Pralatrexate is a specific antimetabolite, called an antifolate, designed to accumulate in cancer cells. Antifolates mimic the structure of naturally occurring molecules involved in DNA synthesis. Cancer cells mistake antimetabolites for normal metabolites allowing the compound to stop or slow critical enzymes involved in DNA synthesis, which then triggers cell death.
Mechlorethamine topical formulation is used in the treatment of mycosis fungoides type cutaneous t-cell lymphoma (MF-CTCL). Mechlorethamine kills cancer cells through a process called alkylation. It used to be called nitrogen mustard, and you may still hear it called this. Alkylation damages the DNA of cells, which prevents them from dividing, and causes them to die.
Monoclonal antibodies are created in a lab to attach to the targets found on specific types of cancer cells. The antibody “calls” the immune system to attack the cell it is attached to, resulting in the immune system killing the cell. These antibodies can work in different ways, including stimulating the immune system to kill the cell, blocking cell growth or other functions necessary for cell growth. Mogamulizumab-kpkc is a CC chemokine receptor type 4 directed monoclonal antibody.
An overview of staging and treatment options for cutaneous T-cell lymphoma (CTCL).