi's Sarcoma (KS), an AIDS-related ..
The impact of an aggressive local control policy and of adjuvant chemotherapy in primary presentation extremity adult soft-tissue sarcoma in sequential cohorts over 20 years at the Princess Margaret Hospital
Presenter: B. O'Sullivan Affiliation: Princess Margaret Hospital Background: Some controversy remains over the optimal management of adult patients with extremity soft tissue sarcomas. This study was performed to determine the ..
Induction Chemotherapy for High Grade Extremity Soft Tissue Sarcomas: Histologic Response and Correlation of Tumor Necrosis to Long Term Disease Free and Overall Patient Survival
Presenter: R.M. Henshaw Affiliation: Washington Cancer Institute at Washington Hospital Center Background: The role of chemotherapy in soft tissue sarcoma remains controversial. Multiple randomized trials have shown no benefit in ..
Radiation Therapy Oncology Group (RTOG) 95-14; a phase II study of neoadjuvant chemotherapy (CT) and radiation therapy (RT) in high risk (HR), high grade, soft tissue sarcomas (STS) of the extremities and body wall: a preliminary report
Presenter: W.G.Kraybill Affiliation: RTOG Background: Radiation therapy plays a central role in the management of many soft tissue sarcomas and allows for a substantial reduction in the extent of surgical ..
Response to neoadjuvant thermochemotherapy as significant prognosticator for long-term survival of patients with retroperitoneal or visceral high-risk soft-tissue sarcoma
Presenter: C.M.Wendtner Affiliation: Ludwig-Maximilian-University Background: The clinical application of hyperthermia with increase of tissue temperatures (range 40-44 degrees C) has been integrated in multimodal anti- cancer strategies. The combination of ..
Neoadjuvant Chemotherapy and Radiotherapy for Large Extremity Soft Tissue Sarcomas
Presenter: T.F. DeLaney Presenter's Affiliation: Massachusetts General Hospital, Boston, MA Type of Session: Scientific Background The management of extremity soft tissue sarcomas has evolved from amputation to limb sparing surgery ..
Neoadjuvant chemotherapy for primary high grade extremity soft tissue sarcoma: A matched case control study
Presenter: S. R. GrobmyerPresenter's Affiliation: Memorial Sloan-Kettering Cancer Center and Dana-Farber Cancer InstituteType of Session: ScientificBackground The investigation of high grade (HG) extremity soft tissue sarcomas (STS) is often challenging ..
Radiation Therapy Oncology Group (RTOG) 9514: A phase II study of neoadjuvant chemotherapy (CT) and radiation therapy (RT) in the management of high risk (HR), high grade (HG) soft tissue sarcomas (STS) of the extremities and body wall
Presenter: W. G. KraybillPresenter's Affiliation: RTOGType of Session: ScientificBackground The preliminary data from this RTOG phase II trial of neoadjuvant chemotherapy and radiation in high risk soft tissue sarcoma patients ..
Outcome of clear cell sarcoma of the kidney (CCSK) treated on the National Wilms Tumor Study-5 (NWTS)
Presenter: Breslow EJ et al.Presenter's Affiliation: Children's National Medical Center, Washington D.C.Type of Session: ScientificBackground CCSK originally described in early 1970s and characterized by tendency to metastasize to bone as ..
Dactinomycin (A) and vincristine (V) with or without cyclophosphamide (C) and radiation therapy (RT) for newly diagnosed patients with low-risk embryonal/botryoid rhabdomyosarcoma (RMS). An IRS-V report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group (STS COG)
Presenter: Walterhouse JL et al.Presenter's Affiliation: Children's Hospital of Los Angeles, Los Angeles, CAType of Session: ScientificBackground The IRS-III and –IV studies defined 3 risk groups of rhabdomyosarcoma patients: low-risk ..
Patient Summary: Outcome of clear cell sarcoma of the kidney (CCSK) treated on the National Wilms Tumor Study-5 (NWTS)
Outcome of clear cell sarcoma of the kidney (CCSK) treated on the National Wilms Tumor Study-5 (NWTS) Clear cell sarcoma of the kidney was first described in the 1970's and ..
Phase II Study of Proton Radiotherapy for Spine and Paraspinal Sarcoma
Presenter: Thomas F. DelaneyPresenter's Affiliation: Massachusetts General Hospital, Boston, MAType of Session: ScientificBackground Sarcomas located in the spinal axis have a poor prognosis, as local control of the disease is ..
A Comparison of 3-D Conformal Proton Therapy, Intensity Modulated Proton Therapy, and Intensity Modulated Photon Therapy for Retroperitoneal Sarcoma
Presenter: Christine S. ChungPresenter's Affiliation: Harvard Radiation Oncology Program, Boston, MAType of Session: ScientificBackground The treatment of retroperitoneal sarcoma usually involves a combination of surgery and radiotherapy. Post-operative radiotherapy can ..
