Using Domeboro Solution for Radiation Therapy Skin Reactions

Author: OncoLink Team
Content Contributor: Abigail F. Neff BSN, RN, OCN
Last Reviewed: July 23, 2023

Radiation treatments can cause skin changes or reactions in the area being treated with radiation. These skin reactions can cause dry and red skin or a moist reaction. The first layer of skin, called the epidermis, sheds (comes off) during a reaction causing dry or red skin. The second layer of skin, or the dermis, is moist. When the epidermis is shed, the dermis is exposed and it causes weeping. To protect this layer of skin and improve healing, your radiation team may suggest the following skincare routine.

Using Domeboro Solution as a Wet Compress

Domeboro solution is medicated to help your skin heal. Follow these steps to perform a Domeboro compress or wet dressing.

Step 1: Dissolve 1 packet in 1 pint (16 oz / 500 ml) of water and shake or stir until fully dissolved. Tap water is fine to use!

Step 2: Moisten a soft, clean cloth or gauze pad in the solution.

Step 3: Apply to affected skin. DO NOT RUB. Lay the cloth or gauze on the skin for 15-30 minutes and remove.

Step 4: Allow skin to air dry. Once dry, apply Aquaphor or other lotion to the skin.

Repeat the soaks 3-4 times per day. You may store and use the remaining solution for up to 7 days.


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