Using Domeboro Solution for Radiation Therapy Skin Reactions

Radiation therapy treatments can cause skin changes or reactions in the area being treated with radiation. These skin reactions can cause dry and red skin or a moist reaction. 

• The first layer of skin, called the epidermis, sheds (comes off) during a reaction, causing dry or red skin. 
• The second layer of skin, or the dermis, is moist (wet). 

When the epidermis sheds, the dermis is exposed, causing the skin to weep (leak fluid). Your radiation team may suggest the following skincare routine to protect this layer of skin and help with healing.

Using Domeboro Solution as a Wet Compress

Domeboro solution is medicated to help your skin heal. Follow these steps to perform a Domeboro compress or wet dressing:

1. Dissolve 1 packet in 2 cups (1 pint/16 oz/500 ml) of cool or warm water and shake or stir until fully dissolved. Tap water is fine to use.
2. Moisten a soft, clean cloth or gauze pad in the solution.
3. Apply to affected skin. DO NOT RUB. Lay the cloth or gauze on the skin for 15 to 30 minutes and remove.
4. Allow skin to air dry. Once dry, apply Aquaphor or other lotion to the skin.

Repeat the soaks 3 to 4 times per day. Discard or throw away any unused solution that you may have left over after each application.