Pazopanib (Votrient®)
Pazopanib is a type of targeted therapy called a tyrosine kinase inhibitor. A kinase is an enzyme that promotes cell growth. There are many types of kinases, which control different phases of cell growth. By blocking a particular enzyme from working, this medication can slow the growth of cancer cells.
Pazopanib is a tyrosine kinase inhibitor that blocks a few targets including VEGF, PDFR, FGFR, cKIT, IL-2, LcK and c-Fms. This means it works by targeting receptors present on the cancer cells. By blocking these targets on cancer cells, tumor growth and angiogenesis (the development of a blood supply to the tumor) are blocked.