Metoclopramide - oral/ IV / IM (Reglan®)

The oral form of metoclopramide may be taken as a scheduled or as-needed medication. If you are taking a scheduled dose, it should be taken 30 minutes before a meal and again at bedtime. The intravenous form of metoclopramide may be given before a chemotherapy regimen or as needed as an IV push (depending on the dose) or as a short infusion. This medication can also be given as an intramuscular (IM, into a muscle) injection if your provider feels this is necessary.

This medication can be affected by certain foods and medications, so they should be avoided. These include: acetaminophen, anti-Parkinson agents including apomorphine, bromocriptine, levodopa, pramipexole, and ropinirole, antipsychotics/mood medications including aripiprazole, haloperidol, quetiapine and risperidone, anxiolytics, atovaquone, cabergoline, bupropion, cyclosporine, fluoxetine, hypnotics, monoamine oxidase inhibitors including linezolid and rasagiline, promethazine, rivastigmine, paroxetine, quinidine, opiates, and sedatives, among others. Be sure to tell your healthcare provider about all medications and supplements you take.

This medication can make you dizzy or sleepy. You should not drink alcohol while taking this medication. You should not drive a car or operate heavy machinery until you know how this medication affects you.

Storage and Handling

For oral (by mouth) administration, store this medication in the original container. Tablets should be stored at room temperature. Keep this medication out of reach of children and pets.

Where do I get this medication?

This medication in the oral form is available through retail/mail order pharmacy. Your oncology team will work with your prescription drug plan to identify an in-network retail/mail order pharmacy for medication distribution. You can work with your provider’s office if this medication needs prior authorization. The intravenous or intramuscular form would be provided to you in a healthcare setting as ordered by your medical team.

Possible Side Effects

This medication is given to manage and/or prevent the side effects of your cancer treatment. If you are having side effects from this medication you should talk to your team about if this medication is necessary to your treatment or if there are other options to help manage the side effect this medication is treating. These are some of the most common side effects:

Fatigue & Drowsiness

This medication, depending on your dose and how often you use it, may make you feel sleepy and tired. Please do not drive or operate heavy machinery until you know how this medication affects your ability to do these activities. Additionally, fatigue is very common during cancer treatment and is an overwhelming feeling of exhaustion that is not usually relieved by rest. While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue. Plan times to rest during the day and conserve energy for more important activities. Exercise can help combat fatigue; a simple daily walk with a friend can help. Talk to your oncology care team for helpful tips on dealing with this side effect.

Reproductive Concerns

You should consult with your provider before becoming pregnant or fathering a child while on this medication. You should consult with your healthcare team before breastfeeding while receiving this medication because fetal risk cannot be ruled out in these situations. Risk versus benefits should be weighed and discussed with your healthcare team.