Percent Necrosis in Extremity Soft Tissue Sarcoma After Preoperative Radiation Alone Versus Preoperative Radiation and Chemotherapy
Presenter: Karl Haglund MD, PhDPresenter's Affiliation: Massachusetts General HospitalType of Session: ScientificBackground Prior studies have found that treatment related necrosis is a prognostic marker in bone sarcomas. Retrospective studies of ..
Inhibition of mTOR Radiosensitizes Soft Tissue Sarcoma and Tumor Vascualture
Presenter: James Murphy, MDPresenter's Affiliation: University of MichiganType of Session: ScientificBackground Rapamycin is an FDA approved immunosuppressant used in organ transplant, especially renal. It was derived from a soil sample from ..
Preliminary Experience with Proton Radiotherapy for Pelvic Bone Sarcomas
Presenter: T. DelaneyPresenter's Affiliation: Massachusetts General HospitalType of Session: ScientificBackground Surgery is commonly used for the definitive treatment of pelvic bone sarcomas. However, acceptable surgical margins are difficult to achieve ..
Proton beam therapy for bone and soft tissue sarcomas: 35-year single institutional retrospective review
Presenter: S. Goldberg Affiliation: Harvard Medical School, Mass General Hospital, Boston, MA Other Authors: A. Agarwal, T. DeLaney, M. Niemerko, A. Niemerko, H. Suit Background Bone and soft tissue extremity ..
Use of Particle Therapy in Treatment of Sarcomas
Presenter: Eugen Hug, M.D.Presenter's Affiliation: Paul Scherrer InstituteType of Session: Scientific Introduction Dr. Eugen Hug initiated his discussion of the indications for particle based radiotherapy in treatment of sarcomas by ..
Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas
Presenter: Dr. Tadashi KamadaPresenter's Affiliation: Research Center for Charged Particle Therapy, Chiba, JapanType of Session: ScientificBackground The results from a phase I/II dose escalation study using carbon ion therapy in ..
Particle Therapy for Sarcomas
Presenter: T. DelaneyPresenter's Affiliation: Massachusetts General Hospital, Boston, MAType of Session: ScientificBackground Sarcomas of bone and soft tissues represent only 1% of adult malignancies. They generally require multidisciplinary treatment, with ..
Particle Therapy for Bone and Soft Tissue Sarcomas: A Retrospective Study
Presenter: Y. Demizu , M. Murakami, D. Miyawaki, M. Mima, K. Terashima, T. Arimura, Y. Niwa, Y. Hishikawa Presenter's Affiliation: Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, JapanType ..
Proton Radiotherapy for Cardiac and Pulmonary Vessel Sarcomas
Presenter: Dr. Yen-Lin Chen Presenter's Affiliation: Massachusetts General Hospital, Radiation Oncology, Boston Background Although cardiac and pulmonary vessel sarcomas are rare, they are not unheard of, and pose significant treatment ..
Long-term Cause-specific Mortality Of Adolescent And Young Adult (AYA) Survivors Of Bone And Soft Tissue Sarcoma (STS): A Population-based Study
Presenting Author: P. Youn Presenter's Affiliation: Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY Background Combined modality therapy has improved outcomes in the treatment ..
Sarcoma: Self-Reported Functional Outcomes and Quality of Life Assessments in Long-Term Survivors of Ewing Sarcoma
Presenting Author: Dr. Bradley Stish Presenting Author Affiliation: Mayo Clinic Ewing sarcoma is a rare soft tissue malignancy that typically affects the bones and soft tissue and is most common ..
Results of a Prospective Study Delivering Limited Margin Radiotherapy for Pediatric Patients with Ewing’s Sarcoma Family of Tumors
Presenter: M.J. KrasinPresenter's Affiliation: St. Jude Children’s Research Hospital, Memphis, TNType of Session: ScientificBackground The Ewing’s sarcoma represents the 2nd most common bone tumor in children, following osteosarcoma. The Ewing’s sarcoma ..
Proton Radiotherapy for Pediatric Ewing's Sarcomas: Initial Clinical Outcomes of 29 Patients
Presenter: B. RombiPresenter's Affiliation: Trento, ItalyType of Session: ScientificBackground Ewing’s sarcoma represents the second most common bone tumor in children; the Ewing’s family of tumors includes osseous Ewing’s sarcoma, extraosseous ..

Expression, Genomic Patterns Predict Sarcoma Progression

Jan 21, 2013 - The Complexity Index in Sarcoma and Genomic Index prognostic signatures are valid independent methods of assessing synovial sarcoma prognosis, according to a study published online Jan. 14 in the Journal of Clinical Oncology.

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