Mitoxantrone

Mitoxantrone is a Topoisomerase II Inhibitor/Anthracenedione. This medication works in two ways. The first is by blocking the action of an enzyme in cells called topoisomerase. Topoisomerase is needed for cell replication and tumor growth. Cells need this enzyme to divide. Blocking this enzyme causes cell death.

This medication also works like an anthracycline. Anthracyclines work by stopping or slowing how the cell’s DNA is copied, which is needed for cancer cell growth. This causes the cancer cells to die, slowing or stopping tumor growth.